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Aliases for GOT2 Gene

Aliases for GOT2 Gene

  • Glutamic-Oxaloacetic Transaminase 2 2 3 5
  • Kynurenine Aminotransferase IV 2 3 4
  • Glutamic-Oxaloacetic Transaminase 2, Mitochondrial (Aspartate Aminotransferase 2) 2 3
  • Plasma Membrane-Associated Fatty Acid-Binding Protein 3 4
  • Kynurenine--Oxoglutarate Transaminase IV 3 4
  • Kynurenine--Oxoglutarate Transaminase 4 3 4
  • Glutamate Oxaloacetate Transaminase 2 3 4
  • Kynurenine Aminotransferase 4 3 4
  • Aspartate Aminotransferase 2 2 3
  • Fatty Acid-Binding Protein 3 4
  • Aspartate Transaminase 2 2 3
  • Transaminase A 3 4
  • EC 2.6.1.1 4 63
  • FABP-1 3 4
  • FABPpm 3 4
  • MAspAT 3 4
  • Glutamic-Oxaloacetic Transaminase 2, Mitochondrial 2
  • EC 2.6.1.7 4
  • EC 2.6.1 63
  • MitAAT 3
  • KATIV 3
  • KYAT4 3
  • KAT4 3

External Ids for GOT2 Gene

Previous GeneCards Identifiers for GOT2 Gene

  • GC16M049137
  • GC16M058827
  • GC16M058475
  • GC16M058516
  • GC16M057298
  • GC16M058741
  • GC16M044606

Summaries for GOT2 Gene

Entrez Gene Summary for GOT2 Gene

  • Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneCards Summary for GOT2 Gene

GOT2 (Glutamic-Oxaloacetic Transaminase 2) is a Protein Coding gene. Diseases associated with GOT2 include localized pulmonary fibrosis and oculoglandular tularemia. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include poly(A) RNA binding and kynurenine-oxoglutarate transaminase activity. An important paralog of this gene is GOT1.

UniProtKB/Swiss-Prot for GOT2 Gene

  • Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Gene Wiki entry for GOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOT2 Gene

Genomics for GOT2 Gene

Regulatory Elements for GOT2 Gene

Promoters for GOT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GOT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GOT2 Gene

Chromosome:
16
Start:
58,707,131 bp from pter
End:
58,734,357 bp from pter
Size:
27,227 bases
Orientation:
Minus strand

Genomic View for GOT2 Gene

Genes around GOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOT2 Gene

Proteins for GOT2 Gene

  • Protein details for GOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00505-AATM_HUMAN
    Recommended name:
    Aspartate aminotransferase, mitochondrial
    Protein Accession:
    P00505
    Secondary Accessions:
    • B4DJA6
    • E7ERW2
    • Q53FL3
    • Q9BWA3

    Protein attributes for GOT2 Gene

    Size:
    430 amino acids
    Molecular mass:
    47518 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

    Alternative splice isoforms for GOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOT2 Gene

Proteomics data for GOT2 Gene at MOPED

Post-translational modifications for GOT2 Gene

  • Ubiquitination at Lys 396
  • Modification sites at PhosphoSitePlus

Other Protein References for GOT2 Gene

Antibody Products

Domains & Families for GOT2 Gene

Graphical View of Domain Structure for InterPro Entry

P00505

UniProtKB/Swiss-Prot:

AATM_HUMAN :
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with GOT2: view

No data available for Gene Families for GOT2 Gene

Function for GOT2 Gene

Molecular function for GOT2 Gene

GENATLAS Biochemistry:
glutamic-oxaloacetic transaminase 2,mitochondrial (aspartate aminotransferase 1)
UniProtKB/Swiss-Prot CatalyticActivity:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
UniProtKB/Swiss-Prot Induction:
Up-regulated by long-time exposure to alcohol.

Enzyme Numbers (IUBMB) for GOT2 Gene

Gene Ontology (GO) - Molecular Function for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016212 kynurenine-oxoglutarate transaminase activity IEA --
GO:0030170 pyridoxal phosphate binding IEA,IBA --
GO:0042802 identical protein binding IBA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with GOT2: view
genes like me logo Genes that share phenotypes with GOT2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOT2 Gene

Localization for GOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOT2 Gene

Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOT2 Gene COMPARTMENTS Subcellular localization image for GOT2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
plasma membrane 5
cytosol 3
peroxisome 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
nucleus 2
vacuole 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005886 plasma membrane IDA 9537447
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with GOT2: view

Pathways & Interactions for GOT2 Gene

genes like me logo Genes that share pathways with GOT2: view

Gene Ontology (GO) - Biological Process for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006107 oxaloacetate metabolic process IEA --
GO:0006531 aspartate metabolic process ISS --
GO:0006532 aspartate biosynthetic process IEA --
GO:0006536 glutamate metabolic process ISS --
GO:0008652 cellular amino acid biosynthetic process TAS --
genes like me logo Genes that share ontologies with GOT2: view

No data available for SIGNOR curated interactions for GOT2 Gene

Drugs & Compounds for GOT2 Gene

(11) Drugs for GOT2 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Aspartic acid Approved Nutra Target NMDA agonist 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 57
L-Cysteine Approved Nutra 0
L-Phenylalanine Approved Nutra 0
L-Tyrosine Approved Nutra 0

(12) Additional Compounds for GOT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
2464-23-5
3-Sulfinylpyruvic acid
  • 3-Sulfinopyruvate
  • 3-Sulfinyl-pyruvate
  • 3-Sulfinylpyruvate
  • 3-Sulphinyl-pyruvate
  • beta-Sulfinylpyruvate
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoate
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxobutanoate
  • 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
4-Hydroxy-L-glutamic acid
  • (2S)-2-amino-4-hydroxypentanedioate
  • (2S)-2-amino-4-hydroxypentanedioic acid
  • 4-Hydroxy-L-glutamate
  • 4-Hydroxy-L-glutamic acid
  • Erythro-4-hydroxyglutamate
2485-33-8
4-Hydroxyphenylpyruvic acid
  • (p-hydroxyphenyl)-Pyruvate
  • (p-hydroxyphenyl)-Pyruvic acid
  • (p-Hydroxyphenyl)pyruvate
  • (p-Hydroxyphenyl)pyruvic acid
  • 3-(4-Hydroxyphenyl)-2-oxo-propanoate
156-39-8
genes like me logo Genes that share compounds with GOT2: view

Transcripts for GOT2 Gene

Unigene Clusters for GOT2 Gene

Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6: - - -
SP7:

Relevant External Links for GOT2 Gene

GeneLoc Exon Structure for
GOT2
ECgene alternative splicing isoforms for
GOT2

Expression for GOT2 Gene

mRNA expression in normal human tissues for GOT2 Gene

mRNA differential expression in normal tissues according to GTEx for GOT2 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.1) and Muscle - Skeletal (x5.5).

Protein differential expression in normal tissues from HIPED for GOT2 Gene

This gene is overexpressed in Liver, secretome (20.2) and Heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOT2 Gene



SOURCE GeneReport for Unigene cluster for GOT2 Gene Hs.599470

genes like me logo Genes that share expression patterns with GOT2: view

Protein tissue co-expression partners for GOT2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GOT2 Gene

Orthologs for GOT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOT2 36
  • 100 (a)
OneToOne
GOT2 35
  • 99.38 (n)
  • 99.77 (a)
cow
(Bos Taurus)
Mammalia GOT2 35
  • 90 (n)
  • 93.02 (a)
GOT2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToMany
GOT2 35
  • 90.78 (n)
  • 93.95 (a)
mouse
(Mus musculus)
Mammalia Got2 16
Got2 36
  • 95 (a)
OneToOne
Got2 35
  • 88.76 (n)
  • 94.65 (a)
oppossum
(Monodelphis domestica)
Mammalia GOT2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOT2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Got2 35
  • 88.29 (n)
  • 94.65 (a)
chicken
(Gallus gallus)
Aves GOT2 35
  • 78.15 (n)
  • 85.04 (a)
GOT2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOT2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia got2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia got2 35
  • 72.68 (n)
  • 82.67 (a)
Str.1247 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9809 35
zebrafish
(Danio rerio)
Actinopterygii got2a 36
  • 79 (a)
OneToMany
got2b 36
  • 77 (a)
OneToMany
got2a 35
  • 72.35 (n)
  • 79.21 (a)
wufb64g01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009685 35
  • 64.33 (n)
  • 68.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4233 37
  • 63 (a)
CG8430 37
  • 48 (a)
Got2 35
  • 62.94 (n)
  • 63.11 (a)
Got2 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea got-2.2 35
  • 64.15 (n)
  • 70.35 (a)
C44E4.3 37
  • 58 (a)
T01C8.4 37
  • 36 (a)
got-2.1 36
  • 61 (a)
OneToMany
got-2.2 36
  • 67 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAT2 36
  • 43 (a)
OneToMany
AAT1 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3126 35
soybean
(Glycine max)
eudicotyledons Gma.1611 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ASP1 35
  • 58.94 (n)
  • 57.43 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.7187 35
rice
(Oryza sativa)
Liliopsida Os.4772 35
Os02g0236000 35
  • 58.04 (n)
  • 56.6 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5314 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08411 35
  • 61.05 (n)
  • 64.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC725.01 35
  • 58.14 (n)
  • 55.7 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14130 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToOne
Species with no ortholog for GOT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GOT2 Gene

ENSEMBL:
Gene Tree for GOT2 (if available)
TreeFam:
Gene Tree for GOT2 (if available)

Paralogs for GOT2 Gene

Paralogs for GOT2 Gene

(3) SIMAP similar genes for GOT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GOT2: view

Variants for GOT2 Gene

Sequence variations from dbSNP and Humsavar for GOT2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11076256 - 58,718,562(-) CTTGC(A/G)GTTTT reference, missense
rs30842 - 58,709,550(-) GAAAG(G/T)CATGG reference, missense
rs17849335 - 58,708,181(+) TGGTG(A/G)CCTGG reference, missense
rs11558171 - 58,734,225(-) CCATG(G/T)CCCTG reference, missense
rs30841 -- 58,709,819(-) gaaaa(A/G)ttgta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOT2 Gene

Variant ID Type Subtype PubMed ID
dgv893e1 CNV Complex 17122850
nsv511049 CNV Complex 20534489
nsv509623 CNV Insertion 20534489
nsv510686 CNV Loss 20534489
esv2714558 CNV Deletion 23290073
esv1039184 CNV Deletion 17803354
nsv1817 CNV Insertion 18451855

Variation tolerance for GOT2 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOT2 Gene

HapMap Linkage Disequilibrium report
GOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOT2 Gene

Disorders for GOT2 Gene

MalaCards: The human disease database

(36) MalaCards diseases for GOT2 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search GOT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GOT2

Genetic Association Database (GAD)
GOT2
Human Genome Epidemiology (HuGE) Navigator
GOT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOT2
genes like me logo Genes that share disorders with GOT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOT2 Gene

Publications for GOT2 Gene

  1. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. (PMID: 21223598) Wineinger N.E. … Tiwari H.K. (BMC Med Genomics 2011) 3 48 67
  2. Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. (PMID: 17442055) Guidetti P. … Schwarcz R. (J. Neurochem. 2007) 2 3
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26

Products for GOT2 Gene

Sources for GOT2 Gene

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