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Aliases for GPC3 Gene

Aliases for GPC3 Gene

  • Glypican 3 2 3
  • Intestinal Protein OCI-5 3 4
  • Glypican Proteoglycan 3 2 3
  • GTR2-2 3 4
  • SGBS1 3 6
  • SDYS 3 6
  • MXR7 3 4
  • Heparan Sulphate Proteoglycan 3
  • Secreted Glypican-3 3
  • Glypican-3 3
  • OCI-5 3
  • DGSX 3
  • SGBS 3
  • OCI5 4
  • SGB 3

External Ids for GPC3 Gene

Previous HGNC Symbols for GPC3 Gene

  • SDYS

Previous GeneCards Identifiers for GPC3 Gene

  • GC0XM127315
  • GC0XM129515
  • GC0XM130614
  • GC0XM131375
  • GC0XM132395
  • GC0XM132497
  • GC0XM132669
  • GC0XM122070

Summaries for GPC3 Gene

Entrez Gene Summary for GPC3 Gene

  • Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

GeneCards Summary for GPC3 Gene

GPC3 (Glypican 3) is a Protein Coding gene. Diseases associated with GPC3 include simpson-golabi-behmel syndrome, type 1 and simpson-golabi-behmel syndrome. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include heparan sulfate proteoglycan binding and peptidyl-dipeptidase inhibitor activity. An important paralog of this gene is GPC4.

UniProtKB/Swiss-Prot for GPC3 Gene

  • Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.

Gene Wiki entry for GPC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPC3 Gene

Genomics for GPC3 Gene

Regulatory Elements for GPC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPC3 Gene

Start:
133,535,745 bp from pter
End:
133,985,895 bp from pter
Size:
450,151 bases
Orientation:
Minus strand

Genomic View for GPC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPC3 Gene

Proteins for GPC3 Gene

  • Protein details for GPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51654-GPC3_HUMAN
    Recommended name:
    Glypican-3
    Protein Accession:
    P51654
    Secondary Accessions:
    • C9JLE3
    • G3V1R0
    • Q2L880
    • Q2L882

    Protein attributes for GPC3 Gene

    Size:
    580 amino acids
    Molecular mass:
    65563 Da
    Quaternary structure:
    • Interacts with DPP4.

    Alternative splice isoforms for GPC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPC3 Gene

Proteomics data for GPC3 Gene at MOPED

Post-translational modifications for GPC3 Gene

  • Glycosylation at Asn124, Asn241, Ser359, Asn418, Ser495, and Ser509
  • Modification sites at PhosphoSitePlus

Other Protein References for GPC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for GPC3 Gene

Domains for GPC3 Gene

Gene Families for GPC3 Gene

HGNC:
  • GPC :Proteoglycans / Cell Surface : Glypicans

Protein Domains for GPC3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P51654

UniProtKB/Swiss-Prot:

GPC3_HUMAN :
  • P51654
Family:
  • Belongs to the glypican family.
genes like me logo Genes that share domains with GPC3: view

Function for GPC3 Gene

Molecular function for GPC3 Gene

GENATLAS Biochemistry: glypican 3,60kDa,putative extracellular proteoglycan,involved in growth control in embryonic mesodermal tissues,complexing with and putative modulator of IGF2,juxtaposed to GPC4,with tumor suppression activity
UniProtKB/Swiss-Prot Function: Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.

Gene Ontology (GO) - Molecular Function for GPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17549790
GO:0043395 heparan sulfate proteoglycan binding IEA --
GO:0060422 peptidyl-dipeptidase inhibitor activity IDA 17549790
genes like me logo Genes that share ontologies with GPC3: view
genes like me logo Genes that share phenotypes with GPC3: view

Animal Models for GPC3 Gene

MGI Knock Outs for GPC3:

Animal Model Products

miRNA for GPC3 Gene

miRTarBase miRNAs that target GPC3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GPC3 Gene

Localization for GPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPC3 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Secreted glypican-3: Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPC3 Gene COMPARTMENTS Subcellular localization image for GPC3 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
lysosome 4
vacuole 4
extracellular 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0005764 lysosome --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GPC3: view

Pathways for GPC3 Gene

genes like me logo Genes that share pathways with GPC3: view

Pathways by source for GPC3 Gene

1 KEGG pathway for GPC3 Gene
2 R&D Systems pathways for GPC3 Gene

Gene Ontology (GO) - Biological Process for GPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001822 kidney development --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
genes like me logo Genes that share ontologies with GPC3: view

Compounds for GPC3 Gene

(5) Novoseek inferred chemical compound relationships for GPC3 Gene

Compound -log(P) Hits PubMed IDs
heparan sulfate 48.7 3
diethylnitrosamine 27.9 2
5-aza-2deoxycytidine 24.9 2
oligonucleotide 0 1
lipid 0 1
genes like me logo Genes that share compounds with GPC3: view

Transcripts for GPC3 Gene

Unigene Clusters for GPC3 Gene

Glypican 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPC3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPC3 Gene

No ASD Table

Relevant External Links for GPC3 Gene

GeneLoc Exon Structure for
GPC3
ECgene alternative splicing isoforms for
GPC3

Expression for GPC3 Gene

mRNA expression in normal human tissues for GPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPC3 Gene

This gene is overexpressed in Lung (7.5), Adipose - Subcutaneous (6.3), Nerve - Tibial (4.6), Adipose - Visceral (Omentum) (4.1), and Breast - Mammary Tissue (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPC3 Gene

SOURCE GeneReport for Unigene cluster for GPC3 Gene Hs.644108

mRNA Expression by UniProt/SwissProt for GPC3 Gene

P51654-GPC3_HUMAN
Tissue specificity: Highly expressed in lung, liver and kidney
genes like me logo Genes that share expressions with GPC3: view

In Situ Assay Products

Orthologs for GPC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPC3 35
  • 99.14 (n)
  • 98.97 (a)
GPC3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPC3 35
  • 93.28 (n)
  • 95.69 (a)
GPC3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPC3 35
  • 92.18 (n)
  • 95.52 (a)
GPC3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpc3 35
  • 90.73 (n)
  • 94.13 (a)
Gpc3 16
Gpc3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPC3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPC3 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpc3 35
  • 90.78 (n)
  • 94.09 (a)
chicken
(Gallus gallus)
Aves GPC3 35
  • 69.84 (n)
  • 68.66 (a)
GPC3 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPC3 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpc3 35
  • 63.69 (n)
  • 59.72 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
gpc3 35
  • 53.76 (n)
  • 48.16 (a)
gpc3 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dally 36
  • 19 (a)
OneToMany
Species with no ortholog for GPC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPC3 Gene

ENSEMBL:
Gene Tree for GPC3 (if available)
TreeFam:
Gene Tree for GPC3 (if available)

Paralogs for GPC3 Gene

Paralogs for GPC3 Gene

Selected SIMAP similar genes for GPC3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPC3: view

Variants for GPC3 Gene

Sequence variations from dbSNP and Humsavar for GPC3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs764519 -- 133,797,028(-) AGTAT(A/G)TAAAT intron-variant
rs879941 -- 133,695,831(+) AATAT(G/T)TCAAT intron-variant
rs926228 -- 133,588,356(+) ATAGG(A/T)CCTAA intron-variant
rs926596 -- 133,792,565(+) CCCCC(C/T)AAGCT intron-variant
rs933250 -- 133,875,805(-) GATTG(A/G)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPC3 Gene

Variant ID Type Subtype PubMed ID
esv2740486 CNV Deletion 23290073

Relevant External Links for GPC3 Gene

HapMap Linkage Disequilibrium report
GPC3
Human Gene Mutation Database (HGMD)
GPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPC3 Gene

Disorders for GPC3 Gene

(2) OMIM Diseases for GPC3 Gene (300037)

UniProtKB/Swiss-Prot

GPC3_HUMAN
  • Simpson-Golabi-Behmel syndrome 1 (SGBS1) [MIM:312870]: A condition characterized by pre- and postnatal overgrowth (gigantism), facial dysmorphism and a variety of inconstant visceral and skeletal malformations. Characteristic dysmorphic features include macrocephaly with coarse, distinctive facies with a large protruding jaw, broad nasal bridge and cleft palate. Cardiac defects are frequent. {ECO:0000269 PubMed:10814714}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for GPC3 Gene

(39) Novoseek inferred disease relationships for GPC3 Gene

Disease -log(P) Hits PubMed IDs
perlman syndrome 88.7 2
embryonal tumor 77.1 4
beckwith-wiedemann syndrome 73 3
hepatocellular carcinoma 71.2 39
gigantism 67.4 3

Relevant External Links for GPC3

GeneTests
GPC3
GeneReviews
GPC3
genes like me logo Genes that share disorders with GPC3: view

Publications for GPC3 Gene

  1. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. (PMID: 8589713) Pilia G. … Schlessinger D. (Nat. Genet. 1996) 2 3 4 23
  2. Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene. (PMID: 9339360) Huber R. … Pilia G. (Genomics 1997) 3 4 23
  3. GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. (PMID: 9787072) Veugelers M. … David G. (Genomics 1998) 2 3 23
  4. Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss- of-function mutations in the GPC3 gene. (PMID: 10814714) Veugelers M. … David G. (Hum. Mol. Genet. 2000) 3 4 23
  5. The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. (PMID: 17549790) Davoodi J. … MacKenzie A.E. (Proteomics 2007) 3 4 23

Products for GPC3 Gene

  • Addgene plasmids for GPC3

Sources for GPC3 Gene

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