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Aliases for GNG3 Gene

Aliases for GNG3 Gene

  • G Protein Subunit Gamma 3 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Gamma 3 2
  • Guanine Nucleotide-Binding Protein Gamma-3 Subunit 2
  • NBP Gamma-3 2
  • GNGT3 4

External Ids for GNG3 Gene

Previous GeneCards Identifiers for GNG3 Gene

  • GC11P064988
  • GC11P064050
  • GC11P062250
  • GC11P062231
  • GC11P062475
  • GC11P058803

Summaries for GNG3 Gene

Entrez Gene Summary for GNG3 Gene

  • Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]

GeneCards Summary for GNG3 Gene

GNG3 (G Protein Subunit Gamma 3) is a Protein Coding gene. Among its related pathways are CCR5 Pathway in Macrophages and Aquaporin-mediated transport. GO annotations related to this gene include GTPase activity and G-protein coupled receptor binding. An important paralog of this gene is GNG2.

UniProtKB/Swiss-Prot for GNG3 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Tocris Summary for GNG3 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNG3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG3 Gene

Genomics for GNG3 Gene

Regulatory Elements for GNG3 Gene

Enhancers for GNG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G062041 1.4 ENCODE dbSUPER 10.6 -661.0 -660995 8.1 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC METTL12 INTS5 SNHG1 NXF1 TMEM138 MTA2 STX5 LOC105369332 TAF6L VPS37C
GH11G062438 1.1 ENCODE dbSUPER 10.7 -267.5 -267475 1.3 ELF3 FOXA2 MLX ZFP64 DMAP1 RAD21 RARA YY1 EGR1 CREM ENSG00000267811 LRRN4CL SCGB1A1 ENSG00000255126 ASRGL1 ENSG00000250659 ENSG00000257058 AHNAK GNG3 EEF1G
GH11G062704 1.1 ENCODE 0.7 +1.6 1568 6.1 HDGF PKNOX1 AGO1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 BSCL2 TTC9C ROM1 ENSG00000267811 GNG3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNG3 on UCSC Golden Path with GeneCards custom track

Promoters for GNG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040464 -222 801 PKNOX1 AGO1 ARID4B SIN3A FEZF1 ZNF2 YY1 GATA2 ELK1 ZNF207

Genomic Location for GNG3 Gene

62,706,422 bp from pter
62,709,206 bp from pter
2,785 bases
Plus strand

Genomic View for GNG3 Gene

Genes around GNG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG3 Gene

Proteins for GNG3 Gene

  • Protein details for GNG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
    Protein Accession:
    Secondary Accessions:
    • B2R4S7
    • P29798
    • Q61014

    Protein attributes for GNG3 Gene

    75 amino acids
    Molecular mass:
    8305 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma. Interacts with SCN8A (PubMed:26900580).

neXtProt entry for GNG3 Gene

Post-translational modifications for GNG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG3 Gene

Domains & Families for GNG3 Gene

Gene Families for GNG3 Gene

Protein Domains for GNG3 Gene

Suggested Antigen Peptide Sequences for GNG3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G protein gamma family.
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG3: view

Function for GNG3 Gene

Molecular function for GNG3 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein) gamma 3 subunit,expressed in brain
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Gene Ontology (GO) - Molecular Function for GNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0003924 GTPase activity TAS 10075696
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 26900580
GO:0031702 type 1 angiotensin receptor binding IEA --
genes like me logo Genes that share ontologies with GNG3: view
genes like me logo Genes that share phenotypes with GNG3: view

Animal Models for GNG3 Gene

MGI Knock Outs for GNG3:

Animal Model Products

  • Taconic Biosciences Mouse Models for GNG3

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNG3 Gene

Localization for GNG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG3 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNG3 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 3
mitochondrion 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with GNG3: view

Pathways & Interactions for GNG3 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
2 ADP signalling through P2Y purinoceptor 12
3 fMLP Pathway
4 Presynaptic function of Kainate receptors
5 Development Dopamine D2 receptor transactivation of EGFR
genes like me logo Genes that share pathways with GNG3: view

SIGNOR curated interactions for GNG3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10075696
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0071377 cellular response to glucagon stimulus TAS --
genes like me logo Genes that share ontologies with GNG3: view

Drugs & Compounds for GNG3 Gene

(3) Drugs for GNG3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for GNG3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
G-Protein antagonist peptide
Pertussis Toxin

(5) Tocris Compounds for GNG3 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3
genes like me logo Genes that share compounds with GNG3: view

Transcripts for GNG3 Gene

mRNA/cDNA for GNG3 Gene

Unigene Clusters for GNG3 Gene

Guanine nucleotide binding protein (G protein), gamma 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG3 Gene

No ASD Table

Relevant External Links for GNG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNG3 Gene

This gene is overexpressed in Brain - Cortex (x7.2), Brain - Frontal Cortex (BA9) (x6.6), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Amygdala (x4.9), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for GNG3 Gene

This gene is overexpressed in Frontal cortex (35.7) and Brain (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GNG3 Gene

Protein tissue co-expression partners for GNG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNG3 Gene:


SOURCE GeneReport for Unigene cluster for GNG3 Gene:


Evidence on tissue expression from TISSUES for GNG3 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with GNG3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNG3 Gene

Orthologs for GNG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GNG3 34 35
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia GNG3 35
  • 99 (a)
(Bos Taurus)
Mammalia GNG3 34 35
  • 97.78 (n)
(Monodelphis domestica)
Mammalia GNG3 35
  • 97 (a)
(Canis familiaris)
Mammalia GNG3 34 35
  • 96 (n)
(Rattus norvegicus)
Mammalia Gng3 34
  • 96 (n)
(Mus musculus)
Mammalia Gng3 34 16 35
  • 94.67 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gng3 34
  • 80 (n)
(Danio rerio)
Actinopterygii gng3 34 35
  • 85.33 (n)
Species where no ortholog for GNG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG3 Gene

Gene Tree for GNG3 (if available)
Gene Tree for GNG3 (if available)

Paralogs for GNG3 Gene

Paralogs for GNG3 Gene

(10) SIMAP similar genes for GNG3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG3: view

Variants for GNG3 Gene

Sequence variations from dbSNP and Humsavar for GNG3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1057517657 Pathogenic 62,705,371(-) TCTTC(C/T)TCTAT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1057517658 Pathogenic 62,705,357(-) TCCTT(-/TT)CTACT nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs1057517659 Pathogenic 62,705,320(-) TCAGC(C/GGA)CTGTG nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs786205068 Pathogenic 62,705,320(-) CTCAG(CC/GGA)CTGTG nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs112877243 Likely benign 62,706,230(+) CAGCC(A/C/T)GCCGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GNG3 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855
nsv555174 CNV gain 21841781

Variation tolerance for GNG3 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG3 Gene

Disorders for GNG3 Gene

Relevant External Links for GNG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GNG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNG3 Gene

Publications for GNG3 Gene

  1. Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy. (PMID: 26900580) Wagnon J.L. … Meisler M.H. (Ann. Clin. Transl. Neurol. 2016) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PMID: 10819326) Hurowitz E.H. … Shizuya H. (DNA Res. 2000) 3 4 64
  4. The G protein subunit gene families. (PMID: 10644457) Downes G.B. … Gautam N. (Genomics 1999) 2 3 64
  5. Interaction of G-protein I^I^ complex with chromatin modulates GPCR-dependent gene regulation. (PMID: 23326349) Bhatnagar A. … Karnik S.S. (PLoS ONE 2013) 3 64

Products for GNG3 Gene

Sources for GNG3 Gene

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