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Aliases for TSPAN13 Gene

Aliases for TSPAN13 Gene

  • Tetraspanin 13 2 3 5
  • Transmembrane 4 Superfamily Member 13 2 3 4
  • Tetraspan NET-6 3 4
  • Tspan-13 3 4
  • TM4SF13 3 4
  • NET6 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-6 3
  • NET-6 3

External Ids for TSPAN13 Gene

Previous HGNC Symbols for TSPAN13 Gene

  • TM4SF13

Previous GeneCards Identifiers for TSPAN13 Gene

  • GC07P016567

Summaries for TSPAN13 Gene

Entrez Gene Summary for TSPAN13 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN13 Gene

TSPAN13 (Tetraspanin 13) is a Protein Coding gene. An important paralog of this gene is TSPAN31.

Gene Wiki entry for TSPAN13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN13 Gene

Genomics for TSPAN13 Gene

Regulatory Elements for TSPAN13 Gene

Enhancers for TSPAN13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN13 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN13 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN13 Gene

16,753,535 bp from pter
16,784,536 bp from pter
31,002 bases
Plus strand

Genomic View for TSPAN13 Gene

Genes around TSPAN13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN13 Gene

Proteins for TSPAN13 Gene

  • Protein details for TSPAN13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for TSPAN13 Gene

    204 amino acids
    Molecular mass:
    22147 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN13 Gene

Proteomics data for TSPAN13 Gene at MOPED

Post-translational modifications for TSPAN13 Gene

  • Glycosylation at Asn 113 and Asn 137
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPAN13 Gene

Domains & Families for TSPAN13 Gene

Gene Families for TSPAN13 Gene

Protein Domains for TSPAN13 Gene

Suggested Antigen Peptide Sequences for TSPAN13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN13: view

Function for TSPAN13 Gene

Gene Ontology (GO) - Molecular Function for TSPAN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IBA --
genes like me logo Genes that share ontologies with TSPAN13: view
genes like me logo Genes that share phenotypes with TSPAN13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN13

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN13 Gene

Localization for TSPAN13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN13 Gene COMPARTMENTS Subcellular localization image for TSPAN13 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TSPAN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane TAS 10719184
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN13: view

Pathways & Interactions for TSPAN13 Gene

SuperPathways for TSPAN13 Gene

No Data Available

Interacting Proteins for TSPAN13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000262067 for TSPAN13 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TSPAN13 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSPAN13 Gene

Drugs & Compounds for TSPAN13 Gene

No Compound Related Data Available

Transcripts for TSPAN13 Gene

mRNA/cDNA for TSPAN13 Gene

Unigene Clusters for TSPAN13 Gene

Tetraspanin 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN13 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP2: - -

Relevant External Links for TSPAN13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN13 Gene

mRNA expression in normal human tissues for TSPAN13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPAN13 Gene

This gene is overexpressed in Islet of Langerhans (25.3), Pancreas (11.4), Breast (8.4), and Oral epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN13 Gene

SOURCE GeneReport for Unigene cluster for TSPAN13 Gene Hs.364544

genes like me logo Genes that share expression patterns with TSPAN13: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPAN13 Gene

Orthologs for TSPAN13 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN13 35
  • 90.52 (n)
  • 97.06 (a)
TSPAN13 36
  • 97 (a)
(Canis familiaris)
Mammalia TSPAN13 35
  • 91.34 (n)
  • 96.57 (a)
TSPAN13 36
  • 78 (a)
(Mus musculus)
Mammalia Tspan13 35
  • 87.91 (n)
  • 95.59 (a)
Tspan13 16
Tspan13 36
  • 96 (a)
(Pan troglodytes)
Mammalia TSPAN13 35
  • 99.84 (n)
  • 100 (a)
TSPAN13 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan13 35
  • 89.22 (n)
  • 95.1 (a)
(Monodelphis domestica)
Mammalia TSPAN13 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN13 36
  • 66 (a)
(Gallus gallus)
Aves TSPAN13 35
  • 78.82 (n)
  • 88.67 (a)
TSPAN13 36
  • 89 (a)
(Anolis carolinensis)
Reptilia TSPAN13 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76122 35
tspan13 35
  • 72.31 (n)
  • 80.6 (a)
(Danio rerio)
Actinopterygii tspan13b 35
  • 68.31 (n)
  • 69.95 (a)
tspan13a 36
  • 58 (a)
tspan13b 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14088 35
fruit fly
(Drosophila melanogaster)
Insecta Tsp97E 35
  • 53.67 (n)
  • 47 (a)
Tsp97E 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10763 36
  • 40 (a)
Species with no ortholog for TSPAN13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN13 Gene

Gene Tree for TSPAN13 (if available)
Gene Tree for TSPAN13 (if available)

Paralogs for TSPAN13 Gene

Paralogs for TSPAN13 Gene

(2) SIMAP similar genes for TSPAN13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPAN13: view

Variants for TSPAN13 Gene

Sequence variations from dbSNP and Humsavar for TSPAN13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs818803 -- 16,755,489(-) AGCAT(A/G)CCTCA intron-variant
rs818804 -- 16,755,745(-) AAAAA(G/T)ATTAT intron-variant
rs818805 -- 16,755,939(-) TTTAC(C/T)GCATA intron-variant
rs818806 -- 16,756,907(+) AGGGC(G/T)TAAAA intron-variant
rs818807 -- 16,756,971(+) TTTTC(A/G)GGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN13 Gene

Variant ID Type Subtype PubMed ID
nsv824019 CNV Loss 20364138
esv2677204 CNV Deletion 23128226
nsv520554 CNV Loss 19592680

Variation tolerance for TSPAN13 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN13 Gene

Disorders for TSPAN13 Gene

Relevant External Links for TSPAN13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN13 Gene

Publications for TSPAN13 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J. … Arhel N.J. (J. Biol. Chem. 2015) 3
  3. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  4. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TSPAN13 Gene

Sources for TSPAN13 Gene