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Aliases for GNG7 Gene

Aliases for GNG7 Gene

  • G Protein Subunit Gamma 7 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 7 2
  • GNGT7 4

External Ids for GNG7 Gene

Previous GeneCards Identifiers for GNG7 Gene

  • GC19M002577
  • GC19M002454
  • GC19M002463
  • GC19M002464
  • GC19M002465
  • GC19M002283

Summaries for GNG7 Gene

GeneCards Summary for GNG7 Gene

GNG7 (G Protein Subunit Gamma 7) is a Protein Coding gene. Among its related pathways are Aquaporin-mediated transport and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG12.

UniProtKB/Swiss-Prot for GNG7 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Tocris Summary for GNG7 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG7 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG7 Gene

Genomics for GNG7 Gene

Regulatory Elements for GNG7 Gene

Enhancers for GNG7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G002693 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +7.7 7651 3.1 SRF ZNF146 ZNF266 ZNF311 ZNF514 NR2F2 ZFHX2 ZNF366 EED BCL6B ZNF77 CACTIN-AS1 DIRAS1 CACTIN GNG7 SLC39A3 ZNF556 LINGO3 ENSG00000276097 PIR43863
GH19G003363 2 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -665.0 -664990 8.1 HDGF PKNOX1 ARNT AGO1 SIN3A YBX1 ZNF2 YY1 ZNF766 ZNF143 CACTIN CACTIN-AS1 ZNF77 APBA3 ENSG00000267139 ENSG00000269807 MATK GNG7 ENSG00000261342 NFIC
GH19G002636 1.4 Ensembl ENCODE dbSUPER 11.1 +65.7 65685 1.7 HDGF SIN3A GLI4 ZNF2 YY1 GLIS2 ZNF143 REST GLIS1 NBN SF3A2 LOC100288123 CACTIN-AS1 SLC39A3 DIRAS1 GNG7 ZNF57 LOC101928631 ZNF77 ENSG00000267214
GH19G002639 1.3 Ensembl ENCODE dbSUPER 11.1 +63.3 63278 0.8 SOX13 FOXA2 ZNF384 TEAD3 RARA NCOR1 NR2F6 GATAD2A TEAD1 NFIA SLC39A3 DIRAS1 GNG7 ZNF57 LOC101928631 ZNF77 GC19P002642 ENSG00000267214
GH19G003605 1.4 ENCODE dbSUPER 9.7 -904.9 -904856 4.6 HDGF PKNOX1 CREB3L1 ARNT SIN3A YBX1 ZNF2 ZNF766 ZNF207 SP3 CACTIN ZNF77 ENSG00000267030 CACTIN-AS1 ZNF555 ENSG00000267769 ENSG00000267205 ZNF554 ENSG00000267138 APBA3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNG7 on UCSC Golden Path with GeneCards custom track

Promoters for GNG7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105926 48 1001 ATF1 FUS ZFP64 ZNF76 KLF17 THRB ZSCAN9 GTF3C2 EGR1 ZNF391

Genomic Location for GNG7 Gene

Chromosome:
19
Start:
2,511,219 bp from pter
End:
2,702,748 bp from pter
Size:
191,530 bases
Orientation:
Minus strand

Genomic View for GNG7 Gene

Genes around GNG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG7 Gene

Proteins for GNG7 Gene

  • Protein details for GNG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60262-GBG7_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Protein Accession:
    O60262
    Secondary Accessions:
    • B2R496

    Protein attributes for GNG7 Gene

    Size:
    68 amino acids
    Molecular mass:
    7522 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma.

neXtProt entry for GNG7 Gene

Post-translational modifications for GNG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG7 Gene

Domains & Families for GNG7 Gene

Gene Families for GNG7 Gene

Protein Domains for GNG7 Gene

Suggested Antigen Peptide Sequences for GNG7 Gene

Graphical View of Domain Structure for InterPro Entry

O60262

UniProtKB/Swiss-Prot:

GBG7_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG7: view

Function for GNG7 Gene

Molecular function for GNG7 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Gene Ontology (GO) - Molecular Function for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with GNG7: view
genes like me logo Genes that share phenotypes with GNG7: view

Animal Models for GNG7 Gene

MGI Knock Outs for GNG7:

Animal Model Products

  • Taconic Biosciences Mouse Models for GNG7

CRISPR Products

miRNA for GNG7 Gene

miRTarBase miRNAs that target GNG7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNG7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG7 Gene

Localization for GNG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG7 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG7 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GNG7: view

Pathways & Interactions for GNG7 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
2 ADP signalling through P2Y purinoceptor 12
3 G-Beta Gamma Signaling
4 Presynaptic function of Kainate receptors
5 ADP signalling through P2Y purinoceptor 1
genes like me logo Genes that share pathways with GNG7: view

Gene Ontology (GO) - Biological Process for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 9600093
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNG7: view

No data available for SIGNOR curated interactions for GNG7 Gene

Drugs & Compounds for GNG7 Gene

(3) Drugs for GNG7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
51116-01-9
CMPD101
865608-11-3
Gallein
2103-64-2
G-Protein antagonist peptide
143675-79-0
Pertussis Toxin
70323-44-3

(5) Tocris Compounds for GNG7 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3
genes like me logo Genes that share compounds with GNG7: view

Transcripts for GNG7 Gene

mRNA/cDNA for GNG7 Gene

Unigene Clusters for GNG7 Gene

Guanine nucleotide binding protein (G protein), gamma 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GNG7

Alternative Splicing Database (ASD) splice patterns (SP) for GNG7 Gene

No ASD Table

Relevant External Links for GNG7 Gene

GeneLoc Exon Structure for
GNG7
ECgene alternative splicing isoforms for
GNG7

Expression for GNG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG7 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x11.8), Brain - Caudate (basal ganglia) (x9.8), and Brain - Nucleus accumbens (basal ganglia) (x9.2).

Protein differential expression in normal tissues from HIPED for GNG7 Gene

This gene is overexpressed in Frontal cortex (23.2) and Spinal cord (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNG7 Gene



Protein tissue co-expression partners for GNG7 Gene

NURSA nuclear receptor signaling pathways regulating expression of GNG7 Gene:

GNG7

SOURCE GeneReport for Unigene cluster for GNG7 Gene:

Hs.515544

mRNA Expression by UniProt/SwissProt for GNG7 Gene:

O60262-GBG7_HUMAN
Tissue specificity: Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.

Evidence on tissue expression from TISSUES for GNG7 Gene

  • Nervous system(4.9)
  • Skin(4)
genes like me logo Genes that share expression patterns with GNG7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG7 Gene

Orthologs for GNG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG7 34 35
  • 98.53 (n)
oppossum
(Monodelphis domestica)
Mammalia GNG7 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNG7 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG7 34 35
  • 90.69 (n)
dog
(Canis familiaris)
Mammalia GNG7 34 35
  • 88.73 (n)
mouse
(Mus musculus)
Mammalia Gng7 34 16 35
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Gng7 34
  • 82.84 (n)
chicken
(Gallus gallus)
Aves GNG7 35
  • 91 (a)
OneToOne
LOC100858976 34
  • 82.84 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gng7 34
  • 76.96 (n)
zebrafish
(Danio rerio)
Actinopterygii gng7 34 35
  • 78.92 (n)
Species where no ortholog for GNG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG7 Gene

ENSEMBL:
Gene Tree for GNG7 (if available)
TreeFam:
Gene Tree for GNG7 (if available)

Paralogs for GNG7 Gene

Paralogs for GNG7 Gene

(10) SIMAP similar genes for GNG7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNG7: view

Variants for GNG7 Gene

Sequence variations from dbSNP and Humsavar for GNG7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000003222 -- 2,543,541(+) TTTTC(A/G)CAGCC intron-variant
rs1000005774 -- 2,512,071(+) CCGAC(A/G)CTGCC reference, synonymous-codon, utr-variant-3-prime
rs1000008173 -- 2,656,732(+) ATCAT(C/G)CATGG intron-variant
rs1000009413 -- 2,664,230(+) AGGCT(A/G)GATAT intron-variant
rs1000033098 -- 2,650,925(+) CCTCC(C/T)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNG7 Gene

Variant ID Type Subtype PubMed ID
dgv1688n106 CNV deletion 24896259
dgv6219n54 CNV gain+loss 21841781
dgv6220n54 CNV loss 21841781
dgv6221n54 CNV gain+loss 21841781
dgv6222n54 CNV gain 21841781
dgv6223n54 CNV loss 21841781
dgv6224n54 CNV loss 21841781
dgv6225n54 CNV loss 21841781
esv1406094 CNV insertion 17803354
esv1706865 CNV deletion 17803354
esv2153598 CNV deletion 18987734
esv23824 CNV loss 19812545
esv2444878 CNV deletion 19546169
esv2657598 CNV deletion 23128226
esv2717899 CNV deletion 23290073
esv2717900 CNV deletion 23290073
esv2717901 CNV deletion 23290073
esv2717902 CNV deletion 23290073
esv2717903 CNV deletion 23290073
esv2717904 CNV deletion 23290073
esv2762019 CNV gain 21179565
esv29337 CNV loss 19812545
esv3368818 CNV insertion 20981092
esv3371283 CNV duplication 20981092
esv3555860 CNV deletion 23714750
esv3555863 CNV deletion 23714750
esv3574275 CNV gain 25503493
esv3643429 CNV loss 21293372
esv3643430 CNV loss 21293372
esv3643431 CNV loss 21293372
esv3643432 CNV loss 21293372
esv3643433 CNV loss 21293372
esv3643434 CNV loss 21293372
nsv1056064 CNV loss 25217958
nsv1064930 CNV gain 25217958
nsv1071890 CNV deletion 25765185
nsv1072839 CNV deletion 25765185
nsv1072840 CNV deletion 25765185
nsv1109158 CNV deletion 24896259
nsv1123208 CNV deletion 24896259
nsv1129614 CNV tandem duplication 24896259
nsv1133437 CNV deletion 24896259
nsv1134741 CNV deletion 24896259
nsv1146074 CNV deletion 26484159
nsv458326 CNV gain 19166990
nsv470109 CNV loss 18288195
nsv470111 CNV gain 18288195
nsv509714 CNV insertion 20534489
nsv526820 CNV loss 19592680
nsv578387 CNV gain 21841781
nsv578388 CNV gain+loss 21841781
nsv578390 CNV loss 21841781
nsv578398 CNV gain 21841781
nsv828397 CNV gain 20364138
nsv833708 CNV loss 17160897
nsv953944 CNV deletion 24416366
nsv953945 CNV deletion 24416366
nsv960771 CNV duplication 23825009
nsv978759 CNV duplication 23825009

Variation tolerance for GNG7 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG7 Gene

Disorders for GNG7 Gene

Relevant External Links for GNG7

Genetic Association Database (GAD)
GNG7
Human Genome Epidemiology (HuGE) Navigator
GNG7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG7

No disorders were found for GNG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG7 Gene

Publications for GNG7 Gene

  1. Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. (PMID: 9600093) Shibata K. … Akiyoshi T. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. (PMID: 18219292) Ohta M. … Mori M. (Br. J. Cancer 2008) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64

Products for GNG7 Gene

  • Addgene plasmids for GNG7

Sources for GNG7 Gene

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