Aliases for GNAO1 Gene
External Ids for GNAO1 Gene
Previous GeneCards Identifiers for GNAO1 Gene
GeneCards Summary for GNAO1 Gene
GNAO1 (Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide O) is a Protein Coding gene. Diseases associated with GNAO1 include epileptic encephalopathy, early infantile, 17 and ohtahara syndrome. Among its related pathways are GPCR Pathway and GPCR Pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAQ.
UniProtKB/Swiss-Prot for GNAO1 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.