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Aliases for LAT Gene

Aliases for LAT Gene

  • Linker For Activation Of T Cells 2 3 2
  • 36 KDa Phospho-Tyrosine Adapter Protein 3 4
  • P36-38 3 4
  • Pp36 3 4
  • Linker For Activation Of T Cells, Transmembrane Adaptor 3
  • Linker For Activation Of T-Cells Family Member 1 3
  • 36 KDa Phospho-Tyrosine Adaptor Protein 3
  • Transmembrane Adaptor 2
  • LAT1 3

External Ids for LAT Gene

Summaries for LAT Gene

Entrez Gene Summary for LAT Gene

  • The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAT Gene

LAT (Linker For Activation Of T Cells) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include protein kinase binding and SH3/SH2 adaptor activity.

UniProtKB/Swiss-Prot for LAT Gene

  • Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Gene Wiki entry for LAT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAT Gene

Genomics for LAT Gene

Genomic Location for LAT Gene

Start:
28,984,826 bp from pter
End:
28,990,783 bp from pter
Size:
5,958 bases
Orientation:
Plus strand

Genomic View for LAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAT Gene

Regulatory Elements for LAT Gene

Transcription factor binding sites by QIAGEN in the LAT gene promoter:

Proteins for LAT Gene

  • Protein details for LAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43561-LAT_HUMAN
    Recommended name:
    Linker for activation of T-cells family member 1
    Protein Accession:
    O43561
    Secondary Accessions:
    • B7WPI0
    • C7C5T6
    • G5E9K3
    • O43919

    Protein attributes for LAT Gene

    Size:
    262 amino acids
    Molecular mass:
    27930 Da
    Quaternary structure:
    • When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity).
    Miscellaneous:
    • Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT

    Alternative splice isoforms for LAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAT Gene

Proteomics data for LAT Gene at MOPED

Post-translational modifications for LAT Gene

  • Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
  • Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys52

No data available for DME Specific Peptides for LAT Gene

Domains for LAT Gene

Protein Domains for LAT Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LAT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LAT Gene

Function for LAT Gene

Molecular function for LAT Gene

UniProtKB/Swiss-Prot Function: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Gene Ontology (GO) - Molecular Function for LAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IDA 9489702
GO:0005515 protein binding IPI 10811803
GO:0019901 protein kinase binding IPI 12186560
genes like me logo Genes that share ontologies with LAT: view
genes like me logo Genes that share phenotypes with LAT: view

Animal Models for LAT Gene

MGI Knock Outs for LAT:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LAT Gene

Localization for LAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAT Gene

Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAT Gene COMPARTMENTS Subcellular localization image for LAT gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for LAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 12646565
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
GO:0008180 COP9 signalosome ISS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with LAT: view

Pathways for LAT Gene

genes like me logo Genes that share pathways with LAT: view

Gene Ontology (GO) - Biological Process for LAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002260 lymphocyte homeostasis IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IDA 15100278
GO:0007165 signal transduction --
GO:0007229 integrin-mediated signaling pathway IDA 15100278
genes like me logo Genes that share ontologies with LAT: view

Compounds for LAT Gene

(1) HMDB Compounds for LAT Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(6) Novoseek inferred chemical compound relationships for LAT Gene

Compound -log(P) Hits PubMed IDs
pp36 92.2 4
tyrosine 62.4 22
phosphatidylinositol 40.1 1
lipid 23.8 5
phenylalanine 19.3 2
genes like me logo Genes that share compounds with LAT: view

Transcripts for LAT Gene

Unigene Clusters for LAT Gene

Linker for activation of T cells:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAT Gene

No ASD Table

Relevant External Links for LAT Gene

GeneLoc Exon Structure for
LAT
ECgene alternative splicing isoforms for
LAT

Expression for LAT Gene

mRNA expression in normal human tissues for LAT Gene

mRNA differential expression in normal tissues according to GTEx for LAT Gene

This gene is overexpressed in Whole Blood (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAT Gene

SOURCE GeneReport for Unigene cluster for LAT Gene Hs.632179

mRNA Expression by UniProt/SwissProt for LAT Gene

O43561-LAT_HUMAN
Tissue specificity: Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
genes like me logo Genes that share expressions with LAT: view

Orthologs for LAT Gene

This gene was present in the common ancestor of mammals.

Orthologs for LAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAT 35
  • 99.25 (n)
  • 98.51 (a)
LAT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LAT 35
  • 77.55 (n)
  • 70.92 (a)
LAT 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAT 35
  • 78.64 (n)
  • 77.35 (a)
LAT 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lat 35
  • 78.15 (n)
  • 68.42 (a)
Lat 16
Lat 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAT 36
  • 29 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lat 35
  • 77.83 (n)
  • 69.38 (a)
Species with no ortholog for LAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LAT Gene

ENSEMBL:
Gene Tree for LAT (if available)
TreeFam:
Gene Tree for LAT (if available)

Paralogs for LAT Gene

No data available for Paralogs for LAT Gene

Variants for LAT Gene

Sequence variations from dbSNP and Humsavar for LAT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1131543 -- 28,986,676(+) GATGC(A/G)GATGA synonymous-codon, reference
rs1802141 -- 28,990,688(+) GTTTC(A/G)CCATC utr-variant-3-prime
rs4788115 -- 28,986,790(+) TCACT(A/T)CCTTT intron-variant
rs7202093 -- 28,987,628(+) TATAC(C/T)CTGGC intron-variant
rs8062374 -- 28,991,267(+) agctg(A/G)gatta downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LAT Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
nsv905702 CNV Gain+Loss 21882294
nsv518648 CNV Loss 19592680
nsv519100 CNV Gain 19592680
nsv457480 CNV Gain 19166990
esv2750677 CNV Loss 17666407

Relevant External Links for LAT Gene

HapMap Linkage Disequilibrium report
LAT
Human Gene Mutation Database (HGMD)
LAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAT Gene

Disorders for LAT Gene

(1) Novoseek inferred disease relationships for LAT Gene

Disease -log(P) Hits PubMed IDs
autoimmune diseases 2.19 1

Relevant External Links for LAT

Genetic Association Database (GAD)
LAT
Human Genome Epidemiology (HuGE) Navigator
LAT
genes like me logo Genes that share disorders with LAT: view

No data available for UniProtKB/Swiss-Prot for LAT Gene

Publications for LAT Gene

  1. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. (PMID: 11259588) Baker J.E. … Weiss A. (Mol. Cell. Biol. 2001) 3 4 23
  2. Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. (PMID: 11368773) Paz P.E. … Abo A. (Biochem. J. 2001) 3 4 23
  3. Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. (PMID: 12186560) Perez-Villar J.J. … Kanner S.B. (Biochemistry 2002) 3 4 23
  4. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (PMID: 9489702) Zhang W. … Samelson L.E. (Cell 1998) 2 3 4
  5. Molecular cloning of the cDNA encoding pp36, a tyrosine- phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. (PMID: 9529333) Weber J.R. … Vaage J.T. (J. Exp. Med. 1998) 3 4

Products for LAT Gene

Sources for LAT Gene

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