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CHMP2A Gene(Protein Coding)

Charged Multivesicular Body Protein 2A

GCID:
GC19M058551
GIFtS:
59
Genes Participants
UDN Logo

Aliases for CHMP2A Gene

Aliases for CHMP2A Gene

  • Charged Multivesicular Body Protein 2A 2 3 5
  • Vacuolar Protein Sorting-Associated Protein 2-1 3 4
  • Putative Breast Adenocarcinoma Marker (32kD) 2 3
  • Putative Breast Adenocarcinoma Marker BC-2 3 4
  • Chromatin Modifying Protein 2A 2 3
  • Vps2-1 3 4
  • CHMP2 3 4
  • BC2 3 4
  • VPS2 Homolog A (S. Cerevisiae) 2
  • Chromatin-Modifying Protein 2a 4
  • VPS2 Homolog A 3
  • HVps2-1 4
  • CHMP2a 4
  • VPS2A 3
  • BC-2 3
  • VPS2 3

External Ids for CHMP2A Gene

Previous GeneCards Identifiers for CHMP2A Gene

  • GC19M063755
  • GC19M059062
  • GC19M055373

Summaries for CHMP2A Gene

Entrez Gene Summary for CHMP2A Gene

  • CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHMP2A Gene

CHMP2A (Charged Multivesicular Body Protein 2A) is a Protein Coding gene. Diseases associated with CHMP2A include brain glioblastoma multiforme and hiv-1. Among its related pathways are Endocytosis and Budding and maturation of HIV virion. GO annotations related to this gene include protein domain specific binding and phosphatidylcholine binding. An important paralog of this gene is CHMP2B.

UniProtKB/Swiss-Prot for CHMP2A Gene

  • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Wiki entry for CHMP2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP2A Gene

Genomics for CHMP2A Gene

Products:

  1. Regulatory Element

Regulatory Elements for CHMP2A Gene

Enhancers for CHMP2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CHMP2A on UCSC Golden Path with GeneCards custom track

Promoters for CHMP2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHMP2A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CHMP2A gene promoter:

Genomic Location for CHMP2A Gene

Chromosome:
19
Start:
58,551,566 bp from pter
End:
58,555,128 bp from pter
Size:
3,563 bases
Orientation:
Minus strand

Genomic View for CHMP2A Gene

Genes around CHMP2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHMP2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHMP2A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHMP2A Gene

Proteins for CHMP2A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CHMP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43633-CHM2A_HUMAN
    Recommended name:
    Charged multivesicular body protein 2a
    Protein Accession:
    O43633
    Secondary Accessions:
    • B2R4W6
    • Q3ZTT0

    Protein attributes for CHMP2A Gene

    Size:
    222 amino acids
    Molecular mass:
    25104 Da
    Quaternary structure:
    • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. In vitro, heteromerizes with CHMP3 (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. Interacts with CHMP1B, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP5. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with MITD1. Interacts with VTA1; the interaction probably involves the open conformation of CHMP2A.
    Miscellaneous:
    • Its overexpression strongly inhibits HIV-1 release.

neXtProt entry for CHMP2A Gene

Proteomics data for CHMP2A Gene at MOPED

Protein Expression for CHMP2A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CHMP2A Gene

  • ISGylated in a CHMP5-dependent manner. Isgylation weakens and inhibits its interactions with VPS4A and VTA1 respectively.
  • Ubiquitination at Lys 52, Lys 64, Lys 89, Lys 94, Lys 104, Lys 108, Lys 118, and Lys 124
  • Modification sites at PhosphoSitePlus

Other Protein References for CHMP2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHMP2A Gene

Domains & Families for CHMP2A Gene

Gene Families for CHMP2A Gene

HGNC:

Protein Domains for CHMP2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CHMP2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43633

UniProtKB/Swiss-Prot:

CHM2A_HUMAN :
  • The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
  • Belongs to the SNF7 family.
Domain:
  • The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
Family:
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP2A: view

Function for CHMP2A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CHMP2A Gene

UniProtKB/Swiss-Prot Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Ontology (GO) - Molecular Function for CHMP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14505570
genes like me logo Genes that share ontologies with CHMP2A: view

Phenotypes for CHMP2A Gene

GenomeRNAi human phenotypes for CHMP2A:
genes like me logo Genes that share phenotypes with CHMP2A: view

Animal Model Products

miRNA for CHMP2A Gene

miRTarBase miRNAs that target CHMP2A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHMP2A Gene

Localization for CHMP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP2A Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHMP2A Gene COMPARTMENTS Subcellular localization image for CHMP2A gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
nucleus 2
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CHMP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031902 late endosome membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CHMP2A: view

Pathways & Interactions for CHMP2A Gene

genes like me logo Genes that share pathways with CHMP2A: view

Gene Ontology (GO) - Biological Process for CHMP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006914 autophagy TAS 20588296
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport IEA --
GO:0010458 exit from mitosis IMP 26040712
genes like me logo Genes that share ontologies with CHMP2A: view

No data available for SIGNOR curated interactions for CHMP2A Gene

Drugs & Compounds for CHMP2A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CHMP2A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CHMP2A Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(286) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHMP2A Gene

Charged multivesicular body protein 2A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP2A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: - - - -

Relevant External Links for CHMP2A Gene

GeneLoc Exon Structure for
CHMP2A
ECgene alternative splicing isoforms for
CHMP2A

Expression for CHMP2A Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CHMP2A Gene

mRNA expression in normal human tissues for CHMP2A Gene
mRNA expression by BioGPS for CHMP2A GenemRNA expression by GTEx for CHMP2A Gene

mRNA differential expression in normal tissues according to GTEx for CHMP2A Gene

This gene is overexpressed in Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for CHMP2A Gene

This gene is overexpressed in Urine (17.8), Peripheral blood mononuclear cells (8.2), and Cervix (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHMP2A Gene



SOURCE GeneReport for Unigene cluster for CHMP2A Gene Hs.12107

genes like me logo Genes that share expression patterns with CHMP2A: view

Protein tissue co-expression partners for CHMP2A Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CHMP2A Gene

Orthologs for CHMP2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHMP2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CHMP2A 35
  • 88.59 (n)
  • 98.2 (a)
CHMP2A 36
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CHMP2A 35
  • 90.54 (n)
  • 99.1 (a)
CHMP2A 36
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Chmp2a 35
  • 90.69 (n)
  • 99.55 (a)
Chmp2a 16
Chmp2a 36
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CHMP2A 35
  • 99.55 (n)
  • 100 (a)
CHMP2A 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Chmp2a 35
  • 90.99 (n)
  • 99.55 (a)
chicken
(Gallus gallus)
 Aves CHMP2A 35
  • 80.61 (n)
  • 87.73 (a)
-- 36
  • 78 (a)
 OneToMany
-- 36
  • 85 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia CHMP2A 36
  • 93 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia chmp2a 35
  • 77.12 (n)
  • 89.09 (a)
Str.7485 35
zebrafish
(Danio rerio)
 Actinopterygii bc2 35
  • 73.79 (n)
  • 87.73 (a)
Dr.2361 35
bc2 36
  • 90 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001285 35
  • 72.08 (n)
  • 75.39 (a)
fruit fly
(Drosophila melanogaster)
 Insecta vps2 35
  • 72.77 (n)
  • 77.49 (a)
vps2 36
  • 63 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea vps-2 35
  • 66.67 (n)
  • 72.77 (a)
vps-2 36
  • 64 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_ABR002C 35
  • 55.37 (n)
  • 50.82 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0B13343g 35
  • 55.37 (n)
  • 49.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes DID4 35
  • 52.28 (n)
  • 46.45 (a)
DID4 36
  • 42 (a)
 OneToMany
DID4 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons VPS2.1 35
  • 62.61 (n)
  • 60.32 (a)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.2446 35
barley
(Hordeum vulgare)
 Liliopsida Hv.7386 35
rice
(Oryza sativa)
 Liliopsida Os07g0236800 35
  • 63.24 (n)
  • 60.54 (a)
wheat
(Triticum aestivum)
 Liliopsida Ta.2133 35
corn
(Zea mays)
 Liliopsida Zm.5893 35
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.3979 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU00435 35
  • 58.29 (n)
  • 52.46 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes did4 35
  • 48.17 (n)
  • 41.76 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 68 (a)
 OneToOne
Species with no ortholog for CHMP2A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CHMP2A Gene

ENSEMBL:
Gene Tree for CHMP2A (if available)
TreeFam:
Gene Tree for CHMP2A (if available)

Paralogs for CHMP2A Gene

Paralogs for CHMP2A Gene

(4) SIMAP similar genes for CHMP2A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHMP2A: view

Variants for CHMP2A Gene

Sequence variations from dbSNP and Humsavar for CHMP2A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7257669 -- 58,553,572(+) TACTC(C/T)GTGTT intron-variant
rs873104 -- 58,554,585(+) TGCAC(C/T)GGTGT intron-variant
rs16988796 -- 58,554,707(-) CTTGT(C/G/T)CTGAG intron-variant
rs1044565 -- 58,554,175(-) AGAGG(A/G)GCTAC reference, missense
rs140029592 -- 58,552,174(+) ATCTG(C/G)GGCAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CHMP2A Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV Gain+Loss 19592680
nsv828657 CNV Gain 20364138
nsv912546 CNV Loss 21882294
dgv4032n71 CNV Loss 21882294
nsv820066 CNV Loss 19587683

Variation tolerance for CHMP2A Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHMP2A Gene

HapMap Linkage Disequilibrium report
CHMP2A
Human Gene Mutation Database (HGMD)
CHMP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHMP2A Gene

Disorders for CHMP2A Gene

MalaCards: The human disease database

(2) MalaCards diseases for CHMP2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
brain glioblastoma multiforme
  • brain glioblastoma
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CHMP2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHMP2A
genes like me logo Genes that share disorders with CHMP2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHMP2A Gene

Publications for CHMP2A Gene

  1. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PMID: 11559748) Howard T.L. … Hollenberg S.M. (J. Cell Sci. 2001) 2 3 4 67
  2. Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. (PMID: 18385515) Shim S. … Hanson P.I. (Mol. Biol. Cell 2008) 3 23
  3. Helical structures of ESCRT-III are disassembled by VPS4. (PMID: 18687924) Lata S. … Weissenhorn W. (Science 2008) 3 23
  4. Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B. (PMID: 15173323) Fujita H. … Himeno M. (J. Cell. Sci. 2004) 2 3
  5. Super-resolution imaging of ESCRT-proteins at HIV-1 assembly sites. (PMID: 25710462) Prescher J. … Lamb D.C. (PLoS Pathog. 2015) 3

Products for CHMP2A Gene

Sources for CHMP2A Gene

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