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Aliases for GOT2 Gene

Aliases for GOT2 Gene

  • Glutamic-Oxaloacetic Transaminase 2, Mitochondrial 2 3
  • Kynurenine Aminotransferase IV 2 3 4
  • Glutamic-Oxaloacetic Transaminase 2, Mitochondrial (Aspartate Aminotransferase 2) 2 3
  • Plasma Membrane-Associated Fatty Acid-Binding Protein 3 4
  • Kynurenine--Oxoglutarate Transaminase IV 3 4
  • Kynurenine--Oxoglutarate Transaminase 4 3 4
  • Glutamate Oxaloacetate Transaminase 2 3 4
  • Kynurenine Aminotransferase 4 3 4
  • Aspartate Aminotransferase 2 2 3
  • Fatty Acid-Binding Protein 3 4
  • Aspartate Transaminase 2 2 3
  • Transaminase A 3 4
  • EC 2.6.1.1 4 63
  • FABP-1 3 4
  • FABPpm 3 4
  • MAspAT 3 4
  • Aspartate Aminotransferase, Mitochondrial 3
  • EC 2.6.1.7 4
  • EC 2.6.1 63
  • MitAAT 3
  • KATIV 3
  • KAT4 3

External Ids for GOT2 Gene

Previous GeneCards Identifiers for GOT2 Gene

  • GC16M049137
  • GC16M058827
  • GC16M058475
  • GC16M058516
  • GC16M057298
  • GC16M058741
  • GC16M044606

Summaries for GOT2 Gene

Entrez Gene Summary for GOT2 Gene

  • Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneCards Summary for GOT2 Gene

GOT2 (Glutamic-Oxaloacetic Transaminase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with GOT2 include reye syndrome and fascioliasis. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include pyridoxal phosphate binding and L-phenylalanine:2-oxoglutarate aminotransferase activity. An important paralog of this gene is GOT1.

UniProtKB/Swiss-Prot for GOT2 Gene

  • Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Gene Wiki entry for GOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOT2 Gene

Genomics for GOT2 Gene

Genomic Location for GOT2 Gene

Start:
58,707,131 bp from pter
End:
58,734,357 bp from pter
Size:
27,227 bases
Orientation:
Minus strand

Genomic View for GOT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOT2 Gene

Proteins for GOT2 Gene

  • Protein details for GOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00505-AATM_HUMAN
    Recommended name:
    Aspartate aminotransferase, mitochondrial
    Protein Accession:
    P00505
    Secondary Accessions:
    • B4DJA6
    • E7ERW2
    • Q53FL3
    • Q9BWA3

    Protein attributes for GOT2 Gene

    Size:
    430 amino acids
    Molecular mass:
    47518 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer
    Miscellaneous:
    • In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes

    Alternative splice isoforms for GOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOT2 Gene

Proteomics data for GOT2 Gene at MOPED

Post-translational modifications for GOT2 Gene

  • Ubiquitination at Lys122 and Lys396
  • Modification sites at PhosphoSitePlus

Other Protein References for GOT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GOT2 Gene

Graphical View of Domain Structure for InterPro Entry

P00505

UniProtKB/Swiss-Prot:

AATM_HUMAN :
  • P00505
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with GOT2: view

No data available for Gene Families for GOT2 Gene

Function for GOT2 Gene

Molecular function for GOT2 Gene

GENATLAS Biochemistry: glutamic-oxaloacetic transaminase 2,mitochondrial (aspartate aminotransferase 1)
UniProtKB/Swiss-Prot CatalyticActivity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
UniProtKB/Swiss-Prot CatalyticActivity: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
UniProtKB/Swiss-Prot Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
UniProtKB/Swiss-Prot Induction: Up-regulated by long-time exposure to alcohol.

Enzyme Numbers (IUBMB) for GOT2 Gene

Gene Ontology (GO) - Molecular Function for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity ISS --
GO:0016212 kynurenine-oxoglutarate transaminase activity IEA --
GO:0030170 pyridoxal phosphate binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity IEA --
genes like me logo Genes that share ontologies with GOT2: view

Phenotypes for GOT2 Gene

GenomeRNAi human phenotypes for GOT2:
genes like me logo Genes that share phenotypes with GOT2: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GOT2 Gene

Localization for GOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOT2 Gene

Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOT2 Gene COMPARTMENTS Subcellular localization image for GOT2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 5
cytosol 3
extracellular 3
peroxisome 3
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
vacuole 1

Gene Ontology (GO) - Cellular Components for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005886 plasma membrane IDA 9537447
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with GOT2: view

Pathways for GOT2 Gene

genes like me logo Genes that share pathways with GOT2: view

Gene Ontology (GO) - Biological Process for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
GO:0006103 2-oxoglutarate metabolic process ISS --
GO:0006107 oxaloacetate metabolic process IEA --
genes like me logo Genes that share ontologies with GOT2: view

Compounds for GOT2 Gene

(16) HMDB Compounds for GOT2 Gene

Compound Synonyms Cas Number PubMed IDs
3-Mercaptopyruvic acid
  • 3-Mercaptopyruvate
2464-23-5
3-Sulfinoalanine
  • 3-Sulphino-L-alanine
1115-65-7
3-Sulfinylpyruvic acid
  • 3-Sulfinopyruvate
Not Available
3-Sulfopyruvic acid
  • 3-sulfopyruvate
98022-26-5
4-Hydroxyphenylpyruvic acid
  • (p-Hydroxyphenyl)pyruvate
156-39-8

(4) Drugbank Compounds for GOT2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
target
L-Aspartic Acid
  • (+)-Aspartic acid
56-84-8 target
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target cofactor
genes like me logo Genes that share compounds with GOT2: view

Transcripts for GOT2 Gene

Unigene Clusters for GOT2 Gene

Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6: - - -
SP7:

Relevant External Links for GOT2 Gene

GeneLoc Exon Structure for
GOT2
ECgene alternative splicing isoforms for
GOT2

Expression for GOT2 Gene

mRNA expression in normal human tissues for GOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GOT2 Gene

This gene is overexpressed in Heart - Left Ventricle (6.1) and Muscle - Skeletal (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOT2 Gene

SOURCE GeneReport for Unigene cluster for GOT2 Gene Hs.599470

genes like me logo Genes that share expressions with GOT2: view

No data available for mRNA Expression by UniProt/SwissProt for GOT2 Gene

Orthologs for GOT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOT2 35
  • 99.38 (n)
  • 99.77 (a)
GOT2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GOT2 35
  • 90 (n)
  • 93.02 (a)
GOT2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToMany
GOT2 35
  • 90.78 (n)
  • 93.95 (a)
mouse
(Mus musculus)
Mammalia Got2 35
  • 88.76 (n)
  • 94.65 (a)
Got2 16
Got2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GOT2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOT2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Got2 35
  • 88.29 (n)
  • 94.65 (a)
chicken
(Gallus gallus)
Aves GOT2 35
  • 78.15 (n)
  • 85.04 (a)
GOT2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOT2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia got2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia got2 35
  • 72.68 (n)
  • 82.67 (a)
Str.1247 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9809 35
zebrafish
(Danio rerio)
Actinopterygii got2a 35
  • 72.35 (n)
  • 79.21 (a)
got2a 36
  • 79 (a)
OneToMany
got2b 36
  • 77 (a)
OneToMany
wufb64g01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009685 35
  • 64.33 (n)
  • 68.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Got2 35
  • 62.94 (n)
  • 63.11 (a)
Got2 36
  • 60 (a)
OneToOne
CG8430 37
  • 48 (a)
CG4233 37
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea got-2.1 36
  • 61 (a)
OneToMany
got-2.2 35
  • 64.15 (n)
  • 70.35 (a)
got-2.2 36
  • 67 (a)
OneToMany
T01C8.4 37
  • 36 (a)
C44E4.3 37
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAT1 38
AAT2 36
  • 43 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3126 35
soybean
(Glycine max)
eudicotyledons Gma.1611 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ASP1 35
  • 58.94 (n)
  • 57.43 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.7187 35
rice
(Oryza sativa)
Liliopsida Os.4772 35
Os02g0236000 35
  • 58.04 (n)
  • 56.6 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5314 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08411 35
  • 61.05 (n)
  • 64.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC725.01 35
  • 58.14 (n)
  • 55.7 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14130 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToOne
Species with no ortholog for GOT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GOT2 Gene

ENSEMBL:
Gene Tree for GOT2 (if available)
TreeFam:
Gene Tree for GOT2 (if available)

Paralogs for GOT2 Gene

Paralogs for GOT2 Gene

Selected SIMAP similar genes for GOT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GOT2: view

Variants for GOT2 Gene

Sequence variations from dbSNP and Humsavar for GOT2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs6993 -- 58,707,463(-) GATGC(C/T)GTACC utr-variant-3-prime
rs14221 -- 58,723,764(+) GGCAG(A/C/G)ACGTA synonymous-codon, reference
rs30834 -- 58,715,394(-) AATTG(A/G/T)TATTT intron-variant
rs30835 -- 58,714,117(-) accag(C/G)ctggg intron-variant
rs30836 -- 58,712,354(-) CTGTA(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOT2 Gene

Variant ID Type Subtype PubMed ID
dgv893e1 CNV Complex 17122850
nsv511049 CNV Complex 20534489
nsv509623 CNV Insertion 20534489
nsv510686 CNV Loss 20534489
esv2714558 CNV Deletion 23290073
esv1039184 CNV Deletion 17803354
nsv1817 CNV Insertion 18451855

Relevant External Links for GOT2 Gene

HapMap Linkage Disequilibrium report
GOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOT2 Gene

Disorders for GOT2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for GOT2 Gene including...

Search for GOT2 Gene in MalaCards »

Relevant External Links for GOT2

Genetic Association Database (GAD)
GOT2
Human Genome Epidemiology (HuGE) Navigator
GOT2
genes like me logo Genes that share disorders with GOT2: view

No data available for UniProtKB/Swiss-Prot for GOT2 Gene

Publications for GOT2 Gene

  1. The primary structure of mitochondrial aspartate aminotransferase from human heart. (PMID: 4052435) Martini F. … Bossa F. (Biochim. Biophys. Acta 1985) 3 4
  2. Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA. (PMID: 3207426) Pol S. … Barouki R. (Biochem. Biophys. Res. Commun. 1988) 3 4
  3. Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells. (PMID: 9537447) Zhou S.L. … Berk P.D. (Hepatology 1998) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GOT2 Gene

Sources for GOT2 Gene

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