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Aliases for GNG4 Gene

Aliases for GNG4 Gene

  • G Protein Subunit Gamma 4 2 3
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 4 2 5
  • GNGT4 4

External Ids for GNG4 Gene

Previous GeneCards Identifiers for GNG4 Gene

  • GC01M233846
  • GC01M231167
  • GC01M232010
  • GC01M232755
  • GC01M232040
  • GC01M235710
  • GC01M206162

Summaries for GNG4 Gene

GeneCards Summary for GNG4 Gene

GNG4 (G Protein Subunit Gamma 4) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG12.

UniProtKB/Swiss-Prot for GNG4 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG4 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG4 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG4 Gene

Genomics for GNG4 Gene

Regulatory Elements for GNG4 Gene

Promoters for GNG4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNG4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNG4 Gene

Chromosome:
1
Start:
235,547,685 bp from pter
End:
235,650,754 bp from pter
Size:
103,070 bases
Orientation:
Minus strand

Genomic View for GNG4 Gene

Genes around GNG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG4 Gene

Proteins for GNG4 Gene

  • Protein details for GNG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50150-GBG4_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
    Protein Accession:
    P50150

    Protein attributes for GNG4 Gene

    Size:
    75 amino acids
    Molecular mass:
    8389 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3 (PubMed:7665596). Interacts with KCNK1 (By similarity).

neXtProt entry for GNG4 Gene

Proteomics data for GNG4 Gene at MOPED

Post-translational modifications for GNG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG4 Gene

No data available for DME Specific Peptides for GNG4 Gene

Domains & Families for GNG4 Gene

Protein Domains for GNG4 Gene

Graphical View of Domain Structure for InterPro Entry

P50150

UniProtKB/Swiss-Prot:

GBG4_HUMAN :
  • Belongs to the G protein gamma family.
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG4: view

No data available for Gene Families for GNG4 Gene

Function for GNG4 Gene

Molecular function for GNG4 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
genes like me logo Genes that share phenotypes with GNG4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNG4 Gene

Localization for GNG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG4 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG4 Gene COMPARTMENTS Subcellular localization image for GNG4 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNG4: view

Pathways & Interactions for GNG4 Gene

SuperPathways for GNG4 Gene

Superpath Contained pathways
1 Circadian entrainment
2 Development Angiotensin activation of ERK
3 fMLP Pathway
4 Presynaptic function of Kainate receptors
5 G-protein activation
genes like me logo Genes that share pathways with GNG4: view

Gene Ontology (GO) - Biological Process for GNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 7665596
genes like me logo Genes that share ontologies with GNG4: view

No data available for SIGNOR curated interactions for GNG4 Gene

Drugs & Compounds for GNG4 Gene

(3) Drugs for GNG4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
mastoparan
72093-21-1
Mastoparan X
72093-22-2
NF 023
104869-31-0
SCH 202676 hydrobromide
265980-25-4

(5) Tocris Compounds for GNG4 Gene

Compound Action Cas Number
[D-Trp7,9,10]-Substance P Inhibits M1 ACh receptor activation of Gq/11 89430-38-6
Mastoparan Activates Gi and Go 72093-21-1
Mastoparan X G protein activator peptide 72093-22-2
NF 023 Selective, competitive P2X1 antagonist 104869-31-0
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors 265980-25-4
genes like me logo Genes that share compounds with GNG4: view

Transcripts for GNG4 Gene

Unigene Clusters for GNG4 Gene

Guanine nucleotide binding protein (G protein), gamma 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for GNG4 Gene

GeneLoc Exon Structure for
GNG4
ECgene alternative splicing isoforms for
GNG4

Expression for GNG4 Gene

mRNA expression in normal human tissues for GNG4 Gene

mRNA differential expression in normal tissues according to GTEx for GNG4 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.1), Brain - Amygdala (x5.0), Pituitary (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for GNG4 Gene

This gene is overexpressed in Retina (21.1), Fetal Brain (14.2), Islet of Langerhans (9.8), Pancreas (8.5), and Ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNG4 Gene



SOURCE GeneReport for Unigene cluster for GNG4 Gene Hs.159711

mRNA Expression by UniProt/SwissProt for GNG4 Gene

P50150-GBG4_HUMAN
Tissue specificity: Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.
genes like me logo Genes that share expression patterns with GNG4: view

Protein tissue co-expression partners for GNG4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GNG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNG4 35
  • 92 (n)
  • 98.67 (a)
GNG4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG4 35
  • 91.56 (n)
  • 98.67 (a)
GNG4 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng4 35
  • 89.78 (n)
  • 98.67 (a)
Gng4 16
Gng4 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNG4 35
  • 99.56 (n)
  • 100 (a)
GNG4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng4 35
  • 90.67 (n)
  • 98.67 (a)
oppossum
(Monodelphis domestica)
Mammalia GNG4 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNG4 35
  • 76.13 (n)
  • 85.14 (a)
GNG4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNG4 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng4 35
  • 79.11 (n)
  • 90.67 (a)
Str.11936 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24553 35
zebrafish
(Danio rerio)
Actinopterygii gng3 35
Species with no ortholog for GNG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG4 Gene

ENSEMBL:
Gene Tree for GNG4 (if available)
TreeFam:
Gene Tree for GNG4 (if available)

Paralogs for GNG4 Gene

Paralogs for GNG4 Gene

(10) SIMAP similar genes for GNG4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNG4: view

Variants for GNG4 Gene

Sequence variations from dbSNP and Humsavar for GNG4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs14326 -- 235,552,223(-) GCAGC(C/G/T)GCGGA reference, synonymous-codon
rs387492 -- 235,552,361(-) CATGT(C/T)GTAGG intron-variant
rs291349 -- 235,561,455(-) cagcc(A/G)ggtgg intron-variant
rs291350 -- 235,561,410(-) ATATA(A/T)AGAGA intron-variant
rs291351 -- 235,561,275(-) tccca(A/G)cactt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNG4 Gene

Variant ID Type Subtype PubMed ID
dgv30n21 CNV Gain 19592680
nsv873322 CNV Gain 21882294
dgv549n71 CNV Gain 21882294
esv2471335 CNV Insertion 19546169
nsv832936 CNV Gain 17160897

Variation tolerance for GNG4 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG4 Gene

HapMap Linkage Disequilibrium report
GNG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG4 Gene

Disorders for GNG4 Gene

Relevant External Links for GNG4

Genetic Association Database (GAD)
GNG4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNG4

No disorders were found for GNG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG4 Gene

Publications for GNG4 Gene

  1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PMID: 7665596) Ray K. … Robishaw J.D. (J. Biol. Chem. 1995) 2 3 4 67
  2. Identification of novel VHL target genes and relationship to hypoxic response pathways. (PMID: 15824735) Maina E.N. … Maher E.R. (Oncogene 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for GNG4 Gene

Sources for GNG4 Gene

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