Aliases for GLI2 Gene
- GLI Family Zinc Finger 2 2 3
- Glioma-Associated Oncogene Family Zinc Finger 2 2 3
- Tax-Responsive Element-2 Holding Protein 2 3
- GLI Family Zinc Finger Protein 2 3 4
- GLI-Kruppel Family Member GLI2 2 3
- Tax Helper Protein 1 2 3
- Tax Helper Protein 2 2 3
- HPE9 3 6
- Tax-Responsive Element-25-Bp Sequence Binding Protein 3
External Ids for GLI2 Gene
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
GeneCards Summary for GLI2 Gene
GLI2 (GLI Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with GLI2 include holoprosencephaly-9 and gli2-related holoprosencephaly. Among its related pathways are Pathways in cancer and Hippo signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is ZIC4.
UniProtKB/Swiss-Prot for GLI2 Gene
Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. May play a role during embryogenesis.
Isoform 1, isoform 2, isoform 3 and isoform 4: Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5-GAACCACCCA-3 which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1. Are involved in the smoothened (SHH) signaling pathway.
Isoform 5: Acts as a transcriptional repressor.