Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AMY2B Gene

Aliases for AMY2B Gene

  • Amylase, Alpha 2B (Pancreatic) 2 3
  • 1,4-Alpha-D-Glucan Glucanohydrolase 2B 3 4
  • Carcinoid Alpha-Amylase 3 4
  • EC 3.2.1.1 4 63
  • Amylase, Alpha 2B; Pancreatic 2
  • Alpha-Amylase 2B 3
  • Glycogenase 3
  • AMY3 3
  • AMY2 3
  • HXA 3

External Ids for AMY2B Gene

Previous Symbols for AMY2B Gene

  • AMY2

Summaries for AMY2B Gene

Entrez Gene Summary for AMY2B Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]

GeneCards Summary for AMY2B Gene

AMY2B (Amylase, Alpha 2B (Pancreatic)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include alpha-amylase activity. An important paralog of this gene is AMY1C.

Gene Wiki entry for AMY2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY2B Gene

Genomics for AMY2B Gene

Genomic Location for AMY2B Gene

Start:
103,553,815 bp from pter
End:
103,579,534 bp from pter
Size:
25,720 bases
Orientation:
Plus strand

Genomic View for AMY2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMY2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY2B Gene

Regulatory Elements for AMY2B Gene

Proteins for AMY2B Gene

  • Protein details for AMY2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19961-AMY2B_HUMAN
    Recommended name:
    Alpha-amylase 2B
    Protein Accession:
    P19961
    Secondary Accessions:
    • B3KTI1
    • B3KXB7
    • D3DT76
    • Q9UBH3

    Protein attributes for AMY2B Gene

    Size:
    511 amino acids
    Molecular mass:
    57710 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Cofactor:
    Name=chloride; Xref=ChEBI:CHEBI:17996; Note=Binds 1 Cl(-) ion per subunit.;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for AMY2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMY2B Gene

Proteomics data for AMY2B Gene at MOPED

Post-translational modifications for AMY2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AMY2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for AMY2B Gene

Suggested Antigen Peptide Sequences for AMY2B Gene

Graphical View of Domain Structure for InterPro Entry

P19961

UniProtKB/Swiss-Prot:

AMY2B_HUMAN
Family:
  • Belongs to the glycosyl hydrolase 13 family.:
    • P19961
genes like me logo Genes that share domains with AMY2B: view

No data available for Gene Families for AMY2B Gene

Function for AMY2B Gene

Molecular function for AMY2B Gene

GENATLAS Biochemistry: amylase,alpha-2B,liver,pancreas,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units

Enzyme Numbers (IUBMB) for AMY2B Gene

Gene Ontology (GO) - Molecular Function for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004556 alpha-amylase activity IEA --
GO:0043169 cation binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMY2B: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AMY2B Gene

Localization for AMY2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMY2B Gene COMPARTMENTS Subcellular localization image for AMY2B gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with AMY2B: view

Pathways for AMY2B Gene

genes like me logo Genes that share pathways with AMY2B: view

Pathways by source for AMY2B Gene

Interacting Proteins for AMY2B Gene

Gene Ontology (GO) - Biological Process for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0007586 digestion TAS 2401405
genes like me logo Genes that share ontologies with AMY2B: view

Compounds for AMY2B Gene

(7) HMDB Compounds for AMY2B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Chlorine
  • Cl2
16887-00-6
Dextrin
  • Caloreen
9004-53-9
Maltodecaose
  • B-cyclodextrin
37331-89-8
Maltoheptaose
  • maltoheptose
34620-77-4

(10) Drugbank Compounds for AMY2B Gene

(5) Novoseek inferred chemical compound relationships for AMY2B Gene

Compound -log(P) Hits PubMed IDs
maltoheptaose 84.4 1
amylose 78.3 2
acarbose 70.3 2
starch 67.3 3
calcium 7.62 1
genes like me logo Genes that share compounds with AMY2B: view

Transcripts for AMY2B Gene

Unigene Clusters for AMY2B Gene

Amylase, alpha 2B (pancreatic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMY2B Gene

No ASD Table

Relevant External Links for AMY2B Gene

GeneLoc Exon Structure for
AMY2B
ECgene alternative splicing isoforms for
AMY2B

Expression for AMY2B Gene

mRNA expression in normal human tissues for AMY2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY2B Gene

This gene is overexpressed in Pancreas (37.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AMY2B Gene

SOURCE GeneReport for Unigene cluster for AMY2B Gene Hs.484588

genes like me logo Genes that share expressions with AMY2B: view

No data available for mRNA Expression by UniProt/SwissProt for AMY2B Gene

Orthologs for AMY2B Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMY2B 35
  • 99.61 (n)
  • 99.61 (a)
AMY2B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
ManyToMany
AMY2B 36
  • 86 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Amy1 36
  • 85 (a)
ManyToMany
Amy2a1 36
  • 82 (a)
ManyToMany
Amy2a2 36
  • 85 (a)
ManyToMany
Amy2a3 36
  • 85 (a)
ManyToMany
Amy2a4 36
  • 85 (a)
ManyToMany
Amy2a5 35
  • 84.51 (n)
  • 85.24 (a)
Amy2a5 36
  • 85 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100911494 35
  • 84.25 (n)
  • 85.04 (a)
chicken
(Gallus gallus)
Aves AMY1A 36
  • 79 (a)
ManyToMany
AMY2A 36
  • 82 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64337 35
tropical clawed frog
(Silurana tropicalis)
Amphibia amy2a 35
  • 73.59 (n)
  • 77.45 (a)
Str.5812 35
zebrafish
(Danio rerio)
Actinopterygii amy2a 35
  • 69.21 (n)
  • 73.39 (a)
amy2a 36
  • 74 (a)
ManyToMany
zgc:66313 36
  • 68 (a)
ManyToMany
zgc:92137 36
  • 69 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002318 35
  • 52.22 (n)
  • 55.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 36
  • 54 (a)
ManyToMany
Amy-p 35
  • 55.81 (n)
  • 56.15 (a)
Amy-p 36
  • 55 (a)
ManyToMany
Amyrel 36
  • 49 (a)
ManyToMany
Amyrel 37
  • 48 (a)
Amy-p 37
  • 51 (a)
Amy-d 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea C50B6.7 36
  • 33 (a)
OneToMany
CELE_C50B6.7 35
  • 55.33 (n)
  • 50.31 (a)
C50B6.7 37
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for AMY2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMY2B Gene

ENSEMBL:
Gene Tree for AMY2B (if available)
TreeFam:
Gene Tree for AMY2B (if available)

Paralogs for AMY2B Gene

Paralogs for AMY2B Gene

Selected SIMAP similar genes for AMY2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMY2B: view

Variants for AMY2B Gene

Sequence variations from dbSNP and Humsavar for AMY2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs516220 -- 103,577,659(+) TTGCA(C/T)TTTAT intron-variant
rs518097 -- 103,577,882(+) GTACC(A/T)GTATG intron-variant
rs554640 -- 103,577,853(-) GATAT(G/T)TACTT intron-variant
rs1827334 -- 103,577,498(+) GTTAA(C/T)GATTG synonymous-codon, reference
rs1832272 -- 103,573,294(+) TAAGG(A/G)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMY2B Gene

Variant ID Type Subtype PubMed ID
dgv14n21 CNV Gain 19592680
nsv830904 CNV Loss 17160897
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
nsv523177 CNV Gain 19592680
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv3n64 CNV Gain 17921354
nsv511132 CNV Gain 21212237
dgv297n71 CNV Gain 21882294
dgv298n71 CNV Gain 21882294
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
esv33927 CNV Gain 17666407
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
nsv442937 CNV CNV 18776908
dgv300n71 CNV Loss 21882294
nsv514909 CNV Complex 21397061
esv1004547 CNV Gain 20482838
nsv823686 CNV Gain 20364138

Relevant External Links for AMY2B Gene

HapMap Linkage Disequilibrium report
AMY2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY2B Gene

Disorders for AMY2B Gene

(1) Novoseek inferred disease relationships for AMY2B Gene

Disease -log(P) Hits PubMed IDs
carcinoid 38.6 2

Relevant External Links for AMY2B

Genetic Association Database (GAD)
AMY2B
Human Genome Epidemiology (HuGE) Navigator
AMY2B
genes like me logo Genes that share disorders with AMY2B: view

No data available for UniProtKB/Swiss-Prot for AMY2B Gene

Publications for AMY2B Gene

  1. Cloning and characterization of a third type of human alpha-amylase gene, AMY2B. (PMID: 2401405) Yokouchi H. … Matsubara K. (Gene 1990) 3 4 23
  2. Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. (PMID: 8268204) Omichi K. … Hase S. (Biochim. Biophys. Acta 1993) 2 3 4
  3. Concerted evolution of human amylase genes. (PMID: 2452973) Gumucio D.L. … Meisler M.H. (Mol. Cell. Biol. 1988) 3 4
  4. A novel type of human alpha-amylase produced in lung carcinoid tumor. (PMID: 2701942) Tomita N. … Matsubara K. (Gene 1989) 3 4
  5. Human pancreatic amylase is encoded by two different genes. (PMID: 3260028) Groot P.C. … Frants R.R. (Nucleic Acids Res. 1988) 3 4

Products for AMY2B Gene

Sources for AMY2B Gene

Back to Top

Content