Aliases for GNGT2 Gene
External Ids for GNGT2 Gene
Previous GeneCards Identifiers for GNGT2 Gene
Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for GNGT2 Gene
GNGT2 (Guanine Nucleotide Binding Protein (G Protein), Gamma Transducing Activity Polypeptide 2) is a Protein Coding gene. Diseases associated with GNGT2 include cll/sll. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include signal transducer activity and GTPase activity. An important paralog of this gene is GNG11.
UniProtKB/Swiss-Prot for GNGT2 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.