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Aliases for GLO1 Gene

Aliases for GLO1 Gene

  • Glyoxalase I 2 3 4 5
  • S-D-Lactoylglutathione Methylglyoxal Lyase 3 4
  • Glyoxalase Domain Containing 1 2 3
  • Ketone-Aldehyde Mutase 3 4
  • Methylglyoxalase 3 4
  • Aldoketomutase 3 4
  • EC 4.4.1.5 4 63
  • Glx I 3 4
  • Epididymis Secretory Protein Li 74 3
  • Lactoyl Glutathione Lyase 3
  • HEL-S-74 3
  • GLOD1 3
  • GLYI 3

External Ids for GLO1 Gene

Previous GeneCards Identifiers for GLO1 Gene

  • GC06M038645
  • GC06M038690
  • GC06M038751
  • GC06M038361

Summaries for GLO1 Gene

Entrez Gene Summary for GLO1 Gene

  • The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLO1 Gene

GLO1 (Glyoxalase I) is a Protein Coding gene. Diseases associated with GLO1 include Paracoccidioidomycosis and Diabetic Neuropathy. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Pyruvate metabolism and Citric Acid (TCA) cycle. GO annotations related to this gene include lactoylglutathione lyase activity.

UniProtKB/Swiss-Prot for GLO1 Gene

  • Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.

Gene Wiki entry for GLO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLO1 Gene

Genomics for GLO1 Gene

Regulatory Elements for GLO1 Gene

Enhancers for GLO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GLO1 on UCSC Golden Path with GeneCards custom track

Promoters for GLO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GLO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GLO1 Gene

Chromosome:
6
Start:
38,675,925 bp from pter
End:
38,703,176 bp from pter
Size:
27,252 bases
Orientation:
Minus strand

Genomic View for GLO1 Gene

Genes around GLO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLO1 Gene

Proteins for GLO1 Gene

  • Protein details for GLO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04760-LGUL_HUMAN
    Recommended name:
    Lactoylglutathione lyase
    Protein Accession:
    Q04760
    Secondary Accessions:
    • B2R6P7
    • B4DDV0
    • P78375
    • Q59EL0
    • Q5TZW3
    • Q96FC0
    • Q96J41

    Protein attributes for GLO1 Gene

    Size:
    184 amino acids
    Molecular mass:
    20778 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAD93038.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GLO1 Gene

    Alternative splice isoforms for GLO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLO1 Gene

Proteomics data for GLO1 Gene at MOPED

Post-translational modifications for GLO1 Gene

  • Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B.
  • Glutathionylation at Cys-139 inhibits enzyme activity.
  • Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B.
  • Ubiquitination at Lys 44, Lys 140, and Lys 148
  • Modification sites at PhosphoSitePlus

Other Protein References for GLO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for GLO1 Gene

Suggested Antigen Peptide Sequences for GLO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04760

UniProtKB/Swiss-Prot:

LGUL_HUMAN :
  • Belongs to the glyoxalase I family.
Family:
  • Belongs to the glyoxalase I family.
genes like me logo Genes that share domains with GLO1: view

No data available for Gene Families for GLO1 Gene

Function for GLO1 Gene

Molecular function for GLO1 Gene

GENATLAS Biochemistry:
glyoxalase I
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.3 mM for methylglyoxal/glutathione (native form) {ECO:0000269 PubMed:20454679}; KM=0.7 mM for methylglyoxal/glutathione (reduced form) {ECO:0000269 PubMed:20454679}; Vmax=0.335 umol/min/mg enzyme with methylglyoxal/glutathione as substrate (native form) {ECO:0000269 PubMed:20454679}; Vmax=0.7 umol/min/mg enzyme with methylglyoxal/glutathione as substrate (reduced form) {ECO:0000269 PubMed:20454679}; Note=Reduction of GLO1 was carried out by incubation with 20 mM betamercaptoethanol prior to kinetic analysis.;
UniProtKB/Swiss-Prot CatalyticActivity:
(R)-S-lactoylglutathione = glutathione + methylglyoxal.
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by oxidation of Cys-139 in response to the redox state of the cell. Results in the alternative formation of cystine or glutathione-bound cysteine, the latter modification leading to reduced enzyme activity.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.

Enzyme Numbers (IUBMB) for GLO1 Gene

Gene Ontology (GO) - Molecular Function for GLO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA,IDA 9705294
genes like me logo Genes that share ontologies with GLO1: view
genes like me logo Genes that share phenotypes with GLO1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLO1

miRNA for GLO1 Gene

miRTarBase miRNAs that target GLO1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLO1 Gene

Localization for GLO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLO1 Gene COMPARTMENTS Subcellular localization image for GLO1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GLO1 Gene

Pathways & Interactions for GLO1 Gene

genes like me logo Genes that share pathways with GLO1: view

Pathways by source for GLO1 Gene

UniProtKB/Swiss-Prot Q04760-LGUL_HUMAN

  • Pathway: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Gene Ontology (GO) - Biological Process for GLO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0006749 glutathione metabolic process IEA --
GO:0009438 methylglyoxal metabolic process IEA --
GO:0043066 negative regulation of apoptotic process TAS 16130169
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GLO1: view

No data available for SIGNOR curated interactions for GLO1 Gene

Drugs & Compounds for GLO1 Gene

(32) Drugs for GLO1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Indomethacin Approved, Investigational Pharma Partial agonist, Agonist, Target, inhibitor Cox inhibitor 107
S-Hexylglutathione Experimental Pharma Target 0
Beta-Mercaptoethanol Experimental Pharma Target 0
methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate Experimental Pharma Target 0

(32) Additional Compounds for GLO1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Pyruvaldehyde
  • 1,2-Propanedione
  • 1-Ketopropionaldehyde
  • 2-Keto Propionaldehyde
  • 2-Ketopropionaldehyde
  • 2-Oxo-Propionaldehyde
78-98-8
S-Lactoylglutathione
  • (R)-S-lactoylglutathione
  • D-Lactoylglutathione
  • delta-Lactoylglutathione
  • N-(N-L-gamma-Glutamyl-S-(2-hydroxy-1-oxopropyl)-L-cysteinyl)-glycine
  • S-D-Lactoyl-glutathione
25138-66-3
genes like me logo Genes that share compounds with GLO1: view

Transcripts for GLO1 Gene

mRNA/cDNA for GLO1 Gene

Unigene Clusters for GLO1 Gene

Glyoxalase I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3: - - - -
SP4:

Relevant External Links for GLO1 Gene

GeneLoc Exon Structure for
GLO1
ECgene alternative splicing isoforms for
GLO1

Expression for GLO1 Gene

mRNA expression in normal human tissues for GLO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GLO1 Gene

This gene is overexpressed in Bone (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GLO1 Gene



SOURCE GeneReport for Unigene cluster for GLO1 Gene Hs.268849

genes like me logo Genes that share expression patterns with GLO1: view

Protein tissue co-expression partners for GLO1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GLO1 Gene

Orthologs for GLO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GLO1 35
  • 90.76 (n)
  • 89.67 (a)
GLO1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLO1 35
  • 91.67 (n)
  • 89.13 (a)
GLO1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glo1 35
  • 82.43 (n)
  • 90.22 (a)
Glo1 16
Glo1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GLO1 35
  • 99.09 (n)
  • 99.46 (a)
GLO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glo1 35
  • 82.25 (n)
  • 90.76 (a)
oppossum
(Monodelphis domestica)
Mammalia GLO1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLO1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLO1 35
  • 82.31 (n)
  • 84.92 (a)
GLO1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLO1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glo1 35
  • 70.15 (n)
  • 78.02 (a)
Str.7707 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5524 35
zebrafish
(Danio rerio)
Actinopterygii glo1 35
glo1 35
  • 69.16 (n)
  • 72.99 (a)
glo1 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1707 37
  • 69 (a)
CG1707 35
  • 60.82 (n)
  • 69.01 (a)
CG1707 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012071 35
  • 55.43 (n)
  • 62.29 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR286C 35
  • 52.31 (n)
  • 47.92 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06226g 35
  • 55.64 (n)
  • 50.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLO1 35
  • 56.25 (n)
  • 49.31 (a)
GLO1 36
  • 22 (a)
OneToOne
GLO1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G08110 35
  • 61.18 (n)
  • 60.98 (a)
soybean
(Glycine max)
eudicotyledons Gma.4045 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.865 35
barley
(Hordeum vulgare)
Liliopsida Hv.11411 35
rice
(Oryza sativa)
Liliopsida Os.11010 35
Os05g0295800 35
  • 63.57 (n)
  • 60.11 (a)
corn
(Zea mays)
Liliopsida Zm.16759 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11135 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04815 35
  • 53.7 (n)
  • 49.31 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes glo1 35
  • 58.02 (n)
  • 51.11 (a)
Species with no ortholog for GLO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLO1 Gene

ENSEMBL:
Gene Tree for GLO1 (if available)
TreeFam:
Gene Tree for GLO1 (if available)

Paralogs for GLO1 Gene

No data available for Paralogs for GLO1 Gene

Variants for GLO1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GLO1 Gene

LGUL_HUMAN-Q04760
Exists in three separable isoforms which originate from two alleles in the genome. These correspond to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties.

Sequence variations from dbSNP and Humsavar for GLO1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs4746 - 38,682,852(-) TGATG(A/C)GACCC reference, missense
rs17855424 - 38,702,999(+) AGCAG(C/T)AACTG reference, missense
rs1049346 -- 38,703,061(-) TGCAG(C/T)GCAGC utr-variant-5-prime
rs1079606 -- 38,682,410(-) AACCT(A/G)TTAAG intron-variant
rs1130534 -- 38,682,812(-) CGAGG(A/T)TTCGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GLO1 Gene

Variant ID Type Subtype PubMed ID
nsv885817 CNV Loss 21882294
dgv1942e1 CNV Complex 17122850
nsv428144 CNV Gain 18775914
nsv830642 CNV Loss 17160897
nsv507326 CNV Insertion 20534489

Variation tolerance for GLO1 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.48; 88.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GLO1 Gene

Human Gene Mutation Database (HGMD)
GLO1

Disorders for GLO1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GLO1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
paracoccidioidomycosis
  • mucocutaneous-lymphangitic paracoccidioidomycosis
diabetic neuropathy
  • diabetic neuropathies
autistic disorder
  • autism
autism spectrum disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards
Search GLO1 in MalaCards View complete list of genes associated with diseases

Genatlas disease for GLO1 Gene

glyoxalase I deficiency

Relevant External Links for GLO1

Genetic Association Database (GAD)
GLO1
Human Genome Epidemiology (HuGE) Navigator
GLO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GLO1
genes like me logo Genes that share disorders with GLO1: view

No data available for UniProtKB/Swiss-Prot for GLO1 Gene

Publications for GLO1 Gene

  1. Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida. (PMID: 7684374) Kim N.-S. … Kato S. (J. Biol. Chem. 1993) 2 3 4 23 67
  2. Allosteric coupling of two different functional active sites in monomeric Plasmodium falciparum glyoxalase I. (PMID: 17664277) Deponte M. … Becker K. (J. Biol. Chem. 2007) 23 25 26
  3. GLO1 overexpression in human malignant melanoma. (PMID: 20093988) Bair W.B. … Wondrak G.T. (Melanoma Res. 2010) 3 23
  4. Posttranslational modification of human glyoxalase 1 indicates redox- dependent regulation. (PMID: 20454679) Birkenmeier G. … Birkemeyer C. (PLoS ONE 2010) 3 23
  5. Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats. (PMID: 19211689) Kumagai T. … Inagi R. (Am. J. Physiol. Renal Physiol. 2009) 3 23

Products for GLO1 Gene

Sources for GLO1 Gene

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