Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPAN13 Gene

Aliases for TSPAN13 Gene

  • Tetraspanin 13 2 3
  • Transmembrane 4 Superfamily Member 13 2 3 4
  • NET6 3 4 6
  • Tetraspan NET-6 3 4
  • Tspan-13 3 4
  • TM4SF13 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-6 3
  • Tetraspanin-13 3
  • NET-6 3

External Ids for TSPAN13 Gene

Previous HGNC Symbols for TSPAN13 Gene

  • TM4SF13

Previous GeneCards Identifiers for TSPAN13 Gene

  • GC07P016567

Summaries for TSPAN13 Gene

Entrez Gene Summary for TSPAN13 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN13 Gene

TSPAN13 (Tetraspanin 13) is a Protein Coding gene. An important paralog of this gene is TSPAN31.

Gene Wiki entry for TSPAN13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN13 Gene

Genomics for TSPAN13 Gene

Regulatory Elements for TSPAN13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSPAN13 Gene

16,753,535 bp from pter
16,784,536 bp from pter
31,002 bases
Plus strand

Genomic View for TSPAN13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN13 Gene

Proteins for TSPAN13 Gene

  • Protein details for TSPAN13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TSPAN13 Gene

    204 amino acids
    Molecular mass:
    22147 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN13 Gene

Proteomics data for TSPAN13 Gene at MOPED

Post-translational modifications for TSPAN13 Gene

  • Glycosylation at Asn113 and Asn137
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TSPAN13 Gene

Domains for TSPAN13 Gene

Gene Families for TSPAN13 Gene

Protein Domains for TSPAN13 Gene

Suggested Antigen Peptide Sequences for TSPAN13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN13: view

Function for TSPAN13 Gene

Phenotypes for TSPAN13 Gene

GenomeRNAi human phenotypes for TSPAN13:
genes like me logo Genes that share phenotypes with TSPAN13: view

Animal Model Products

CRISPR Products

miRNA for TSPAN13 Gene

miRTarBase miRNAs that target TSPAN13

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN13

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSPAN13 Gene

Localization for TSPAN13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN13 Gene COMPARTMENTS Subcellular localization image for TSPAN13 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TSPAN13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10719184
GO:0016020 membrane TAS 10719184
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TSPAN13: view

Pathways for TSPAN13 Gene

SuperPathways for TSPAN13 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TSPAN13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000262067 for TSPAN13 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TSPAN13 Gene


No data available for Pathways by source for TSPAN13 Gene

Transcripts for TSPAN13 Gene

mRNA/cDNA for TSPAN13 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(372) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPAN13 Gene

Tetraspanin 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN13 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP2: - -

Relevant External Links for TSPAN13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN13 Gene

mRNA expression in normal human tissues for TSPAN13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TSPAN13 Gene

This gene is overexpressed in Islet of Langerhans (25.3), Pancreas (11.4), Breast (8.4), and Oral epithelium (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN13 Gene

SOURCE GeneReport for Unigene cluster for TSPAN13 Gene Hs.364544

genes like me logo Genes that share expressions with TSPAN13: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for TSPAN13 Gene

Orthologs for TSPAN13 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN13 35
  • 90.52 (n)
  • 97.06 (a)
TSPAN13 36
  • 97 (a)
(Canis familiaris)
Mammalia TSPAN13 35
  • 91.34 (n)
  • 96.57 (a)
TSPAN13 36
  • 78 (a)
(Mus musculus)
Mammalia Tspan13 35
  • 87.91 (n)
  • 95.59 (a)
Tspan13 16
Tspan13 36
  • 96 (a)
(Pan troglodytes)
Mammalia TSPAN13 35
  • 99.84 (n)
  • 100 (a)
TSPAN13 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan13 35
  • 89.22 (n)
  • 95.1 (a)
(Monodelphis domestica)
Mammalia TSPAN13 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN13 36
  • 66 (a)
(Gallus gallus)
Aves TSPAN13 35
  • 78.82 (n)
  • 88.67 (a)
TSPAN13 36
  • 89 (a)
(Anolis carolinensis)
Reptilia TSPAN13 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76122 35
tspan13 35
  • 72.31 (n)
  • 80.6 (a)
(Danio rerio)
Actinopterygii tspan13b 35
  • 68.31 (n)
  • 69.95 (a)
tspan13a 36
  • 58 (a)
tspan13b 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14088 35
fruit fly
(Drosophila melanogaster)
Insecta Tsp97E 35
  • 53.67 (n)
  • 47 (a)
Tsp97E 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10763 36
  • 40 (a)
Species with no ortholog for TSPAN13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN13 Gene

Gene Tree for TSPAN13 (if available)
Gene Tree for TSPAN13 (if available)

Paralogs for TSPAN13 Gene

Paralogs for TSPAN13 Gene

(2) SIMAP similar genes for TSPAN13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPAN13: view

Variants for TSPAN13 Gene

Sequence variations from dbSNP and Humsavar for TSPAN13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6616 -- 16,784,353(-) GAGAA(A/C)TTTCA utr-variant-3-prime
rs7728 -- 16,784,380(-) GGTTT(A/G)ACAAG utr-variant-3-prime
rs11491 -- 16,783,470(-) GGATT(A/C/G/T)GCGCG synonymous-codon, reference
rs697528 -- 16,774,774(+) CAAGT(C/T)CATAT intron-variant
rs706054 -- 16,751,733(+) agttt(C/T)agtag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSPAN13 Gene

Variant ID Type Subtype PubMed ID
nsv824019 CNV Loss 20364138
esv2677204 CNV Deletion 23128226
nsv520554 CNV Loss 19592680

Relevant External Links for TSPAN13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN13 Gene

Disorders for TSPAN13 Gene

No disorders were found for TSPAN13 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TSPAN13 Gene

Publications for TSPAN13 Gene

  1. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. (PMID: 15958618) Huang H. … Geradts J. (Clin. Cancer Res. 2005) 3
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3

Products for TSPAN13 Gene

Sources for TSPAN13 Gene

Back to Top