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Aliases for GNAZ Gene

Aliases for GNAZ Gene

  • Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide 2 3
  • G(X) Alpha Chain 3 4
  • Gz-Alpha 3 4
  • Transducin Alpha 3

External Ids for GNAZ Gene

Previous GeneCards Identifiers for GNAZ Gene

  • GC22P020136
  • GC22P021737
  • GC22P021728
  • GC22P023413
  • GC22P006380

Summaries for GNAZ Gene

Entrez Gene Summary for GNAZ Gene

  • The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNAZ Gene

GNAZ (Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide) is a Protein Coding gene. Diseases associated with GNAZ include autosomal dominant congenital stationary night blindness and achromatopsia. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNAZ Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems

Tocris Summary for GNAZ Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for GNAZ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAZ Gene

Genomics for GNAZ Gene

Regulatory Elements for GNAZ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNAZ Gene

Chromosome:
22
Start:
23,070,361 bp from pter
End:
23,125,037 bp from pter
Size:
54,677 bases
Orientation:
Plus strand

Genomic View for GNAZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAZ Gene

Proteins for GNAZ Gene

  • Protein details for GNAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19086-GNAZ_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(z) subunit alpha
    Protein Accession:
    P19086
    Secondary Accessions:
    • B2R6C1
    • Q4QRJ6

    Protein attributes for GNAZ Gene

    Size:
    355 amino acids
    Molecular mass:
    40924 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site

neXtProt entry for GNAZ Gene

Proteomics data for GNAZ Gene at MOPED

Post-translational modifications for GNAZ Gene

  • Ubiquitination at Lys 189
  • Modification sites at PhosphoSitePlus

Other Protein References for GNAZ Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GNAZ (G-alpha(z))

No data available for DME Specific Peptides for GNAZ Gene

Domains & Families for GNAZ Gene

Graphical View of Domain Structure for InterPro Entry

P19086

UniProtKB/Swiss-Prot:

GNAZ_HUMAN :
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Family:
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
genes like me logo Genes that share domains with GNAZ: view

No data available for Gene Families for GNAZ Gene

Function for GNAZ Gene

Molecular function for GNAZ Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein (G protein),alpha,z polypeptide
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems

Gene Ontology (GO) - Molecular Function for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0004871 signal transducer activity --
GO:0005057 receptor signaling protein activity TAS 2456569
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with GNAZ: view
genes like me logo Genes that share phenotypes with GNAZ: view

Animal Models for GNAZ Gene

MGI Knock Outs for GNAZ:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNAZ

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GNAZ Gene

Localization for GNAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAZ Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNAZ Gene COMPARTMENTS Subcellular localization image for GNAZ gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
nucleus 4
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS 2117645
GO:0005783 endoplasmic reticulum TAS 2117645
GO:0005829 cytosol IEA --
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNAZ: view

Pathways & Interactions for GNAZ Gene

genes like me logo Genes that share pathways with GNAZ: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GNAZ Gene

Selected Interacting proteins: P19086-GNAZ_HUMAN for GNAZ Gene via I2D

SIGNOR curated interactions for GNAZ Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GNAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007186 G-protein coupled receptor signaling pathway TAS 3129724
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GNAZ: view

Drugs & Compounds for GNAZ Gene

(6) Drugs for GNAZ Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
arachidonic acid Experimental Nutra Potentiation, Activator 27
cgmp Pharma Activation, Activator 0

(9) Additional Compounds for GNAZ Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[D-Trp7,9,10]-Substance P
89430-38-6
G-Protein antagonist peptide
143675-79-0
mastoparan
72093-21-1
Mastoparan X
72093-22-2
SCH 202676 hydrobromide
265980-25-4
genes like me logo Genes that share compounds with GNAZ: view

Transcripts for GNAZ Gene

mRNA/cDNA for GNAZ Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNAZ Gene

Guanine nucleotide binding protein (G protein), alpha z polypeptide:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNAZ

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNAZ Gene

No ASD Table

Relevant External Links for GNAZ Gene

GeneLoc Exon Structure for
GNAZ
ECgene alternative splicing isoforms for
GNAZ

Expression for GNAZ Gene

mRNA expression in normal human tissues for GNAZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNAZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5), Frontal cortex (13.1), Brain (9.6), Platelet (8.8), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GNAZ Gene



SOURCE GeneReport for Unigene cluster for GNAZ Gene Hs.584760

genes like me logo Genes that share expression patterns with GNAZ: view

Protein tissue co-expression partners for GNAZ Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNAZ Gene

Orthologs for GNAZ Gene

This gene was present in the common ancestor of animals.

Orthologs for GNAZ Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GNAZ 35
  • 93.33 (n)
  • 99.15 (a)
GNAZ 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnaz 35
  • 92.21 (n)
  • 98.31 (a)
Gnaz 16
Gnaz 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNAZ 35
  • 99.62 (n)
  • 100 (a)
GNAZ 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnaz 35
  • 91.64 (n)
  • 98.31 (a)
cow
(Bos Taurus)
Mammalia GNAZ 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNAZ 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNAZ 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNAZ 35
  • 82.25 (n)
  • 97.18 (a)
GNAZ 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNAZ 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnaz 35
  • 81.69 (n)
  • 96.34 (a)
zebrafish
(Danio rerio)
Actinopterygii gnaz 35
  • 80.25 (n)
  • 93.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gpa-11 37
  • 38 (a)
gpa-14 37
  • 32 (a)
gpa-15 37
  • 41 (a)
gpa-2 37
  • 42 (a)
gpa-3 37
  • 47 (a)
gpa-4 37
  • 50 (a)
gpa-5 37
  • 32 (a)
gpa-6 37
  • 37 (a)
gpa-7 37
  • 52 (a)
gpa-9 37
  • 34 (a)
odr-3 37
  • 44 (a)
Species with no ortholog for GNAZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNAZ Gene

ENSEMBL:
Gene Tree for GNAZ (if available)
TreeFam:
Gene Tree for GNAZ (if available)

Paralogs for GNAZ Gene

(19) SIMAP similar genes for GNAZ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GNAZ: view

Variants for GNAZ Gene

Structural Variations from Database of Genomic Variants (DGV) for GNAZ Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv4900n71 CNV Gain 21882294
nsv521695 CNV Loss 19592680
esv34158 CNV Loss 18971310
dgv4902n71 CNV Loss 21882294
esv24055 CNV Loss 19812545
dgv19e24 CNV Loss 17666407
nsv914577 CNV Loss 21882294
nsv3573 CNV Loss 18451855
nsv525485 CNV Loss 19592680
esv33363 CNV Gain+Loss 17666407

Variation tolerance for GNAZ Gene

Residual Variation Intolerance Score: 13.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNAZ Gene

HapMap Linkage Disequilibrium report
GNAZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GNAZ Gene

Disorders for GNAZ Gene

MalaCards: The human disease database

(4) MalaCards diseases for GNAZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autosomal dominant congenital stationary night blindness
  • csnbad
achromatopsia
  • achm
pertussis
  • whooping cough
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association
Search GNAZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNAZ

Genetic Association Database (GAD)
GNAZ
Human Genome Epidemiology (HuGE) Navigator
GNAZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNAZ
genes like me logo Genes that share disorders with GNAZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNAZ Gene

Publications for GNAZ Gene

  1. Alloimmune retinopathy associated with antibodies to transducin-alpha as a complication of chronic graft-versus-host disease. (PMID: 20053338) Wood W. … Serody J. (Biol. Blood Marrow Transplant. 2010) 23 67
  2. Complementary interactions of the rod PDE6 inhibitory subunit with the catalytic subunits and transducin. (PMID: 20231289) Guo L.W. … Ruoho A.E. (J. Biol. Chem. 2010) 23 67
  3. Umami taste transduction mechanisms. (PMID: 19571214) Kinnamon S.C. (Am. J. Clin. Nutr. 2009) 23 67
  4. Molecular biomarkers for autoimmune retinopathies: significance of anti-transducin-alpha autoantibodies. (PMID: 19744478) Adamus G. … Weleber R.G. (Exp. Mol. Pathol. 2009) 23 67
  5. The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits. (PMID: 18258741) Zurita A.R. … Birnbaumer L. (Proc. Natl. Acad. Sci. U.S.A. 2008) 23 67

Products for GNAZ Gene

Sources for GNAZ Gene

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