Aliases for POLL Gene
External Ids for POLL Gene
Previous GeneCards Identifiers for POLL Gene
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]
GeneCards Summary for POLL Gene
POLL (Polymerase (DNA Directed), Lambda) is a Protein Coding gene. Diseases associated with POLL include histrionic personality disorder and patent foramen ovale. Among its related pathways are DNA Double-Strand Break Repair and G2/M DNA damage checkpoint. GO annotations related to this gene include lyase activity and DNA polymerase activity. An important paralog of this gene is POLB.
UniProtKB/Swiss-Prot for POLL Gene
Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5-deoxyribose-5-phosphate lyase (dRP lyase) activity.