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Aliases for ZNF330 Gene

Aliases for ZNF330 Gene

  • Zinc Finger Protein 330 2 3 5
  • Nucleolar Cysteine-Rich Protein 3 4
  • Nucleolar Autoantigen 36 3 4
  • NOA36 3 4
  • Zinc Finger Autoantigen 330 3
  • HSA6591 3

External Ids for ZNF330 Gene

Previous GeneCards Identifiers for ZNF330 Gene

  • GC04P142719
  • GC04P142499
  • GC04P142361
  • GC04P142142
  • GC04P137871

Summaries for ZNF330 Gene

GeneCards Summary for ZNF330 Gene

ZNF330 (Zinc Finger Protein 330) is a Protein Coding gene.

Gene Wiki entry for ZNF330 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF330 Gene

Genomics for ZNF330 Gene

Regulatory Elements for ZNF330 Gene

Enhancers for ZNF330 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G141220 1 ENCODE 25.1 +1.0 982 2.0 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 BRCA1 ZNF48 YY1 ETS1 ZNF330 GC04P141235 PIR58194
GH04G141245 1 Ensembl ENCODE 17.4 +26.6 26598 3.0 CBX3 TAL1 TCF12 ZNF316 NCOR1 FOS MAFK MTA2 NR2F1 CEBPB ZNF330 PIR58194 GC04P141235 ENSG00000248747
GH04G141131 1 ENCODE 16.3 -87.1 -87136 3.8 PKNOX1 ARNT SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 SP3 YY2 ZNF330 GC04M141077 GC04P141205
GH04G141328 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.7 +109.4 109368 3.1 HDAC1 TBP JUN MAX CEBPG KAT2B RFX5 GATA3 POLR2A RCOR1 LINC02432 IL15 ZNF330 ENSG00000248747
GH04G141642 1.3 FANTOM5 Ensembl ENCODE 9.4 +423.2 423165 1.8 PKNOX1 MTA2 GATAD2B DPF2 TBX21 ZBTB40 ZSCAN21 JUND PRDM6 IKZF1 IL15 ZNF330 GC04P141671
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF330 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF330 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000173938 1106 2001 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 BRCA1 ZNF48 YY1 ETS1

Genomic Location for ZNF330 Gene

Chromosome:
4
Start:
141,220,294 bp from pter
End:
141,234,697 bp from pter
Size:
14,404 bases
Orientation:
Plus strand

Genomic View for ZNF330 Gene

Genes around ZNF330 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF330 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF330 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF330 Gene

Proteins for ZNF330 Gene

  • Protein details for ZNF330 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3S2-ZN330_HUMAN
    Recommended name:
    Zinc finger protein 330
    Protein Accession:
    Q9Y3S2
    Secondary Accessions:
    • B2RDA3

    Protein attributes for ZNF330 Gene

    Size:
    320 amino acids
    Molecular mass:
    36201 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF330 Gene

Post-translational modifications for ZNF330 Gene

  • Ubiquitination at isoforms=44, posLast=113113, and isoforms=255
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF330 Gene

Domains & Families for ZNF330 Gene

Gene Families for ZNF330 Gene

Protein Domains for ZNF330 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF330 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3S2

UniProtKB/Swiss-Prot:

ZN330_HUMAN :
  • Belongs to the NOA36 family.
Family:
  • Belongs to the NOA36 family.
genes like me logo Genes that share domains with ZNF330: view

Function for ZNF330 Gene

Gene Ontology (GO) - Molecular Function for ZNF330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15231747
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding NAS 10593942
genes like me logo Genes that share ontologies with ZNF330: view
genes like me logo Genes that share phenotypes with ZNF330: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF330 Gene

Localization for ZNF330 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF330 Gene

Nucleus. Nucleus, nucleolus. Chromosome, centromere. Note=Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF330 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 10593942
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA 10593942
GO:0030496 midbody IDA 10593942
genes like me logo Genes that share ontologies with ZNF330: view

Pathways & Interactions for ZNF330 Gene

SuperPathways for ZNF330 Gene

No Data Available

Interacting Proteins for ZNF330 Gene

Gene Ontology (GO) - Biological Process for ZNF330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF330: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF330 Gene

Transcripts for ZNF330 Gene

Unigene Clusters for ZNF330 Gene

Zinc finger protein 330:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF330 Gene

No ASD Table

Relevant External Links for ZNF330 Gene

GeneLoc Exon Structure for
ZNF330
ECgene alternative splicing isoforms for
ZNF330

Expression for ZNF330 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF330 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF330 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.4).

Protein differential expression in normal tissues from HIPED for ZNF330 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.3) and Islet of Langerhans (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF330 Gene



Protein tissue co-expression partners for ZNF330 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF330 Gene:

ZNF330

SOURCE GeneReport for Unigene cluster for ZNF330 Gene:

Hs.120766

mRNA Expression by UniProt/SwissProt for ZNF330 Gene:

Q9Y3S2-ZN330_HUMAN
Tissue specificity: Widely expressed. Higher expression seen in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for ZNF330 Gene

  • Kidney(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ZNF330: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF330 Gene

Orthologs for ZNF330 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF330 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF330 34 35
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia ZNF330 34 35
  • 94.48 (n)
-- 35
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF330 34 35
  • 92.81 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF330 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF330 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp330 34 16 35
  • 89.66 (n)
rat
(Rattus norvegicus)
Mammalia Zfp330 34
  • 88.64 (n)
chicken
(Gallus gallus)
Aves ZNF330 34 35
  • 82.29 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF330 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf330 34
  • 77.08 (n)
Str.11074 34
African clawed frog
(Xenopus laevis)
Amphibia noa36-pending-prov 34
zebrafish
(Danio rerio)
Actinopterygii znf330 34 35
  • 75.71 (n)
Dr.14880 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6501 34
fruit fly
(Drosophila melanogaster)
Insecta Noa36 34 35
  • 62.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008157 34
  • 60.98 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7222 35
  • 67 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5433 34
Species where no ortholog for ZNF330 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF330 Gene

ENSEMBL:
Gene Tree for ZNF330 (if available)
TreeFam:
Gene Tree for ZNF330 (if available)

Paralogs for ZNF330 Gene

No data available for Paralogs for ZNF330 Gene

Variants for ZNF330 Gene

Sequence variations from dbSNP and Humsavar for ZNF330 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000198602 -- 141,230,706(+) CTGTG(A/G)AGGTT intron-variant
rs1000588792 -- 141,230,625(+) CCTCC(C/T)GTAAG intron-variant
rs1001000446 -- 141,224,680(+) GTGGT(A/G)AGTTT intron-variant
rs1001204613 -- 141,228,967(+) TGATA(C/T)AGAAT intron-variant
rs1001759635 -- 141,231,863(+) CATTC(A/G)TTCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF330 Gene

Variant ID Type Subtype PubMed ID
esv2759287 CNV loss 17122850

Variation tolerance for ZNF330 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF330 Gene

Human Gene Mutation Database (HGMD)
ZNF330
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF330

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF330 Gene

Disorders for ZNF330 Gene

Relevant External Links for ZNF330

Genetic Association Database (GAD)
ZNF330
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF330

No disorders were found for ZNF330 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF330 Gene

Publications for ZNF330 Gene

  1. Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans. (PMID: 10593942) Bolivar J. … Valdivia M.M. (J. Biol. Chem. 1999) 2 3 4 64
  2. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick D.M. … Bierut L. (Mol. Psychiatry 2011) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Genomic structure and chromosome location of the human gene encoding the zinc finger autoantigen ZNF330. (PMID: 11528117) BolA-var J. … Valdivia M.M. (Cytogenet. Cell Genet. 2001) 2 3 64

Products for ZNF330 Gene

Sources for ZNF330 Gene

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