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Aliases for ZBTB11 Gene

Aliases for ZBTB11 Gene

  • Zinc Finger And BTB Domain Containing 11 2 3
  • ZNF-U69274 3
  • ZNF913 3

External Ids for ZBTB11 Gene

Previous GeneCards Identifiers for ZBTB11 Gene

  • GC03M102690
  • GC03M102850
  • GC03M101367
  • GC03M098737

Summaries for ZBTB11 Gene

GeneCards Summary for ZBTB11 Gene

ZBTB11 (Zinc Finger And BTB Domain Containing 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZBTB11 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZBTB11 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB11 Gene

Genomics for ZBTB11 Gene

Regulatory Elements for ZBTB11 Gene

Genomic Location for ZBTB11 Gene

Chromosome:
3
Start:
101,648,889 bp from pter
End:
101,677,495 bp from pter
Size:
28,607 bases
Orientation:
Minus strand

Genomic View for ZBTB11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB11 Gene

Proteins for ZBTB11 Gene

  • Protein details for ZBTB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95625-ZBT11_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 11
    Protein Accession:
    O95625
    Secondary Accessions:
    • Q2NKP9

    Protein attributes for ZBTB11 Gene

    Size:
    1053 amino acids
    Molecular mass:
    119384 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB11 Gene

Proteomics data for ZBTB11 Gene at MOPED

Post-translational modifications for ZBTB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB11 Gene

Domains & Families for ZBTB11 Gene

Protein Domains for ZBTB11 Gene

Suggested Antigen Peptide Sequences for ZBTB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95625

UniProtKB/Swiss-Prot:

ZBT11_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB11: view

Function for ZBTB11 Gene

Molecular function for ZBTB11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003674 molecular_function ND --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB11: view
genes like me logo Genes that share phenotypes with ZBTB11: view

Animal Model Products

miRNA for ZBTB11 Gene

miRTarBase miRNAs that target ZBTB11

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB11 Gene

Localization for ZBTB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB11 Gene COMPARTMENTS Subcellular localization image for ZBTB11 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB11: view

Pathways & Interactions for ZBTB11 Gene

SuperPathways for ZBTB11 Gene

No Data Available

Interacting Proteins for ZBTB11 Gene

Gene Ontology (GO) - Biological Process for ZBTB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZBTB11: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB11 Gene

Drugs & Compounds for ZBTB11 Gene

No Compound Related Data Available

Transcripts for ZBTB11 Gene

Unigene Clusters for ZBTB11 Gene

Zinc finger and BTB domain containing 11:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB11 Gene

No ASD Table

Relevant External Links for ZBTB11 Gene

GeneLoc Exon Structure for
ZBTB11
ECgene alternative splicing isoforms for
ZBTB11

Expression for ZBTB11 Gene

mRNA expression in normal human tissues for ZBTB11 Gene

Protein differential expression in normal tissues from HIPED for ZBTB11 Gene

This gene is overexpressed in Serum (59.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB11 Gene



SOURCE GeneReport for Unigene cluster for ZBTB11 Gene Hs.655286

genes like me logo Genes that share expression patterns with ZBTB11: view

Protein tissue co-expression partners for ZBTB11 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB11 Gene

Orthologs for ZBTB11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBTB11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB11 35
  • 91.25 (n)
  • 92.58 (a)
ZBTB11 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB11 35
  • 91.36 (n)
  • 93.07 (a)
ZBTB11 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb11 35
  • 87.08 (n)
  • 89.52 (a)
Zbtb11 16
Rpl24 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB11 35
  • 99.68 (n)
  • 99.81 (a)
ZBTB11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb11 35
  • 85.84 (n)
  • 89.54 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB11 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB11 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB11 35
  • 72.2 (n)
  • 74.6 (a)
ZBTB11 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB11 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb11 35
  • 70.2 (n)
  • 74.79 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-98p3.1 35
  • 62.45 (n)
  • 63.92 (a)
ZBTB11 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha-i1 36
  • 27 (a)
OneToOne
Species with no ortholog for ZBTB11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB11 Gene

ENSEMBL:
Gene Tree for ZBTB11 (if available)
TreeFam:
Gene Tree for ZBTB11 (if available)

Paralogs for ZBTB11 Gene

(2) SIMAP similar genes for ZBTB11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZBTB11: view

No data available for Paralogs for ZBTB11 Gene

Variants for ZBTB11 Gene

Sequence variations from dbSNP and Humsavar for ZBTB11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2288272 -- 101,659,632(+) GGAAT(C/T)ACCTT intron-variant
rs2288273 -- 101,660,083(+) TAACT(A/G)AAACT intron-variant
rs11925001 -- 101,655,122(+) CTACC(C/T)GCCTT intron-variant
rs12636557 -- 101,655,860(+) TTTCA(C/T)CGTGT intron-variant
rs13061565 -- 101,673,426(+) ACAAA(C/T)GAAAA intron-variant

Variation tolerance for ZBTB11 Gene

Residual Variation Intolerance Score: 5.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB11 Gene

HapMap Linkage Disequilibrium report
ZBTB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB11 Gene

Disorders for ZBTB11 Gene

Relevant External Links for ZBTB11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB11
genes like me logo Genes that share disorders with ZBTB11: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB11 Gene

Publications for ZBTB11 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  3. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PMID: 22586326) Tsai Y.C. … Cristea I.M. (Mol. Cell. Proteomics 2012) 67
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  5. Protein phosphatase 1I+ interacting proteins in the human brain. (PMID: 22321011) Esteves S.L. … da Cruz e Silva E.F. (OMICS 2012) 67

Products for ZBTB11 Gene

Sources for ZBTB11 Gene

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