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Aliases for CIDEB Gene

Aliases for CIDEB Gene

  • Cell Death-Inducing DFFA-Like Effector B 2 3 4

External Ids for CIDEB Gene

Previous GeneCards Identifiers for CIDEB Gene

  • GC14M022146
  • GC14M018561
  • GC14M022764
  • GC14M023844
  • GC14M024774
  • GC14M004889

Summaries for CIDEB Gene

GeneCards Summary for CIDEB Gene

CIDEB (Cell Death-Inducing DFFA-Like Effector B) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is CIDEC.

UniProtKB/Swiss-Prot for CIDEB Gene

  • Activates apoptosis

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIDEB Gene

Genomics for CIDEB Gene

Regulatory Elements for CIDEB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CIDEB Gene

Chromosome:
14
Start:
24,305,096 bp from pter
End:
24,311,430 bp from pter
Size:
6,335 bases
Orientation:
Minus strand

Genomic View for CIDEB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CIDEB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIDEB Gene

Proteins for CIDEB Gene

  • Protein details for CIDEB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHD4-CIDEB_HUMAN
    Recommended name:
    Cell death activator CIDE-B
    Protein Accession:
    Q9UHD4
    Secondary Accessions:
    • D3DS73
    • Q546V8
    • Q9NNW9

    Protein attributes for CIDEB Gene

    Size:
    219 amino acids
    Molecular mass:
    24678 Da
    Quaternary structure:
    • Inhibited by DFFB. Interacts with DFFA and DFFB.

    Three dimensional structures from OCA and Proteopedia for CIDEB Gene

neXtProt entry for CIDEB Gene

Proteomics data for CIDEB Gene at MOPED

Post-translational modifications for CIDEB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIDEB Gene

Antibody Products

No data available for DME Specific Peptides for CIDEB Gene

Domains & Families for CIDEB Gene

Protein Domains for CIDEB Gene

Suggested Antigen Peptide Sequences for CIDEB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHD4

UniProtKB/Swiss-Prot:

CIDEB_HUMAN :
  • Contains 1 CIDE-N domain.
Domain:
  • Contains 1 CIDE-N domain.
genes like me logo Genes that share domains with CIDEB: view

No data available for Gene Families for CIDEB Gene

Function for CIDEB Gene

Molecular function for CIDEB Gene

GENATLAS Biochemistry:
cell death-inducing DFFA-like effector B,interacting with the DFFA/DFFB complex and putatively involved in apoptotic DNA fragmentation
UniProtKB/Swiss-Prot Function:
Activates apoptosis

Gene Ontology (GO) - Molecular Function for CIDEB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12595532
GO:0042802 identical protein binding IPI 12595532
genes like me logo Genes that share ontologies with CIDEB: view
genes like me logo Genes that share phenotypes with CIDEB: view

Animal Models for CIDEB Gene

MGI Knock Outs for CIDEB:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIDEB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CIDEB Gene

Localization for CIDEB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CIDEB Gene COMPARTMENTS Subcellular localization image for CIDEB gene
Compartment Confidence
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CIDEB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005811 lipid particle IBA --
GO:0005829 cytosol IDA 12429024
GO:0048471 perinuclear region of cytoplasm IDA 12595532
genes like me logo Genes that share ontologies with CIDEB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CIDEB Gene

Pathways & Interactions for CIDEB Gene

SuperPathways for CIDEB Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for CIDEB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 12429024
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage TAS 10619428
GO:0010942 positive regulation of cell death IDA 12595532
GO:0090200 positive regulation of release of cytochrome c from mitochondria IDA 12595532
GO:0097194 execution phase of apoptosis ISS 9564035
genes like me logo Genes that share ontologies with CIDEB: view

No data available for Pathways by source and SIGNOR curated interactions for CIDEB Gene

Drugs & Compounds for CIDEB Gene

No Compound Related Data Available

Transcripts for CIDEB Gene

Unigene Clusters for CIDEB Gene

Cell death-inducing DFFA-like effector b:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CIDEB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIDEB Gene

No ASD Table

Relevant External Links for CIDEB Gene

GeneLoc Exon Structure for
CIDEB
ECgene alternative splicing isoforms for
CIDEB

Expression for CIDEB Gene

mRNA expression in normal human tissues for CIDEB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CIDEB Gene

This gene is overexpressed in CD4 Tcells (30.9), Liver (26.3), and Gallbladder (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CIDEB Gene



SOURCE GeneReport for Unigene cluster for CIDEB Gene Hs.708040

mRNA Expression by UniProt/SwissProt for CIDEB Gene

Q9UHD4-CIDEB_HUMAN
Tissue specificity: Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.
genes like me logo Genes that share expression patterns with CIDEB: view

Protein tissue co-expression partners for CIDEB Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CIDEB Gene

Orthologs for CIDEB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIDEB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CIDEB 35
  • 85.08 (n)
  • 82.19 (a)
CIDEB 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cideb 35
  • 83.33 (n)
  • 86.11 (a)
Cideb 16
Cideb 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CIDEB 35
  • 99.54 (n)
  • 99.09 (a)
CIDEB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cideb 35
  • 83.58 (n)
  • 85.57 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
OneToMany
CIDEB 36
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CIDEB 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CIDEB 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cideb 35
  • 61.75 (n)
  • 58.06 (a)
zebrafish
(Danio rerio)
Actinopterygii cideb 35
  • 55.95 (n)
  • 49.49 (a)
cideb 36
  • 39 (a)
OneToOne
Species with no ortholog for CIDEB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CIDEB Gene

ENSEMBL:
Gene Tree for CIDEB (if available)
TreeFam:
Gene Tree for CIDEB (if available)

Paralogs for CIDEB Gene

Paralogs for CIDEB Gene

(2) SIMAP similar genes for CIDEB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CIDEB: view

Variants for CIDEB Gene

Structural Variations from Database of Genomic Variants (DGV) for CIDEB Gene

Variant ID Type Subtype PubMed ID
esv2669637 CNV Deletion 23128226
dgv1855n71 CNV Loss 21882294

Variation tolerance for CIDEB Gene

Residual Variation Intolerance Score: 75.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CIDEB Gene

HapMap Linkage Disequilibrium report
CIDEB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CIDEB Gene

Disorders for CIDEB Gene

Relevant External Links for CIDEB

Genetic Association Database (GAD)
CIDEB
Human Genome Epidemiology (HuGE) Navigator
CIDEB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CIDEB
genes like me logo Genes that share disorders with CIDEB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIDEB Gene

Publications for CIDEB Gene

  1. Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss. (PMID: 19661960) Hall A.M. … Finck B.N. (Obesity (Silver Spring) 2010) 23 67
  2. Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis. (PMID: 10837461) Chen Z. … Li P. (J. Biol. Chem. 2000) 2 67
  3. Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. (PMID: 10619428) Lugovskoy A.A. … Wagner G. (Cell 1999) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Investigating the antiviral role of cell death-inducing DFF45-like effector B in HCV replication. (PMID: 24980280) Singaravelu R. … Pezacki J.P. (FEBS J. 2014) 67

Products for CIDEB Gene

Sources for CIDEB Gene

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