Aliases for PDCD4 Gene
Aliases for PDCD4 Gene
External Ids for PDCD4 Gene
- HGNC: 8763
- Entrez Gene: 27250
- Ensembl: ENSG00000150593
- OMIM: 608610
- UniProtKB: Q53EL6
Previous GeneCards Identifiers for PDCD4 Gene
- GC10P111524
- GC10P111865
- GC10P112762
- GC10P112296
- GC10P112618
- GC10P106260
Summaries for PDCD4 Gene
-
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for PDCD4 Gene
PDCD4 (Programmed Cell Death 4) is a Protein Coding gene. Diseases associated with PDCD4 include Colorectal Cancer and Lung Cancer. Among its related pathways are MAPK Signaling: Mitogen Stimulation Pathway and mTOR signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include RNA binding and binding.
UniProtKB/Swiss-Prot for PDCD4 Gene
-
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD4 Gene
Genomics for PDCD4 Gene
GeneHancer (GH) Regulatory Elements for PDCD4 Gene
- Top Transcription factor binding sites by QIAGEN in the PDCD4 gene promoter:
Regulatory Element Products
Genomic Locations for PDCD4 Gene
- chr10:110,871,795-110,900,006
- (GRCh38/hg38)
- Size:
- 28,212 bases
- Orientation:
- Plus strand
- chr10:112,631,553-112,659,764
- (GRCh37/hg19)
Genomic View for PDCD4 Gene
- Cytogenetic band:
-
- 10q25.2 by Ensembl
- 10q25.2 by Entrez Gene
- 10q25.2 by HGNC


RefSeq DNA sequence for PDCD4 Gene
Proteins for PDCD4 Gene
-
Protein details for PDCD4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q53EL6-PDCD4_HUMAN
- Recommended name:
- Programmed cell death protein 4
- Protein Accession:
- Q53EL6
- B2RCV4
- B5ME91
- O15501
- Q5VZS6
- Q6PJI5
- Q8TAR5
- Q99834
Protein attributes for PDCD4 Gene
- Size:
- 469 amino acids
- Molecular mass:
- 51735 Da
- Quaternary structure:
-
- Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
- SequenceCaution:
-
- Sequence=AAB42218.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH15036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PDCD4 Gene
Protein Expression for PDCD4 Gene
Post-translational modifications for PDCD4 Gene
- Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
- Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
Other Protein References for PDCD4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PDCD4 (PDCD4)
- Cell Signaling Technology (CST) Antibodies for PDCD4 (PDCD4)
-
Custom Antibody ServicesOriGene Antibodies for PDCD4
- Novus Biologicals Antibodies for PDCD4
-
Abcam antibodies for PDCD4
- Invitrogen Antibodies for PDCD4
- GeneTex PDCD4 antibody for PDCD4
-
Custom Antibody ServicesProSci Antibodies for PDCD4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDCD4
- Sino Biological Antibodies for PDCD4
Protein Products
-
OriGene Purified Proteins for PDCD4
- Search Origene for MassSpec and Protein Over-expression Lysates for PDCD4
- Origene Custom Protein Services for PDCD4
- ProSpec Recombinant Proteins for PDCD4
- Search GeneTex for Proteins for PDCD4
-
ProSci Proteins for PDCD4
-
Abcam proteins for PDCD4
Assay Products
-
Cloud-Clone Corp. Assay Kits for PDCD4
No data available for DME Specific Peptides for PDCD4 Gene
Domains & Families for PDCD4 Gene
Gene Families for PDCD4 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PDCD4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDCD4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q53EL6- Domain:
-
- Binds EIF4A1 via both MI domains.
- Family:
-
- Belongs to the PDCD4 family.
Function for PDCD4 Gene
Molecular function for PDCD4 Gene
- GENATLAS Biochemistry:
- programmed cell death (apoptosis),inhibited by topoisomerase inhibitors (TIS)
- UniProtKB/Swiss-Prot Function:
- Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
- UniProtKB/Swiss-Prot Induction:
- IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression.
Phenotypes From GWAS Catalog for PDCD4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 12054647 |
Phenotypes for PDCD4 Gene
- MGI mutant phenotypes for PDCD4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PDCD4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDCD4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PDCD4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDCD4 gene
- Search ViGene Biosciences for PDCD4
CRISPR Products
-
OriGene CRISPR knockouts for PDCD4
- genomics-online: gRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
- Applied Biological Materials CRISPR for PDCD4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
- GenScript: Design CRISPR guide RNA sequences for PDCD4
miRNA for PDCD4 Gene
- miRTarBase miRNAs that target PDCD4
-
- hsa-mir-16-5p (MIRT000809)
- hsa-mir-15a-5p (MIRT000810)
- hsa-mir-1-3p (MIRT002785)
- hsa-mir-21-5p (MIRT003054)
- hsa-mir-200a-3p (MIRT004005)
- hsa-mir-183-5p (MIRT005547)
- hsa-mir-499a-5p (MIRT006699)
- hsa-mir-182-5p (MIRT007155)
- hsa-mir-335-5p (MIRT019086)
- hsa-mir-155-5p (MIRT021056)
- hsa-mir-196a-5p (MIRT026027)
- hsa-mir-197-3p (MIRT048135)
- hsa-mir-10b-5p (MIRT053003)
- hsa-mir-548j-3p (MIRT055342)
- hsa-mir-548x-3p (MIRT055345)
- hsa-mir-548ae-3p (MIRT055348)
- hsa-mir-548ah-3p (MIRT055349)
- hsa-mir-548aj-3p (MIRT055350)
- hsa-mir-548am-3p (MIRT055351)
- hsa-mir-548aq-3p (MIRT055352)
- hsa-mir-5582-3p (MIRT055354)
- hsa-mir-548c-3p (MIRT055360)
- hsa-mir-513b-3p (MIRT055361)
- hsa-mir-3163 (MIRT055362)
- hsa-mir-3662 (MIRT055363)
- hsa-mir-6826-3p (MIRT055365)
- hsa-mir-590-5p (MIRT055366)
- hsa-mir-548m (MIRT055367)
- hsa-mir-3653-3p (MIRT055368)
- hsa-mir-3658 (MIRT055369)
- hsa-mir-4436b-5p (MIRT055371)
- hsa-mir-5197-3p (MIRT055372)
- hsa-mir-5579-3p (MIRT055373)
- hsa-mir-6509-3p (MIRT055374)
- hsa-mir-15b-5p (MIRT125922)
- hsa-mir-195-5p (MIRT125925)
- hsa-mir-320a (MIRT125926)
- hsa-mir-4804-3p (MIRT125944)
- hsa-mir-655-5p (MIRT329824)
- hsa-mir-5003-3p (MIRT329826)
- gga-mir-21-5p (MIRT438450)
- hsa-mir-524-5p (MIRT555729)
- hsa-mir-520d-5p (MIRT555730)
- hsa-mir-6756-3p (MIRT566476)
- hsa-mir-3127-3p (MIRT566477)
- hsa-mir-329-5p (MIRT566478)
- hsa-mir-4748 (MIRT566479)
- hsa-mir-4464 (MIRT566480)
- hsa-mir-340-5p (MIRT566481)
- hsa-mir-218-5p (MIRT611737)
- hsa-mir-4720-3p (MIRT611738)
- hsa-mir-5089-5p (MIRT678636)
- hsa-mir-4279 (MIRT678637)
- hsa-mir-6778-3p (MIRT678638)
- hsa-mir-6506-5p (MIRT678639)
- hsa-mir-619-5p (MIRT678640)
- hsa-mir-1976 (MIRT678641)
- hsa-mir-3653-5p (MIRT678642)
- hsa-mir-150-5p (MIRT678643)
- hsa-mir-6747-3p (MIRT678644)
- hsa-mir-6727-3p (MIRT678645)
- hsa-mir-4722-3p (MIRT678646)
- hsa-mir-6814-5p (MIRT678647)
- hsa-mir-5697 (MIRT678648)
- hsa-mir-5571-5p (MIRT678649)
- hsa-mir-562 (MIRT678650)
- hsa-mir-93-3p (MIRT731482)
- hsa-mir-202-3p (MIRT731769)
- rno-mir-499-5p (MIRT731835)
- hsa-mir-21-3p (MIRT732883)
- hsa-mir-181b-5p (MIRT733056)
- hsa-mir-93-5p (MIRT733146)
- hsa-mir-208a-3p (MIRT733324)
- hsa-mir-744-3p (MIRT734420)
- hsa-mir-330-3p (MIRT735170)
- hsa-mir-129-1-3p (MIRT762288)
- hsa-mir-129-2-3p (MIRT762311)
- hsa-mir-216a-5p (MIRT763882)
- hsa-mir-4763-5p (MIRT772027)
- hsa-mir-938 (MIRT782777)
miRNA Products
- Search ViGene Biosciences for PDCD4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
- genomics-online: shRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDCD4 gene
Clone Products
- Sino Biological Human cDNA Clone for PDCD4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PDCD4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDCD4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDCD4
- Applied Biological Materials Clones for PDCD4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PDCD4
-
ViGene Biosciences adenoviral particle packaged cDNA for PDCD4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PDCD4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDCD4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDCD4 Gene
Localization for PDCD4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDCD4 Gene
- Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269 PubMed:16357133}.
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS,IMP | -- |
GO:0005737 | cytoplasm | IMP | 16357133 |
GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PDCD4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK Signaling: Mitogen Stimulation Pathway | ||
2 | MicroRNAs in cancer | ||
3 | Proteoglycans in cancer | ||
4 | Apoptosis and Autophagy | ||
5 | Translational Control |
Pathways by source for PDCD4 Gene
1 GeneTex pathway for PDCD4 Gene
2 Cell Signaling Technology pathways for PDCD4 Gene
2 BioSystems pathways for PDCD4 Gene
2 KEGG pathways for PDCD4 Gene
3 R&D Systems pathways for PDCD4 Gene
Interacting Proteins for PDCD4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | NAS,TAS | 12054647 |
GO:0007569 | cell aging | IDA | 12054647 |
GO:0030509 | BMP signaling pathway | IDA | 18548003 |
GO:0034393 | positive regulation of smooth muscle cell apoptotic process | IEA | -- |
GO:0035722 | interleukin-12-mediated signaling pathway | TAS | -- |
Transcripts for PDCD4 Gene
mRNA/cDNA for PDCD4 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (434) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PDCD4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PDCD4
- genomics-online: gRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
- Applied Biological Materials CRISPR for PDCD4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
- GenScript: Design CRISPR guide RNA sequences for PDCD4
miRNA Products
- Search ViGene Biosciences for PDCD4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
- genomics-online: shRNA clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDCD4 gene
Clone Products
- Sino Biological Human cDNA Clone for PDCD4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PDCD4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDCD4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PDCD4
- Applied Biological Materials Clones for PDCD4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: |
ExUns: | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||
SP3: | |||||||||||||||||||||
SP4: | |||||||||||||||||||||
SP5: | |||||||||||||||||||||
SP6: | |||||||||||||||||||||
SP7: | |||||||||||||||||||||
SP8: | |||||||||||||||||||||
SP9: | |||||||||||||||||||||
SP10: | |||||||||||||||||||||
SP11: | |||||||||||||||||||||
SP12: | |||||||||||||||||||||
SP13: | - | ||||||||||||||||||||
SP14: | |||||||||||||||||||||
SP15: | |||||||||||||||||||||
SP16: |
Expression for PDCD4 Gene
mRNA differential expression in normal tissues according to GTEx for PDCD4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDCD4 Gene
NURSA nuclear receptor signaling pathways regulating expression of PDCD4 Gene:
PDCD4SOURCE GeneReport for Unigene cluster for PDCD4 Gene:
Hs.711490mRNA Expression by UniProt/SwissProt for PDCD4 Gene:
Q53EL6-PDCD4_HUMANEvidence on tissue expression from TISSUES for PDCD4 Gene
- Nervous system(4.8)
- Blood(4.6)
- Liver(4.5)
- Skin(4.5)
- Spleen(4.5)
- Intestine(3.2)
- Lung(2.9)
- Heart(2.8)
- Pancreas(2.8)
- Lymph node(2.6)
- Muscle(2.5)
- Thyroid gland(2.2)
- Stomach(2.1)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for PDCD4
-
OriGene qPCR primer pairs and template standards for PDCD4
- genomics-online: primer clones - Search results for 147 available PDCD4 gene related products
- Overview of 147 available PDCD4 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD4 Gene
Orthologs for PDCD4 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PDCD4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | PDCD4 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PDCD4 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | PDCD4 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
mouse (Mus musculus) |
Mammalia | Pdcd4 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Pdcd4 33 |
|
||
chicken (Gallus gallus) |
Aves | PDCD4 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | PDCD4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | pdcd4 33 |
|
||
Str.6786 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | pdcd4-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | pdcd4b 33 34 |
|
||
pdcd4 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1132 33 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000378 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Pdcd4 33 34 |
|
||
CG10990 35 |
|
|
|||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G24800 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os08g0120500 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2910 34 |
|
OneToOne | |
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4897 33 |
|
- Species where no ortholog for PDCD4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PDCD4 Gene
No data available for Paralogs for PDCD4 Gene
Variants for PDCD4 Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs515726134 | pathogenic, Bardet-Biedl syndrome, Bardet-Biedl syndrome 18 | 110,900,466(+) | A/C | downstream_transcript_variant | |
VAR_036375 | A breast cancer sample | p.Gly120Arg | |||
rs1000017355 | -- | 110,871,845(+) | C/G | 5_prime_UTR_variant | |
rs1000056963 | -- | 110,873,634(+) | C/T | intron_variant | |
rs1000072080 | -- | 110,871,624(+) | C/G | upstream_transcript_variant |
Additional Variant Information for PDCD4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD4 Gene
Disorders for PDCD4 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
colorectal cancer |
|
|
lung cancer |
|
|
Additional Disease Information for PDCD4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PDCD4 Gene
Publications for PDCD4 Gene
- Structural basis for translational inhibition by the tumour suppressor Pdcd4. (PMID: 19153607) Loh PG … Song H (The EMBO journal 2009) 3 4 22 58
- Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. (PMID: 16449643) Yang HS … Colburn NH (Molecular and cellular biology 2006) 3 4 22 58
- Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. (PMID: 16357133) Palamarchuk A … Pekarsky Y (Cancer research 2005) 3 4 22 58
- Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. (PMID: 10632927) Yoshinaga H … Masaki Z (Pathology international 1999) 3 4 22 58
- Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. (PMID: 9759869) Azzoni L … Perussia B (Journal of immunology (Baltimore, Md. : 1950) 1998) 2 3 4 58
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Sources for PDCD4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (27) AceView
- (28) ASD
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- (34) PanEnsembl
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- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
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- (42) GenAtlas
- (43) HGMD
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- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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- (60) TGDB
- (61) Tocris
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (92) COMPARTMENTS
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