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Aliases for CHMP2A Gene

Aliases for CHMP2A Gene

  • Charged Multivesicular Body Protein 2A 2 3
  • BC2 3 4 6
  • Vacuolar Protein Sorting-Associated Protein 2-1 3 4
  • Putative Breast Adenocarcinoma Marker (32kD) 2 3
  • Putative Breast Adenocarcinoma Marker BC-2 3 4
  • Chromatin Modifying Protein 2A 2 3
  • Vps2-1 3 4
  • VPS2A 3 6
  • CHMP2 3 4
  • VPS2 3 6
  • VPS2 Homolog A (S. Cerevisiae) 2
  • Chromatin-Modifying Protein 2a 4
  • VPS2 Homolog A 3
  • HVps2-1 4
  • CHMP2a 4
  • BC-2 3

External Ids for CHMP2A Gene

Summaries for CHMP2A Gene

Entrez Gene Summary for CHMP2A Gene

  • CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHMP2A Gene

CHMP2A (Charged Multivesicular Body Protein 2A) is a Protein Coding gene. Diseases associated with CHMP2A include fibrosarcomatous osteosarcoma and adenocarcinoma. Among its related pathways are Disease and Endocytosis. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is CHMP2B.

UniProtKB/Swiss-Prot for CHMP2A Gene

  • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Wiki entry for CHMP2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP2A Gene

Genomics for CHMP2A Gene

Genomic Location for CHMP2A Gene

Start:
58,551,566 bp from pter
End:
58,555,128 bp from pter
Size:
3,563 bases
Orientation:
Minus strand

Genomic View for CHMP2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHMP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP2A Gene

Regulatory Elements for CHMP2A Gene

Transcription factor binding sites by QIAGEN in the CHMP2A gene promoter:

Proteins for CHMP2A Gene

  • Protein details for CHMP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43633-CHM2A_HUMAN
    Recommended name:
    Charged multivesicular body protein 2a
    Protein Accession:
    O43633
    Secondary Accessions:
    • B2R4W6
    • Q3ZTT0

    Protein attributes for CHMP2A Gene

    Size:
    222 amino acids
    Molecular mass:
    25104 Da
    Quaternary structure:
    • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. In vitro, heteromerizes with CHMP3 (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. Interacts with CHMP1B, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP5. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with MITD1. Interacts with VTA1; the interaction probably involves the open conformation of CHMP2A.
    Miscellaneous:
    • Its overexpression strongly inhibits HIV-1 release

neXtProt entry for CHMP2A Gene

Proteomics data for CHMP2A Gene at MOPED

Post-translational modifications for CHMP2A Gene

  • ISGylated in a CHMP5-dependent manner. Isgylation weakens and inhibits its interactions with VPS4A and VTA1 respectively.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys52, Lys64, Lys89, Lys94, Lys104, Lys108, Lys118, and Lys124

Other Protein References for CHMP2A Gene

No data available for DME Specific Peptides for CHMP2A Gene

Domains for CHMP2A Gene

Gene Families for CHMP2A Gene

HGNC:
  • CHMP :Charged multivesicular body proteins

Protein Domains for CHMP2A Gene

UniProtKB/Swiss-Prot:

CHM2A_HUMAN
Domain:
  • The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components:
    • O43633
Family:
  • Belongs to the SNF7 family.:
    • O43633
genes like me logo Genes that share domains with CHMP2A: view

Function for CHMP2A Gene

Molecular function for CHMP2A Gene

UniProtKB/Swiss-Prot Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Ontology (GO) - Molecular Function for CHMP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14505570
GO:0019904 protein domain specific binding IPI 17928862
GO:0031210 phosphatidylcholine binding IMP 18687924
genes like me logo Genes that share ontologies with CHMP2A: view
genes like me logo Genes that share phenotypes with CHMP2A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHMP2A Gene

Localization for CHMP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP2A Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHMP2A Gene COMPARTMENTS Subcellular localization image for CHMP2A gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHMP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0030117 membrane coat IMP 24878737
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with CHMP2A: view

Pathways for CHMP2A Gene

genes like me logo Genes that share pathways with CHMP2A: view

Pathways by source for CHMP2A Gene

1 KEGG pathway for CHMP2A Gene

Gene Ontology (GO) - Biological Process for CHMP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport IEA --
GO:0007080 mitotic metaphase plate congression IMP 20616062
genes like me logo Genes that share ontologies with CHMP2A: view

Transcripts for CHMP2A Gene

Unigene Clusters for CHMP2A Gene

Charged multivesicular body protein 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP2A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: - - - -

Relevant External Links for CHMP2A Gene

GeneLoc Exon Structure for
CHMP2A
ECgene alternative splicing isoforms for
CHMP2A

Expression for CHMP2A Gene

mRNA expression in normal human tissues for CHMP2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHMP2A Gene

This gene is overexpressed in Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHMP2A Gene

SOURCE GeneReport for Unigene cluster for CHMP2A Gene Hs.12107

genes like me logo Genes that share expressions with CHMP2A: view

Orthologs for CHMP2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHMP2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHMP2A 36
  • 99.55 (n)
  • 100 (a)
CHMP2A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHMP2A 36
  • 88.59 (n)
  • 98.2 (a)
CHMP2A 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHMP2A 36
  • 90.54 (n)
  • 99.1 (a)
CHMP2A 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chmp2a 36
  • 90.69 (n)
  • 99.55 (a)
Chmp2a 16
Chmp2a 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chmp2a 36
  • 90.99 (n)
  • 99.55 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 78 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
CHMP2A 36
  • 80.61 (n)
  • 87.73 (a)
lizard
(Anolis carolinensis)
Reptilia CHMP2A 37
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chmp2a 36
  • 77.12 (n)
  • 89.09 (a)
Str.7485 36
zebrafish
(Danio rerio)
Actinopterygii bc2 36
  • 73.79 (n)
  • 87.73 (a)
bc2 37
  • 90 (a)
OneToOne
Dr.2361 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001285 36
  • 72.08 (n)
  • 75.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta vps2 36
  • 72.77 (n)
  • 77.49 (a)
vps2 37
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vps-2 36
  • 66.67 (n)
  • 72.77 (a)
vps-2 37
  • 64 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR002C 36
  • 55.37 (n)
  • 50.82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DID4 36
  • 52.28 (n)
  • 46.45 (a)
DID4 37
  • 42 (a)
OneToMany
DID4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13343g 36
  • 55.37 (n)
  • 49.73 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2446 36
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS2.1 36
  • 62.61 (n)
  • 60.32 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.7386 36
corn
(Zea mays)
Liliopsida Zm.5893 36
rice
(Oryza sativa)
Liliopsida Os07g0236800 36
  • 63.24 (n)
  • 60.54 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2133 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00435 36
  • 58.29 (n)
  • 52.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes did4 36
  • 48.17 (n)
  • 41.76 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3979 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 68 (a)
OneToOne
Species with no ortholog for CHMP2A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CHMP2A Gene

ENSEMBL:
Gene Tree for CHMP2A (if available)
TreeFam:
Gene Tree for CHMP2A (if available)

Paralogs for CHMP2A Gene

Paralogs for CHMP2A Gene

Selected SIMAP similar genes for CHMP2A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHMP2A: view

Variants for CHMP2A Gene

Sequence variations from dbSNP and Humsavar for CHMP2A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs873104 -- 58,554,585(+) TGCAC(C/T)GGTGT intron-variant
rs1044565 -- 58,554,175(-) AGAGG(A/G)GCTAC reference, missense
rs7257669 -- 58,553,572(+) TACTC(C/T)GTGTT intron-variant
rs10414125 -- 58,552,960(+) AAAAC(C/T)CTCTC intron-variant
rs10414380 -- 58,553,129(+) cttgg(A/C)tcact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHMP2A Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV Gain+Loss 19592680
nsv828657 CNV Gain 20364138
nsv912546 CNV Loss 21882294
dgv4032n71 CNV Loss 21882294
nsv820066 CNV Loss 19587683

Relevant External Links for CHMP2A Gene

HapMap Linkage Disequilibrium report
CHMP2A
Human Gene Mutation Database (HGMD)
CHMP2A

Disorders for CHMP2A Gene

(1) University of Copenhagen DISEASES for CHMP2A Gene

genes like me logo Genes that share disorders with CHMP2A: view

No data available for UniProtKB/Swiss-Prot for CHMP2A Gene

Publications for CHMP2A Gene

  1. Helical structures of ESCRT-III are disassembled by VPS4. (PMID: 18687924) Lata S. … Weissenhorn W. (Science 2008) 3 4 23
  2. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PMID: 11559748) Howard T.L. … Hollenberg S.M. (J. Cell Sci. 2001) 2 3 4
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  4. The protein network of HIV budding. (PMID: 14505570) von Schwedler U.K. … Sundquist W.I. (Cell 2003) 3 4
  5. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. (PMID: 14519844) Martin-Serrano J. … Bieniasz P.D. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4

Products for CHMP2A Gene

Sources for CHMP2A Gene

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