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Aliases for AMY2B Gene

Aliases for AMY2B Gene

  • Amylase, Alpha 2B (Pancreatic) 2 3
  • 1,4-Alpha-D-Glucan Glucanohydrolase 2B 3 4
  • Carcinoid Alpha-Amylase 3 4
  • EC 4 63
  • Amylase, Alpha 2B; Pancreatic 2
  • Alpha-Amylase 2B 3
  • Glycogenase 3
  • AMY3 3
  • AMY2 3
  • HXA 3

External Ids for AMY2B Gene

Previous HGNC Symbols for AMY2B Gene

  • AMY2

Previous GeneCards Identifiers for AMY2B Gene

  • GC01P104761
  • GC01P103104
  • GC01P103251
  • GC01P103424
  • GC01P103426
  • GC01P103781
  • GC01P103809
  • GC01P103897
  • GC01P104096
  • GC01P102153

Summaries for AMY2B Gene

Entrez Gene Summary for AMY2B Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]

GeneCards Summary for AMY2B Gene

AMY2B (Amylase, Alpha 2B (Pancreatic)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include alpha-amylase activity. An important paralog of this gene is AMY1C.

Gene Wiki entry for AMY2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY2B Gene

Genomics for AMY2B Gene

Regulatory Elements for AMY2B Gene

Genomic Location for AMY2B Gene

103,553,815 bp from pter
103,579,534 bp from pter
25,720 bases
Plus strand

Genomic View for AMY2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMY2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY2B Gene

Proteins for AMY2B Gene

  • Protein details for AMY2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-amylase 2B
    Protein Accession:
    Secondary Accessions:
    • B3KTI1
    • B3KXB7
    • D3DT76
    • Q9UBH3

    Protein attributes for AMY2B Gene

    511 amino acids
    Molecular mass:
    57710 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Name=chloride; Xref=ChEBI:CHEBI:17996; Note=Binds 1 Cl(-) ion per subunit.;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for AMY2B Gene


neXtProt entry for AMY2B Gene

Proteomics data for AMY2B Gene at MOPED

Post-translational modifications for AMY2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AMY2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AMY2B (AMY2B)

Domains for AMY2B Gene

Suggested Antigen Peptide Sequences for AMY2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 13 family.
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY2B: view

No data available for Gene Families for AMY2B Gene

Function for AMY2B Gene

Molecular function for AMY2B Gene

GENATLAS Biochemistry:
amylase,alpha-2B,liver,pancreas,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units

Enzyme Numbers (IUBMB) for AMY2B Gene

Gene Ontology (GO) - Molecular Function for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004556 alpha-amylase activity IEA --
GO:0043169 cation binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMY2B: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY2B

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMY2B Gene

Localization for AMY2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY2B Gene


Subcellular locations from

Jensen Localization Image for AMY2B Gene COMPARTMENTS Subcellular localization image for AMY2B gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with AMY2B: view

Pathways for AMY2B Gene

genes like me logo Genes that share pathways with AMY2B: view

Pathways by source for AMY2B Gene

Interacting Proteins for AMY2B Gene

Gene Ontology (GO) - Biological Process for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0007586 digestion TAS 2401405
genes like me logo Genes that share ontologies with AMY2B: view

Drugs for AMY2B Gene

(9) Drugbank Compounds for AMY2B Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
445999 Target experimental
46936472 Target experimental
46936574 Target experimental
1109-28-0 46936192 Target experimental
50-99-7 6992084 Target experimental

(8) HMDB Compounds for AMY2B Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
Chloride ion
  • Bertholite
  • British gum
  • 1-alpha-D-Glucopyranosyl-4-alpha-D-glucopyranose
  • (+)-mannose

(5) Novoseek inferred chemical compound relationships for AMY2B Gene

Compound -log(P) Hits PubMed IDs
maltoheptaose 84.4 1
amylose 78.3 2
acarbose 70.3 2
starch 67.3 3
calcium 7.62 1
genes like me logo Genes that share compounds with AMY2B: view

Transcripts for AMY2B Gene

Unigene Clusters for AMY2B Gene

Amylase, alpha 2B (pancreatic):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMY2B Gene

No ASD Table

Relevant External Links for AMY2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMY2B Gene

mRNA expression in normal human tissues for AMY2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY2B Gene

This gene is overexpressed in Pancreas (37.3).

Protein differential expression in normal tissues for AMY2B Gene

This gene is overexpressed in Saliva (29.0), Pancreatic juice (27.7), and Urine (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AMY2B Gene

SOURCE GeneReport for Unigene cluster for AMY2B Gene Hs.484588

genes like me logo Genes that share expressions with AMY2B: view

Expression partners for AMY2B Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AMY2B Gene

Orthologs for AMY2B Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY2B Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Amy2a5 35
  • 84.51 (n)
  • 85.24 (a)
Amy1 36
  • 85 (a)
Amy2a1 36
  • 82 (a)
Amy2a2 36
  • 85 (a)
Amy2a3 36
  • 85 (a)
Amy2a4 36
  • 85 (a)
Amy2a5 36
  • 85 (a)
(Pan troglodytes)
Mammalia AMY2B 35
  • 99.61 (n)
  • 99.61 (a)
AMY2B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100911494 35
  • 84.25 (n)
  • 85.04 (a)
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
AMY2B 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
-- 36
  • 91 (a)
-- 36
  • 89 (a)
-- 36
  • 90 (a)
-- 36
  • 91 (a)
-- 36
  • 91 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
(Gallus gallus)
Aves AMY1A 36
  • 79 (a)
AMY2A 36
  • 82 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia amy2a 35
  • 73.59 (n)
  • 77.45 (a)
Str.5812 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64337 35
(Danio rerio)
Actinopterygii amy2a 35
  • 69.21 (n)
  • 73.39 (a)
amy2a 36
  • 74 (a)
zgc:66313 36
  • 68 (a)
zgc:92137 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 37
  • 51 (a)
Amy-p 37
  • 51 (a)
Amyrel 37
  • 48 (a)
Amy-p 35
  • 55.81 (n)
  • 56.15 (a)
Amy-d 36
  • 54 (a)
Amy-p 36
  • 55 (a)
Amyrel 36
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002318 35
  • 52.22 (n)
  • 55.85 (a)
(Caenorhabditis elegans)
Secernentea C50B6.7 37
  • 44 (a)
CELE_C50B6.7 35
  • 55.33 (n)
  • 50.31 (a)
C50B6.7 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for AMY2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMY2B Gene

Gene Tree for AMY2B (if available)
Gene Tree for AMY2B (if available)

Paralogs for AMY2B Gene

Paralogs for AMY2B Gene

(4) SIMAP similar genes for AMY2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMY2B: view

Variants for AMY2B Gene

Sequence variations from dbSNP and Humsavar for AMY2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs516220 -- 103,577,659(+) TTGCA(C/T)TTTAT intron-variant
rs518097 -- 103,577,882(+) GTACC(A/T)GTATG intron-variant
rs554640 -- 103,577,853(-) GATAT(G/T)TACTT intron-variant
rs1827334 -- 103,577,498(+) GTTAA(C/T)GATTG synonymous-codon, reference
rs1832272 -- 103,573,294(+) TAAGG(A/G)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMY2B Gene

Variant ID Type Subtype PubMed ID
dgv14n21 CNV Gain 19592680
nsv830904 CNV Loss 17160897
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
nsv523177 CNV Gain 19592680
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv3n64 CNV Gain 17921354
nsv511132 CNV Gain 21212237
dgv297n71 CNV Gain 21882294
dgv298n71 CNV Gain 21882294
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
esv33927 CNV Gain 17666407
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
nsv442937 CNV CNV 18776908
dgv300n71 CNV Loss 21882294
nsv514909 CNV Complex 21397061
esv1004547 CNV Gain 20482838
nsv823686 CNV Gain 20364138

Relevant External Links for AMY2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY2B Gene

Disorders for AMY2B Gene

(1) Novoseek inferred disease relationships for AMY2B Gene

Disease -log(P) Hits PubMed IDs
carcinoid 38.6 2

Relevant External Links for AMY2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AMY2B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for AMY2B Gene

Publications for AMY2B Gene

  1. Cloning and characterization of a third type of human alpha-amylase gene, AMY2B. (PMID: 2401405) Yokouchi H. … Matsubara K. (Gene 1990) 3 4 23
  2. Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. (PMID: 8268204) Omichi K. … Hase S. (Biochim. Biophys. Acta 1993) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Concerted evolution of human amylase genes. (PMID: 2452973) Gumucio D.L. … Meisler M.H. (Mol. Cell. Biol. 1988) 3 4
  5. A novel type of human alpha-amylase produced in lung carcinoid tumor. (PMID: 2701942) Tomita N. … Matsubara K. (Gene 1989) 3 4

Products for AMY2B Gene

Sources for AMY2B Gene

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