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Aliases for SALL3 Gene

Aliases for SALL3 Gene

  • Spalt-Like Transcription Factor 3 2 3
  • Zinc Finger Protein 796 3 4
  • ZNF796 3 4
  • HSALL3 3 4
  • C2H2 Zinc Finger Protein SALL3 3
  • Spalt-Like Zinc Finger Protein 3
  • Zinc Finger Protein SALL3 4
  • Sal (Drosophila)-Like 3 2
  • Sal-Like 3 (Drosophila) 2
  • Sal-Like Protein 3 3

External Ids for SALL3 Gene

Summaries for SALL3 Gene

Entrez Gene Summary for SALL3 Gene

  • This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

GeneCards Summary for SALL3 Gene

SALL3 (Spalt-Like Transcription Factor 3) is a Protein Coding gene. An important paralog of this gene is SALL4.

UniProtKB/Swiss-Prot for SALL3 Gene

  • Probable transcription factor

Gene Wiki entry for SALL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SALL3 Gene

Genomics for SALL3 Gene

Genomic Location for SALL3 Gene

Start:
78,980,275 bp from pter
End:
79,002,677 bp from pter
Size:
22,403 bases
Orientation:
Plus strand

Genomic View for SALL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SALL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SALL3 Gene

Regulatory Elements for SALL3 Gene

Proteins for SALL3 Gene

  • Protein details for SALL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXA9-SALL3_HUMAN
    Recommended name:
    Sal-like protein 3
    Protein Accession:
    Q9BXA9
    Secondary Accessions:
    • Q9UGH1

    Protein attributes for SALL3 Gene

    Size:
    1300 amino acids
    Molecular mass:
    135346 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SALL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SALL3 Gene

Proteomics data for SALL3 Gene at MOPED

Post-translational modifications for SALL3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys1198

Other Protein References for SALL3 Gene

No data available for DME Specific Peptides for SALL3 Gene

Domains for SALL3 Gene

Gene Families for SALL3 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for SALL3 Gene

UniProtKB/Swiss-Prot:

SALL3_HUMAN
Family:
  • Belongs to the sal C2H2-type zinc-finger protein family.:
    • Q9BXA9
Similarity:
  • Contains 9 C2H2-type zinc fingers.:
    • Q9BXA9
genes like me logo Genes that share domains with SALL3: view

Function for SALL3 Gene

Molecular function for SALL3 Gene

GENATLAS Biochemistry: spalt (sal)-like,Drosophila SAL like gene 3,expressed in fetal brain and in several adult tissues,haploinsufficency in the 18q deletion syndrome and may be contributing to the phenotype
UniProtKB/Swiss-Prot Function: Probable transcription factor

Gene Ontology (GO) - Molecular Function for SALL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SALL3: view
genes like me logo Genes that share phenotypes with SALL3: view

Animal Models for SALL3 Gene

MGI Knock Outs for SALL3:

miRNA for SALL3 Gene

miRTarBase miRNAs that target SALL3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SALL3 Gene

Localization for SALL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SALL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SALL3 Gene COMPARTMENTS Subcellular localization image for SALL3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SALL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SALL3: view

Pathways for SALL3 Gene

SuperPathways for SALL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SALL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0021891 olfactory bulb interneuron development IEA --
GO:0035136 forelimb morphogenesis IEA --
GO:0035137 hindlimb morphogenesis IEA --
genes like me logo Genes that share ontologies with SALL3: view

No data available for Pathways by source for SALL3 Gene

Transcripts for SALL3 Gene

mRNA/cDNA for SALL3 Gene

Unigene Clusters for SALL3 Gene

Sal-like 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SALL3 Gene

No ASD Table

Relevant External Links for SALL3 Gene

GeneLoc Exon Structure for
SALL3
ECgene alternative splicing isoforms for
SALL3

Expression for SALL3 Gene

mRNA expression in normal human tissues for SALL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SALL3 Gene

This gene is overexpressed in Vagina (6.1), Brain - Spinal cord (cervical c-1) (5.5), Brain - Caudate (basal ganglia) (4.4), Brain - Amygdala (4.2), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SALL3 Gene

SOURCE GeneReport for Unigene cluster for SALL3 Gene Hs.700557

mRNA Expression by UniProt/SwissProt for SALL3 Gene

Q9BXA9-SALL3_HUMAN
Tissue specificity: Widely expressed in adult with highest levels in heart. Expressed in fetal brain (in neurons of hippocampus, cortex, mediodorsal and ventrolateral thalamic nuclei, putamen, cerebellum and brainstem)
genes like me logo Genes that share expressions with SALL3: view

Orthologs for SALL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SALL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SALL3 36
  • 98.4 (n)
  • 98.61 (a)
SALL3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SALL3 36
  • 83.16 (n)
  • 83.55 (a)
dog
(Canis familiaris)
Mammalia SALL3 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sall3 36
  • 79 (n)
  • 81.86 (a)
Sall3 16
Sall3 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SALL3 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SALL3 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sall3 36
  • 80.99 (n)
  • 85.5 (a)
chicken
(Gallus gallus)
Aves SALL3 36
  • 71.51 (n)
  • 77.61 (a)
SALL3 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SALL3 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sal1-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sall3 36
  • 65.82 (n)
  • 73.52 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560775 36
  • 65.3 (n)
  • 69.01 (a)
sall3a 37
  • 56 (a)
OneToMany
sall3b 37
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta salm 37
  • 26 (a)
ManyToMany
salr 37
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea sem-4 37
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FZF1 37
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
Species with no ortholog for SALL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SALL3 Gene

ENSEMBL:
Gene Tree for SALL3 (if available)
TreeFam:
Gene Tree for SALL3 (if available)

Paralogs for SALL3 Gene

Paralogs for SALL3 Gene

Pseudogenes.org Pseudogenes for SALL3 Gene

genes like me logo Genes that share paralogs with SALL3: view

Variants for SALL3 Gene

Sequence variations from dbSNP and Humsavar for SALL3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs473557 -- 78,984,817(-) AACGC(C/T)TCCCT intron-variant
rs485446 -- 78,986,681(-) TGGAT(C/T)TTCAG intron-variant
rs493105 -- 78,987,910(-) TTTGC(A/G)CACTA intron-variant
rs496809 -- 78,996,673(-) AATGA(A/G)TGCGG intron-variant
rs497785 -- 78,987,412(-) AAAGA(C/T)GATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SALL3 Gene

Variant ID Type Subtype PubMed ID
esv2717497 CNV Deletion 23290073
dgv3478n71 CNV Loss 21882294
dgv3479n71 CNV Loss 21882294
nsv458313 CNV Loss 19166990
dgv564n67 CNV Gain 20364138
nsv828333 CNV Loss 20364138
dgv3480n71 CNV Loss 21882294
nsv828338 CNV Gain 20364138
dgv565n67 CNV Gain 20364138
nsv828342 CNV Gain 20364138
esv2666555 CNV Deletion 23128226
esv29012 CNV Loss 19812545
nsv2377 CNV Insertion 18451855

Relevant External Links for SALL3 Gene

HapMap Linkage Disequilibrium report
SALL3

Disorders for SALL3 Gene

Relevant External Links for SALL3

Genetic Association Database (GAD)
SALL3
Human Genome Epidemiology (HuGE) Navigator
SALL3
genes like me logo Genes that share disorders with SALL3: view

No data available for UniProtKB/Swiss-Prot for SALL3 Gene

Publications for SALL3 Gene

  1. SALL3, a new member of the human spalt-like gene family, maps to 18q23. (PMID: 10610715) Kohlhase J. … Engel W. (Genomics 1999) 2 3 4
  2. Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. (PMID: 18668548) JuliA A. … Marsal S. (Arthritis Rheum. 2008) 3 49
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 49
  4. Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. (PMID: 21532573) Engelen E. … Poot R.A. (Nat. Genet. 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for SALL3 Gene

Sources for SALL3 Gene

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