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GNG11 Gene(Protein Coding)

G Protein Subunit Gamma 11

GCID:
GC07P093921
GIFtS:
54
Genes Participants
UDN Logo

Aliases for GNG11 Gene

Aliases for GNG11 Gene

  • G Protein Subunit Gamma 11 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 11 2 3 5
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Gamma-11 Subunit 2 3
  • G Protein Gamma-11 Subunit 2 3
  • GNGT11 3 4

External Ids for GNG11 Gene

Previous GeneCards Identifiers for GNG11 Gene

  • GC07P092086
  • GC07P093149
  • GC07P093163
  • GC07P093195
  • GC07P093388
  • GC07P093551
  • GC07P088158

Summaries for GNG11 Gene

Entrez Gene Summary for GNG11 Gene

  • This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNG11 Gene

GNG11 (G Protein Subunit Gamma 11) is a Protein Coding gene. Diseases associated with GNG11 include Splenic Marginal Zone Lymphoma. Among its related pathways are Thromboxane signalling through TP receptor and EphB-EphrinB Signaling. GO annotations related to this gene include GTPase activity and signal transducer activity. An important paralog of this gene is GNGT1.

UniProtKB/Swiss-Prot for GNG11 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG11 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG11 Gene

Genomics for GNG11 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GNG11 Gene

Enhancers for GNG11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNG11 on UCSC Golden Path with GeneCards custom track

Promoters for GNG11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNG11 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GNG11 gene promoter:

Genomic Location for GNG11 Gene

Chromosome:
7
Start:
93,921,699 bp from pter
End:
93,928,610 bp from pter
Size:
6,912 bases
Orientation:
Plus strand

Genomic View for GNG11 Gene

Genes around GNG11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GNG11 Gene

Proteins for GNG11 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GNG11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61952-GBG11_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
    Protein Accession:
    P61952
    Secondary Accessions:
    • P50152

    Protein attributes for GNG11 Gene

    Size:
    73 amino acids
    Molecular mass:
    8481 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.

neXtProt entry for GNG11 Gene

Proteomics data for GNG11 Gene at MOPED

Protein Expression for GNG11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GNG11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG11 Gene

Domains & Families for GNG11 Gene

Protein Domains for GNG11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GNG11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61952

UniProtKB/Swiss-Prot:

GBG11_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG11: view

No data available for Gene Families for GNG11 Gene

Function for GNG11 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GNG11 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Phenotypes for GNG11 Gene

GenomeRNAi human phenotypes for GNG11:
genes like me logo Genes that share phenotypes with GNG11: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNG11 Gene

Localization for GNG11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG11 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG11 Gene COMPARTMENTS Subcellular localization image for GNG11 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNG11: view

Pathways & Interactions for GNG11 Gene

genes like me logo Genes that share pathways with GNG11: view

Gene Ontology (GO) - Biological Process for GNG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007165 signal transduction TAS 7665596
genes like me logo Genes that share ontologies with GNG11: view

No data available for SIGNOR curated interactions for GNG11 Gene

Drugs & Compounds for GNG11 Gene

Products:

  1. Drug

(3) Drugs for GNG11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG11 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG11 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG11: view

Transcripts for GNG11 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GNG11 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(120) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNG11 Gene

Guanine nucleotide binding protein (G protein), gamma 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG11 Gene

No ASD Table

Relevant External Links for GNG11 Gene

GeneLoc Exon Structure for
GNG11
ECgene alternative splicing isoforms for
GNG11

Expression for GNG11 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for GNG11 Gene

mRNA expression in normal human tissues for GNG11 Gene
mRNA expression by BioGPS for GNG11 GenemRNA expression by GTEx for GNG11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNG11 Gene

This gene is overexpressed in Platelet (32.7) and Peripheral blood mononuclear cells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNG11 Gene



SOURCE GeneReport for Unigene cluster for GNG11 Gene Hs.83381

mRNA Expression by UniProt/SwissProt for GNG11 Gene

P61952-GBG11_HUMAN
Tissue specificity: Abundantly expressed in all tissues tested except for brain.
genes like me logo Genes that share expression patterns with GNG11: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for GNG11 Gene

Orthologs for GNG11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GNG11 35
  • 91.78 (n)
  • 97.26 (a)
GNG11 36
  • 97 (a)
 OneToMany
GNG11 36
  • 97 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia GNG11 35
  • 91.32 (n)
  • 98.63 (a)
GNG11 36
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gng11 35
  • 91.78 (n)
  • 100 (a)
Gng11 16
Gng11 36
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GNG11 35
  • 100 (n)
  • 100 (a)
GNG11 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Gng11 35
  • 91.78 (n)
  • 100 (a)
chicken
(Gallus gallus)
 Aves GNG11 35
  • 76.26 (n)
  • 84.93 (a)
lizard
(Anolis carolinensis)
 Reptilia GNG11 36
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.12711 35
zebrafish
(Danio rerio)
 Actinopterygii gngt1 36
  • 60 (a)
 OneToMany
Species with no ortholog for GNG11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG11 Gene

ENSEMBL:
Gene Tree for GNG11 (if available)
TreeFam:
Gene Tree for GNG11 (if available)

Paralogs for GNG11 Gene

Paralogs for GNG11 Gene

(11) SIMAP similar genes for GNG11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNG11: view

Variants for GNG11 Gene

Variation tolerance for GNG11 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GNG11 Gene

Disorders for GNG11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GNG11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
splenic marginal zone lymphoma
  • smzl
- elite association - COSMIC cancer census association via MalaCards
Search GNG11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNG11

Genetic Association Database (GAD)
GNG11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG11
genes like me logo Genes that share disorders with GNG11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNG11 Gene

Publications for GNG11 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K. … Robishaw J.D. (J. Biol. Chem. 1995) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. (PMID: 25241761) Chen T.C. … Huang C.Y. (J. Proteome Res. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M. … Loos R.J. (Nat. Genet. 2013) 3

Products for GNG11 Gene

Sources for GNG11 Gene

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