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Aliases for GNG5 Gene

Aliases for GNG5 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 5 2 3
  • GNGT5 4

External Ids for GNG5 Gene

Previous GeneCards Identifiers for GNG5 Gene

  • GC01P085584
  • GC01M084102
  • GC01M084252
  • GC01M084386
  • GC01M084676
  • GC01M084964
  • GC01M083074

Summaries for GNG5 Gene

Entrez Gene Summary for GNG5 Gene

  • G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

GeneCards Summary for GNG5 Gene

GNG5 (Guanine Nucleotide Binding Protein (G Protein), Gamma 5) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include signal transducer activity and GTPase activity. An important paralog of this gene is GNG7.

UniProtKB/Swiss-Prot for GNG5 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNG5 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG5 Gene

Genomics for GNG5 Gene

Regulatory Elements for GNG5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNG5 Gene

Start:
84,498,323 bp from pter
End:
84,506,579 bp from pter
Size:
8,257 bases
Orientation:
Minus strand

Genomic View for GNG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG5 Gene

Proteins for GNG5 Gene

  • Protein details for GNG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63218-GBG5_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
    Protein Accession:
    P63218
    Secondary Accessions:
    • B2R5A0
    • P30670
    • Q5VX54
    • Q61015

    Protein attributes for GNG5 Gene

    Size:
    68 amino acids
    Molecular mass:
    7318 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNG5 Gene

Proteomics data for GNG5 Gene at MOPED

Post-translational modifications for GNG5 Gene

  • Ubiquitination at Lys11, Lys12, and Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for GNG5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG5 Gene

Domains for GNG5 Gene

Protein Domains for GNG5 Gene

Suggested Antigen Peptide Sequences for GNG5 Gene

Graphical View of Domain Structure for InterPro Entry

P63218

UniProtKB/Swiss-Prot:

GBG5_HUMAN :
  • P63218
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG5: view

No data available for Gene Families for GNG5 Gene

Function for GNG5 Gene

Molecular function for GNG5 Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein),gamma,polypeptide 5 with alternative transcriptional start sites resulting from two separate,closely linked 5 promoters
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10819326
GO:0004871 signal transducer activity NAS 20277477
GO:0005515 protein binding IPI 25416956
GO:0030165 PDZ domain binding IDA 23209302
genes like me logo Genes that share ontologies with GNG5: view

Phenotypes for GNG5 Gene

genes like me logo Genes that share phenotypes with GNG5: view

Animal Model Products

CRISPR Products

miRNA for GNG5 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GNG5 Gene

Localization for GNG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG5 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG5 Gene COMPARTMENTS Subcellular localization image for GNG5 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex NAS 9790912
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GNG5: view

Pathways for GNG5 Gene

SuperPathways for GNG5 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 ERK Signaling
genes like me logo Genes that share pathways with GNG5: view

Gene Ontology (GO) - Biological Process for GNG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction NAS 9790912
GO:0007186 G-protein coupled receptor signaling pathway NAS 20277477
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with GNG5: view

Compounds for GNG5 Gene

(5) Tocris Compounds for GNG5 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNG5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNG5: view

Transcripts for GNG5 Gene

mRNA/cDNA for GNG5 Gene

Unigene Clusters for GNG5 Gene

Guanine nucleotide binding protein (G protein), gamma 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNG5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNG5 Gene

No ASD Table

Relevant External Links for GNG5 Gene

GeneLoc Exon Structure for
GNG5
ECgene alternative splicing isoforms for
GNG5

Expression for GNG5 Gene

mRNA expression in normal human tissues for GNG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG5 Gene

This gene is overexpressed in Whole Blood (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNG5 Gene

SOURCE GeneReport for Unigene cluster for GNG5 Gene Hs.645427

genes like me logo Genes that share expressions with GNG5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GNG5 Gene

Orthologs for GNG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG5 35
  • 100 (n)
  • 100 (a)
GNG5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG5 35
  • 94.61 (n)
  • 100 (a)
GNG5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG5 35
  • 92.16 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Gng5 35
  • 93.14 (n)
  • 100 (a)
Gng5 16
Gng5 36
  • 100 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gng5 35
  • 93.63 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 93 (a)
OneToMany
GNG5 35
  • 80.88 (n)
  • 92.65 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gng5 35
  • 80.39 (n)
  • 91.18 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13816 35
zebrafish
(Danio rerio)
Actinopterygii gng5 35
  • 72.55 (n)
  • 83.82 (a)
gng5 36
  • 84 (a)
OneToMany
iktdsubc_2c12 35
Species with no ortholog for GNG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG5 Gene

ENSEMBL:
Gene Tree for GNG5 (if available)
TreeFam:
Gene Tree for GNG5 (if available)

Paralogs for GNG5 Gene

Paralogs for GNG5 Gene

Selected SIMAP similar genes for GNG5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG5: view

Variants for GNG5 Gene

Sequence variations from dbSNP and Humsavar for GNG5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2063038 -- 84,501,506(+) CTTGG(G/T)GACTC intron-variant
rs7545970 -- 84,500,262(+) aagca(A/G)TGCTT intron-variant
rs7555773 -- 84,499,741(+) CCTGT(A/G)TTATT intron-variant
rs12140555 -- 84,499,681(+) CCTGT(C/T)GTCTT intron-variant
rs17110474 -- 84,501,083(+) ACATG(A/C)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNG5 Gene

Variant ID Type Subtype PubMed ID
nsv830437 CNV Gain+Loss 17160897

Relevant External Links for GNG5 Gene

HapMap Linkage Disequilibrium report
GNG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG5 Gene

Disorders for GNG5 Gene

Relevant External Links for GNG5

Genetic Association Database (GAD)
GNG5
Human Genome Epidemiology (HuGE) Navigator
GNG5
genes like me logo Genes that share disorders with GNG5: view

No data available for UniProtKB/Swiss-Prot for GNG5 Gene

Publications for GNG5 Gene

  1. Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22. (PMID: 7606925) Ahmad W. … Aronson N.N. (Cytogenet. Cell Genet. 1995) 2 3
  2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4
  3. Structure of human G protein Ggamma5 gene GNG5. (PMID: 9790912) Liu B. … Aronson N.N. Jr. (Biochem. Biophys. Res. Commun. 1998) 3 4
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GNG5 Gene

Sources for GNG5 Gene

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