Aliases for GNA12 Gene
External Ids for GNA12 Gene
Previous GeneCards Identifiers for GNA12 Gene
GeneCards Summary for GNA12 Gene
GNA12 (G Protein Subunit Alpha 12) is a Protein Coding gene. Diseases associated with GNA12 include Familial Hyperaldosteronism. Among its related pathways are EphB-EphrinB Signaling and p70S6K Signaling. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is GNAS.
UniProtKB/Swiss-Prot for GNA12 Gene
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade.
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.