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Aliases for IL37 Gene

Aliases for IL37 Gene

  • Interleukin 37 2 3 5
  • Interleukin-1-Related Protein 2 3 4
  • Interleukin-1 Homolog 4 2 3 4
  • Interleukin 1, Zeta 2 3
  • Interleukin-23 3 4
  • FIL1 Zeta 3 4
  • IL-1 Zeta 3 4
  • IL-1RP1 3 4
  • IL-1F7 3 4
  • IL-1H4 3 4
  • IL1RP1 3 4
  • IL1F7 3 4
  • FIL1Z 3 4
  • IL-1H 3 4
  • IL-37 3 4
  • IL1H4 3 4
  • Interleukin 1 Family, Member 7 (Zeta) 2
  • IL1F7 (Canonical Product IL-1F7b) 3
  • IL-1F7b (IL-1H4, IL-1H, IL-1RP1) 3
  • Interleukin 1 Family Member 7 3
  • Interleukin-1 Family Member 7 4
  • Interleukin-1 Superfamily Z 3
  • Interleukin-1 Zeta 4
  • Interleukin-37 3
  • IL-1X Protein 3
  • FIL1(ZETA) 3
  • IL-1X 4
  • FIL1 3

External Ids for IL37 Gene

Previous HGNC Symbols for IL37 Gene

  • IL1F7

Previous GeneCards Identifiers for IL37 Gene

  • GC02P113672
  • GC02P112912
  • GC02P112914

Summaries for IL37 Gene

Entrez Gene Summary for IL37 Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL37 Gene

IL37 (Interleukin 37) is a Protein Coding gene. Diseases associated with IL37 include Rheumatoid Arthritis. Among its related pathways are Innate Immune System and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL36G.

UniProtKB/Swiss-Prot for IL37 Gene

  • Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.

Gene Wiki entry for IL37 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL37 Gene

Genomics for IL37 Gene

Regulatory Elements for IL37 Gene

Enhancers for IL37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G112811 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.2 -97.8 -97759 4.3 PKNOX1 ATF1 GATA2 FOS JUNB TBX21 ZNF592 SMARCA4 MYNN ETV4 IL1B IL1RN IL1A IL37 IL36B IL36G CKAP2L IL36RN GC02M112788
GH02G112884 1.6 FANTOM5 ENCODE dbSUPER 16.3 -25.7 -25718 1.3 CBX3 WRNIP1 ARID4B THRB ZNF48 RAD21 RARA ZSCAN5C ZNF143 ZNF207 IL1B IL1RN IL1A IL37 IL36G CKAP2L IL36B IL36RN PIR39579 PIR40727
GH02G112867 1.6 Ensembl ENCODE dbSUPER 15.9 -41.8 -41824 3.6 PKNOX1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZNF143 ZNF207 FOS MXD4 IL1B IL1A IL37 CKAP2L PIR40727 XIAPP3
GH02G112875 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -32.0 -32048 7.2 FOXA2 PKNOX1 RAD21 RARA TCF12 GATA2 EGR1 FOS ETV6 IKZF2 IL1B IL1RN IL1A IL36B IL37 IL36G CKAP2L IL36RN PIR40727 XIAPP3
GH02G112781 1.5 Ensembl ENCODE dbSUPER 14.5 -127.4 -127430 3.9 ATF1 PKNOX1 CREB3L1 ARNT CBX5 FOS KLF13 JUNB TBX21 ZNF592 IL37 IL1B ENSG00000243389 CHCHD5 ENSG00000207383 IL1A CKAP2L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL37 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL37 Gene

Chromosome:
2
Start:
112,911,064 bp from pter
End:
112,918,882 bp from pter
Size:
7,819 bases
Orientation:
Plus strand

Genomic View for IL37 Gene

Genes around IL37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL37 Gene

Proteins for IL37 Gene

  • Protein details for IL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZH6-IL37_HUMAN
    Recommended name:
    Interleukin-37
    Protein Accession:
    Q9NZH6
    Secondary Accessions:
    • B5BU97
    • Q56AP9
    • Q8TD04
    • Q8TD05
    • Q9HBF2
    • Q9HBF3
    • Q9UHA6

    Protein attributes for IL37 Gene

    Size:
    218 amino acids
    Molecular mass:
    24126 Da
    Quaternary structure:
    • Interacts with SMAD3. Binds IL18R1, but not to IL1R1, with lower affinity than IL18, and does not seem to act as a receptor antagonist for IL18.

    Three dimensional structures from OCA and Proteopedia for IL37 Gene

    Alternative splice isoforms for IL37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL37 Gene

Post-translational modifications for IL37 Gene

  • Proteolytically converted to the mature form by CASP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for IL37
  • Santa Cruz Biotechnology (SCBT) Antibodies for IL37

No data available for DME Specific Peptides for IL37 Gene

Domains & Families for IL37 Gene

Gene Families for IL37 Gene

Protein Domains for IL37 Gene

Suggested Antigen Peptide Sequences for IL37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZH6

UniProtKB/Swiss-Prot:

IL37_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL37: view

Function for IL37 Gene

Molecular function for IL37 Gene

UniProtKB/Swiss-Prot Function:
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
UniProtKB/Swiss-Prot Induction:
Highly induced by bacterial lipopolysaccharides (LPS) and TGFB1, more moderately by IFNG, IL18, IL1B, TNF and the dinucleotide CpG (at protein level). Constitutive expression in bone marrow macrophages is down-regulated in the presence of IL4 and CSF2. Induced by phorbol myristate acetate (PMA) in different cell lines.

Gene Ontology (GO) - Molecular Function for IL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005149 interleukin-1 receptor binding TAS 10625660
genes like me logo Genes that share ontologies with IL37: view

Phenotypes for IL37 Gene

GenomeRNAi human phenotypes for IL37:
genes like me logo Genes that share phenotypes with IL37: view

Animal Model Products

miRNA for IL37 Gene

miRTarBase miRNAs that target IL37

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL37 Gene

Localization for IL37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL37 Gene

Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL37 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10744718
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IL37: view

Pathways & Interactions for IL37 Gene

genes like me logo Genes that share pathways with IL37: view

Pathways by source for IL37 Gene

Gene Ontology (GO) - Biological Process for IL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response NAS 10625660
GO:0019221 cytokine-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with IL37: view

No data available for SIGNOR curated interactions for IL37 Gene

Transcripts for IL37 Gene

Unigene Clusters for IL37 Gene

Interleukin 37:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3:
SP4: - - -
SP5: - -

Relevant External Links for IL37 Gene

GeneLoc Exon Structure for
IL37
ECgene alternative splicing isoforms for
IL37

Expression for IL37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL37 Gene

mRNA differential expression in normal tissues according to GTEx for IL37 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x28.2) and Skin - Not Sun Exposed (Suprapubic) (x22.9).

Protein differential expression in normal tissues from HIPED for IL37 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL37 Gene



Protein tissue co-expression partners for IL37 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL37 Gene:

IL37

SOURCE GeneReport for Unigene cluster for IL37 Gene:

Hs.166371

mRNA Expression by UniProt/SwissProt for IL37 Gene:

Q9NZH6-IL37_HUMAN
Tissue specificity: In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.

Evidence on tissue expression from TISSUES for IL37 Gene

  • Blood(4.3)
  • Lung(4.2)
  • Intestine(4.1)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with IL37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL37 Gene

Orthologs for IL37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL37 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IL37 34 35
  • 81.38 (n)
cow
(Bos Taurus)
Mammalia IL37 34 35
  • 73.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
Species where no ortholog for IL37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL37 Gene

ENSEMBL:
Gene Tree for IL37 (if available)
TreeFam:
Gene Tree for IL37 (if available)

Paralogs for IL37 Gene

Paralogs for IL37 Gene

(2) SIMAP similar genes for IL37 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL37: view

Variants for IL37 Gene

Sequence variations from dbSNP and Humsavar for IL37 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000272376 -- 112,914,573(+) CAGGT(A/G)TGTAA intron-variant, upstream-variant-2KB
rs1000372026 -- 112,907,921(+) TAGGT(A/G)TATCT upstream-variant-2KB
rs1000387037 -- 112,917,383(+) CCAGG(C/G)ACTAG intron-variant
rs1000569633 -- 112,915,408(+) CCAGT(A/G)TGCAC intron-variant
rs1000705713 -- 112,909,430(+) AACCT(C/T)CTATA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IL37 Gene

Variant ID Type Subtype PubMed ID
esv3584019 CNV loss 25503493
nsv1003372 CNV loss 25217958
nsv2879 CNV insertion 18451855

Variation tolerance for IL37 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.54; 82.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL37 Gene

Disorders for IL37 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL37 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards
Search IL37 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL37
genes like me logo Genes that share disorders with IL37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL37 Gene

Publications for IL37 Gene

  1. Four new members expand the IL-1 superfamily. (PMID: 10625660) Smith D.E. … Sims J.E. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. The IL-1 family member 7b translocates to the nucleus and down- regulates proinflammatory cytokines. (PMID: 18390730) Sharma S. … Bufler P. (J. Immunol. 2008) 3 4 22 64
  3. IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL- 1Rrp. (PMID: 11145836) Pan G. … Vandlen R. (Cytokine 2001) 3 4 22 64
  4. IL-37 is a fundamental inhibitor of innate immunity. (PMID: 20935647) Nold M.F. … Dinarello C.A. (Nat. Immunol. 2010) 3 4 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64

Products for IL37 Gene

Sources for IL37 Gene

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