Aliases for GOT1 Gene
External Ids for GOT1 Gene
Previous GeneCards Identifiers for GOT1 Gene
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
GeneCards Summary for GOT1 Gene
GOT1 (Glutamic-Oxaloacetic Transaminase 1, Soluble) is a Protein Coding gene. Diseases associated with GOT1 include aspartate aminotransferase, serum level of, qtl1 and oculoglandular tularemia. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include pyridoxal phosphate binding and carboxylic acid binding. An important paralog of this gene is GOT1L1.
UniProtKB/Swiss-Prot for GOT1 Gene
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.