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Aliases for SLC39A1 Gene

Aliases for SLC39A1 Gene

  • Solute Carrier Family 39 Member 1 2 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 1 2 3 5
  • Zrt- And Irt-Like Protein 1 3 4
  • ZIRTL 3 4
  • ZIP1 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 3 3
  • Zinc/Iron Regulated Transporter-Like 2
  • Zinc-Iron-Regulated Transporter-Like 4
  • ZIP-1 4
  • HZIP1 4
  • IRT1 4

External Ids for SLC39A1 Gene

Previous HGNC Symbols for SLC39A1 Gene

  • ZIRTL

Previous GeneCards Identifiers for SLC39A1 Gene

  • GC01M151748
  • GC01M149662
  • GC01M150706
  • GC01M151148
  • GC01M150744
  • GC01M152198
  • GC01M125294

Summaries for SLC39A1 Gene

Entrez Gene Summary for SLC39A1 Gene

  • This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for SLC39A1 Gene

SLC39A1 (Solute Carrier Family 39 Member 1) is a Protein Coding gene. Diseases associated with SLC39A1 include prostate cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Senescence and Autophagy. GO annotations related to this gene include receptor binding and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A3.

UniProtKB/Swiss-Prot for SLC39A1 Gene

  • Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.

Gene Wiki entry for SLC39A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A1 Gene

Genomics for SLC39A1 Gene

Regulatory Elements for SLC39A1 Gene

Promoters for SLC39A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC39A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC39A1 Gene

Chromosome:
1
Start:
153,959,099 bp from pter
End:
153,968,184 bp from pter
Size:
9,086 bases
Orientation:
Minus strand

Genomic View for SLC39A1 Gene

Genes around SLC39A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A1 Gene

Proteins for SLC39A1 Gene

  • Protein details for SLC39A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY26-S39A1_HUMAN
    Recommended name:
    Zinc transporter ZIP1
    Protein Accession:
    Q9NY26
    Secondary Accessions:
    • B4DDY7
    • Q5T4K1
    • Q8N2H7
    • Q9BTV0
    • Q9UBI7
    • Q9Y2Z7
    • Q9Y380

    Protein attributes for SLC39A1 Gene

    Size:
    324 amino acids
    Molecular mass:
    34250 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake.
    SequenceCaution:
    • Sequence=AAD27717.1; Type=Frameshift; Positions=16, 40; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC39A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A1 Gene

Proteomics data for SLC39A1 Gene at MOPED

Post-translational modifications for SLC39A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SLC39A1 Gene

Domains & Families for SLC39A1 Gene

Gene Families for SLC39A1 Gene

Protein Domains for SLC39A1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NY26

UniProtKB/Swiss-Prot:

S39A1_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A1: view

Function for SLC39A1 Gene

Molecular function for SLC39A1 Gene

UniProtKB/Swiss-Prot Function:
Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.

Gene Ontology (GO) - Molecular Function for SLC39A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A1: view
genes like me logo Genes that share phenotypes with SLC39A1: view

Animal Models for SLC39A1 Gene

MGI Knock Outs for SLC39A1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC39A1 Gene

Localization for SLC39A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A1 Gene COMPARTMENTS Subcellular localization image for SLC39A1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC39A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,TAS 10610721
genes like me logo Genes that share ontologies with SLC39A1: view

Pathways & Interactions for SLC39A1 Gene

genes like me logo Genes that share pathways with SLC39A1: view

Gene Ontology (GO) - Biological Process for SLC39A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060173 limb development IEA --
GO:0071577 zinc II ion transmembrane transport IMP 11301334
genes like me logo Genes that share ontologies with SLC39A1: view

No data available for SIGNOR curated interactions for SLC39A1 Gene

Drugs & Compounds for SLC39A1 Gene

(2) Drugs for SLC39A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC39A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC39A1: view

Transcripts for SLC39A1 Gene

Unigene Clusters for SLC39A1 Gene

Solute carrier family 39 (zinc transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9: -
SP10:

ExUns: 9h
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SLC39A1 Gene

GeneLoc Exon Structure for
SLC39A1
ECgene alternative splicing isoforms for
SLC39A1

Expression for SLC39A1 Gene

mRNA expression in normal human tissues for SLC39A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC39A1 Gene

This gene is overexpressed in Bone (58.6) and Adrenal (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A1 Gene



SOURCE GeneReport for Unigene cluster for SLC39A1 Gene Hs.7854

mRNA Expression by UniProt/SwissProt for SLC39A1 Gene

Q9NY26-S39A1_HUMAN
Tissue specificity: Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.
genes like me logo Genes that share expression patterns with SLC39A1: view

Protein tissue co-expression partners for SLC39A1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC39A1 Gene

Orthologs for SLC39A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC39A1 35
  • 89.71 (n)
  • 94.44 (a)
SLC39A1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A1 35
  • 89.92 (n)
  • 95.68 (a)
SLC39A1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a1 35
  • 86.93 (n)
  • 93.83 (a)
Slc39a1 16
Slc39a1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC39A1 35
  • 99.59 (n)
  • 99.69 (a)
SLC39A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc39a1 35
  • 86.83 (n)
  • 94.14 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC39A1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC39A1 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a1 35
  • 61.44 (n)
  • 52.94 (a)
Str.7666 35
zebrafish
(Danio rerio)
Actinopterygii slc39a3 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9430 36
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F31C3.4 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
Species with no ortholog for SLC39A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A1 Gene

ENSEMBL:
Gene Tree for SLC39A1 (if available)
TreeFam:
Gene Tree for SLC39A1 (if available)

Paralogs for SLC39A1 Gene

Paralogs for SLC39A1 Gene

(2) SIMAP similar genes for SLC39A1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SLC39A1 Gene

genes like me logo Genes that share paralogs with SLC39A1: view

Variants for SLC39A1 Gene

Sequence variations from dbSNP and Humsavar for SLC39A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2280966 -- 153,960,799(-) GCATC(G/T)CACTC intron-variant
rs3791186 -- 153,961,827(-) TTGCT(A/G)ACCTT intron-variant
rs3791187 -- 153,961,727(-) TGGAT(A/G)GTGGG intron-variant
rs7526227 -- 153,965,037(+) TATAG(G/T)TGTCA intron-variant, upstream-variant-2KB
rs12027783 -- 153,965,388(+) cacct(C/T)tgcac intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC39A1 Gene

Variant ID Type Subtype PubMed ID
nsv872450 CNV Loss 21882294

Variation tolerance for SLC39A1 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A1 Gene

HapMap Linkage Disequilibrium report
SLC39A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A1 Gene

Disorders for SLC39A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC39A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC39A1

Genetic Association Database (GAD)
SLC39A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A1
genes like me logo Genes that share disorders with SLC39A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC39A1 Gene

Publications for SLC39A1 Gene

  1. Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. (PMID: 10610721) Lioumi M. … Ragoussis J. (Genomics 1999) 2 3 4 23 67
  2. A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein. (PMID: 17635580) Huang L. … Kirschke C.P. (FEBS J. 2007) 3 23
  3. Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells. (PMID: 16203195) Tang Z. … Gupta A. (Bone 2006) 3 23
  4. hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. (PMID: 16153295) Franklin R.B. … Costello L.C. (Mol. Cancer 2005) 3 23
  5. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. (PMID: 14525987) Dufner-Beattie J. … Andrews G.K. (J. Biol. Chem. 2003) 3 23

Products for SLC39A1 Gene

Sources for SLC39A1 Gene

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