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Aliases for GNG11 Gene

Aliases for GNG11 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 11 2 3
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Gamma-11 Subunit 2 3
  • G Protein Gamma-11 Subunit 2 3
  • GNGT11 3 4
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-11 3

External Ids for GNG11 Gene

Summaries for GNG11 Gene

Entrez Gene Summary for GNG11 Gene

  • This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNG11 Gene

GNG11 (Guanine Nucleotide Binding Protein (G Protein), Gamma 11) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include signal transducer activity and GTPase activity. An important paralog of this gene is GNGT1.

UniProtKB/Swiss-Prot for GNG11 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNG11 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the off state. Ligand-receptor binding results in detachment of the G protein, switching it to an on state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG11 Gene

Genomics for GNG11 Gene

Genomic Location for GNG11 Gene

Start:
93,921,699 bp from pter
End:
93,928,610 bp from pter
Size:
6,912 bases
Orientation:
Plus strand

Genomic View for GNG11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG11 Gene

Regulatory Elements for GNG11 Gene

Proteins for GNG11 Gene

  • Protein details for GNG11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61952-GBG11_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
    Protein Accession:
    P61952
    Secondary Accessions:
    • P50152

    Protein attributes for GNG11 Gene

    Size:
    73 amino acids
    Molecular mass:
    8481 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2

neXtProt entry for GNG11 Gene

Proteomics data for GNG11 Gene at MOPED

Post-translational modifications for GNG11 Gene

No Post-translational modifications

Other Protein References for GNG11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG11 Gene

Domains for GNG11 Gene

Protein Domains for GNG11 Gene

UniProtKB/Swiss-Prot:

GBG11_HUMAN
Family:
  • Belongs to the G protein gamma family.:
    • P61952
genes like me logo Genes that share domains with GNG11: view

No data available for Gene Families for GNG11 Gene

Function for GNG11 Gene

Molecular function for GNG11 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 7665596
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with GNG11: view

Phenotypes for GNG11 Gene

genes like me logo Genes that share phenotypes with GNG11: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GNG11 Gene

Localization for GNG11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG11 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG11 Gene COMPARTMENTS Subcellular localization image for GNG11 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNG11: view

Pathways for GNG11 Gene

SuperPathways for GNG11 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 ERK Signaling
genes like me logo Genes that share pathways with GNG11: view

Gene Ontology (GO) - Biological Process for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction TAS 7665596
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GNG11: view

Compounds for GNG11 Gene

(5) Tocris Compounds for GNG11 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
Gallein Inhibitor of betagamma signaling [2103-64-2]
G-Protein antagonist peptide Inhibits G protein activation by GPCRs [143675-79-0]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]

(3) HMDB Compounds for GNG11 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNG11: view

Transcripts for GNG11 Gene

mRNA/cDNA for GNG11 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(120) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG11 Gene

Guanine nucleotide binding protein (G protein), gamma 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG11 Gene

No ASD Table

Relevant External Links for GNG11 Gene

GeneLoc Exon Structure for
GNG11
ECgene alternative splicing isoforms for
GNG11

Expression for GNG11 Gene

mRNA expression in normal human tissues for GNG11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GNG11 Gene

SOURCE GeneReport for Unigene cluster for GNG11 Gene Hs.83381

mRNA Expression by UniProt/SwissProt for GNG11 Gene

P61952-GBG11_HUMAN
Tissue specificity: Abundantly expressed in all tissues tested except for brain
genes like me logo Genes that share expressions with GNG11: view

Orthologs for GNG11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG11 36
  • 100 (n)
  • 100 (a)
GNG11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG11 36
  • 91.78 (n)
  • 97.26 (a)
GNG11 37
  • 97 (a)
OneToMany
GNG11 37
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GNG11 36
  • 91.32 (n)
  • 98.63 (a)
GNG11 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng11 36
  • 91.78 (n)
  • 100 (a)
Gng11 16
Gng11 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng11 36
  • 91.78 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves GNG11 36
  • 76.26 (n)
  • 84.93 (a)
lizard
(Anolis carolinensis)
Reptilia GNG11 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12711 36
zebrafish
(Danio rerio)
Actinopterygii gngt1 37
  • 60 (a)
OneToMany
Species with no ortholog for GNG11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG11 Gene

ENSEMBL:
Gene Tree for GNG11 (if available)
TreeFam:
Gene Tree for GNG11 (if available)

Paralogs for GNG11 Gene

Paralogs for GNG11 Gene

Selected SIMAP similar genes for GNG11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNG11: view

Variants for GNG11 Gene

Sequence variations from dbSNP and Humsavar for GNG11 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4262 -- 93,922,116(-) GGCTC(A/G)GGCTA utr-variant-5-prime
rs180233 -- 93,925,999(-) TACAA(G/T)AAGTT intron-variant
rs180234 -- 93,925,971(-) ATTTA(C/T)ATATA intron-variant
rs180235 -- 93,925,664(-) TGCTA(A/G)TGAGC intron-variant
rs180236 -- 93,924,029(-) AGTTT(C/T)TTTTA intron-variant

Relevant External Links for GNG11 Gene

HapMap Linkage Disequilibrium report
GNG11

No data available for Structural Variations from Database of Genomic Variants (DGV) for GNG11 Gene

Disorders for GNG11 Gene

Relevant External Links for GNG11

Genetic Association Database (GAD)
GNG11
genes like me logo Genes that share disorders with GNG11: view

No data available for UniProtKB/Swiss-Prot for GNG11 Gene

Publications for GNG11 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K. … Robishaw J.D. (J. Biol. Chem. 1995) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  5. Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis. (PMID: 15914563) Ruiz-Ballesteros E. … Piris M.A. (Blood 2005) 3

Products for GNG11 Gene

  • antibodies-online proteins for GNG11
  • antibodies-online antibodies for GNG11
  • antibodies-online kits for GNG11

Sources for GNG11 Gene

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