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Aliases for ATP5S Gene

Aliases for ATP5S Gene

  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit S (Factor B) 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit S (Factor B) 2 3
  • Mitochondrial ATP Synthase Regulatory Component Factor B 3 4
  • ATP Synthase-Coupling Factor B 3 4
  • ATPW 3 4
  • FB 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit S (Factor B) 2
  • ATP Synthase Coupling Factor B, Mitochondrial 3
  • ATP Synthase Coupling Factor B-Like 1 3
  • ATP Synthase Subunit S, Mitochondrial 3
  • HSU79253 3

External Ids for ATP5S Gene

Previous GeneCards Identifiers for ATP5S Gene

  • GC14P044575
  • GC14P048769
  • GC14P049848
  • GC14P050782
  • GC14P030904

Summaries for ATP5S Gene

Entrez Gene Summary for ATP5S Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5S Gene

ATP5S (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit S (Factor B)) is a Protein Coding gene. Among its related pathways are Metabolism and purine nucleotides de novo biosynthesis. GO annotations related to this gene include hydrogen ion transmembrane transporter activity. An important paralog of this gene is ATP5SL.

UniProtKB/Swiss-Prot for ATP5S Gene

  • Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity).

Gene Wiki entry for ATP5S Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5S Gene

Genomics for ATP5S Gene

Regulatory Elements for ATP5S Gene

Enhancers for ATP5S Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F050311 0.6 ENCODE 33.9 +0.0 4 2.4 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 ZNF263 ATP5S VCPKMT SOS2 L2HGDH
GH14F050319 0.4 ENCODE 33.6 +8.5 8464 3.5 PKNOX1 ATF1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 FOS SP3 ATP5S CDKL1 PIR33272 L2HGDH
GH14F050332 1 Ensembl ENCODE 31.2 +20.8 20766 1.0 ZNF687 RFX1 STAT1 CEBPB DPF2 EP300 ZNF592 CTBP1 GATA3 FOS ATP5S ATL1 MAP4K5 GC14P050330 GC14M050341 GC14M050342
GH14F050334 1 Ensembl ENCODE 29.5 +23.4 23404 2.5 CTCF PKNOX1 TAL1 TEAD4 MAX FEZF1 ZIC2 RAD21 ZNF7 ZNF121 ATP5S CDKL1 ATL1 MAP4K5 SOS2 GC14M050341 GC14M050342 GC14P050330
GH14F050339 0.2 ENCODE 27.6 +28.0 28023 0.8 ATP5S CDKL1 ATL1 MAP4K5 NIN GC14M050341 GC14M050342 GC14P050330
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ATP5S on UCSC Golden Path with GeneCards custom track

Promoters for ATP5S Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001457022 -425 2600 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 ZNF263

Genomic Location for ATP5S Gene

Chromosome:
14
Start:
50,312,326 bp from pter
End:
50,335,558 bp from pter
Size:
23,233 bases
Orientation:
Plus strand

Genomic View for ATP5S Gene

Genes around ATP5S on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5S Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5S Gene

Proteins for ATP5S Gene

  • Protein details for ATP5S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99766-ATP5S_HUMAN
    Recommended name:
    ATP synthase subunit s, mitochondrial
    Protein Accession:
    Q99766
    Secondary Accessions:
    • A8K1U3
    • D9N156
    • Q8WWX3
    • Q96F77

    Protein attributes for ATP5S Gene

    Size:
    215 amino acids
    Molecular mass:
    24866 Da
    Quaternary structure:
    • Homotetramer. Associates with ATP synthase (By similarity).

    Alternative splice isoforms for ATP5S Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP5S Gene

Post-translational modifications for ATP5S Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATP5S Gene

Domains & Families for ATP5S Gene

Protein Domains for ATP5S Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP5S Gene

Graphical View of Domain Structure for InterPro Entry

Q99766

UniProtKB/Swiss-Prot:

ATP5S_HUMAN :
  • Belongs to the ATP synthase subunit s family.
  • Contains 4 LRR (leucine-rich) repeats.
Family:
  • Belongs to the ATP synthase subunit s family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ATP5S: view

No data available for Gene Families for ATP5S Gene

Function for ATP5S Gene

Molecular function for ATP5S Gene

UniProtKB/Swiss-Prot Function:
Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity).

Gene Ontology (GO) - Molecular Function for ATP5S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 hydrogen ion transmembrane transporter activity NAS 6143319
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ATP5S: view
genes like me logo Genes that share phenotypes with ATP5S: view

Animal Models for ATP5S Gene

MGI Knock Outs for ATP5S:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5S Gene

Localization for ATP5S Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5S Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5S Gene COMPARTMENTS Subcellular localization image for ATP5S gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ATP5S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) IEA --
genes like me logo Genes that share ontologies with ATP5S: view

Pathways & Interactions for ATP5S Gene

genes like me logo Genes that share pathways with ATP5S: view

Gene Ontology (GO) - Biological Process for ATP5S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015992 proton transport NAS 6143319
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
genes like me logo Genes that share ontologies with ATP5S: view

No data available for SIGNOR curated interactions for ATP5S Gene

Transcripts for ATP5S Gene

Unigene Clusters for ATP5S Gene

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5S Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - - -
SP10: - -
SP11: - - - -
SP12: - -

Relevant External Links for ATP5S Gene

GeneLoc Exon Structure for
ATP5S
ECgene alternative splicing isoforms for
ATP5S

Expression for ATP5S Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATP5S Gene

Protein differential expression in normal tissues from HIPED for ATP5S Gene

This gene is overexpressed in Monocytes (14.2) and Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP5S Gene



Protein tissue co-expression partners for ATP5S Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP5S Gene:

ATP5S

SOURCE GeneReport for Unigene cluster for ATP5S Gene:

Hs.438489
genes like me logo Genes that share expression patterns with ATP5S: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP5S Gene

Orthologs for ATP5S Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP5S Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5S 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia ATP5S 34 35
  • 91.04 (n)
cow
(Bos Taurus)
Mammalia ATP5S 34 35
  • 89.83 (n)
mouse
(Mus musculus)
Mammalia Atp5s 34 16 35
  • 84.67 (n)
rat
(Rattus norvegicus)
Mammalia Atp5s 34
  • 83.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ATP5S 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5S 34 35
  • 68.35 (n)
lizard
(Anolis carolinensis)
Reptilia ATP5S 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5s 34
  • 66.5 (n)
zebrafish
(Danio rerio)
Actinopterygii atp5s 34 35
  • 62.12 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004478 34
  • 49.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10731 34 35
  • 46.78 (n)
worm
(Caenorhabditis elegans)
Secernentea C05C8.1 35
  • 25 (a)
OneToOne
Species where no ortholog for ATP5S was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5S Gene

ENSEMBL:
Gene Tree for ATP5S (if available)
TreeFam:
Gene Tree for ATP5S (if available)

Paralogs for ATP5S Gene

Paralogs for ATP5S Gene

genes like me logo Genes that share paralogs with ATP5S: view

Variants for ATP5S Gene

Sequence variations from dbSNP and Humsavar for ATP5S Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2275591 Likely benign 50,312,098(+) CGAAA(A/C)GCCCG intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs35710558 Likely benign 50,312,052(-) GGGAG(G/T)CCAAG intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs113626637 Uncertain significance 50,312,145(+) GCTGG(A/C)ACCAT intron-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs10133342 -- 50,326,666(+) CTGAA(A/T)ACAAA downstream-variant-500B, utr-variant-3-prime
rs10137270 -- 50,324,344(+) TCTAC(A/G)TTAAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATP5S Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV gain+loss 19812545
nsv1052059 CNV loss 25217958
nsv564835 CNV gain 21841781
nsv832793 CNV loss 17160897

Variation tolerance for ATP5S Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5S Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5S

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5S Gene

Disorders for ATP5S Gene

Relevant External Links for ATP5S

Genetic Association Database (GAD)
ATP5S
Human Genome Epidemiology (HuGE) Navigator
ATP5S
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5S

No disorders were found for ATP5S Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5S Gene

Publications for ATP5S Gene

  1. Factor B and the mitochondrial ATP synthase complex. (PMID: 11744738) Belogrudov G.I. … Hatefi Y. (J. Biol. Chem. 2002) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4 64
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64
  5. MiR-34a is Involved in the Decrease of ATP Contents Induced by Resistin Through Target on ATP5S in HepG2 Cells. (PMID: 26385595) Wen F. … Zhang H. (Biochem. Genet. 2015) 3 64

Products for ATP5S Gene

Sources for ATP5S Gene

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