Aliases for GLO1 Gene
External Ids for GLO1 Gene
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
GeneCards Summary for GLO1 Gene
GLO1 (Glyoxalase I) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism and Pyruvate metabolism. GO annotations related to this gene include lactoylglutathione lyase activity.
UniProtKB/Swiss-Prot for GLO1 Gene
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.