Aliases for PDCD4 Gene
Aliases for PDCD4 Gene
External Ids for PDCD4 Gene
- HGNC: 8763
- Entrez Gene: 27250
- Ensembl: ENSG00000150593
- OMIM: 608610
- UniProtKB: Q53EL6
Previous GeneCards Identifiers for PDCD4 Gene
- GC10P111524
- GC10P111865
- GC10P112762
- GC10P112296
- GC10P112618
- GC10P106260
Summaries for PDCD4 Gene
-
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for PDCD4 Gene
PDCD4 (Programmed Cell Death 4) is a Protein Coding gene. Diseases associated with PDCD4 include Tonsil Cancer and Colorectal Cancer. Among its related pathways are MAPK Signaling: Mitogen Stimulation Pathway and Apoptosis and Autophagy. GO annotations related to this gene include RNA binding and binding.
UniProtKB/Swiss-Prot for PDCD4 Gene
-
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD4 Gene
Genomics for PDCD4 Gene
Regulatory Elements for PDCD4 Gene
Enhancers for PDCD4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PDCD4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PDCD4 gene promoter:
Regulatory Element Products
Genomic Location for PDCD4 Gene
- Chromosome:
- 10
- Start:
- 110,871,795 bp from pter
- End:
- 110,900,006 bp from pter
- Size:
- 28,212 bases
- Orientation:
- Plus strand
Genomic View for PDCD4 Gene
Genes around PDCD4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q25.2 by Ensembl
- 10q25.2 by Entrez Gene
- 10q25.2 by HGNC
PDCD4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDCD4 Gene
Proteins for PDCD4 Gene
-
Protein details for PDCD4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q53EL6-PDCD4_HUMAN
- Recommended name:
- Programmed cell death protein 4
- Protein Accession:
- Q53EL6
- B2RCV4
- B5ME91
- O15501
- Q5VZS6
- Q6PJI5
- Q8TAR5
- Q99834
Protein attributes for PDCD4 Gene
- Size:
- 469 amino acids
- Molecular mass:
- 51735 Da
- Quaternary structure:
-
- Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
- SequenceCaution:
-
- Sequence=AAB42218.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH15036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PDCD4 Gene
Protein Expression for PDCD4 Gene
Post-translational modifications for PDCD4 Gene
- Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
- Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PDCD4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PDCD4
- R&D Systems Antibodies for PDCD4 (PDCD4)
- Cell Signaling Technology (CST) Antibodies for PDCD4 (PDCD4)
-
Custom Antibody ServicesOriGene Antibodies for PDCD4
- Novus Biologicals Antibodies for PDCD4
- Invitrogen Antibodies for PDCD4
- antibodies-online Antibodies for PDCD4: See all 223
- GeneTex PDCD4 antibody for PDCD4
-
Custom Antibody ServicesProSci Antibodies for PDCD4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDCD4
Protein Products
-
OriGene Purified Proteins for PDCD4
- Search Origene for MassSpec and Protein Over-expression Lysates for PDCD4
- Origene Custom Protein Services for PDCD4
- antibodies-online Proteins for PDCD4: See all 15
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PDCD4
-
ProSci Proteins for PDCD4
Assay Products
- antibodies-online Kits for PDCD4: See all 11
No data available for DME Specific Peptides for PDCD4 Gene
Domains & Families for PDCD4 Gene
Protein Domains for PDCD4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDCD4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q53EL6- Domain:
-
- Binds EIF4A1 via both MI domains.
- Family:
-
- Belongs to the PDCD4 family.
No data available for Gene Families for PDCD4 Gene
Function for PDCD4 Gene
Molecular function for PDCD4 Gene
- GENATLAS Biochemistry:
- programmed cell death (apoptosis),inhibited by topoisomerase inhibitors (TIS)
- UniProtKB/Swiss-Prot Function:
- Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
- UniProtKB/Swiss-Prot Induction:
- IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 12054647 |
Phenotypes for PDCD4 Gene
- MGI mutant phenotypes for PDCD4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PDCD4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PDCD4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDCD4 gene
- Search ViGene Biosciences for PDCD4
CRISPR Products
-
OriGene CRISPR knockouts for PDCD4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
- GenScript: Design CRISPR guide RNA sequences for PDCD4
miRNA for PDCD4 Gene
- miRTarBase miRNAs that target PDCD4
-
- hsa-mir-16-5p (MIRT000809)
- hsa-mir-15a-5p (MIRT000810)
- hsa-mir-1-3p (MIRT002785)
- hsa-mir-21-5p (MIRT003054)
- hsa-mir-200a-3p (MIRT004005)
- hsa-mir-183-5p (MIRT005547)
- hsa-mir-499a-5p (MIRT006699)
- hsa-mir-182-5p (MIRT007155)
- hsa-mir-335-5p (MIRT019086)
- hsa-mir-155-5p (MIRT021056)
- hsa-mir-196a-5p (MIRT026027)
- hsa-mir-197-3p (MIRT048135)
- hsa-mir-10b-5p (MIRT053003)
- hsa-mir-548j-3p (MIRT055342)
- hsa-mir-548x-3p (MIRT055345)
- hsa-mir-548ae-3p (MIRT055348)
- hsa-mir-548ah-3p (MIRT055349)
- hsa-mir-548aj-3p (MIRT055350)
- hsa-mir-548am-3p (MIRT055351)
- hsa-mir-548aq-3p (MIRT055352)
- hsa-mir-5582-3p (MIRT055354)
- hsa-mir-548c-3p (MIRT055360)
- hsa-mir-513b-3p (MIRT055361)
- hsa-mir-3163 (MIRT055362)
- hsa-mir-3662 (MIRT055363)
- hsa-mir-6826-3p (MIRT055365)
- hsa-mir-590-5p (MIRT055366)
- hsa-mir-548m (MIRT055367)
- hsa-mir-3653-3p (MIRT055368)
- hsa-mir-3658 (MIRT055369)
- hsa-mir-4436b-5p (MIRT055371)
- hsa-mir-5197-3p (MIRT055372)
- hsa-mir-5579-3p (MIRT055373)
- hsa-mir-6509-3p (MIRT055374)
- hsa-mir-15b-5p (MIRT125922)
- hsa-mir-195-5p (MIRT125925)
- hsa-mir-4804-3p (MIRT125944)
- hsa-mir-655-5p (MIRT329824)
- hsa-mir-5003-3p (MIRT329826)
- mmu-mir-21a-5p (MIRT437779)
- gga-mir-21-5p (MIRT438450)
- hsa-mir-524-5p (MIRT555729)
- hsa-mir-520d-5p (MIRT555730)
- hsa-mir-6756-3p (MIRT566476)
- hsa-mir-3127-3p (MIRT566477)
- hsa-mir-329-5p (MIRT566478)
- hsa-mir-4748 (MIRT566479)
- hsa-mir-4464 (MIRT566480)
- hsa-mir-340-5p (MIRT566481)
- hsa-mir-218-5p (MIRT611737)
- hsa-mir-4720-3p (MIRT611738)
- hsa-mir-5089-5p (MIRT678636)
- hsa-mir-4279 (MIRT678637)
- hsa-mir-6778-3p (MIRT678638)
- hsa-mir-6506-5p (MIRT678639)
- hsa-mir-619-5p (MIRT678640)
- hsa-mir-1976 (MIRT678641)
- hsa-mir-3653-5p (MIRT678642)
- hsa-mir-150-5p (MIRT678643)
- hsa-mir-6747-3p (MIRT678644)
- hsa-mir-6727-3p (MIRT678645)
- hsa-mir-4722-3p (MIRT678646)
- hsa-mir-6814-5p (MIRT678647)
- hsa-mir-5697 (MIRT678648)
- hsa-mir-5571-5p (MIRT678649)
- hsa-mir-562 (MIRT678650)
miRNA Products
- Search ViGene Biosciences for PDCD4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
-
ViGene Biosciences ready-to-package AAV shRNAs for PDCD4 gene
Clone Products
- Sino Biological Human cDNA Clone for PDCD4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PDCD4
Cell Line Products
-
Horizon Cell Lines for PDCD4
-
ViGene Biosciences adenoviral particle packaged cDNA for PDCD4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PDCD4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDCD4 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA6-13745) for PDCD4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDCD4 Gene
Localization for PDCD4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PDCD4 Gene
- Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269 PubMed:16357133}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | IMP | 16357133 |
| GO:0005829 | cytosol | IDA | 12054647 |
Pathways & Interactions for PDCD4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK Signaling: Mitogen Stimulation Pathway | ||
| 2 | MicroRNAs in cancer | ||
| 3 | Proteoglycans in cancer | ||
| 4 | Apoptosis and Autophagy | ||
| 5 | Translational Control | ||
Pathways by source for PDCD4 Gene
1 GeneTex pathway for PDCD4 Gene
2 Cell Signaling Technology pathways for PDCD4 Gene
2 BioSystems pathways for PDCD4 Gene
2 KEGG pathways for PDCD4 Gene
3 R&D Systems pathways for PDCD4 Gene
Interacting Proteins for PDCD4 Gene
Selected Interacting proteins:
ENSP00000280154
Q53EL6-PDCD4_HUMAN
for PDCD4 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | NAS,TAS | 12054647 |
| GO:0007569 | cell aging | IDA | 12054647 |
| GO:0030509 | BMP signaling pathway | IDA | 18548003 |
| GO:0034393 | positive regulation of smooth muscle cell apoptotic process | IEA | -- |
| GO:0043066 | negative regulation of apoptotic process | IEA | -- |
Transcripts for PDCD4 Gene
mRNA/cDNA for PDCD4 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (434) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PDCD4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PDCD4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
- GenScript: Design CRISPR guide RNA sequences for PDCD4
miRNA Products
- Search ViGene Biosciences for PDCD4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
-
ViGene Biosciences ready-to-package AAV shRNAs for PDCD4 gene
Clone Products
- Sino Biological Human cDNA Clone for PDCD4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PDCD4
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA6-13745) for PDCD4
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | - | ||||||||||||||||||||
| SP14: | |||||||||||||||||||||
| SP15: | |||||||||||||||||||||
| SP16: |
Expression for PDCD4 Gene
mRNA differential expression in normal tissues according to GTEx for PDCD4 Gene
This gene is overexpressed in Pancreas (x8.8).
This gene is overexpressed in Lymph node (8.1), Tlymphocyte (7.1), and Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDCD4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PDCD4 Gene:
PDCD4SOURCE GeneReport for Unigene cluster for PDCD4 Gene:
Hs.711490mRNA Expression by UniProt/SwissProt for PDCD4 Gene:
Q53EL6-PDCD4_HUMAN
Tissue specificity:
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
Evidence on tissue expression from TISSUES for PDCD4 Gene
- Nervous system(4.8)
- Blood(4.6)
- Liver(4.5)
- Skin(4.5)
- Spleen(4.5)
- Intestine(3.2)
- Lung(2.9)
- Pancreas(2.8)
- Heart(2.7)
- Lymph node(2.6)
- Muscle(2.5)
- Thyroid gland(2.5)
- Stomach(2.1)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PDCD4
-
OriGene qPCR primer pairs for PDCD4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD4 Gene
Orthologs for PDCD4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PDCD4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PDCD4 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PDCD4 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PDCD4 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Pdcd4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pdcd4 34 |
|
||
| chicken (Gallus gallus) |
Aves | PDCD4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PDCD4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pdcd4 34 |
|
||
| Str.6786 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pdcd4-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pdcd4b 34 35 |
|
||
| pdcd4 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1132 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000378 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Pdcd4 34 35 |
|
||
| CG10990 36 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G24800 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os08g0120500 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2910 35 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4897 34 |
|
- Species where no ortholog for PDCD4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PDCD4 Gene
No data available for Paralogs for PDCD4 Gene
Variants for PDCD4 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036375 | A breast cancer sample | ||||
| rs515726134 | Pathogenic | 110,900,466(+) | ATTTT(A/C)AGGGT | downstream-variant-500B, reference, utr-variant-3-prime, stop-gained | |
| rs1000017355 | -- | 110,871,845(+) | ACCAC(C/G)CGGCC | upstream-variant-2KB, utr-variant-5-prime | |
| rs1000056963 | -- | 110,873,634(+) | AATAG(C/T)GTTTG | intron-variant | |
| rs1000072080 | -- | 110,871,624(+) | ATCCT(C/G)GTCCC | upstream-variant-2KB |
Residual Variation Intolerance Score:
13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.25;
24.97% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PDCD4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD4 Gene
Disorders for PDCD4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tonsil cancer |
|
|
| colorectal cancer |
|
Search PDCD4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PDCD4
No data available for UniProtKB/Swiss-Prot and Genatlas for PDCD4 Gene
Publications for PDCD4 Gene
- Structural basis for translational inhibition by the tumour suppressor Pdcd4. (PMID: 19153607) Loh P.G. … Song H. (EMBO J. 2009) 3 4 22 64
- Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. (PMID: 16449643) Yang H.-S. … Colburn N.H. (Mol. Cell. Biol. 2006) 3 4 22 64
- Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. (PMID: 16357133) Palamarchuk A. … Pekarsky Y. (Cancer Res. 2005) 3 4 22 64
- Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. (PMID: 10632927) Yoshinaga H. … Masaki Z. (Pathol. Int. 1999) 3 4 22 64
- Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. (PMID: 9759869) Azzoni L. … Perussia B. (J. Immunol. 1998) 2 3 4 64
Products for PDCD4 Gene
- R&D Systems Antibodies for PDCD4 (PDCD4)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PDCD4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PDCD4
- Search Origene for MassSpec and Protein Over-expression Lysates for PDCD4
- Origene Custom Protein Services for PDCD4
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PDCD4
- Browse OriGene Inhibitory RNA Products For PDCD4
- OriGene qPCR primer pairs and template standards for PDCD4
- OriGene qPCR primer pairs for PDCD4
- OriGene CRISPR knockouts for PDCD4
- OriGene ORF clones in human for PDCD4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PDCD4
- GenScript: Next-day shipping cDNA ORF clone for PDCD4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PDCD4
- GenScript Custom Assay Services for PDCD4
- GenScript Custom overexpressing Cell Line Services for PDCD4
- GenScript: Design CRISPR guide RNA sequences for PDCD4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PDCD4
- Cell Signaling Technology (CST) Antibodies for PDCD4 (PDCD4)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for PDCD4
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for PDCD4
- Novus Biologicals proteins and lysates for PDCD4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for PDCD4
- antibodies-online Antibodies for PDCD4: See all 223
- antibodies-online Kits for PDCD4: See all 11
- antibodies-online Proteins for PDCD4: See all 15
- Search antibodies-online for peptides
- GeneTex PDCD4 antibody for PDCD4
- Search GeneTex for Proteins for PDCD4
- ViGene Biosciences adenoviral particle packaged cDNA for PDCD4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PDCD4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PDCD4 gene
- Search ViGene Biosciences for PDCD4
- Santa Cruz Biotechnology (SCBT) Antibodies for PDCD4
- Search Santa Cruz Biotechnology (SCBT) for PDCD4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PDCD4
- Custom Antibody ServicesProSci Antibodies for PDCD4
- ProSci Proteins for PDCD4
- Horizon Cell Lines for PDCD4
- Cyagen custom Knockout/knockin (KOKI) mouse models for PDCD4
- VectorBuilder custom plasmid, inducible vectors for PDCD4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDCD4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PDCD4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer