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Aliases for GLA Gene

Aliases for GLA Gene

  • Galactosidase, Alpha 2 3
  • Alpha-D-Galactosidase A 3 4
  • EC 4 63
  • Melibiase 3 4
  • Alpha-D-Galactoside Galactohydrolase 1 3
  • Alpha-D-Galactoside Galactohydrolase 4
  • Alpha-Galactosidase A 3
  • Agalsidase Alfa 3
  • Alpha-Gal A 3
  • Agalsidase 4
  • EC 3.2.1 63
  • GALA 3

External Ids for GLA Gene

Previous GeneCards Identifiers for GLA Gene

  • GC0XM095944
  • GC0XM097623
  • GC0XM098688
  • GC0XM099424
  • GC0XM100458
  • GC0XM100539
  • GC0XM100652
  • GC0XM090459

Summaries for GLA Gene

Entrez Gene Summary for GLA Gene

  • This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLA Gene

GLA (Galactosidase, Alpha) is a Protein Coding gene. Diseases associated with GLA include fabry disease and priapism. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include protein homodimerization activity and hydrolase activity. An important paralog of this gene is NAGA.

Gene Wiki entry for GLA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLA Gene

Genomics for GLA Gene

Regulatory Elements for GLA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GLA Gene

101,397,791 bp from pter
101,408,013 bp from pter
10,223 bases
Minus strand

Genomic View for GLA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLA Gene

Proteins for GLA Gene

  • Protein details for GLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-galactosidase A
    Protein Accession:
    Secondary Accessions:
    • Q6LER7

    Protein attributes for GLA Gene

    429 amino acids
    Molecular mass:
    48767 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GLA Gene

neXtProt entry for GLA Gene

Proteomics data for GLA Gene at MOPED

Selected DME Specific Peptides for GLA Gene

Post-translational modifications for GLA Gene

  • Ubiquitination at Lys240, Lys326, and Lys393
  • Glycosylation at Asn139, Asn192, and Asn215
  • Modification sites at PhosphoSitePlus

Other Protein References for GLA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for GLA (alpha-Galactosidase A/GLA)

Domains for GLA Gene

Suggested Antigen Peptide Sequences for GLA Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 27 family.
  • Belongs to the glycosyl hydrolase 27 family.
genes like me logo Genes that share domains with GLA: view

No data available for Gene Families for GLA Gene

Function for GLA Gene

Molecular function for GLA Gene

GENATLAS Biochemistry:
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids

Enzyme Numbers (IUBMB) for GLA Gene

Gene Ontology (GO) - Molecular Function for GLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IDA 39940
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004557 alpha-galactosidase activity TAS --
GO:0005102 receptor binding IDA 1332979
GO:0005515 protein binding IPI 1332979
genes like me logo Genes that share ontologies with GLA: view
genes like me logo Genes that share phenotypes with GLA: view

Animal Models for GLA Gene

MGI Knock Outs for GLA:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLA TF1483 Gla

miRNA for GLA Gene

miRTarBase miRNAs that target GLA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLA

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for GLA Gene

Localization for GLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLA Gene


Subcellular locations from

Jensen Localization Image for GLA Gene COMPARTMENTS Subcellular localization image for GLA gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
golgi apparatus 4
endosome 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IMP 1332979
GO:0005737 cytoplasm IMP 1332979
GO:0005764 lysosome TAS 3029062
GO:0005794 Golgi apparatus IMP 1332979
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with GLA: view

Pathways for GLA Gene

genes like me logo Genes that share pathways with GLA: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nitric Oxide Signaling Pathway in human,mouse,rat

Interacting Proteins for GLA Gene

Gene Ontology (GO) - Biological Process for GLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006665 sphingolipid metabolic process TAS --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0009311 oligosaccharide metabolic process IDA 39940
GO:0016139 glycoside catabolic process IBA --
genes like me logo Genes that share ontologies with GLA: view

Compounds for GLA Gene

(1) Drugbank Compounds for GLA Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Target investigational


Pharmaceutical: Available under the names Replagal (from Shire) and Fabrazyme (from Genzyme). Used as a long-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease. The differences between Replagal (also known as agalsidase alpha) and Fabrazyme (also known as agalsidase beta) lies in the glycosylation patterns. Agalsidase beta is produced in the hamster CHO cell line while agalsidase alpha is produced in human cell lines

(50) HMDB Compounds for GLA Gene

Compound Synonyms Cas Number PubMed IDs
  • 1,2 Di-(9Z,12Z,15Z-octadecatrienoyl)-3-(Gala1-6Galb1)-sn-glycerol
Not Available
  • Digalactosyl diacyl glycerol
Not Available
  • (+)-Galactose
  • (+)-Glucose
  • DL-mannose

(58) Novoseek inferred chemical compound relationships for GLA Gene

Compound -log(P) Hits PubMed IDs
ceramidetrihexoside 88.4 2
fabrazyme 87.7 1
glycosphingolipid 83.2 14
melibiose 81.3 8
p-nitrophenyl alpha-d-galactopyranoside 78.6 2
genes like me logo Genes that share compounds with GLA: view

Transcripts for GLA Gene

Unigene Clusters for GLA Gene

Galactosidase, alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - - - -
SP5: - - - -

Relevant External Links for GLA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLA Gene

mRNA expression in normal human tissues for GLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLA Gene

This gene is overexpressed in Whole Blood (6.1).

Protein differential expression in normal tissues for GLA Gene

This gene is overexpressed in Urine (10.9), Seminal vesicle (10.4), Fetal gut (7.6), and Adrenal (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GLA Gene

SOURCE GeneReport for Unigene cluster for GLA Gene Hs.69089

genes like me logo Genes that share expressions with GLA: view

Expression partners for GLA Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GLA Gene

Orthologs for GLA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GLA 35
  • 87.01 (n)
  • 80.87 (a)
GLA 36
  • 76 (a)
(Canis familiaris)
Mammalia GLA 35
  • 88.32 (n)
  • 85.28 (a)
GLA 36
  • 83 (a)
(Mus musculus)
Mammalia Gla 35
  • 82.3 (n)
  • 78.23 (a)
Gla 16
Gla 36
  • 78 (a)
(Pan troglodytes)
Mammalia GLA 35
  • 99.53 (n)
  • 98.6 (a)
GLA 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Gla 35
  • 83.33 (n)
  • 79.19 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
-- 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia GLA 36
  • 74 (a)
(Gallus gallus)
Aves GLA 35
  • 68.31 (n)
  • 69.63 (a)
GLA 36
  • 69 (a)
(Anolis carolinensis)
Reptilia GLA 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gla 35
  • 65.22 (n)
  • 66.75 (a)
(Danio rerio)
Actinopterygii gla 35
  • 64.02 (n)
  • 64.76 (a)
gla 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5731 37
  • 47 (a)
CG7997 37
  • 46 (a)
CG7997 35
  • 54.3 (n)
  • 48.12 (a)
CG5731 36
  • 46 (a)
CG7997 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005846 35
  • 52.06 (n)
  • 47.94 (a)
(Caenorhabditis elegans)
Secernentea R07B7.11 37
  • 43 (a)
gana-1 36
  • 39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AGAL2 35
  • 50.99 (n)
  • 46.71 (a)
(Glycine max)
eudicotyledons Gma.5910 35
(Oryza sativa)
Liliopsida Os.17491 35
Os10g0493600 35
  • 50.11 (n)
  • 45.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mel1 35
  • 49.79 (n)
  • 42.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for GLA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLA Gene

Gene Tree for GLA (if available)
Gene Tree for GLA (if available)

Paralogs for GLA Gene

Paralogs for GLA Gene

(1) SIMAP similar genes for GLA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GLA: view

Variants for GLA Gene

Sequence variations from dbSNP and Humsavar for GLA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_000431 Fabry disease (FD)
VAR_000432 Fabry disease (FD)
VAR_000433 Fabry disease (FD)
VAR_000434 Fabry disease (FD)
VAR_000435 Fabry disease (FD)

Relevant External Links for GLA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GLA Gene

Disorders for GLA Gene

(1) OMIM Diseases for GLA Gene (300644)


  • Fabry disease (FD) [MIM:301500]: Rare X-linked sphingolipidosis disease where glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaosylceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Clinical recognition in males results from characteristic skin lesions (angiokeratomas) over the lower trunk. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease. Heterozygous females may exhibit the disorder in an attenuated form, they are more likely to show corneal opacities. {ECO:0000269 PubMed:10090526, ECO:0000269 PubMed:10208848, ECO:0000269 PubMed:10666480, ECO:0000269 PubMed:10916280, ECO:0000269 PubMed:11076046, ECO:0000269 PubMed:11295840, ECO:0000269 PubMed:11668641, ECO:0000269 PubMed:11889412, ECO:0000269 PubMed:12694230, ECO:0000269 PubMed:1315715, ECO:0000269 PubMed:15162124, ECO:0000269 PubMed:15712228, ECO:0000269 PubMed:16533976, ECO:0000269 PubMed:1846223, ECO:0000269 PubMed:19621417, ECO:0000269 PubMed:2152885, ECO:0000269 PubMed:2171331, ECO:0000269 PubMed:2539398, ECO:0000269 PubMed:7504405, ECO:0000269 PubMed:7531540, ECO:0000269 PubMed:7575533, ECO:0000269 PubMed:7596372, ECO:0000269 PubMed:7599642, ECO:0000269 PubMed:7759078, ECO:0000269 PubMed:8069316, ECO:0000269 PubMed:8395937, ECO:0000269 PubMed:8738659, ECO:0000269 PubMed:8807334, ECO:0000269 PubMed:8834244, ECO:0000269 PubMed:8863162, ECO:0000269 PubMed:8875188, ECO:0000269 PubMed:8931708, ECO:0000269 PubMed:9100224, ECO:0000269 PubMed:9105656, ECO:0000269 PubMed:9452068, ECO:0000269 PubMed:9452090, ECO:0000269 PubMed:9452111, ECO:0000269 PubMed:9554750}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(6) University of Copenhagen DISEASES for GLA Gene

(27) Novoseek inferred disease relationships for GLA Gene

Disease -log(P) Hits PubMed IDs
fabry disease 97 122
lysosomal storage diseases 77.8 7
gangliosidosis gm1 50.7 1
proteinuria 49.8 1
anhidrosis 47 1

Genatlas disease for GLA Gene

diffuse angiokeratoderma,Fabry disease,typical and atypical

Relevant External Links for GLA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GLA: view

Publications for GLA Gene

  1. Newborn screening for Fabry disease in Taiwan reveals a high incidence of the later-onset GLA mutation c.936+919G>A (IVS4+919G>A). (PMID: 19621417) Hwu W.L. … Hsu L.W. (Hum. Mutat. 2009) 3 4 23 48
  2. Mutations of the GLA gene in young patients with stroke: the PORTYSTROKE study--screening genetic conditions in Portuguese young stroke patients. (PMID: 20110537) Baptista M.V. … Ferro J.M. (Stroke 2010) 3 23 48
  3. Detection of alpha-galactosidase a mutations causing Fabry disease by denaturing high performance liquid chromatography. (PMID: 15712228) Shabbeer J. … Desnick R.J. (Hum. Mutat. 2005) 3 4 23
  4. Thirty-four novel mutations of the GLA gene in 121 patients with Fabry disease. (PMID: 15776423) SchAofer E. … Gal A. (Hum. Mutat. 2005) 3 23 48
  5. Two-tier approach for the detection of alpha-galactosidase A deficiency in a predominantly female haemodialysis population. (PMID: 17804462) Terryn W. … De Schoenmakere G. (Nephrol. Dial. Transplant. 2008) 3 23 48

Products for GLA Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nitric Oxide Signaling Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GLA
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GLA
    • Block miRNA regulation of GLA using miScript Target Protectors

    Sources for GLA Gene

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