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Aliases for POLM Gene

Aliases for POLM Gene

  • Polymerase (DNA Directed), Mu 2 3
  • Terminal Transferase 3 4
  • Pol Iota 2 3
  • Pol Mu 3 4
  • DNA-Directed DNA/RNA Polymerase Mu 3
  • Polymerase (DNA-Directed), Mu 3
  • DNA Polymerase Mu 3
  • EC 2.7.7.7 4
  • Tdt-N 3
  • Polmu 4

External Ids for POLM Gene

Previous GeneCards Identifiers for POLM Gene

  • GC07M043758
  • GC07M043818
  • GC07M043852
  • GC07M043886
  • GC07M044078
  • GC07M043997
  • GC07M044111

Summaries for POLM Gene

GeneCards Summary for POLM Gene

POLM (Polymerase (DNA Directed), Mu) is a Protein Coding gene. Diseases associated with POLM include lung adenoma. Among its related pathways are Non-homologous end-joining and Non-homologous end-joining. GO annotations related to this gene include DNA-directed DNA polymerase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot for POLM Gene

  • Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.

Gene Wiki entry for POLM Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLM Gene

Genomics for POLM Gene

Regulatory Elements for POLM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POLM Gene

Start:
44,072,062 bp from pter
End:
44,082,540 bp from pter
Size:
10,479 bases
Orientation:
Minus strand

Genomic View for POLM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLM Gene

Proteins for POLM Gene

  • Protein details for POLM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP87-DPOLM_HUMAN
    Recommended name:
    DNA-directed DNA/RNA polymerase mu
    Protein Accession:
    Q9NP87
    Secondary Accessions:
    • D3DVK4
    • Q6P5X8
    • Q86WQ9

    Protein attributes for POLM Gene

    Size:
    494 amino acids
    Molecular mass:
    54816 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DPOLM has a reduced ability to distinguish dNTP and rNTP as substrates, and elongates them on DNA primer strand with a similar efficiency. It is able to polymerize nucleotides on RNA primer strands

    Three dimensional structures from OCA and Proteopedia for POLM Gene

    Alternative splice isoforms for POLM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLM Gene

Proteomics data for POLM Gene at MOPED

Post-translational modifications for POLM Gene

  • Ubiquitination at Lys187
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for POLM Gene

Domains for POLM Gene

Gene Families for POLM Gene

HGNC:
  • POL :DNA polymerases

Graphical View of Domain Structure for InterPro Entry

Q9NP87

UniProtKB/Swiss-Prot:

DPOLM_HUMAN :
  • Q9NP87
Domain:
  • Contains 1 BRCT domain.
Family:
  • Belongs to the DNA polymerase type-X family.
genes like me logo Genes that share domains with POLM: view

Function for POLM Gene

Molecular function for POLM Gene

GENATLAS Biochemistry:
polymerase (DNA-directed), mu
UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
UniProtKB/Swiss-Prot Function:
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.

Enzyme Numbers (IUBMB) for POLM Gene

Gene Ontology (GO) - Molecular Function for POLM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0005515 protein binding IPI 22458338
GO:0034061 DNA polymerase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with POLM: view

Phenotypes for POLM Gene

genes like me logo Genes that share phenotypes with POLM: view

Animal Models for POLM Gene

MGI Knock Outs for POLM:

miRNA for POLM Gene

miRTarBase miRNAs that target POLM

No data available for Transcription Factor Targeting and HOMER Transcription for POLM Gene

Localization for POLM Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLM Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLM Gene COMPARTMENTS Subcellular localization image for POLM gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for POLM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with POLM: view

Pathways for POLM Gene

genes like me logo Genes that share pathways with POLM: view

Pathways by source for POLM Gene

1 KEGG pathway for POLM Gene
1 GeneGo (Thomson Reuters) pathway for POLM Gene

Gene Ontology (GO) - Biological Process for POLM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0016446 somatic hypermutation of immunoglobulin genes IEA --
GO:0030183 B cell differentiation IEA --
GO:0071897 DNA biosynthetic process IEA --
genes like me logo Genes that share ontologies with POLM: view

Compounds for POLM Gene

(7) HMDB Compounds for POLM Gene

Compound Synonyms Cas Number PubMed IDs
dATP
  • 2'-Deoxy-5'-ATP
1927-31-7
dCTP
  • 2'-deoxycytidine-5'-triphosphate
2056-98-6
dGTP
  • 2'-Deoxyguanosine 5'-triphosphate
2564-35-4
Magnesium
  • Magnesium
7439-95-4
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
genes like me logo Genes that share compounds with POLM: view

Transcripts for POLM Gene

Unigene Clusters for POLM Gene

Polymerase (DNA directed), mu:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLM Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8:
SP9: - - - - -
SP10: -
SP11:
SP12: -
SP13:
SP14:
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - - -
SP17:
SP18:

ExUns: 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f · 16g
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7: -
SP8: - -
SP9: -
SP10:
SP11: - -
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for POLM Gene

GeneLoc Exon Structure for
POLM
ECgene alternative splicing isoforms for
POLM

Expression for POLM Gene

mRNA expression in normal human tissues for POLM Gene

Protein differential expression in normal tissues for POLM Gene

This gene is overexpressed in Urine (65.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLM Gene

SOURCE GeneReport for Unigene cluster for POLM Gene Hs.596982

mRNA Expression by UniProt/SwissProt for POLM Gene

Q9NP87-DPOLM_HUMAN
Tissue specificity: Expressed in a number of tissues. Abundant in thymus
genes like me logo Genes that share expressions with POLM: view

Expression partners for POLM Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for POLM Gene

Orthologs for POLM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLM 35
  • 83.23 (n)
  • 81.31 (a)
POLM 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polm 35
  • 79.38 (n)
  • 77.08 (a)
Polm 16
Polm 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLM 35
  • 99.19 (n)
  • 98.79 (a)
POLM 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polm 35
  • 78.03 (n)
  • 76.27 (a)
dog
(Canis familiaris)
Mammalia POLM 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLM 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia polm 35
  • 55.92 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii polm 35
  • 55.37 (n)
  • 50.92 (a)
zgc56122 35
polm 36
  • 31 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01321 35
  • 44.69 (n)
  • 29.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for POLM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLM Gene

ENSEMBL:
Gene Tree for POLM (if available)
TreeFam:
Gene Tree for POLM (if available)

Paralogs for POLM Gene

Paralogs for POLM Gene

genes like me logo Genes that share paralogs with POLM: view

Variants for POLM Gene

Sequence variations from dbSNP and Humsavar for POLM Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1139270 -- 44,075,830(-) GCCCG(A/G)GAGGT intron-variant, upstream-variant-2KB
rs3218653 -- 44,079,429(-) GCCAC(C/G)CTCTG intron-variant
rs3218654 -- 44,079,791(-) AGGTG(A/G)GGGAT intron-variant
rs3218655 -- 44,082,337(-) TACCT(G/T)GTCGA reference, synonymous-codon, nc-transcript-variant
rs3218656 -- 44,080,024(-) AAGCC(A/G)GTACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLM Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv830980 CNV Loss 17160897
nsv8082 CNV Gain 18304495
nsv887996 CNV Loss 21882294
nsv470210 CNV Loss 18288195
nsv830983 CNV Loss 17160897

Relevant External Links for POLM Gene

HapMap Linkage Disequilibrium report
POLM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLM Gene

Disorders for POLM Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for POLM Gene in MalaCards »

(1) Diseases for POLM Gene including...

(2) University of Copenhagen DISEASES for POLM Gene

(1) Novoseek inferred disease relationships for POLM Gene

Disease -log(P) Hits PubMed IDs
burkitt lymphoma 39.4 1

Relevant External Links for POLM

Genetic Association Database (GAD)
POLM
Human Genome Epidemiology (HuGE) Navigator
POLM
genes like me logo Genes that share disorders with POLM: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for POLM Gene

Publications for POLM Gene

  1. DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. (PMID: 10747040) Dominguez O. … Blanco L. (EMBO J. 2000) 3 4 23
  2. Polymerase mu is a DNA-directed DNA/RNA polymerase. (PMID: 12640116) Nick McElhinny S.A. … Ramsden D.A. (Mol. Cell. Biol. 2003) 3 4 23
  3. Two novel human and mouse DNA polymerases of the polX family. (PMID: 10982892) Aoufouchi S. … Reynaud C.-A. (Nucleic Acids Res. 2000) 2 3 4
  4. Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells. (PMID: 17483519) Capp J.P. … Canitrot Y. (Nucleic Acids Res. 2007) 4 23
  5. Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining. (PMID: 17915942) DeRose E.F. … Lee A.L. (Biochemistry 2007) 4 23

Products for POLM Gene

Sources for POLM Gene

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