Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDCD4 Gene

Aliases for PDCD4 Gene

  • Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) 2 3 5
  • Neoplastic Transformation Inhibitor Protein 3 4
  • Nuclear Antigen H731 2 3
  • Protein 197/15a 3 4
  • H731 3 4
  • Nuclear Antigen H731-Like 4

External Ids for PDCD4 Gene

Previous GeneCards Identifiers for PDCD4 Gene

  • GC10P111524
  • GC10P111865
  • GC10P112762
  • GC10P112296
  • GC10P112618
  • GC10P106260

Summaries for PDCD4 Gene

Entrez Gene Summary for PDCD4 Gene

  • This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for PDCD4 Gene

PDCD4 (Programmed Cell Death 4 (Neoplastic Transformation Inhibitor)) is a Protein Coding gene. Diseases associated with PDCD4 include Colorectal Cancer. Among its related pathways are Akt Signaling Pathway and Proteoglycans in cancer. GO annotations related to this gene include RNA binding and binding.

UniProtKB/Swiss-Prot for PDCD4 Gene

  • Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

Gene Wiki entry for PDCD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD4 Gene

Genomics for PDCD4 Gene

Regulatory Elements for PDCD4 Gene

Enhancers for PDCD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDCD4 on UCSC Golden Path with GeneCards custom track

Promoters for PDCD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDCD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDCD4 Gene

Chromosome:
10
Start:
110,871,795 bp from pter
End:
110,900,006 bp from pter
Size:
28,212 bases
Orientation:
Plus strand

Genomic View for PDCD4 Gene

Genes around PDCD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD4 Gene

Proteins for PDCD4 Gene

  • Protein details for PDCD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53EL6-PDCD4_HUMAN
    Recommended name:
    Programmed cell death protein 4
    Protein Accession:
    Q53EL6
    Secondary Accessions:
    • B2RCV4
    • B5ME91
    • O15501
    • Q5VZS6
    • Q6PJI5
    • Q8TAR5
    • Q99834

    Protein attributes for PDCD4 Gene

    Size:
    469 amino acids
    Molecular mass:
    51735 Da
    Quaternary structure:
    • Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
    SequenceCaution:
    • Sequence=AAB42218.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH15036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDCD4 Gene

    Alternative splice isoforms for PDCD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCD4 Gene

Proteomics data for PDCD4 Gene at MOPED

Post-translational modifications for PDCD4 Gene

  • Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
  • Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDCD4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDCD4 (PDCD4)

No data available for DME Specific Peptides for PDCD4 Gene

Domains & Families for PDCD4 Gene

Protein Domains for PDCD4 Gene

Suggested Antigen Peptide Sequences for PDCD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53EL6

UniProtKB/Swiss-Prot:

PDCD4_HUMAN :
  • Binds EIF4A1 via both MI domains.
  • Belongs to the PDCD4 family.
Domain:
  • Binds EIF4A1 via both MI domains.
  • Contains 2 MI domains.
Family:
  • Belongs to the PDCD4 family.
genes like me logo Genes that share domains with PDCD4: view

No data available for Gene Families for PDCD4 Gene

Function for PDCD4 Gene

Molecular function for PDCD4 Gene

GENATLAS Biochemistry:
programmed cell death (apoptosis),inhibited by topoisomerase inhibitors (TIS)
UniProtKB/Swiss-Prot Function:
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
UniProtKB/Swiss-Prot Induction:
IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression.
genes like me logo Genes that share phenotypes with PDCD4: view

Animal Models for PDCD4 Gene

MGI Knock Outs for PDCD4:

Animal Model Products

miRNA for PDCD4 Gene

miRTarBase miRNAs that target PDCD4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDCD4 Gene

Localization for PDCD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCD4 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269 PubMed:16357133}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDCD4 Gene COMPARTMENTS Subcellular localization image for PDCD4 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for PDCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IMP 16357133
genes like me logo Genes that share ontologies with PDCD4: view

Pathways & Interactions for PDCD4 Gene

genes like me logo Genes that share pathways with PDCD4: view

Pathways by source for PDCD4 Gene

1 GeneTex pathway for PDCD4 Gene
2 Cell Signaling Technology pathways for PDCD4 Gene
1 BioSystems pathway for PDCD4 Gene

SIGNOR curated interactions for PDCD4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PDCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 12054647
GO:0007569 cell aging IDA 12054647
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043508 negative regulation of JUN kinase activity ISS --
GO:1904761 negative regulation of myofibroblast differentiation IMP 20533548
genes like me logo Genes that share ontologies with PDCD4: view

Drugs & Compounds for PDCD4 Gene

No Compound Related Data Available

Transcripts for PDCD4 Gene

Unigene Clusters for PDCD4 Gene

Programmed cell death 4 (neoplastic transformation inhibitor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10: - - - - - - -
SP11: - -
SP12:
SP13:
SP14: - - - -
SP15:
SP16:

ExUns: 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:

Relevant External Links for PDCD4 Gene

GeneLoc Exon Structure for
PDCD4
ECgene alternative splicing isoforms for
PDCD4

Expression for PDCD4 Gene

mRNA expression in normal human tissues for PDCD4 Gene

mRNA differential expression in normal tissues according to GTEx for PDCD4 Gene

This gene is overexpressed in Pancreas (x8.8).

Protein differential expression in normal tissues from HIPED for PDCD4 Gene

This gene is overexpressed in Lymph node (8.1), Tlymphocyte (7.1), and Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDCD4 Gene



SOURCE GeneReport for Unigene cluster for PDCD4 Gene Hs.711490

mRNA Expression by UniProt/SwissProt for PDCD4 Gene

Q53EL6-PDCD4_HUMAN
Tissue specificity: Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
genes like me logo Genes that share expression patterns with PDCD4: view

Protein tissue co-expression partners for PDCD4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PDCD4 Gene

Orthologs for PDCD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDCD4 35
  • 93.89 (n)
  • 96.59 (a)
PDCD4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDCD4 35
  • 95.17 (n)
  • 98.51 (a)
PDCD4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcd4 35
  • 89.55 (n)
  • 96.8 (a)
Pdcd4 16
Pdcd4 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDCD4 35
  • 99.64 (n)
  • 99.57 (a)
PDCD4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdcd4 35
  • 88.7 (n)
  • 96.8 (a)
oppossum
(Monodelphis domestica)
Mammalia PDCD4 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves PDCD4 35
  • 80.23 (n)
  • 85.22 (a)
PDCD4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDCD4 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd4 35
  • 70.97 (n)
  • 74.84 (a)
Str.6786 35
African clawed frog
(Xenopus laevis)
Amphibia pdcd4-prov 35
zebrafish
(Danio rerio)
Actinopterygii pdcd4 35
pdcd4b 35
  • 66.31 (n)
  • 70.02 (a)
pdcd4b 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1132 35
fruit fly
(Drosophila melanogaster)
Insecta CG10990 37
  • 39 (a)
Pdcd4 35
  • 47.88 (n)
  • 42.69 (a)
Pdcd4 36
  • 38 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000378 35
  • 49.82 (n)
  • 50.28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24800 35
  • 46.25 (n)
  • 34.32 (a)
rice
(Oryza sativa)
Liliopsida Os08g0120500 35
  • 48.25 (n)
  • 36.11 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4897 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2910 36
  • 40 (a)
OneToOne
Species with no ortholog for PDCD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCD4 Gene

ENSEMBL:
Gene Tree for PDCD4 (if available)
TreeFam:
Gene Tree for PDCD4 (if available)

Paralogs for PDCD4 Gene

No data available for Paralogs for PDCD4 Gene

Variants for PDCD4 Gene

Sequence variations from dbSNP and Humsavar for PDCD4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7081726 - 110,881,295(+) AGGAA(A/G/T)TAAAG reference, missense
rs11548765 - 110,881,332(+) AGCAT(A/C)CTCCA reference, missense
VAR_036375 A breast cancer sample
rs1535559 -- 110,880,953(+) ATGCT(G/T)CTTTT intron-variant
rs1885788 -- 110,879,100(+) AAAAG(C/T)GTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD4 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
dgv819n71 CNV Gain 21882294
nsv831985 CNV Gain+Loss 17160897
nsv7548 CNV Insertion 18451855

Variation tolerance for PDCD4 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDCD4 Gene

Human Gene Mutation Database (HGMD)
PDCD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD4 Gene

Disorders for PDCD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDCD4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PDCD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDCD4

Genetic Association Database (GAD)
PDCD4
Human Genome Epidemiology (HuGE) Navigator
PDCD4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDCD4
genes like me logo Genes that share disorders with PDCD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDCD4 Gene

Publications for PDCD4 Gene

  1. Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. (PMID: 9759869) Azzoni L. … Perussia B. (J. Immunol. 1998) 2 3 4 67
  2. Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells. (PMID: 19784072) Wang Q. … Yang H.S. (Oncogene 2010) 3 23
  3. Pdcd4, a colon cancer prognostic that is regulated by a microRNA. (PMID: 19836969) Allgayer H. (Crit. Rev. Oncol. Hematol. 2010) 3 23
  4. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. (PMID: 19946272) Sheedy F.J. … O'Neill L.A. (Nat. Immunol. 2010) 3 23
  5. Structural basis for translational inhibition by the tumour suppressor Pdcd4. (PMID: 19153607) Loh P.G. … Song H. (EMBO J. 2009) 3 23

Products for PDCD4 Gene

Sources for PDCD4 Gene

Content