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Aliases for FOXD3 Gene

Aliases for FOXD3 Gene

  • Forkhead Box D3 2 3
  • HNF3/FH Transcription Factor Genesis 3 4
  • VAMAS2 3 6
  • AIS1 3 6
  • HFH2 3 4
  • Forkhead Box Protein D3 3
  • Genesis 3

External Ids for FOXD3 Gene

Summaries for FOXD3 Gene

Entrez Gene Summary for FOXD3 Gene

  • This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]

GeneCards Summary for FOXD3 Gene

FOXD3 (Forkhead Box D3) is a Protein Coding gene. Diseases associated with FOXD3 include autoimmune disease 1 and vestibular nystagmus. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Neural Crest Differentiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and double-stranded DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXD3 Gene

  • Binds to the consensus sequence 5-A[AT]T[AG]TTTGTTT-3 and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.

Gene Wiki entry for FOXD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD3 Gene

Genomics for FOXD3 Gene

Genomic Location for FOXD3 Gene

Start:
63,323,041 bp from pter
End:
63,325,126 bp from pter
Size:
2,086 bases
Orientation:
Plus strand

Genomic View for FOXD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD3 Gene

Regulatory Elements for FOXD3 Gene

Proteins for FOXD3 Gene

  • Protein details for FOXD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJU5-FOXD3_HUMAN
    Recommended name:
    Forkhead box protein D3
    Protein Accession:
    Q9UJU5
    Secondary Accessions:
    • Q9BYM2
    • Q9UDD1

    Protein attributes for FOXD3 Gene

    Size:
    478 amino acids
    Molecular mass:
    47630 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD3 Gene

Proteomics data for FOXD3 Gene at MOPED

Post-translational modifications for FOXD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD3 Gene

Domains for FOXD3 Gene

Gene Families for FOXD3 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXD3 Gene

UniProtKB/Swiss-Prot:

FOXD3_HUMAN
Domain:
  • Contains 1 fork-head DNA-binding domain.:
    • Q9UJU5
genes like me logo Genes that share domains with FOXD3: view

Function for FOXD3 Gene

Molecular function for FOXD3 Gene

GENATLAS Biochemistry: transcription factor-like,restrictively expressed in hematopoietic cells,with a Drosophila homeo fork head DNA binding domain,mouse hepatocyte nuclear factor 3 homolog
UniProtKB/Swiss-Prot Function: Binds to the consensus sequence 5-A[AT]T[AG]TTTGTTT-3 and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.

Gene Ontology (GO) - Molecular Function for FOXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 22306510
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 22306510
GO:0003677 DNA binding --
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
genes like me logo Genes that share ontologies with FOXD3: view
genes like me logo Genes that share phenotypes with FOXD3: view

Animal Models for FOXD3 Gene

MGI Knock Outs for FOXD3:

miRNA for FOXD3 Gene

miRTarBase miRNAs that target FOXD3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FOXD3 Gene

Localization for FOXD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXD3 Gene COMPARTMENTS Subcellular localization image for FOXD3 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FOXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 22306510
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with FOXD3: view

Pathways for FOXD3 Gene

genes like me logo Genes that share pathways with FOXD3: view

Pathways by source for FOXD3 Gene

Gene Ontology (GO) - Biological Process for FOXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001701 in utero embryonic development ISS --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0001892 embryonic placenta development IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FOXD3: view

Transcripts for FOXD3 Gene

mRNA/cDNA for FOXD3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD3 Gene

Forkhead box D3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD3 Gene

No ASD Table

Relevant External Links for FOXD3 Gene

GeneLoc Exon Structure for
FOXD3
ECgene alternative splicing isoforms for
FOXD3

Expression for FOXD3 Gene

mRNA expression in normal human tissues for FOXD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXD3 Gene

This gene is overexpressed in Nerve - Tibial (20.9) and Colon - Sigmoid (4.1).

SOURCE GeneReport for Unigene cluster for FOXD3 Gene Hs.546573

mRNA Expression by UniProt/SwissProt for FOXD3 Gene

Q9UJU5-FOXD3_HUMAN
Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.
genes like me logo Genes that share expressions with FOXD3: view

Orthologs for FOXD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXD3 36
  • 99.37 (n)
  • 99.58 (a)
FOXD3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXD3 36
  • 89.26 (n)
  • 93.93 (a)
FOXD3 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXD3 36
  • 91.01 (n)
  • 93.32 (a)
FOXD3 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxd3 36
  • 85.91 (n)
  • 86.91 (a)
Foxd3 16
Foxd3 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxd3 36
  • 87.41 (n)
  • 87.41 (a)
lizard
(Anolis carolinensis)
Reptilia FOXD3 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia foxd3b-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia foxd3 36
  • 76.85 (n)
  • 82.2 (a)
Str.11302 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3286 36
zebrafish
(Danio rerio)
Actinopterygii foxd3 36
  • 74.98 (n)
  • 80.12 (a)
foxd3 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fd59A 37
  • 29 (a)
OneToMany
fd96Cb 38
  • 45 (a)
fd59A 38
  • 88 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-130 37
  • 35 (a)
OneToMany
unc-130 38
  • 77 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.311 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
ManyToMany
CSA.2032 37
  • 29 (a)
ManyToMany
Species with no ortholog for FOXD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXD3 Gene

ENSEMBL:
Gene Tree for FOXD3 (if available)
TreeFam:
Gene Tree for FOXD3 (if available)

Paralogs for FOXD3 Gene

Selected SIMAP similar genes for FOXD3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD3: view

Variants for FOXD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXD3 Gene

Variant ID Type Subtype PubMed ID
nsv461672 CNV Gain 19166990
nsv470714 CNV Gain 18288195

Relevant External Links for FOXD3 Gene

HapMap Linkage Disequilibrium report
FOXD3
Human Gene Mutation Database (HGMD)
FOXD3

No data available for Sequence variations from dbSNP and Humsavar for FOXD3 Gene

Disorders for FOXD3 Gene

(1) OMIM Diseases for FOXD3 Gene (611539)

UniProtKB/Swiss-Prot

FOXD3_HUMAN
  • Autoimmune disease 1 (AIS1) [MIM:607836]: An autoimmune disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). {ECO:0000269 PubMed:16098053}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for FOXD3 Gene

Relevant External Links for FOXD3

Genetic Association Database (GAD)
FOXD3
Human Genome Epidemiology (HuGE) Navigator
FOXD3
genes like me logo Genes that share disorders with FOXD3: view

Publications for FOXD3 Gene

  1. Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. (PMID: 8499623) Hromas R. … Klemsz M. (Blood 1993) 2 3 4
  2. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. (PMID: 11891324) Guo Y. … Hromas R. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  3. Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo. (PMID: 16098053) Alkhateeb A. … Spritz R.A. (J. Invest. Dermatol. 2005) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. (PMID: 19034670) Buescher J.L. … Ikezu T. (J Neuroimmune Pharmacol 2009) 3

Products for FOXD3 Gene

Sources for FOXD3 Gene

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