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Aliases for GNAO1 Gene

Aliases for GNAO1 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide O 2 3
  • EIEE17 3 6
  • Guanine Nucleotide-Binding Protein G(O) Subunit Alpha 3
  • G-ALPHA-O 3
  • GNAO 3

External Ids for GNAO1 Gene

Summaries for GNAO1 Gene

GeneCards Summary for GNAO1 Gene

GNAO1 (Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide O) is a Protein Coding gene. Diseases associated with GNAO1 include epileptic encephalopathy, early infantile, 17 and ohtahara syndrome. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.

UniProtKB/Swiss-Prot for GNAO1 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14

Tocris Summary for GNAO1 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the off state. Ligand-receptor binding results in detachment of the G protein, switching it to an on state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

Gene Wiki entry for GNAO1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNAO1 Gene

Genomics for GNAO1 Gene

Genomic Location for GNAO1 Gene

56,191,339 bp from pter
56,357,444 bp from pter
166,106 bases
Plus strand

Genomic View for GNAO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNAO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNAO1 Gene

Regulatory Elements for GNAO1 Gene

Proteins for GNAO1 Gene

  • Protein details for GNAO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein G(o) subunit alpha
    Protein Accession:
    Secondary Accessions:
    • P29777
    • Q8TD72
    • Q9UMV4

    Protein attributes for GNAO1 Gene

    354 amino acids
    Molecular mass:
    40051 Da
    Quaternary structure:
    • Interacts with RGS14 (By similarity). G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

    Alternative splice isoforms for GNAO1 Gene


neXtProt entry for GNAO1 Gene

Proteomics data for GNAO1 Gene at MOPED

Post-translational modifications for GNAO1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys46

Other Protein References for GNAO1 Gene

No data available for DME Specific Peptides for GNAO1 Gene

Domains for GNAO1 Gene


  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.:
    • P09471
genes like me logo Genes that share domains with GNAO1: view

No data available for Gene Families for GNAO1 Gene

Function for GNAO1 Gene

Molecular function for GNAO1 Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein),alpha activating,polypeptide O
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14

Gene Ontology (GO) - Molecular Function for GNAO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0004871 signal transducer activity IBA --
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with GNAO1: view
genes like me logo Genes that share phenotypes with GNAO1: view

Animal Models for GNAO1 Gene

MGI Knock Outs for GNAO1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GNAO1 Gene

Localization for GNAO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNAO1 Gene

Cell membrane.

Subcellular locations from

Jensen Localization Image for GNAO1 Gene COMPARTMENTS Subcellular localization image for GNAO1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for GNAO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with GNAO1: view

Pathways for GNAO1 Gene

genes like me logo Genes that share pathways with GNAO1: view

Gene Ontology (GO) - Biological Process for GNAO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006936 muscle contraction TAS 9050846
GO:0007165 signal transduction --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with GNAO1: view

Compounds for GNAO1 Gene

(5) Tocris Compounds for GNAO1 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
Gallein Inhibitor of betagamma signaling [2103-64-2]
G-Protein antagonist peptide Inhibits G protein activation by GPCRs [143675-79-0]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]

(3) HMDB Compounds for GNAO1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with GNAO1: view

Transcripts for GNAO1 Gene

Unigene Clusters for GNAO1 Gene

Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNAO1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - -
SP9: - - -

Relevant External Links for GNAO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNAO1 Gene

mRNA expression in normal human tissues for GNAO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNAO1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (4.5), Brain - Caudate (basal ganglia) (4.1), and Brain - Amygdala (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNAO1 Gene

SOURCE GeneReport for Unigene cluster for GNAO1 Gene Hs.644524

genes like me logo Genes that share expressions with GNAO1: view

Orthologs for GNAO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNAO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GNAO1 36
  • 99.91 (n)
  • 100 (a)
GNAO1 37
  • 94 (a)
(Bos Taurus)
Mammalia GNAO1 36
  • 95.29 (n)
  • 99.15 (a)
GNAO1 37
  • 92 (a)
(Canis familiaris)
Mammalia GNAO1 36
  • 95.76 (n)
  • 100 (a)
GNAO1 37
  • 94 (a)
(Mus musculus)
Mammalia Gnao1 36
  • 93.79 (n)
  • 98.02 (a)
Gnao1 16
Gnao1 37
  • 92 (a)
(Monodelphis domestica)
Mammalia GNAO1 37
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia GNAO1 37
  • 94 (a)
(Rattus norvegicus)
Mammalia Gnao1 36
  • 94.16 (n)
  • 98.59 (a)
(Gallus gallus)
Aves GNAO1 36
  • 88.51 (n)
  • 98.31 (a)
GNAO1 37
  • 97 (a)
(Anolis carolinensis)
Reptilia GNAO1 37
  • 93 (a)
African clawed frog
(Xenopus laevis)
Amphibia gnao1-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gnao1 36
  • 84.46 (n)
  • 98.59 (a)
Str.4190 36
(Danio rerio)
Actinopterygii gnao1a 36
  • 82.58 (n)
  • 95.76 (a)
gnao1a 37
  • 91 (a)
zgc73315 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005773 36
  • 68.84 (n)
  • 76.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta G-oalpha47A 36
  • 71.09 (n)
  • 83.05 (a)
G-oalpha47A 37
  • 83 (a)
G-ialpha65A 38
  • 65 (a)
G-oalpha47A 38
  • 82 (a)
(Caenorhabditis elegans)
Secernentea goa-1 36
  • 70.9 (n)
  • 82.2 (a)
goa-1 37
  • 83 (a)
odr-3 38
  • 50 (a)
gpa-14 38
  • 31 (a)
gpa-6 38
  • 40 (a)
gpa-4 38
  • 54 (a)
goa-1 38
  • 82 (a)
gpa-10 38
  • 35 (a)
gpa-15 38
  • 45 (a)
gpa-8 38
  • 39 (a)
gpa-3 38
  • 53 (a)
gpa-9 38
  • 36 (a)
gpa-1 38
  • 47 (a)
gpa-7 38
  • 56 (a)
gpa-11 38
  • 40 (a)
gpa-2 38
  • 45 (a)
Species with no ortholog for GNAO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNAO1 Gene

Gene Tree for GNAO1 (if available)
Gene Tree for GNAO1 (if available)

Paralogs for GNAO1 Gene

Paralogs for GNAO1 Gene

genes like me logo Genes that share paralogs with GNAO1: view

Variants for GNAO1 Gene

Sequence variations from dbSNP and Humsavar for GNAO1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs730300 -- 56,259,151(+) GAGGG(C/T)GTGGA intron-variant
rs730301 -- 56,259,404(+) TCTAC(C/G)CCTTC intron-variant
rs744302 -- 56,259,079(+) AGTGG(A/G)CGTCA intron-variant
rs746501 -- 56,248,778(+) ATGGC(A/G)GGAGG intron-variant
rs748272 -- 56,318,722(+) tattg(G/T)tatca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNAO1 Gene

Variant ID Type Subtype PubMed ID
dgv2865n71 CNV Gain 21882294
esv272874 CNV Insertion 20981092
nsv833242 CNV Loss 17160897
nsv906714 CNV Loss 21882294
esv2714509 CNV Deletion 23290073
nsv519979 CNV Loss 19592680
nsv906715 CNV Loss 21882294
nsv523649 CNV Loss 19592680
nsv521726 CNV Loss 19592680
dgv2870n71 CNV Loss 21882294
nsv906717 CNV Loss 21882294
nsv519346 CNV Loss 19592680
nsv525929 CNV Loss 19592680

Relevant External Links for GNAO1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for GNAO1 Gene

(1) OMIM Diseases for GNAO1 Gene (139311)


  • Epileptic encephalopathy, early infantile, 17 (EIEE17) [MIM:615473]: A severe neurologic disorder characterized by onset of intractable seizures in the first weeks or months of life and usually associated with EEG abnormalities. Affected infants have very poor psychomotor development and may have brain abnormalities, such as cerebral atrophy or thin corpus callosum. Some patients may show involuntary movements. {ECO:0000269 PubMed:23993195}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GNAO1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GNAO1: view

Publications for GNAO1 Gene

  1. Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha. (PMID: 3124840) Lavu S. … Kung H.-F. (Biochem. Biophys. Res. Commun. 1988) 3 4
  2. Identification and expression of GO1 and 2 alpha-subunit transcripts in human myometrium in relation to pregnancy. (PMID: 10330115) Duc-Goiran P. … Ferre F. (Biol. Reprod. 1999) 3 4
  3. Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels. (PMID: 11395521) Kinoshita M. … Kaneko S. (J. Biol. Chem. 2001) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 49

Products for GNAO1 Gene

Sources for GNAO1 Gene

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