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Aliases for MOCS3 Gene

Aliases for MOCS3 Gene

  • Molybdenum Cofactor Synthesis 3 2 3 5
  • UBA4 2 3 4
  • Ubiquitin-Like Modifier Activating Enzyme 4 2 3
  • Molybdenum Cofactor Synthesis Protein 3 3 4
  • Molybdopterin Synthase Sulfurylase 3 4
  • MPT Synthase Sulfurylase 3 4
  • Ubiquitin-Activating Enzyme E1 Homolog (Yeast) 2
  • UBA4, Ubiquitin-Activating Enzyme E1 Homolog 3

External Ids for MOCS3 Gene

Previous GeneCards Identifiers for MOCS3 Gene

  • GC20P049303
  • GC20P050213
  • GC20P050260
  • GC20P049008
  • GC20P049575
  • GC20P046323

Summaries for MOCS3 Gene

Entrez Gene Summary for MOCS3 Gene

  • Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]

GeneCards Summary for MOCS3 Gene

MOCS3 (Molybdenum Cofactor Synthesis 3) is a Protein Coding gene. Diseases associated with MOCS3 include molybdenum cofactor deficiency. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include nucleotidyltransferase activity and sulfurtransferase activity. An important paralog of this gene is UBA5.

UniProtKB/Swiss-Prot for MOCS3 Gene

  • Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

Gene Wiki entry for MOCS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOCS3 Gene

Genomics for MOCS3 Gene

Regulatory Elements for MOCS3 Gene

Promoters for MOCS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOCS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOCS3 Gene

Chromosome:
20
Start:
50,958,814 bp from pter
End:
50,963,931 bp from pter
Size:
5,118 bases
Orientation:
Plus strand

Genomic View for MOCS3 Gene

Genes around MOCS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOCS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOCS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOCS3 Gene

Proteins for MOCS3 Gene

  • Protein details for MOCS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95396-MOCS3_HUMAN
    Recommended name:
    Adenylyltransferase and sulfurtransferase MOCS3
    Protein Accession:
    O95396

    Protein attributes for MOCS3 Gene

    Size:
    460 amino acids
    Molecular mass:
    49669 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with NFS1.

    Three dimensional structures from OCA and Proteopedia for MOCS3 Gene

neXtProt entry for MOCS3 Gene

Proteomics data for MOCS3 Gene at MOPED

Post-translational modifications for MOCS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOCS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MOCS3 Gene

Domains & Families for MOCS3 Gene

Gene Families for MOCS3 Gene

Suggested Antigen Peptide Sequences for MOCS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95396

UniProtKB/Swiss-Prot:

MOCS3_HUMAN :
  • Contains 1 rhodanese domain.
  • In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
Domain:
  • Contains 1 rhodanese domain.
Family:
  • In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
genes like me logo Genes that share domains with MOCS3: view

Function for MOCS3 Gene

Molecular function for MOCS3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.25 mM for thiosulfate {ECO:0000269 PubMed:15073332}; KM=0.28 mM for cyanide {ECO:0000269 PubMed:15073332};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP.
UniProtKB/Swiss-Prot CatalyticActivity:
[Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase.
UniProtKB/Swiss-Prot Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

Gene Ontology (GO) - Molecular Function for MOCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004792 thiosulfate sulfurtransferase activity IMP 15073332
GO:0008641 small protein activating enzyme activity IEA --
GO:0016783 sulfurtransferase activity TAS --
GO:0061605 molybdopterin-synthase adenylyltransferase activity IEA --
genes like me logo Genes that share ontologies with MOCS3: view
genes like me logo Genes that share phenotypes with MOCS3: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOCS3 Gene

Localization for MOCS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOCS3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOCS3 Gene COMPARTMENTS Subcellular localization image for MOCS3 gene
Compartment Confidence
cytosol 5
plasma membrane 3
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MOCS3 Gene

Pathways & Interactions for MOCS3 Gene

genes like me logo Genes that share pathways with MOCS3: view

Pathways by source for MOCS3 Gene

UniProtKB/Swiss-Prot O95396-MOCS3_HUMAN

  • Pathway: Cofactor biosynthesis; molybdopterin biosynthesis.
  • Pathway: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.

Gene Ontology (GO) - Biological Process for MOCS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018117 protein adenylylation IBA --
GO:0018192 enzyme active site formation via cysteine modification to L-cysteine persulfide IDA 15910006
GO:0032324 molybdopterin cofactor biosynthetic process TAS --
GO:0032447 protein urmylation IBA --
genes like me logo Genes that share ontologies with MOCS3: view

No data available for SIGNOR curated interactions for MOCS3 Gene

Drugs & Compounds for MOCS3 Gene

(4) Drugs for MOCS3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(3) Additional Compounds for MOCS3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
molybdopterin
  • MoCo
  • Molybdenum cofactor
  • Molybdenum enzyme molybdenum cofactor
  • Molybdoenzyme molybdenum-containing cofactor
  • Nitrate reductase molybdenum cofactor
73508-07-3
genes like me logo Genes that share compounds with MOCS3: view

Transcripts for MOCS3 Gene

mRNA/cDNA for MOCS3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOCS3 Gene

Molybdenum cofactor synthesis 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOCS3 Gene

No ASD Table

Relevant External Links for MOCS3 Gene

GeneLoc Exon Structure for
MOCS3
ECgene alternative splicing isoforms for
MOCS3

Expression for MOCS3 Gene

mRNA expression in normal human tissues for MOCS3 Gene

Protein differential expression in normal tissues from HIPED for MOCS3 Gene

This gene is overexpressed in Heart (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOCS3 Gene



SOURCE GeneReport for Unigene cluster for MOCS3 Gene Hs.159410

genes like me logo Genes that share expression patterns with MOCS3: view

Protein tissue co-expression partners for MOCS3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MOCS3 Gene

Orthologs for MOCS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOCS3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MOCS3 35
  • 86.54 (n)
  • 91.92 (a)
MOCS3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mocs3 35
  • 77.97 (n)
  • 79.78 (a)
Mocs3 16
Mocs3 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOCS3 35
  • 99.57 (n)
  • 99.57 (a)
MOCS3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mocs3 35
  • 77.58 (n)
  • 80.79 (a)
cow
(Bos Taurus)
Mammalia MOCS3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOCS3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOCS3 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOCS3 35
  • 64.63 (n)
  • 65.14 (a)
MOCS3 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOCS3 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491723 35
  • 57.49 (n)
  • 63.64 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
mocs3 35
  • 59 (n)
  • 61.95 (a)
mocs3 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13090 37
  • 49 (a)
CG13090 35
  • 53.08 (n)
  • 51.25 (a)
CG13090 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MOCS3_ANOGA 35
  • 56.68 (n)
  • 53.3 (a)
worm
(Caenorhabditis elegans)
Secernentea F42G8.6 37
  • 45 (a)
moc-3 35
  • 49.58 (n)
  • 46.95 (a)
moc-3 36
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER248W 35
  • 47.99 (n)
  • 41.62 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21363g 35
  • 45.79 (n)
  • 40.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBA4 35
  • 46.48 (n)
  • 41.75 (a)
UBA4 36
  • 37 (a)
OneToMany
UBA4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CNX5 35
  • 48.42 (n)
  • 44.14 (a)
soybean
(Glycine max)
eudicotyledons Gma.773 35
rice
(Oryza sativa)
Liliopsida Os02g0525400 35
  • 52.42 (n)
  • 44.44 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00736 35
  • 48.86 (n)
  • 42.78 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2G11.10c 35
  • 45.87 (n)
  • 44.53 (a)
Species with no ortholog for MOCS3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOCS3 Gene

ENSEMBL:
Gene Tree for MOCS3 (if available)
TreeFam:
Gene Tree for MOCS3 (if available)

Paralogs for MOCS3 Gene

Paralogs for MOCS3 Gene

Pseudogenes.org Pseudogenes for MOCS3 Gene

genes like me logo Genes that share paralogs with MOCS3: view

Variants for MOCS3 Gene

Sequence variations from dbSNP and Humsavar for MOCS3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_049349 -
rs2143538 -- 50,961,119(+) TGTTT(C/T)CTTAA utr-variant-3-prime
rs5841821 -- 50,961,866(+) AAAGA(-/T)GGCTG downstream-variant-500B
rs6013047 -- 50,961,558(+) TGTAT(C/T)TCTGT utr-variant-3-prime
rs11469824 -- 50,961,326(+) TTTAC(-/TTA)ACATT cds-indel

Structural Variations from Database of Genomic Variants (DGV) for MOCS3 Gene

Variant ID Type Subtype PubMed ID
nsv834002 CNV Loss 17160897

Variation tolerance for MOCS3 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOCS3 Gene

HapMap Linkage Disequilibrium report
MOCS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOCS3 Gene

Disorders for MOCS3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MOCS3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
molybdenum cofactor deficiency
  • combined deficiency of sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase
- elite association - COSMIC cancer census association via MalaCards
Search MOCS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOCS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOCS3
genes like me logo Genes that share disorders with MOCS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOCS3 Gene

Publications for MOCS3 Gene

  1. Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. (PMID: 15910006) Matthies A. … Leimkuehler S. (Biochemistry 2005) 2 3 4 67
  2. The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins. (PMID: 18491921) Schmitz J. … Leimkuehler S. (Biochemistry 2008) 3 23
  3. Site-directed mutagenesis of the active site loop of the rhodanese- like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs. (PMID: 17459099) Krepinsky K. … Leimkuehler S. (FEBS J. 2007) 3 23
  4. Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans. (PMID: 15073332) Matthies A. … Leimkuehler S. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23
  5. Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH. (PMID: 12754701) Reiss J. … Johnson J.L. (Hum. Mutat. 2003) 3 23

Products for MOCS3 Gene

Sources for MOCS3 Gene

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