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Aliases for GNG7 Gene

Aliases for GNG7 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 7 2 3
  • GNGT7 4

External Ids for GNG7 Gene

Summaries for GNG7 Gene

GeneCards Summary for GNG7 Gene

GNG7 (Guanine Nucleotide Binding Protein (G Protein), Gamma 7) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG4.

UniProtKB/Swiss-Prot for GNG7 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Tocris Summary for GNG7 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the off state. Ligand-receptor binding results in detachment of the G protein, switching it to an on state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG7 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG7 Gene

Genomics for GNG7 Gene

Genomic Location for GNG7 Gene

Start:
2,511,219 bp from pter
End:
2,702,748 bp from pter
Size:
191,530 bases
Orientation:
Minus strand

Genomic View for GNG7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG7 Gene

Regulatory Elements for GNG7 Gene

Proteins for GNG7 Gene

  • Protein details for GNG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60262-GBG7_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Protein Accession:
    O60262
    Secondary Accessions:
    • B2R496

    Protein attributes for GNG7 Gene

    Size:
    68 amino acids
    Molecular mass:
    7522 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNG7 Gene

Proteomics data for GNG7 Gene at MOPED

Post-translational modifications for GNG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG7 Gene

Domains for GNG7 Gene

Protein Domains for GNG7 Gene

UniProtKB/Swiss-Prot:

GBG7_HUMAN
Family:
  • Belongs to the G protein gamma family.:
    • O60262
genes like me logo Genes that share domains with GNG7: view

No data available for Gene Families for GNG7 Gene

Function for GNG7 Gene

Molecular function for GNG7 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Gene Ontology (GO) - Molecular Function for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with GNG7: view
genes like me logo Genes that share phenotypes with GNG7: view

Animal Models for GNG7 Gene

MGI Knock Outs for GNG7:

miRNA for GNG7 Gene

miRTarBase miRNAs that target GNG7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GNG7 Gene

Localization for GNG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG7 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG7 Gene COMPARTMENTS Subcellular localization image for GNG7 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GNG7: view

Pathways for GNG7 Gene

SuperPathways for GNG7 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 ERK Signaling
genes like me logo Genes that share pathways with GNG7: view

Gene Ontology (GO) - Biological Process for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0006112 energy reserve metabolic process TAS --
GO:0007168 receptor guanylyl cyclase signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with GNG7: view

Compounds for GNG7 Gene

(5) Tocris Compounds for GNG7 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
Gallein Inhibitor of betagamma signaling [2103-64-2]
G-Protein antagonist peptide Inhibits G protein activation by GPCRs [143675-79-0]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]

(3) HMDB Compounds for GNG7 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNG7: view

Transcripts for GNG7 Gene

mRNA/cDNA for GNG7 Gene

Unigene Clusters for GNG7 Gene

Guanine nucleotide binding protein (G protein), gamma 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG7 Gene

No ASD Table

Relevant External Links for GNG7 Gene

GeneLoc Exon Structure for
GNG7
ECgene alternative splicing isoforms for
GNG7

Expression for GNG7 Gene

mRNA expression in normal human tissues for GNG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG7 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (11.8), Brain - Caudate (basal ganglia) (9.8), and Brain - Nucleus accumbens (basal ganglia) (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNG7 Gene

SOURCE GeneReport for Unigene cluster for GNG7 Gene Hs.515544

mRNA Expression by UniProt/SwissProt for GNG7 Gene

O60262-GBG7_HUMAN
Tissue specificity: Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.
genes like me logo Genes that share expressions with GNG7: view

Orthologs for GNG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG7 36
  • 98.53 (n)
  • 100 (a)
GNG7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG7 36
  • 90.69 (n)
  • 97.06 (a)
GNG7 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG7 36
  • 88.73 (n)
  • 97.06 (a)
GNG7 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng7 36
  • 83.33 (n)
  • 94.12 (a)
Gng7 16
Gng7 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNG7 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNG7 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng7 36
  • 82.84 (n)
  • 94.12 (a)
chicken
(Gallus gallus)
Aves GNG7 37
  • 91 (a)
OneToOne
LOC100858976 36
  • 82.84 (n)
  • 91.18 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gng7 36
  • 76.96 (n)
  • 88.24 (a)
zebrafish
(Danio rerio)
Actinopterygii gng7 36
  • 78.92 (n)
  • 94.12 (a)
gng7 37
  • 94 (a)
OneToOne
Species with no ortholog for GNG7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG7 Gene

ENSEMBL:
Gene Tree for GNG7 (if available)
TreeFam:
Gene Tree for GNG7 (if available)

Paralogs for GNG7 Gene

Paralogs for GNG7 Gene

Selected SIMAP similar genes for GNG7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNG7: view

Variants for GNG7 Gene

Sequence variations from dbSNP and Humsavar for GNG7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs736306 -- 2,528,825(+) AGGTT(A/C)CTGTG intron-variant
rs740054 -- 2,529,036(+) CCCCT(C/G)ACCTG intron-variant
rs740670 -- 2,539,809(+) CTAAA(C/T)ACACA intron-variant
rs744058 -- 2,528,989(+) GCTCT(A/T)GAGAA intron-variant
rs758473 -- 2,550,109(+) CCCTG(C/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNG7 Gene

Variant ID Type Subtype PubMed ID
dgv3637n71 CNV Loss 21882294
nsv910660 CNV Loss 21882294
nsv910668 CNV Loss 21882294
nsv910669 CNV Loss 21882294
nsv910670 CNV Gain+Loss 21882294
dgv3640n71 CNV Loss 21882294
nsv910672 CNV Loss 21882294
nsv910674 CNV Loss 21882294
nsv509714 CNV Insertion 20534489
nsv833708 CNV Loss 17160897
nsv526820 CNV Loss 19592680
esv1406094 CNV Insertion 17803354
nsv910675 CNV Loss 21882294
nsv470109 CNV Loss 18288195
esv2444878 CNV Deletion 19546169
nsv458326 CNV Gain 19166990
esv2717899 CNV Deletion 23290073
esv2717900 CNV Deletion 23290073
esv2717901 CNV Deletion 23290073
nsv470111 CNV Gain 18288195
esv2657598 CNV Deletion 23128226
esv1706865 CNV Deletion 17803354
nsv910676 CNV Loss 21882294
esv2717902 CNV Deletion 23290073
esv2717903 CNV Deletion 23290073
dgv3641n71 CNV Loss 21882294
esv2717904 CNV Deletion 23290073
nsv910678 CNV Loss 21882294
nsv910680 CNV Loss 21882294
nsv828397 CNV Gain 20364138
esv29337 CNV Loss 19812545
esv2153598 CNV Deletion 18987734
nsv910681 CNV Loss 21882294
dgv3642n71 CNV Loss 21882294
esv23824 CNV Loss 19812545

Relevant External Links for GNG7 Gene

HapMap Linkage Disequilibrium report
GNG7

Disorders for GNG7 Gene

Relevant External Links for GNG7

Genetic Association Database (GAD)
GNG7
Human Genome Epidemiology (HuGE) Navigator
GNG7
genes like me logo Genes that share disorders with GNG7: view

No data available for UniProtKB/Swiss-Prot for GNG7 Gene

Publications for GNG7 Gene

  1. Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. (PMID: 9600093) Shibata K. … Akiyoshi T. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for GNG7 Gene

Sources for GNG7 Gene

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