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Aliases for ZNF638 Gene

Aliases for ZNF638 Gene

  • Zinc Finger Protein 638 2 3
  • NP220 3 4 6
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se33-1 3 4
  • Zinc Finger Matrin-Like Protein 3 4
  • CTCL-Associated Antigen Se33-1 3 4
  • Nuclear Protein 220 3 4
  • ZFML 3 4
  • CTCL Tumor Antigen Se33-1 3
  • Zinc Finger, Matrin-Like 2
  • NP220 Nuclear Protein 3
  • Zfp638 3

External Ids for ZNF638 Gene

Previous Symbols for ZNF638 Gene

  • ZFML

Summaries for ZNF638 Gene

Entrez Gene Summary for ZNF638 Gene

  • The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF638 Gene

ZNF638 (Zinc Finger Protein 638) is a Protein Coding gene. GO annotations related to this gene include RNA binding and double-stranded DNA binding.

UniProtKB/Swiss-Prot for ZNF638 Gene

  • Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA.

Gene Wiki entry for ZNF638 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF638 Gene

Genomics for ZNF638 Gene

Genomic Location for ZNF638 Gene

Start:
71,276,561 bp from pter
End:
71,435,069 bp from pter
Size:
158,509 bases
Orientation:
Plus strand

Genomic View for ZNF638 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF638 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF638 Gene

Regulatory Elements for ZNF638 Gene

Proteins for ZNF638 Gene

  • Protein details for ZNF638 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14966-ZN638_HUMAN
    Recommended name:
    Zinc finger protein 638
    Protein Accession:
    Q14966
    Secondary Accessions:
    • B5MDV1
    • B7ZLD1
    • Q53R34
    • Q5XJ05
    • Q68DP3
    • Q6P2H2
    • Q7Z3T7
    • Q8NF92
    • Q8TCA1
    • Q9H2G1
    • Q9NP37

    Protein attributes for ZNF638 Gene

    Size:
    1978 amino acids
    Molecular mass:
    220625 Da
    Quaternary structure:
    • Interacts with FHL2. Interacts with CEBPA, CEBPD and CEBPG (By similarity).
    Miscellaneous:
    • Isoform 5 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients
    SequenceCaution:
    • Sequence=AAH64530.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF638 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF638 Gene

Proteomics data for ZNF638 Gene at MOPED

Post-translational modifications for ZNF638 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF638 Gene

Domains for ZNF638 Gene

Gene Families for ZNF638 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for ZNF638 Gene

UniProtKB/Swiss-Prot:

ZN638_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • Q14966
Similarity:
  • Contains 1 matrin-type zinc finger.:
    • Q14966
genes like me logo Genes that share domains with ZNF638: view

Function for ZNF638 Gene

Molecular function for ZNF638 Gene

UniProtKB/Swiss-Prot Function: Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA.

Gene Ontology (GO) - Molecular Function for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003690 double-stranded DNA binding TAS 8647861
GO:0003723 RNA binding TAS 8647861
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZNF638: view

Phenotypes for ZNF638 Gene

GenomeRNAi human phenotypes for ZNF638:
genes like me logo Genes that share phenotypes with ZNF638: view

miRNA for ZNF638 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF638 Gene

Localization for ZNF638 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF638 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF638 Gene COMPARTMENTS Subcellular localization image for ZNF638 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 8647861
GO:0016607 nuclear speck IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ZNF638: view

Pathways for ZNF638 Gene

SuperPathways for ZNF638 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008380 RNA splicing TAS 8647861
genes like me logo Genes that share ontologies with ZNF638: view

No data available for Pathways by source for ZNF638 Gene

Compounds for ZNF638 Gene

(1) HMDB Compounds for ZNF638 Gene

Compound Synonyms Cas Number PubMed IDs
Cytidine
  • 1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
65-46-3
genes like me logo Genes that share compounds with ZNF638: view

Transcripts for ZNF638 Gene

Unigene Clusters for ZNF638 Gene

Zinc finger protein 638:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF638 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6: -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZNF638 Gene

GeneLoc Exon Structure for
ZNF638
ECgene alternative splicing isoforms for
ZNF638

Expression for ZNF638 Gene

mRNA expression in normal human tissues for ZNF638 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF638 Gene

SOURCE GeneReport for Unigene cluster for ZNF638 Gene Hs.434401

genes like me logo Genes that share expressions with ZNF638: view

Orthologs for ZNF638 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF638 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF638 36
  • 99.53 (n)
  • 99.14 (a)
ZNF638 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF638 36
  • 89.61 (n)
  • 84.26 (a)
ZNF638 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF638 36
  • 90.59 (n)
  • 86.14 (a)
ZNF638 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfml 36
  • 85.12 (n)
  • 77.84 (a)
Zfml 16
Zfml 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 59 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 43 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp638 36
  • 85.45 (n)
  • 78.98 (a)
chicken
(Gallus gallus)
Aves ZNF638 37
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF638 37
  • 38 (a)
OneToOne
Species with no ortholog for ZNF638:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF638 Gene

ENSEMBL:
Gene Tree for ZNF638 (if available)
TreeFam:
Gene Tree for ZNF638 (if available)

Paralogs for ZNF638 Gene

Selected SIMAP similar genes for ZNF638 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF638 Gene

genes like me logo Genes that share paralogs with ZNF638: view

No data available for Paralogs for ZNF638 Gene

Variants for ZNF638 Gene

Sequence variations from dbSNP and Humsavar for ZNF638 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1398 -- 71,434,819(-) TCTTT(C/T)CTTTC utr-variant-3-prime, nc-transcript-variant
rs714200 -- 71,279,675(-) GGGAG(A/G)TGAAG intron-variant
rs764854 -- 71,289,833(-) acaaa(C/T)ggggc intron-variant
rs1019375 -- 71,387,662(+) TCTCT(A/C/T)AAAAA intron-variant
rs1019376 -- 71,387,663(+) ctctc(A/C)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF638 Gene

Variant ID Type Subtype PubMed ID
nsv521345 CNV Loss 19592680
nsv519545 CNV Loss 19592680
nsv526102 CNV Gain 19592680

Relevant External Links for ZNF638 Gene

HapMap Linkage Disequilibrium report
ZNF638
Human Gene Mutation Database (HGMD)
ZNF638

Disorders for ZNF638 Gene

Relevant External Links for ZNF638

Genetic Association Database (GAD)
ZNF638
Human Genome Epidemiology (HuGE) Navigator
ZNF638
genes like me logo Genes that share disorders with ZNF638: view

No data available for UniProtKB/Swiss-Prot for ZNF638 Gene

Publications for ZNF638 Gene

  1. A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain. (PMID: 8647861) Inagaki H. … Kitagawa Y. (J. Biol. Chem. 1996) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  4. Interaction of the heart-specific LIM domain protein, FHL2, with DNA- binding nuclear protein, hNP220. (PMID: 11813260) Ng E.K.O. … Fung K.P. (J. Cell. Biochem. 2002) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for ZNF638 Gene

Sources for ZNF638 Gene

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