Aliases for SLC39A1 Gene
Aliases for SLC39A1 Gene
External Ids for SLC39A1 Gene
- HGNC: 12876
- Entrez Gene: 27173
- Ensembl: ENSG00000143570
- OMIM: 604740
- UniProtKB: Q9NY26
Previous HGNC Symbols for SLC39A1 Gene
- ZIRTL
Previous GeneCards Identifiers for SLC39A1 Gene
- GC01M151748
- GC01M149662
- GC01M150706
- GC01M151148
- GC01M150744
- GC01M152198
- GC01M125294
Summaries for SLC39A1 Gene
-
This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
GeneCards Summary for SLC39A1 Gene
SLC39A1 (Solute Carrier Family 39 Member 1) is a Protein Coding gene. Diseases associated with SLC39A1 include Prostate Cancer and Alzheimer Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Senescence and Autophagy in Cancer. GO annotations related to this gene include receptor binding and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A2.
UniProtKB/Swiss-Prot for SLC39A1 Gene
-
Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A1 Gene
Genomics for SLC39A1 Gene
Regulatory Elements for SLC39A1 Gene
Enhancers for SLC39A1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SLC39A1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SLC39A1 gene promoter:
Regulatory Element Products
Genomic Location for SLC39A1 Gene
- Chromosome:
- 1
- Start:
- 153,959,099 bp from pter
- End:
- 153,968,184 bp from pter
- Size:
- 9,086 bases
- Orientation:
- Minus strand
Genomic View for SLC39A1 Gene
Genes around SLC39A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
SLC39A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC39A1 Gene
Proteins for SLC39A1 Gene
-
Protein details for SLC39A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NY26-S39A1_HUMAN
- Recommended name:
- Zinc transporter ZIP1
- Protein Accession:
- Q9NY26
- B4DDY7
- Q5T4K1
- Q8N2H7
- Q9BTV0
- Q9UBI7
- Q9Y2Z7
- Q9Y380
Protein attributes for SLC39A1 Gene
- Size:
- 324 amino acids
- Molecular mass:
- 34250 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake.
- SequenceCaution:
-
- Sequence=AAD27717.1; Type=Frameshift; Positions=16, 40; Evidence={ECO:0000305};
Protein Expression for SLC39A1 Gene
Post-translational modifications for SLC39A1 Gene
Other Protein References for SLC39A1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for SLC39A1
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- Invitrogen Antibodies for SLC39A1
- antibodies-online Antibodies for SLC39A1: See all 23
- GeneTex SLC39A1 antibody for SLC39A1
-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC39A1
Protein Products
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OriGene Purified Proteins for SLC39A1
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-
ProSci Proteins for SLC39A1
Assay Products
- antibodies-online Kits for SLC39A1: See all 1
No data available for DME Specific Peptides for SLC39A1 Gene
Domains & Families for SLC39A1 Gene
Gene Families for SLC39A1 Gene
- HGNC:
- IUPHAR :
Protein Domains for SLC39A1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC39A1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57100, highly similar to Zinc transporter ZIP1 (B4DDY7_HUMAN)
- cDNA FLJ51719, highly similar to Zinc transporter ZIP1 (B4DNN0_HUMAN)
- cDNA FLJ90462 fis, clone NT2RP3002015, highly similar to Zinc transporter ZIP1 (Q5T4K1_HUMAN)
- SLC39A1 protein (Q6IAD8_HUMAN)
- Zrt- and Irt-like protein 1 (S39A1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NY26- Family:
-
- Belongs to the ZIP transporter (TC 2.A.5) family.
Function for SLC39A1 Gene
Molecular function for SLC39A1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | IEA | -- |
| GO:0005385 | zinc ion transmembrane transporter activity | TAS | -- |
| GO:0022890 | inorganic cation transmembrane transporter activity | TAS | 10610721 |
| GO:0046873 | metal ion transmembrane transporter activity | IEA | -- |
Phenotypes for SLC39A1 Gene
- MGI mutant phenotypes for SLC39A1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SLC39A1:
Animal Model Products
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-
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CRISPR Products
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC39A1
- GenScript: Design CRISPR guide RNA sequences for SLC39A1
miRNA for SLC39A1 Gene
- miRTarBase miRNAs that target SLC39A1
-
- hsa-mir-215-5p (MIRT024724)
- hsa-mir-192-5p (MIRT026105)
- hsa-mir-96-5p (MIRT027938)
- hsa-mir-877-5p (MIRT037329)
- hsa-mir-30c-5p (MIRT047939)
- hsa-mir-6788-3p (MIRT693582)
- hsa-mir-1231 (MIRT693583)
- hsa-mir-632 (MIRT693584)
- hsa-mir-4288 (MIRT693585)
- hsa-mir-1227-5p (MIRT693586)
- hsa-mir-642a-5p (MIRT693587)
- hsa-mir-346 (MIRT693588)
- hsa-mir-128-2-5p (MIRT693589)
- hsa-mir-128-1-5p (MIRT693590)
- hsa-mir-6845-5p (MIRT693591)
- hsa-mir-6762-5p (MIRT693592)
- hsa-mir-4726-5p (MIRT693593)
- hsa-mir-4640-5p (MIRT693594)
- hsa-mir-4515 (MIRT693595)
- hsa-mir-6781-3p (MIRT693596)
- hsa-mir-2682-3p (MIRT693597)
- hsa-mir-3194-5p (MIRT693598)
- hsa-mir-3655 (MIRT693599)
- hsa-mir-18a-3p (MIRT693600)
- hsa-mir-324-3p (MIRT693601)
- hsa-mir-1913 (MIRT693602)
- hsa-mir-6758-3p (MIRT693603)
- hsa-mir-2276-5p (MIRT693604)
- hsa-mir-6892-3p (MIRT693605)
- hsa-mir-6877-3p (MIRT693606)
- hsa-mir-6819-3p (MIRT693607)
miRNA Products
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Inhibitory RNA Products
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Cell Line Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC39A1 Gene
Localization for SLC39A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC39A1 Gene
- Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 3 |
| nucleus | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA,TAS | 10610721 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for SLC39A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metal ion SLC transporters |
.38
|
|
| 2 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 3 | NRF2 pathway | ||
| 4 | Senescence and Autophagy in Cancer | ||
Pathways by source for SLC39A1 Gene
3 BioSystems pathways for SLC39A1 Gene
Interacting Proteins for SLC39A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006812 | cation transport | TAS | 10610721 |
| GO:0006829 | zinc II ion transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC39A1 Gene
Transcripts for SLC39A1 Gene
mRNA/cDNA for SLC39A1 Gene
- (6) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (822) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC39A1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLC39A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC39A1
- GenScript: Design CRISPR guide RNA sequences for SLC39A1
miRNA Products
- Search ViGene Biosciences for SLC39A1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for SLC39A1
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-
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Clone Products
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f | · | 9g | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 9h |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: |
Expression for SLC39A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Hypothalamus
- Thalamus
- Striatum
- Medulla Oblongata
- Neural Tube (Nervous System)
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
- Thymus (Hematopoietic System)
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
This gene is overexpressed in Bone (58.6) and Adrenal (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC39A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC39A1 Gene:
SLC39A1SOURCE GeneReport for Unigene cluster for SLC39A1 Gene:
Hs.7854mRNA Expression by UniProt/SwissProt for SLC39A1 Gene:
Q9NY26-S39A1_HUMAN
Tissue specificity:
Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.
Evidence on tissue expression from TISSUES for SLC39A1 Gene
- Lung(4.8)
- Kidney(4.7)
- Nervous system(4.5)
- Muscle(4.3)
- Thyroid gland(4.3)
- Intestine(3.6)
- Skin(2.9)
- Pancreas(2.4)
- Blood(2)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for SLC39A1
-
OriGene qPCR primer pairs and template standards for SLC39A1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC39A1 Gene
Orthologs for SLC39A1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC39A1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SLC39A1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SLC39A1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc39a1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc39a1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLC39A1 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SLC39A1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slc39a1 34 |
|
||
| Str.7666 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | slc39a3 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG9430 35 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | F31C3.4 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany |
- Species where no ortholog for SLC39A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SLC39A1 Gene
(2) SIMAP similar genes for SLC39A1 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for SLC39A1 Gene
Variants for SLC39A1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000069787 | -- | 153,967,407(+) | TCCCG(C/G)AGCTT | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000101967 | -- | 153,967,761(+) | TGAGA(A/G)GGTAG | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000906345 | -- | 153,962,801(+) | GGGGC(A/C)AGGAA | intron-variant, upstream-variant-2KB | |
| rs1001142587 | -- | 153,966,841(+) | ACCTG(C/T)ATCAG | intron-variant, upstream-variant-2KB | |
| rs1001172019 | -- | 153,967,289(+) | CCTGC(C/G)GAGCG | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.77;
16.21% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SLC39A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC39A1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC39A1 Gene
Disorders for SLC39A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostate cancer |
|
|
| alzheimer disease |
|
|
Search SLC39A1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for SLC39A1
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC39A1 Gene
Publications for SLC39A1 Gene
- Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. (PMID: 10610721) Lioumi M. … Ragoussis J. (Genomics 1999) 2 3 4 22 64
- The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. (PMID: 11301334) Gaither L.A. … Eide D.J. (J. Biol. Chem. 2001) 3 4 22 64
- A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein. (PMID: 17635580) Huang L. … Kirschke C.P. (FEBS J. 2007) 3 22 64
- Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells. (PMID: 16203195) Tang Z. … Gupta A. (Bone 2006) 3 22 64
- hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. (PMID: 16153295) Franklin R.B. … Costello L.C. (Mol. Cancer 2005) 3 22 64
Products for SLC39A1 Gene
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SLC39A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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