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Aliases for GNG7 Gene

Aliases for GNG7 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 7 2 3
  • GNGT7 4

External Ids for GNG7 Gene

Previous GeneCards Identifiers for GNG7 Gene

  • GC19M002577
  • GC19M002454
  • GC19M002463
  • GC19M002464
  • GC19M002465
  • GC19M002283

Summaries for GNG7 Gene

GeneCards Summary for GNG7 Gene

GNG7 (Guanine Nucleotide Binding Protein (G Protein), Gamma 7) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG4.

UniProtKB/Swiss-Prot for GNG7 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Tocris Summary for GNG7 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG7 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG7 Gene

Genomics for GNG7 Gene

Regulatory Elements for GNG7 Gene

Genomic Location for GNG7 Gene

Chromosome:
19
Start:
2,511,219 bp from pter
End:
2,702,748 bp from pter
Size:
191,530 bases
Orientation:
Minus strand

Genomic View for GNG7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG7 Gene

Proteins for GNG7 Gene

  • Protein details for GNG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60262-GBG7_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Protein Accession:
    O60262
    Secondary Accessions:
    • B2R496

    Protein attributes for GNG7 Gene

    Size:
    68 amino acids
    Molecular mass:
    7522 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNG7 Gene

Proteomics data for GNG7 Gene at MOPED

Post-translational modifications for GNG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG7 Gene

Domains & Families for GNG7 Gene

Protein Domains for GNG7 Gene

Suggested Antigen Peptide Sequences for GNG7 Gene

Graphical View of Domain Structure for InterPro Entry

O60262

UniProtKB/Swiss-Prot:

GBG7_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG7: view

No data available for Gene Families for GNG7 Gene

Function for GNG7 Gene

Molecular function for GNG7 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).

Gene Ontology (GO) - Molecular Function for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with GNG7: view
genes like me logo Genes that share phenotypes with GNG7: view

Animal Models for GNG7 Gene

MGI Knock Outs for GNG7:

Animal Model Products

miRNA for GNG7 Gene

miRTarBase miRNAs that target GNG7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GNG7 Gene

Localization for GNG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG7 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG7 Gene COMPARTMENTS Subcellular localization image for GNG7 gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GNG7: view

Pathways & Interactions for GNG7 Gene

genes like me logo Genes that share pathways with GNG7: view

Gene Ontology (GO) - Biological Process for GNG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0006112 energy reserve metabolic process TAS --
GO:0007168 receptor guanylyl cyclase signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with GNG7: view

No data available for SIGNOR curated interactions for GNG7 Gene

Drugs & Compounds for GNG7 Gene

(3) Drugs for GNG7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
mastoparan
72093-21-1
Mastoparan X
72093-22-2
SCH 202676 hydrobromide
265980-25-4
genes like me logo Genes that share compounds with GNG7: view

Transcripts for GNG7 Gene

mRNA/cDNA for GNG7 Gene

Unigene Clusters for GNG7 Gene

Guanine nucleotide binding protein (G protein), gamma 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG7 Gene

No ASD Table

Relevant External Links for GNG7 Gene

GeneLoc Exon Structure for
GNG7
ECgene alternative splicing isoforms for
GNG7

Expression for GNG7 Gene

mRNA expression in normal human tissues for GNG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG7 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x11.8), Brain - Caudate (basal ganglia) (x9.8), and Brain - Nucleus accumbens (basal ganglia) (x9.2).

Protein differential expression in normal tissues from HIPED for GNG7 Gene

This gene is overexpressed in Frontal cortex (23.2) and Spinal cord (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNG7 Gene



SOURCE GeneReport for Unigene cluster for GNG7 Gene Hs.515544

mRNA Expression by UniProt/SwissProt for GNG7 Gene

O60262-GBG7_HUMAN
Tissue specificity: Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.
genes like me logo Genes that share expression patterns with GNG7: view

Protein tissue co-expression partners for GNG7 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for GNG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNG7 35
  • 90.69 (n)
  • 97.06 (a)
GNG7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG7 35
  • 88.73 (n)
  • 97.06 (a)
GNG7 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng7 35
  • 83.33 (n)
  • 94.12 (a)
Gng7 16
Gng7 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNG7 35
  • 98.53 (n)
  • 100 (a)
GNG7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng7 35
  • 82.84 (n)
  • 94.12 (a)
oppossum
(Monodelphis domestica)
Mammalia GNG7 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNG7 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858976 35
  • 82.84 (n)
  • 91.18 (a)
GNG7 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng7 35
  • 76.96 (n)
  • 88.24 (a)
zebrafish
(Danio rerio)
Actinopterygii gng7 35
  • 78.92 (n)
  • 94.12 (a)
gng7 36
  • 94 (a)
OneToOne
Species with no ortholog for GNG7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG7 Gene

ENSEMBL:
Gene Tree for GNG7 (if available)
TreeFam:
Gene Tree for GNG7 (if available)

Paralogs for GNG7 Gene

Paralogs for GNG7 Gene

(10) SIMAP similar genes for GNG7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNG7: view

Variants for GNG7 Gene

Sequence variations from dbSNP and Humsavar for GNG7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs736306 -- 2,528,825(+) AGGTT(A/C)CTGTG intron-variant
rs740054 -- 2,529,036(+) CCCCT(C/G)ACCTG intron-variant
rs740670 -- 2,539,809(+) CTAAA(C/T)ACACA intron-variant
rs744058 -- 2,528,989(+) GCTCT(A/T)GAGAA intron-variant
rs758473 -- 2,550,109(+) CCCTG(C/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNG7 Gene

Variant ID Type Subtype PubMed ID
dgv3637n71 CNV Loss 21882294
nsv910660 CNV Loss 21882294
nsv910668 CNV Loss 21882294
nsv910669 CNV Loss 21882294
nsv910670 CNV Gain+Loss 21882294
dgv3640n71 CNV Loss 21882294
nsv910672 CNV Loss 21882294
nsv910674 CNV Loss 21882294
nsv509714 CNV Insertion 20534489
nsv833708 CNV Loss 17160897
nsv526820 CNV Loss 19592680
esv1406094 CNV Insertion 17803354
nsv910675 CNV Loss 21882294
nsv470109 CNV Loss 18288195
esv2444878 CNV Deletion 19546169
nsv458326 CNV Gain 19166990
esv2717899 CNV Deletion 23290073
esv2717900 CNV Deletion 23290073
esv2717901 CNV Deletion 23290073
nsv470111 CNV Gain 18288195
esv2657598 CNV Deletion 23128226
esv1706865 CNV Deletion 17803354
nsv910676 CNV Loss 21882294
esv2717902 CNV Deletion 23290073
esv2717903 CNV Deletion 23290073
dgv3641n71 CNV Loss 21882294
esv2717904 CNV Deletion 23290073
nsv910678 CNV Loss 21882294
nsv910680 CNV Loss 21882294
nsv828397 CNV Gain 20364138
esv29337 CNV Loss 19812545
esv2153598 CNV Deletion 18987734
nsv910681 CNV Loss 21882294
dgv3642n71 CNV Loss 21882294
esv23824 CNV Loss 19812545

Variation tolerance for GNG7 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG7 Gene

HapMap Linkage Disequilibrium report
GNG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG7 Gene

Disorders for GNG7 Gene

Relevant External Links for GNG7

Genetic Association Database (GAD)
GNG7
Human Genome Epidemiology (HuGE) Navigator
GNG7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG7
genes like me logo Genes that share disorders with GNG7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG7 Gene

Publications for GNG7 Gene

  1. Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. (PMID: 9600093) Shibata K. … Akiyoshi T. (Biochem. Biophys. Res. Commun. 1998) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. Identification of guanine nucleotide-binding protein I^-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling. (PMID: 23403885) Demokan S. … Califano J.A. (Int. J. Oncol. 2013) 67
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67

Products for GNG7 Gene

Sources for GNG7 Gene

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