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Aliases for GOLGA2 Gene

Aliases for GOLGA2 Gene

  • Golgin A2 2 3
  • Golgi Autoantigen, Golgin Subfamily A, 2 2 3
  • 130 KDa Cis-Golgi Matrix Protein 3 4
  • Golgi Matrix Protein GM130 2 3
  • GM130 Autoantigen 3 4
  • SY11 Protein 2 3
  • Golgin-95 3 4
  • GM130 3 4
  • Golgin Subfamily A Member 2 3

External Ids for GOLGA2 Gene

Previous GeneCards Identifiers for GOLGA2 Gene

  • GC09M122134
  • GC09M122665
  • GC09M124471
  • GC09M126394
  • GC09M128097
  • GC09M130057
  • GC09M131018
  • GC09M100631

Summaries for GOLGA2 Gene

Entrez Gene Summary for GOLGA2 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]

GeneCards Summary for GOLGA2 Gene

GOLGA2 (Golgin A2) is a Protein Coding gene. Diseases associated with GOLGA2 include mucopolysaccharidosis iii. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. An important paralog of this gene is GOLGA6B.

UniProtKB/Swiss-Prot for GOLGA2 Gene

  • Golgi auto-antigen; probably involved in maintaining cis-Golgi structure

Gene Wiki entry for GOLGA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA2 Gene

Genomics for GOLGA2 Gene

Regulatory Elements for GOLGA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GOLGA2 Gene

Start:
128,255,829 bp from pter
End:
128,276,007 bp from pter
Size:
20,179 bases
Orientation:
Minus strand

Genomic View for GOLGA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOLGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA2 Gene

Proteins for GOLGA2 Gene

  • Protein details for GOLGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08379-GOGA2_HUMAN
    Recommended name:
    Golgin subfamily A member 2
    Protein Accession:
    Q08379
    Secondary Accessions:
    • Q6GRM9
    • Q9BRB0
    • Q9NYF9

    Protein attributes for GOLGA2 Gene

    Size:
    1002 amino acids
    Molecular mass:
    113086 Da
    Quaternary structure:
    • Part of a larger oligomeric complex. Interacts with p115 (By similarity). Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1.
    SequenceCaution:
    • Sequence=AAH69268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP35912.1; Type=Miscellaneous discrepancy; Note=Sequence differs from that shown after position 826 due to an internal deletion.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA2 Gene

Proteomics data for GOLGA2 Gene at MOPED

Post-translational modifications for GOLGA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA2 Gene

Antibody Products

  • R&D Systems Antibodies for GOLGA2 (GM130/GOLGA2)
  • Cell Signaling Technology (CST) Antibodies for GOLGA2 (GM130)

No data available for DME Specific Peptides for GOLGA2 Gene

Domains for GOLGA2 Gene

Protein Domains for GOLGA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q08379

UniProtKB/Swiss-Prot:

GOGA2_HUMAN :
  • Q08379
Domain:
  • Extended rod-like protein with coiled-coil domains
Family:
  • Belongs to the GOLGA2 family.
genes like me logo Genes that share domains with GOLGA2: view

No data available for Gene Families for GOLGA2 Gene

Function for GOLGA2 Gene

Molecular function for GOLGA2 Gene

UniProtKB/Swiss-Prot Function: Golgi auto-antigen; probably involved in maintaining cis-Golgi structure

Gene Ontology (GO) - Molecular Function for GOLGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15037601
GO:0019901 protein kinase binding IPI 20332113
GO:0019905 syntaxin binding IPI 18167358
GO:0051082 unfolded protein binding --
genes like me logo Genes that share ontologies with GOLGA2: view

Animal Model Products

CRISPR Products

miRNA for GOLGA2 Gene

miRTarBase miRNAs that target GOLGA2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GOLGA2 Gene

Localization for GOLGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA2 Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLGA2 Gene COMPARTMENTS Subcellular localization image for GOLGA2 gene
Compartment Confidence
golgi apparatus 5
nucleus 3
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GOLGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IDA 17488291
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IDA 18166528
genes like me logo Genes that share ontologies with GOLGA2: view

Pathways for GOLGA2 Gene

genes like me logo Genes that share pathways with GOLGA2: view

Pathways by source for GOLGA2 Gene

1 Cell Signaling Technology pathway for GOLGA2 Gene
1 BioSystems pathway for GOLGA2 Gene

Gene Ontology (GO) - Biological Process for GOLGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007021 tubulin complex assembly --
GO:0032091 negative regulation of protein binding IDA 18167358
genes like me logo Genes that share ontologies with GOLGA2: view

Compounds for GOLGA2 Gene

(1) HMDB Compounds for GOLGA2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GOLGA2: view

Transcripts for GOLGA2 Gene

Unigene Clusters for GOLGA2 Gene

Golgin A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GOLGA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20 ^
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GOLGA2 Gene

GeneLoc Exon Structure for
GOLGA2
ECgene alternative splicing isoforms for
GOLGA2

Expression for GOLGA2 Gene

mRNA expression in normal human tissues for GOLGA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLGA2 Gene

SOURCE GeneReport for Unigene cluster for GOLGA2 Gene Hs.155827

genes like me logo Genes that share expressions with GOLGA2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GOLGA2 Gene

Orthologs for GOLGA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA2 35
  • 99.57 (n)
  • 99.3 (a)
GOLGA2 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
OneToMany
GOLGA2 35
  • 80.1 (n)
  • 76.02 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
OneToMany
GOLGA2 35
  • 81 (n)
  • 76.04 (a)
mouse
(Mus musculus)
Mammalia Golga2 35
  • 79.29 (n)
  • 76.35 (a)
Golga2 16
Golga2 36
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Golga2 35
  • 79.45 (n)
  • 76.81 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
GOLGA2 35
  • 64.83 (n)
  • 61.25 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.28684 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492442 35
  • 62.54 (n)
  • 58.38 (a)
zebrafish
(Danio rerio)
Actinopterygii golga2 35
  • 59.56 (n)
  • 52 (a)
golga2 36
  • 46 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011337 35
  • 46 (n)
  • 30.35 (a)
Species with no ortholog for GOLGA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA2 Gene

ENSEMBL:
Gene Tree for GOLGA2 (if available)
TreeFam:
Gene Tree for GOLGA2 (if available)

Paralogs for GOLGA2 Gene

genes like me logo Genes that share paralogs with GOLGA2: view

Variants for GOLGA2 Gene

Sequence variations from dbSNP and Humsavar for GOLGA2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs4734 -- 128,256,360(-) TAGCA(A/C)ATAAG utr-variant-3-prime
rs1046074 -- 128,255,904(-) CGGGG(A/G)TGGGG utr-variant-3-prime
rs2006280 -- 128,256,404(-) CATGT(C/G)CCTGC utr-variant-3-prime
rs2240961 - 128,257,459(-) ATGGC(A/G)GATTC reference, missense
rs2416982 -- 128,269,960(-) CAGTT(G/T)TAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA2 Gene

Variant ID Type Subtype PubMed ID
nsv893891 CNV Loss 21882294
dgv8294n71 CNV Loss 21882294
nsv893896 CNV Loss 21882294
nsv831728 CNV Loss 17160897

Relevant External Links for GOLGA2 Gene

HapMap Linkage Disequilibrium report
GOLGA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA2 Gene

Disorders for GOLGA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GOLGA2 Gene including...

Search for GOLGA2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GOLGA2 Gene

Relevant External Links for GOLGA2

Human Genome Epidemiology (HuGE) Navigator
GOLGA2
genes like me logo Genes that share disorders with GOLGA2: view

No data available for UniProtKB/Swiss-Prot for GOLGA2 Gene

Publications for GOLGA2 Gene

  1. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. (PMID: 8315394) Fritzler M.J. … Chan E.K.L. (J. Exp. Med. 1993) 2 3 4 23
  2. The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b. (PMID: 11306556) Weide T. … Barnekow A. (EMBO Rep. 2001) 3 4 23
  3. Human golgin-95 gene (GOLGA2). Map position 9q32-34.1. (PMID: 10560974) Bouchireb N. … Clark M.S. (Chromosome Res. 1999) 3 23
  4. Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus. (PMID: 10744704) Linstedt A.D. … Sztul E. (J. Biol. Chem. 2000) 3 23
  5. The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130. (PMID: 10769027) Lowe M. … Warren G. (J. Cell Biol. 2000) 3 23

Products for GOLGA2 Gene

  • antibodies-online proteins for GOLGA2
  • antibodies-online antibodies for GOLGA2
  • antibodies-online kits for GOLGA2

Sources for GOLGA2 Gene

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