Aliases for GNG11 Gene
Aliases for GNG11 Gene
External Ids for GNG11 Gene
- HGNC: 4403
- Entrez Gene: 2791
- Ensembl: ENSG00000127920
- OMIM: 604390
- UniProtKB: P61952
Previous GeneCards Identifiers for GNG11 Gene
- GC07P092086
- GC07P093149
- GC07P093163
- GC07P093195
- GC07P093388
- GC07P093551
- GC07P088158
Summaries for GNG11 Gene
-
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]
GeneCards Summary for GNG11 Gene
GNG11 (G Protein Subunit Gamma 11) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Translation Translation regulation by Alpha-1 adrenergic receptors. Gene Ontology (GO) annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNGT1.
UniProtKB/Swiss-Prot for GNG11 Gene
-
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
-
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.
Additional gene information for GNG11 Gene
- Monarch Initiative
- Search for GNG11 at DataMed
- Search for GNG11 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG11 Gene
Genomics for GNG11 Gene
GeneHancer (GH) Regulatory Elements for GNG11 Gene
Promoters and enhancers for GNG11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GNG11 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GNG11 Gene
Genomic Locations for GNG11 Gene
- chr7:93,921,699-93,928,610
- (GRCh38/hg38)
- Size:
- 6,912 bases
- Orientation:
- Plus strand
- chr7:93,551,011-93,557,922
- (GRCh37/hg19)
Genomic View for GNG11 Gene
Genes around GNG11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q21.3 by Ensembl
- 7q21.3 by Entrez Gene
- 7q21.3 by HGNC
GNG11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GNG11 Gene
Proteins for GNG11 Gene
-
Protein details for GNG11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61952-GBG11_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
- Protein Accession:
- P61952
- P50152
Protein attributes for GNG11 Gene
- Size:
- 73 amino acids
- Molecular mass:
- 8481 Da
- Quaternary structure:
-
- G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.
Protein Expression for GNG11 Gene
Post-translational modifications for GNG11 Gene
No Post-translational modifications
Other Protein References for GNG11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GNG11
-
Abcam antibodies for GNG11
- Invitrogen Antibodies for GNG11
- Search GeneTex for Antibodies for GNG11
Protein Products
-
OriGene Purified Proteins for GNG11
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-
Abcam proteins for GNG11
Assay Products
No data available for DME Specific Peptides for GNG11 Gene
Domains & Families for GNG11 Gene
Gene Families for GNG11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GNG11 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GNG11 Gene
Graphical View of Domain Structure for InterPro Entry
P61952- Family:
-
- Belongs to the G protein gamma family.
Function for GNG11 Gene
Molecular function for GNG11 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Phenotypes From GWAS Catalog for GNG11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | TAS | 7665596 |
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0005515 | protein binding | IPI | -- |
Phenotypes for GNG11 Gene
- GenomeRNAi human phenotypes for GNG11:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Increased G1 DNA content
- G0/1 arrest
- Increased HPV18 LCR reporter activity
- Decreased viability
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for GNG11 gene
-
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- Search ViGene Biosciences for GNG11
CRISPR Products
-
OriGene CRISPR knockouts for GNG11
- genomics-online: gRNA clones - Search results for 88 available GNG11 gene related products
- Overview of 88 available GNG11 gene related products
- Applied Biological Materials CRISPR for GNG11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GNG11
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miRNA Products
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Inhibitory RNA Products
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- Overview of 88 available GNG11 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GNG11 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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-
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Cell Line Products
-
Horizon Cell Lines for GNG11
-
ViGene Biosciences adenoviral particle packaged cDNA for GNG11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GNG11 gene
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNG11 Gene
Localization for GNG11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GNG11 Gene
- Cell membrane; Lipid-anchor; Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| cytosol | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005834 | heterotrimeric G-protein complex | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GNG11 Gene
Pathways & Interactions for GNG11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Development Angiotensin activation of ERK | ||
| 2 | G-Beta Gamma Signaling |
.46
.44
|
.37
|
| 3 | ADP signalling through P2Y purinoceptor 12 | ||
| 4 | Presynaptic function of Kainate receptors | ||
| 5 | ADP signalling through P2Y purinoceptor 1 | ||
Pathways by source for GNG11 Gene
3 BioSystems pathways for GNG11 Gene
47 Reactome pathways for GNG11 Gene
16 KEGG pathways for GNG11 Gene
34 GeneGo (Thomson Reuters) pathways for GNG11 Gene
Interacting Proteins for GNG11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | 7665596 |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0071377 | cellular response to glucagon stimulus | TAS | -- |
No data available for SIGNOR curated interactions for GNG11 Gene
Drugs & Compounds for GNG11 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| G-Protein antagonist peptide |
|
143675-79-0 |
|
|
(5) Tocris Compounds for GNG11 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [D-Trp7,9,10]-Substance P | Inhibits M1 ACh receptor activation of Gq/11 | 89430-38-6 |
| G-Protein antagonist peptide | Inhibits G protein activation by GPCRs | 143675-79-0 |
| Gue 1654 | Selective inhibitor of OXE-R Gbetagamma signaling | 397290-30-1 |
| Mastoparan | Activates Gi and Go | 72093-21-1 |
| SCH 202676 hydrobromide | Inhibitor of ligand binding to G-protein-coupled receptors | 265980-25-4 |
Transcripts for GNG11 Gene
mRNA/cDNA for GNG11 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (120) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GNG11 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GNG11
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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- Overview of 88 available GNG11 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GNG11 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for GNG11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GNG11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Endothelium (Cardiovascular System)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Platelet (32.7) and Peripheral blood mononuclear cells (22.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNG11 Gene
NURSA nuclear receptor signaling pathways regulating expression of GNG11 Gene:
GNG11SOURCE GeneReport for Unigene cluster for GNG11 Gene:
Hs.83381mRNA Expression by UniProt/SwissProt for GNG11 Gene:
P61952-GBG11_HUMAN
Tissue specificity:
Abundantly expressed in all tissues tested except for brain.
Evidence on tissue expression from TISSUES for GNG11 Gene
- Lung(4.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for GNG11
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No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG11 Gene
Orthologs for GNG11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GNG11 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GNG11 33 34 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Gng11 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100912034 33 |
|
||
| dog (Canis familiaris) |
Mammalia | GNG11 34 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GNG11 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GNG11 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.12711 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gngt1 34 |
|
OneToMany |
- Species where no ortholog for GNG11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GNG11 Gene
Variants for GNG11 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000016433 | -- | 93,921,801(+) | G/T | 5_prime_UTR_variant | |
| rs1000139722 | -- | 93,925,827(+) | GACCAACGACCAAC/GACCAAC | intron_variant | |
| rs1000536198 | -- | 93,921,333(+) | C/T | upstream_transcript_variant | |
| rs1000975201 | -- | 93,926,984(+) | C/T | downstream_transcript_variant | |
| rs1001048813 | -- | 93,925,023(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3614175 | CNV | loss | 21293372 |
| nsv1023193 | CNV | gain | 25217958 |
| nsv607849 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.21;
4.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GNG11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GNG11
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG11 Gene
Disorders for GNG11 Gene
Additional Disease Information for GNG11
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GNG11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG11 Gene
Publications for GNG11 Gene
- Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K … Robishaw JD (The Journal of biological chemistry 1995) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
- GNG11 (G-protein subunit γ 11) suppresses cell growth with induction of reactive oxygen species and abnormal nuclear morphology in human SUSM-1 cells. (PMID: 28380310) Takauji Y … Ayusawa D (Biochemistry and cell biology = Biochimie et biologie cellulaire 2017) 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
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Sources for GNG11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew