Aliases for FOXD3 Gene
External Ids for FOXD3 Gene
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]
GeneCards Summary for FOXD3 Gene
FOXD3 (Forkhead Box D3) is a Protein Coding gene. Diseases associated with FOXD3 include autoimmune disease 1 and vestibular nystagmus. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Neural Crest Differentiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and double-stranded DNA binding. An important paralog of this gene is FOXE3.
UniProtKB/Swiss-Prot for FOXD3 Gene
Binds to the consensus sequence 5-A[AT]T[AG]TTTGTTT-3 and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.