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Aliases for ZNF330 Gene

Aliases for ZNF330 Gene

  • Zinc Finger Protein 330 2 3 5
  • Nucleolar Cysteine-Rich Protein 3 4
  • Nucleolar Autoantigen 36 3 4
  • NOA36 3 4
  • Zinc Finger Autoantigen 330 3
  • HSA6591 3

External Ids for ZNF330 Gene

Previous GeneCards Identifiers for ZNF330 Gene

  • GC04P142719
  • GC04P142499
  • GC04P142361
  • GC04P142142
  • GC04P137871

Summaries for ZNF330 Gene

GeneCards Summary for ZNF330 Gene

ZNF330 (Zinc Finger Protein 330) is a Protein Coding gene.

Gene Wiki entry for ZNF330 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF330 Gene

Genomics for ZNF330 Gene

Regulatory Elements for ZNF330 Gene

Enhancers for ZNF330 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF330 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF330 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF330 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF330 Gene

141,220,294 bp from pter
141,234,697 bp from pter
14,404 bases
Plus strand

Genomic View for ZNF330 Gene

Genes around ZNF330 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF330 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF330 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF330 Gene

Proteins for ZNF330 Gene

  • Protein details for ZNF330 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 330
    Protein Accession:
    Secondary Accessions:
    • B2RDA3

    Protein attributes for ZNF330 Gene

    320 amino acids
    Molecular mass:
    36201 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF330 Gene

Proteomics data for ZNF330 Gene at MOPED

Post-translational modifications for ZNF330 Gene

  • Ubiquitination at Lys 44, Lys 113, and Lys 255
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF330 Gene

Domains & Families for ZNF330 Gene

Gene Families for ZNF330 Gene

Protein Domains for ZNF330 Gene


Suggested Antigen Peptide Sequences for ZNF330 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NOA36 family.
  • Belongs to the NOA36 family.
genes like me logo Genes that share domains with ZNF330: view

Function for ZNF330 Gene

genes like me logo Genes that share phenotypes with ZNF330: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF330 Gene

Localization for ZNF330 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF330 Gene

Nucleus. Nucleus, nucleolus. Chromosome, centromere. Note=Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis.

Subcellular locations from

Jensen Localization Image for ZNF330 Gene COMPARTMENTS Subcellular localization image for ZNF330 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 10593942
GO:0030496 midbody IDA 10593942
genes like me logo Genes that share ontologies with ZNF330: view

Pathways & Interactions for ZNF330 Gene

SuperPathways for ZNF330 Gene

No Data Available

Interacting Proteins for ZNF330 Gene

Gene Ontology (GO) - Biological Process for ZNF330 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF330 Gene

Drugs & Compounds for ZNF330 Gene

No Compound Related Data Available

Transcripts for ZNF330 Gene

Unigene Clusters for ZNF330 Gene

Zinc finger protein 330:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF330 Gene

No ASD Table

Relevant External Links for ZNF330 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF330 Gene

mRNA expression in normal human tissues for ZNF330 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF330 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.4).

Protein differential expression in normal tissues from HIPED for ZNF330 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.3) and Islet of Langerhans (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF330 Gene

SOURCE GeneReport for Unigene cluster for ZNF330 Gene Hs.120766

mRNA Expression by UniProt/SwissProt for ZNF330 Gene

Tissue specificity: Widely expressed. Higher expression seen in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with ZNF330: view

Protein tissue co-expression partners for ZNF330 Gene

Primer Products

Orthologs for ZNF330 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF330 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF330 35
  • 94.48 (n)
  • 98.12 (a)
-- 36
  • 94 (a)
ZNF330 36
  • 98 (a)
(Canis familiaris)
Mammalia ZNF330 35
  • 92.81 (n)
  • 96.87 (a)
ZNF330 36
  • 97 (a)
(Mus musculus)
Mammalia Zfp330 35
  • 89.66 (n)
  • 95.89 (a)
Zfp330 16
Zfp330 36
  • 96 (a)
(Pan troglodytes)
Mammalia ZNF330 35
  • 99.79 (n)
  • 100 (a)
ZNF330 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp330 35
  • 88.64 (n)
  • 96.53 (a)
(Monodelphis domestica)
Mammalia ZNF330 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF330 36
  • 92 (a)
(Gallus gallus)
Aves ZNF330 35
  • 82.29 (n)
  • 89.69 (a)
ZNF330 36
  • 90 (a)
(Anolis carolinensis)
Reptilia ZNF330 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11074 35
znf330 35
  • 77.08 (n)
  • 82.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia noa36-pending-prov 35
(Danio rerio)
Actinopterygii Dr.14880 35
znf330 35
  • 75.71 (n)
  • 84.88 (a)
znf330 36
  • 74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6501 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008157 35
  • 60.98 (n)
  • 67.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Noa36 35
  • 62.32 (n)
  • 68.58 (a)
Noa36 36
  • 59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5433 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7222 36
  • 67 (a)
Species with no ortholog for ZNF330:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF330 Gene

Gene Tree for ZNF330 (if available)
Gene Tree for ZNF330 (if available)

Paralogs for ZNF330 Gene

No data available for Paralogs for ZNF330 Gene

Variants for ZNF330 Gene

Sequence variations from dbSNP and Humsavar for ZNF330 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs35353789 - 141,222,453(-) TATAG(C/T)GCTTC reference, missense, utr-variant-5-prime
rs34631212 - 141,233,918(-) AAACA(A/T)ATCTG reference, missense
rs732624 -- 141,230,419(+) AAACA(A/G)AACAG intron-variant
rs1435134 -- 141,232,189(-) GGGAT(A/G)GAGAC intron-variant
rs1897925 -- 141,229,184(+) ATTCA(A/G)TGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF330 Gene

Variant ID Type Subtype PubMed ID
dgv1680e1 CNV Complex 17122850

Variation tolerance for ZNF330 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF330 Gene

Disorders for ZNF330 Gene

Relevant External Links for ZNF330

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF330 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF330 Gene

Publications for ZNF330 Gene

  1. Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans. (PMID: 10593942) Bolivar J. … Valdivia M.M. (J. Biol. Chem. 1999) 2 3 4 67
  2. Genomic structure and chromosome location of the human gene encoding the zinc finger autoantigen ZNF330. (PMID: 11528117) BolA-var J. … Valdivia M.M. (Cytogenet. Cell Genet. 2001) 2 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. NOA36 protein contains a highly conserved nucleolar localization signal capable of directing functional proteins to the nucleolus, in mammalian cells. (PMID: 23516598) de Melo I.S. … BolA-var J. (PLoS ONE 2013) 3
  5. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick D.M. … Bierut L. (Mol. Psychiatry 2011) 3

Products for ZNF330 Gene

Sources for ZNF330 Gene