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Aliases for RRP7A Gene

Aliases for RRP7A Gene

  • Ribosomal RNA Processing 7 Homolog A 2 3 5
  • Gastric Cancer Antigen Zg14 3 4
  • Ribosomal RNA Processing 7 Homolog A (S. Cerevisiae) 2
  • CTA-126B4.5 3
  • BK126B4.3 3
  • CGI-96 3

External Ids for RRP7A Gene

Previous GeneCards Identifiers for RRP7A Gene

  • GC22M041238
  • GC22M042905

Summaries for RRP7A Gene

GeneCards Summary for RRP7A Gene

RRP7A (Ribosomal RNA Processing 7 Homolog A) is a Protein Coding gene. Among its related pathways are Gene Expression and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and nucleotide binding.

Gene Wiki entry for RRP7A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP7A Gene

Genomics for RRP7A Gene

Regulatory Elements for RRP7A Gene

Promoters for RRP7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRP7A on UCSC Golden Path with GeneCards custom track

Genomic Location for RRP7A Gene

Chromosome:
22
Start:
42,508,335 bp from pter
End:
42,519,823 bp from pter
Size:
11,489 bases
Orientation:
Minus strand

Genomic View for RRP7A Gene

Genes around RRP7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP7A Gene

Proteins for RRP7A Gene

  • Protein details for RRP7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3A4-RRP7A_HUMAN
    Recommended name:
    Ribosomal RNA-processing protein 7 homolog A
    Protein Accession:
    Q9Y3A4
    Secondary Accessions:
    • A4FTX2
    • B2RBG4
    • Q0VAD0
    • Q5JZ94
    • Q6P4B5
    • Q8IVR9
    • Q8IVY0
    • Q8N5Q3
    • Q8NEY6
    • Q9Y3H5

    Protein attributes for RRP7A Gene

    Size:
    280 amino acids
    Molecular mass:
    32334 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RRP7A Gene

Proteomics data for RRP7A Gene at MOPED

Post-translational modifications for RRP7A Gene

  • Ubiquitination at Lys 33 and Lys 149
  • Modification sites at PhosphoSitePlus

Other Protein References for RRP7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP7A Gene

Domains & Families for RRP7A Gene

Protein Domains for RRP7A Gene

Suggested Antigen Peptide Sequences for RRP7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3A4

UniProtKB/Swiss-Prot:

RRP7A_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRP7 family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRP7 family.
genes like me logo Genes that share domains with RRP7A: view

No data available for Gene Families for RRP7A Gene

Function for RRP7A Gene

Gene Ontology (GO) - Molecular Function for RRP7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with RRP7A: view

Phenotypes for RRP7A Gene

GenomeRNAi human phenotypes for RRP7A:
genes like me logo Genes that share phenotypes with RRP7A: view

Animal Model Products

CRISPR Products

miRNA for RRP7A Gene

miRTarBase miRNAs that target RRP7A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP7A Gene

Localization for RRP7A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRP7A Gene COMPARTMENTS Subcellular localization image for RRP7A gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RRP7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0034456 UTP-C complex IBA --
genes like me logo Genes that share ontologies with RRP7A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RRP7A Gene

Pathways & Interactions for RRP7A Gene

genes like me logo Genes that share pathways with RRP7A: view

Pathways by source for RRP7A Gene

Gene Ontology (GO) - Biological Process for RRP7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA,TAS --
genes like me logo Genes that share ontologies with RRP7A: view

No data available for SIGNOR curated interactions for RRP7A Gene

Drugs & Compounds for RRP7A Gene

No Compound Related Data Available

Transcripts for RRP7A Gene

mRNA/cDNA for RRP7A Gene

Unigene Clusters for RRP7A Gene

Ribosomal RNA processing 7 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP7A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: - -

Relevant External Links for RRP7A Gene

GeneLoc Exon Structure for
RRP7A
ECgene alternative splicing isoforms for
RRP7A

Expression for RRP7A Gene

mRNA expression in normal human tissues for RRP7A Gene

Protein differential expression in normal tissues from HIPED for RRP7A Gene

This gene is overexpressed in CD8 Tcells (14.7), Pancreas (12.9), Peripheral blood mononuclear cells (9.1), and Blymphocyte (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RRP7A Gene



SOURCE GeneReport for Unigene cluster for RRP7A Gene Hs.745006

genes like me logo Genes that share expression patterns with RRP7A: view

Protein tissue co-expression partners for RRP7A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRP7A Gene

Orthologs for RRP7A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRP7A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RRP7A 35
  • 86.37 (n)
  • 87.36 (a)
RRP7A 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrp7a 35
  • 82.74 (n)
  • 83.93 (a)
Rrp7a 16
Rrp7a 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rrp7a 35
  • 83.57 (n)
  • 84.29 (a)
cow
(Bos Taurus)
Mammalia RRP7A 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRP7A 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRP7A 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
chicken
(Gallus gallus)
Aves RRP7A 35
  • 66.91 (n)
  • 65.81 (a)
RRP7A 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRP7A 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp7a 35
  • 61.83 (n)
  • 60.22 (a)
Str.10145 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15159 35
zebrafish
(Danio rerio)
Actinopterygii rrp7a 35
  • 56.68 (n)
  • 46.44 (a)
rrp7a 36
  • 43 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7695 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001656 35
  • 49.8 (n)
  • 40.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9107 35
  • 52.08 (n)
  • 37.11 (a)
CG9107 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP7 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2355 36
  • 37 (a)
OneToOne
Species with no ortholog for RRP7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RRP7A Gene

ENSEMBL:
Gene Tree for RRP7A (if available)
TreeFam:
Gene Tree for RRP7A (if available)

Paralogs for RRP7A Gene

(1) SIMAP similar genes for RRP7A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RRP7A Gene

genes like me logo Genes that share paralogs with RRP7A: view

No data available for Paralogs for RRP7A Gene

Variants for RRP7A Gene

Sequence variations from dbSNP and Humsavar for RRP7A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs8139383 - 42,516,130(+) GGACA(G/T)GCTCT reference, missense
rs1812240 - 42,516,100(+) CTGGA(C/T)GAGGC reference, missense
rs11553441 - 42,516,091(-) AGTCT(A/C/G)TAGAG reference, missense
rs137061 -- 42,513,624(+) CAGCC(A/G)CAGCA intron-variant
rs1137212 -- 42,515,251(-) GCCTA(C/T)GTGGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RRP7A Gene

Variant ID Type Subtype PubMed ID
dgv1407e1 CNV Complex 17122850
nsv428391 CNV Gain 18775914
essv4940 CNV CNV 17122850
esv32632 CNV Gain 17666407
esv2724283 CNV Deletion 23290073
esv28197 CNV Gain 19812545
nsv9912 CNV Gain+Loss 18304495
nsv829246 CNV Loss 20364138
dgv773n67 CNV Gain 20364138
dgv103e180 CNV Gain 20482838
essv20414 CNV CNV 17122850
dgv781e201 CNV Deletion 23290073
nsv442798 CNV CNV 18776908
esv2659886 CNV Deletion 23128226
nsv482078 CNV Gain 20164927
nsv436074 CNV Insertion 17901297
nsv511642 CNV Loss 21212237
nsv915179 CNV Gain 21882294

Variation tolerance for RRP7A Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRP7A Gene

HapMap Linkage Disequilibrium report
RRP7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP7A Gene

Disorders for RRP7A Gene

Relevant External Links for RRP7A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRP7A

No disorders were found for RRP7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP7A Gene

Publications for RRP7A Gene

  1. Serological identification and expression analysis of gastric cancer- associated genes. (PMID: 12087473) Line A. … Rees R.C. (Br. J. Cancer 2002) 2 3 4 67
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for RRP7A Gene

Sources for RRP7A Gene

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