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Aliases for GLO1 Gene

Aliases for GLO1 Gene

  • Glyoxalase I 2 3 4
  • S-D-Lactoylglutathione Methylglyoxal Lyase 3 4
  • Glyoxalase Domain Containing 1 2 3
  • Ketone-Aldehyde Mutase 3 4
  • Methylglyoxalase 3 4
  • Aldoketomutase 3 4
  • EC 4.4.1.5 4 63
  • Glx I 3 4
  • Epididymis Secretory Protein Li 74 3
  • Lactoyl Glutathione Lyase 3
  • Lactoylglutathione Lyase 3
  • HEL-S-74 3
  • GLOD1 3
  • GLYI 3

External Ids for GLO1 Gene

Previous GeneCards Identifiers for GLO1 Gene

  • GC06M038645
  • GC06M038690
  • GC06M038751
  • GC06M038361

Summaries for GLO1 Gene

Entrez Gene Summary for GLO1 Gene

  • The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLO1 Gene

GLO1 (Glyoxalase I) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism and Pyruvate metabolism. GO annotations related to this gene include lactoylglutathione lyase activity.

UniProtKB/Swiss-Prot for GLO1 Gene

  • Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.

Gene Wiki entry for GLO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLO1 Gene

Genomics for GLO1 Gene

Regulatory Elements for GLO1 Gene

Genomic Location for GLO1 Gene

Start:
38,675,925 bp from pter
End:
38,703,176 bp from pter
Size:
27,252 bases
Orientation:
Minus strand

Genomic View for GLO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLO1 Gene

Proteins for GLO1 Gene

  • Protein details for GLO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04760-LGUL_HUMAN
    Recommended name:
    Lactoylglutathione lyase
    Protein Accession:
    Q04760
    Secondary Accessions:
    • B2R6P7
    • B4DDV0
    • P78375
    • Q59EL0
    • Q5TZW3
    • Q96FC0
    • Q96J41

    Protein attributes for GLO1 Gene

    Size:
    184 amino acids
    Molecular mass:
    20778 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAD93038.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GLO1 Gene

    Alternative splice isoforms for GLO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLO1 Gene

Proteomics data for GLO1 Gene at MOPED

Post-translational modifications for GLO1 Gene

  • Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B
  • Glutathionylation at Cys-139 inhibits enzyme activity.
  • Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B.
  • Ubiquitination at Lys44, Lys140, and Lys148
  • Modification sites at PhosphoSitePlus

Other Protein References for GLO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for GLO1 Gene

Suggested Antigen Peptide Sequences for GLO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04760

UniProtKB/Swiss-Prot:

LGUL_HUMAN :
  • Q04760
Family:
  • Belongs to the glyoxalase I family.
genes like me logo Genes that share domains with GLO1: view

No data available for Gene Families for GLO1 Gene

Function for GLO1 Gene

Molecular function for GLO1 Gene

GENATLAS Biochemistry: glyoxalase I
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.3 mM for methylglyoxal/glutathione (native form) {ECO:0000269 PubMed:20454679}; KM=0.7 mM for methylglyoxal/glutathione (reduced form) {ECO:0000269 PubMed:20454679}; Vmax=0.335 umol/min/mg enzyme with methylglyoxal/glutathione as substrate (native form) {ECO:0000269 PubMed:20454679}; Vmax=0.7 umol/min/mg enzyme with methylglyoxal/glutathione as substrate (reduced form) {ECO:0000269 PubMed:20454679}; Note=Reduction of GLO1 was carried out by incubation with 20 mM betamercaptoethanol prior to kinetic analysis.;
UniProtKB/Swiss-Prot CatalyticActivity: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
UniProtKB/Swiss-Prot EnzymeRegulation: Regulated by oxidation of Cys-139 in response to the redox state of the cell. Results in the alternative formation of cystine or glutathione-bound cysteine, the latter modification leading to reduced enzyme activity.
UniProtKB/Swiss-Prot Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.

Enzyme Numbers (IUBMB) for GLO1 Gene

Gene Ontology (GO) - Molecular Function for GLO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004462 lactoylglutathione lyase activity IDA 11489834
GO:0008270 zinc ion binding IDA 9705294
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with GLO1: view

Phenotypes for GLO1 Gene

genes like me logo Genes that share phenotypes with GLO1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GLO1 Gene

Localization for GLO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GLO1 Gene COMPARTMENTS Subcellular localization image for GLO1 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GLO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 16130169
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GLO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GLO1 Gene

Pathways for GLO1 Gene

genes like me logo Genes that share pathways with GLO1: view

Pathways by source for GLO1 Gene

1 BioSystems pathway for GLO1 Gene
1 KEGG pathway for GLO1 Gene

UniProtKB/Swiss-Prot Q04760-LGUL_HUMAN

  • Pathway: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2

Gene Ontology (GO) - Biological Process for GLO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006749 glutathione metabolic process IEA --
GO:0009438 methylglyoxal metabolic process IEA --
GO:0030316 osteoclast differentiation ISS --
genes like me logo Genes that share ontologies with GLO1: view

Compounds for GLO1 Gene

(3) HMDB Compounds for GLO1 Gene

Compound Synonyms Cas Number PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8
Pyruvaldehyde
  • 1,2-Propanedione
78-98-8
S-Lactoylglutathione
  • (R)-S-lactoylglutathione
25138-66-3

(8) Drugbank Compounds for GLO1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Beta-Mercaptoethanol
60-24-2 target
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target
Indomethacin
  • IMN
53-86-1 target inhibitor
methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
target
S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione
target

(55) Novoseek inferred chemical compound relationships for GLO1 Gene

Compound -log(P) Hits PubMed IDs
methylglyoxal 95.3 85
s-d-lactoylglutathione 94.9 12
s-(p-bromobenzyl)glutathione 94.1 6
2-crotonyloxymethyl-2-cyclohexenone 89.5 2
s-p-nitrobenzoxycarbonylglutathione 86.3 2
genes like me logo Genes that share compounds with GLO1: view

Transcripts for GLO1 Gene

mRNA/cDNA for GLO1 Gene

(850) Selected AceView cDNA sequences:
(14) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLO1 Gene

Glyoxalase I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GLO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3: - - - -
SP4:

Relevant External Links for GLO1 Gene

GeneLoc Exon Structure for
GLO1
ECgene alternative splicing isoforms for
GLO1

Expression for GLO1 Gene

mRNA expression in normal human tissues for GLO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GLO1 Gene

SOURCE GeneReport for Unigene cluster for GLO1 Gene Hs.268849

genes like me logo Genes that share expressions with GLO1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GLO1 Gene

Orthologs for GLO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLO1 35
  • 99.09 (n)
  • 99.46 (a)
GLO1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLO1 35
  • 90.76 (n)
  • 89.67 (a)
GLO1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLO1 35
  • 91.67 (n)
  • 89.13 (a)
GLO1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Glo1 35
  • 82.43 (n)
  • 90.22 (a)
Glo1 16
Glo1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLO1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLO1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glo1 35
  • 82.25 (n)
  • 90.76 (a)
chicken
(Gallus gallus)
Aves GLO1 35
  • 82.31 (n)
  • 84.92 (a)
GLO1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLO1 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5524 35
tropical clawed frog
(Silurana tropicalis)
Amphibia glo1 35
  • 70.15 (n)
  • 78.02 (a)
Str.7707 35
zebrafish
(Danio rerio)
Actinopterygii glo1 35
glo1 35
  • 69.16 (n)
  • 72.99 (a)
glo1 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012071 35
  • 55.43 (n)
  • 62.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1707 35
  • 60.82 (n)
  • 69.01 (a)
CG1707 36
  • 67 (a)
OneToOne
CG1707 37
  • 69 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR286C 35
  • 52.31 (n)
  • 47.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLO1 35
  • 56.25 (n)
  • 49.31 (a)
GLO1 36
  • 22 (a)
OneToOne
GLO1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06226g 35
  • 55.64 (n)
  • 50.36 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.865 35
soybean
(Glycine max)
eudicotyledons Gma.4045 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G08110 35
  • 61.18 (n)
  • 60.98 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11411 35
corn
(Zea mays)
Liliopsida Zm.16759 35
rice
(Oryza sativa)
Liliopsida Os.11010 35
Os05g0295800 35
  • 63.57 (n)
  • 60.11 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04815 35
  • 53.7 (n)
  • 49.31 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes glo1 35
  • 58.02 (n)
  • 51.11 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11135 35
Species with no ortholog for GLO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLO1 Gene

ENSEMBL:
Gene Tree for GLO1 (if available)
TreeFam:
Gene Tree for GLO1 (if available)

Paralogs for GLO1 Gene

No data available for Paralogs for GLO1 Gene

Variants for GLO1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GLO1 Gene

Q04760-LGUL_HUMAN
Exists in three separable isoforms which originate from two alleles in the genome. These correspond to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties

Sequence variations from dbSNP and Humsavar for GLO1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4746 Uncertain significance, - 38,682,852(-) TGATG(A/C)GACCC reference, missense
rs7604 -- 38,676,020(-) TTTTG(A/G)GTGAA utr-variant-3-prime
rs909284 -- 38,677,645(-) tgagg(C/G)cagga intron-variant
rs937662 -- 38,678,593(-) GAGGA(A/G)CAAGA intron-variant
rs1049346 -- 38,703,061(-) TGCAG(C/T)GCAGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GLO1 Gene

Variant ID Type Subtype PubMed ID
nsv885817 CNV Loss 21882294
dgv1942e1 CNV Complex 17122850
nsv428144 CNV Gain 18775914
nsv830642 CNV Loss 17160897
nsv507326 CNV Insertion 20534489

Relevant External Links for GLO1 Gene

HapMap Linkage Disequilibrium report
GLO1
Human Gene Mutation Database (HGMD)
GLO1

Disorders for GLO1 Gene

(27) Novoseek inferred disease relationships for GLO1 Gene

Disease -log(P) Hits PubMed IDs
uremia 26.3 1
spinocerebellar ataxias 25.4 2
hyperglycemia 16.5 1
leukemia 14.6 5
cancer 4.59 9

Genatlas disease for GLO1 Gene

glyoxalase I deficiency

Relevant External Links for GLO1

Genetic Association Database (GAD)
GLO1
Human Genome Epidemiology (HuGE) Navigator
GLO1
genes like me logo Genes that share disorders with GLO1: view

No data available for UniProtKB/Swiss-Prot for GLO1 Gene

Publications for GLO1 Gene

  1. Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida. (PMID: 7684374) Kim N.-S. … Kato S. (J. Biol. Chem. 1993) 2 3 4 23
  2. Cloning and characterization of human colon glyoxalase-I. (PMID: 8449929) Ranganathan S. … Tew K.D. (J. Biol. Chem. 1993) 2 3 4 23
  3. Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. (PMID: 10521255) Cameron A.D. … Mannervik B. (Biochemistry 1999) 3 4 23
  4. Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation. (PMID: 10564821) Ranganathan S. … Tew K.D. (Gene 1999) 3 4 23
  5. [Analysis of heterozygosity levels at P1,TF, PGM1, ACP1, HP, GC, GLO, C3, and ESD loci in pulmonary tuberculosis patients with different treatment outcomes]. (PMID: 11785295) Sergeev A.S. … Perel'man M.I. (Genetika 2001) 3 23 48

Products for GLO1 Gene

Sources for GLO1 Gene

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