Aliases for GNB2 Gene
- G Protein Subunit Beta 2 2 3
- Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2 2 5
- Transducin Beta Chain 2 2 4
- Signal-Transducing Guanine Nucleotide-Binding Regulatory Protein Beta Subunit 2
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 2 2
- G Protein Subunit Beta-2 4
- Beta-2 Subunit 2
- G Protein 2
External Ids for GNB2 Gene
Previous GeneCards Identifiers for GNB2 Gene
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]
GeneCards Summary for GNB2 Gene
GNB2 (G Protein Subunit Beta 2) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chemokine Signaling. GO annotations related to this gene include GTPase activity and protein complex binding. An important paralog of this gene is GNB4.
UniProtKB/Swiss-Prot for GNB2 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.