Aliases for CHMP2A Gene
Aliases for CHMP2A Gene
External Ids for CHMP2A Gene
- HGNC: 30216
- Entrez Gene: 27243
- Ensembl: ENSG00000130724
- OMIM: 610893
- UniProtKB: O43633
Previous GeneCards Identifiers for CHMP2A Gene
- GC19M063755
- GC19M059062
- GC19M055373
Summaries for CHMP2A Gene
-
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CHMP2A Gene
CHMP2A (Charged Multivesicular Body Protein 2A) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Necroptosis. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and phosphatidylcholine binding. An important paralog of this gene is CHMP2B.
UniProtKB/Swiss-Prot for CHMP2A Gene
-
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
-
(Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release.
Additional gene information for CHMP2A Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP2A Gene
Genomics for CHMP2A Gene
GeneHancer (GH) Regulatory Elements for CHMP2A Gene
- Top Transcription factor binding sites by QIAGEN in the CHMP2A gene promoter:
Regulatory Element Products
Genomic Locations for CHMP2A Gene
- chr19:58,551,566-58,555,128
- (GRCh38/hg38)
- Size:
- 3,563 bases
- Orientation:
- Minus strand
- chr19:59,062,933-59,066,491
- (GRCh37/hg19)
Genomic View for CHMP2A Gene
- Cytogenetic band:
-
- 19q13.43 by Ensembl
- 19q13.43 by Entrez Gene
- 19q13.43 by HGNC


RefSeq DNA sequence for CHMP2A Gene
Proteins for CHMP2A Gene
-
Protein details for CHMP2A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43633-CHM2A_HUMAN
- Recommended name:
- Charged multivesicular body protein 2a
- Protein Accession:
- O43633
- B2R4W6
- Q3ZTT0
Protein attributes for CHMP2A Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25104 Da
- Quaternary structure:
-
- Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. In vitro, heteromerizes with CHMP3 (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. Interacts with CHMP1B, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP5. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with MITD1. Interacts with VTA1; the interaction probably involves the open conformation of CHMP2A.
- Miscellaneous:
-
- Its overexpression strongly inhibits HIV-1 release.
Protein Expression for CHMP2A Gene
Post-translational modifications for CHMP2A Gene
- ISGylated in a CHMP5-dependent manner. Isgylation weakens and inhibits its interactions with VPS4A and VTA1 respectively.
- Ubiquitination at Lys52, posLast=6464, Lys89, posLast=9494, posLast=104104, posLast=108108, Lys118, and Lys124
Other Protein References for CHMP2A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for CHMP2A
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Protein Products
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-
Abcam proteins for CHMP2A
Assay Products
No data available for DME Specific Peptides for CHMP2A Gene
Domains & Families for CHMP2A Gene
Gene Families for CHMP2A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CHMP2A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CHMP2A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43633UniProtKB/Swiss-Prot:
CHM2A_HUMAN :- The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
- Belongs to the SNF7 family.
- Domain:
-
- The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
- Family:
-
- Belongs to the SNF7 family.
Function for CHMP2A Gene
Molecular function for CHMP2A Gene
- UniProtKB/Swiss-Prot Function:
- Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 14505570 |
GO:0019904 | protein domain specific binding | IPI | 17928862 |
GO:0031210 | phosphatidylcholine binding | IMP | 18687924 |
Phenotypes for CHMP2A Gene
- GenomeRNAi human phenotypes for CHMP2A:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- FOXO1 nuclear localization
- Decreased viability
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased Hepatitis C virus replication
- Increased Sindbis virus (SINV) infection
- HIV Rev nuclear localization
- Decreased viability with cisplatin
- Increased shRNA abundance with PLX4720
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-
-
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miRNA for CHMP2A Gene
- miRTarBase miRNAs that target CHMP2A
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Clone Products
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-
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- Mammalian expression: PiggyBac
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHMP2A Gene
Localization for CHMP2A Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHMP2A Gene
- Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
- Cytosol (2)
- Plasma membrane (2)
- Nucleus (1)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | colocalizes_with chromatin | IDA | 28242692 |
GO:0000815 | ESCRT III complex | IDA,TAS | 20588296 |
GO:0005622 | intracellular | IEA | -- |
GO:0005635 | nuclear envelope | IDA | 26040712 |
GO:0005768 | endosome | IEA | -- |
Pathways & Interactions for CHMP2A Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Life Cycle |
.92
.65
|
.45
|
2 | Clathrin derived vesicle budding | ||
3 | Budding and maturation of HIV virion | ||
4 | Vesicle-mediated transport | ||
5 | Endocytosis |
Pathways by source for CHMP2A Gene
14 Reactome pathways for CHMP2A Gene
2 KEGG pathways for CHMP2A Gene
Interacting Proteins for CHMP2A Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000920 | cell separation after cytokinesis | IMP | 20616062 |
GO:0006810 | transport | IEA | -- |
GO:0006997 | nucleus organization | IMP | 20616062 |
GO:0007034 | vacuolar transport | IEA | -- |
GO:0007080 | mitotic metaphase plate congression | IMP | 20616062 |
No data available for SIGNOR curated interactions for CHMP2A Gene
Transcripts for CHMP2A Gene
mRNA/cDNA for CHMP2A Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (286) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHMP2A Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHMP2A
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for CHMP2A gene
Clone Products
- Sino Biological Human cDNA Clone for CHMP2A
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CHMP2A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||
SP8: | - | - | - | - |
Expression for CHMP2A Gene
mRNA differential expression in normal tissues according to GTEx for CHMP2A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHMP2A Gene
NURSA nuclear receptor signaling pathways regulating expression of CHMP2A Gene:
CHMP2ASOURCE GeneReport for Unigene cluster for CHMP2A Gene:
Hs.12107Evidence on tissue expression from TISSUES for CHMP2A Gene
- Liver(4.6)
- Blood(4.4)
- Muscle(4.4)
- Skin(4.4)
- Nervous system(3.5)
- Heart(2.2)
- Intestine(2.2)
- Kidney(2.2)
- Spleen(2.1)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for CHMP2A
-
OriGene qPCR primer pairs and template standards for CHMP2A
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHMP2A Gene
Orthologs for CHMP2A Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CHMP2A 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Chmp2a 33 |
|
||
mouse (Mus musculus) |
Mammalia | Chmp2a 33 16 34 |
|
||
dog (Canis familiaris) |
Mammalia | CHMP2A 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | CHMP2A 33 34 |
|
||
chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
CHMP2A 33 |
|
||||
-- 34 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | CHMP2A 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | chmp2a 33 |
|
||
Str.7485 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | bc2 34 33 |
|
OneToOne | |
Dr.2361 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | vps2 34 33 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001285 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | vps-2 34 33 |
|
OneToOne | |
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B13343g 33 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ABR002C 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DID4 33 34 36 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | VPS2.1 33 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.2446 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os07g0236800 33 |
|
||
barley (Hordeum vulgare) |
Liliopsida | Hv.7386 33 |
|
||
wheat (Triticum aestivum) |
Liliopsida | Ta.2133 33 |
|
||
corn (Zea mays) |
Liliopsida | Zm.5893 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU00435 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | did4 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3979 33 |
|
- Species where no ortholog for CHMP2A was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for CHMP2A Gene
(4) SIMAP similar genes for CHMP2A Gene using alignment to 4 proteins:
Variants for CHMP2A Gene
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000133837 | -- | 58,555,279(-) | C/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
rs1000273072 | -- | 58,551,367(-) | A/G | downstream_transcript_variant | |
rs1002136063 | -- | 58,553,557(-) | G/C | intron_variant | |
rs1002232576 | -- | 58,553,818(-) | C/A | intron_variant | |
rs1002285561 | -- | 58,555,552(-) | T/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3687n100 | CNV | gain | 25217958 |
dgv3688n100 | CNV | gain | 25217958 |
nsv1057077 | CNV | gain | 25217958 |
nsv1057206 | CNV | gain | 25217958 |
nsv1160670 | CNV | deletion | 26073780 |
nsv515731 | CNV | gain+loss | 19592680 |
nsv820066 | CNV | loss | 19587683 |
nsv828657 | CNV | gain | 20364138 |
nsv952156 | CNV | deletion | 24416366 |
Additional Variant Information for CHMP2A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHMP2A Gene
Disorders for CHMP2A Gene
Additional Disease Information for CHMP2A
No disorders were found for CHMP2A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHMP2A Gene
Publications for CHMP2A Gene
- Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. (PMID: 18385515) Shim S … Hanson PI (Molecular biology of the cell 2008) 3 4 22 58
- Helical structures of ESCRT-III are disassembled by VPS4. (PMID: 18687924) Lata S … Weissenhorn W (Science (New York, N.Y.) 2008) 3 4 22 58
- CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PMID: 11559748) Howard TL … Hollenberg SM (Journal of cell science 2001) 2 3 4 58
- Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. (PMID: 26040712) Vietri M … Stenmark H (Nature 2015) 3 4 58
- Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15. (PMID: 21543490) Kuang Z … Leis J (Journal of virology 2011) 3 4 58
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- Invitrogen Antibodies for CHMP2A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHMP2A
- VectorBuilder custom plasmid, inducible vectors for CHMP2A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHMP2A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 50 available CHMP2A Antibodies ranked by validation data
- Compare Top CHMP2A Antibodies
- antibodies-online: Search results for available CHMP2A related products ranked by validation data
- antibodies-online: Search results for 12 available CHMP2A Proteins ranked by validation data
- Compare Top CHMP2A Proteins
- GeneTex CHMP2A antibody for CHMP2A
- Search GeneTex for Proteins for CHMP2A
- ViGene Biosciences adenoviral particle packaged cDNA for CHMP2A gene
- ViGene Biosciences lentiviral particle packaged cDNA for CHMP2A gene
- ViGene Biosciences ready-to-package AAV shRNAs for CHMP2A gene
- Search ViGene Biosciences for CHMP2A
- genomics-online: cdna clones - Search results for 131 available CHMP2A gene related products
- Overview of 131 available CHMP2A gene related products
- orf clones - Search results for 131 available CHMP2A gene related products
- Overview of 131 available CHMP2A gene related products
- genomics-online: gRNA clones - Search results for 131 available CHMP2A gene related products
- Overview of 131 available CHMP2A gene related products
- genomics-online: primer clones - Search results for 131 available CHMP2A gene related products
- Overview of 131 available CHMP2A gene related products
- genomics-online: shRNA clones - Search results for 131 available CHMP2A gene related products
- Overview of 131 available CHMP2A gene related products
Sources for CHMP2A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew