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Aliases for ABL2 Gene

Aliases for ABL2 Gene

  • ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase 2 3
  • ABLL 3 4 6
  • ARG 3 4 6
  • V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 2 3
  • C-Abl Oncogene 2, Non-Receptor Tyrosine Kinase 2 3
  • Abelson-Related Gene Protein 3 4
  • Tyrosine-Protein Kinase ARG 3 4
  • EC 2.7.10.2 4 63
  • V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (Arg, Abelson-Related Gene) 2
  • Abelson Murine Leukemia Viral Oncogene Homolog 2 4
  • Abelson Tyrosine-Protein Kinase 2 3
  • Abelson-Related Gene 2
  • EC 2.7.10 63

External Ids for ABL2 Gene

Previous HGNC Symbols for ABL2 Gene

  • ABLL

Previous GeneCards Identifiers for ABL2 Gene

  • GC01M176601
  • GC01M174505
  • GC01M175616
  • GC01M176316
  • GC01M175804
  • GC01M177339
  • GC01M179068
  • GC01M150296

Summaries for ABL2 Gene

Entrez Gene Summary for ABL2 Gene

  • This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for ABL2 Gene

ABL2 (ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ABL2 include leukemia. Among its related pathways are Ras signaling pathway and L1CAM interactions. GO annotations related to this gene include magnesium ion binding and protein tyrosine kinase activity. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot for ABL2 Gene

  • Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Gene Wiki entry for ABL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABL2 Gene

Genomics for ABL2 Gene

Regulatory Elements for ABL2 Gene

Genomic Location for ABL2 Gene

Start:
179,099,327 bp from pter
End:
179,229,684 bp from pter
Size:
130,358 bases
Orientation:
Minus strand

Genomic View for ABL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABL2 Gene

Proteins for ABL2 Gene

  • Protein details for ABL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42684-ABL2_HUMAN
    Recommended name:
    Abelson tyrosine-protein kinase 2
    Protein Accession:
    P42684
    Secondary Accessions:
    • A0M8X0
    • B7UEF2
    • B7UEF3
    • B7UEF4
    • B7UEF5
    • Q5T0X6
    • Q5W0C5
    • Q6NZY6
    • Q7Z301

    Protein attributes for ABL2 Gene

    Size:
    1182 amino acids
    Molecular mass:
    128343 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with PSMA7. Interacts with CTTN. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.
    SequenceCaution:
    • Sequence=CAD98092.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABL2 Gene

    Alternative splice isoforms for ABL2 Gene

neXtProt entry for ABL2 Gene

Proteomics data for ABL2 Gene at MOPED

Post-translational modifications for ABL2 Gene

  • Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity).
  • Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ABL2 Gene

Gene Families for ABL2 Gene

Graphical View of Domain Structure for InterPro Entry

P42684

UniProtKB/Swiss-Prot:

ABL2_HUMAN :
  • P42684
Domain:
  • Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are required to bundle actin filaments (By similarity).
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
genes like me logo Genes that share domains with ABL2: view

Function for ABL2 Gene

Molecular function for ABL2 Gene

GENATLAS Biochemistry: Abelson murine leukemia viral (v-abl) oncogene homolog 2
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By similarity).
UniProtKB/Swiss-Prot Function: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Enzyme Numbers (IUBMB) for ABL2 Gene

Gene Ontology (GO) - Molecular Function for ABL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15886098
GO:0003785 actin monomer binding TAS 20841568
GO:0004672 protein kinase activity TAS 2198571
GO:0004713 protein tyrosine kinase activity IDA 15886098
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS 20841568
genes like me logo Genes that share ontologies with ABL2: view
genes like me logo Genes that share phenotypes with ABL2: view

Animal Models for ABL2 Gene

MGI Knock Outs for ABL2:

miRNA for ABL2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for ABL2 Gene

Localization for ABL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABL2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABL2 Gene COMPARTMENTS Subcellular localization image for ABL2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ABL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup IEA --
GO:0005829 cytosol TAS --
GO:0015629 actin cytoskeleton TAS 20841568
GO:0030027 lamellipodium IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with ABL2: view

Pathways for ABL2 Gene

genes like me logo Genes that share pathways with ABL2: view

Gene Ontology (GO) - Biological Process for ABL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 2198571
GO:0006468 protein phosphorylation --
GO:0006909 phagocytosis IEA --
GO:0006930 substrate-dependent cell migration, cell extension IEA --
GO:0007015 actin filament organization --
genes like me logo Genes that share ontologies with ABL2: view

Compounds for ABL2 Gene

(4) HMDB Compounds for ABL2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5

(3) Drugbank Compounds for ABL2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
target
Adenosine triphosphate
  • 5'-ATP
56-65-5 target inhibitor
Dasatinib
302962-49-8 target multitarget

(5) Novoseek inferred chemical compound relationships for ABL2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 68.7 34
imatinib 41.7 3
h2o2 15 4
retinoic acid 12.1 2
oxygen 0 1
genes like me logo Genes that share compounds with ABL2: view

Transcripts for ABL2 Gene

Unigene Clusters for ABL2 Gene

V-abl Abelson murine leukemia viral oncogene homolog 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABL2 Gene

No ASD Table

Relevant External Links for ABL2 Gene

GeneLoc Exon Structure for
ABL2
ECgene alternative splicing isoforms for
ABL2

Expression for ABL2 Gene

mRNA expression in normal human tissues for ABL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABL2 Gene

SOURCE GeneReport for Unigene cluster for ABL2 Gene Hs.159472

mRNA Expression by UniProt/SwissProt for ABL2 Gene

P42684-ABL2_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with ABL2: view

No data available for mRNA differential expression in normal tissues for ABL2 Gene

Orthologs for ABL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABL2 35
  • 99.81 (n)
  • 100 (a)
ABL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABL2 35
  • 93.23 (n)
  • 96.11 (a)
ABL2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABL2 35
  • 94.42 (n)
  • 97.7 (a)
ABL2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abl2 35
  • 90.62 (n)
  • 94.92 (a)
Abl2 16
Abl2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABL2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABL2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abl2 35
  • 89.93 (n)
  • 92.86 (a)
chicken
(Gallus gallus)
Aves ABL2 35
  • 81.05 (n)
  • 88.55 (a)
ABL2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABL2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abl2 35
  • 69.9 (n)
  • 77.71 (a)
zebrafish
(Danio rerio)
Actinopterygii abl2 35
  • 67.98 (n)
  • 74.95 (a)
abl2 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Abl 36
  • 29 (a)
OneToMany
Abl 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea abl-1 36
  • 31 (a)
OneToMany
F23C8.7 37
  • 31 (a)
ZK593.9 37
  • 29 (a)
T25B9.5 37
  • 31 (a)
C25A8.5 37
  • 31 (a)
spe-8 37
  • 32 (a)
T21G5.1 37
  • 35 (a)
T25B9.4 37
  • 31 (a)
W01B6.5 37
  • 30 (a)
kin-9 37
  • 34 (a)
F22B3.8 37
  • 32 (a)
Y52D5A.2 37
  • 28 (a)
F57B9.8 37
  • 32 (a)
K09B11.5 37
  • 29 (a)
Y38H6C.20 37
  • 32 (a)
R11E3.1 37
  • 29 (a)
kin-26 37
  • 31 (a)
W04G5.10 37
  • 33 (a)
Y69E1A.3 37
  • 30 (a)
abl-1 37
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for ABL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABL2 Gene

ENSEMBL:
Gene Tree for ABL2 (if available)
TreeFam:
Gene Tree for ABL2 (if available)

Paralogs for ABL2 Gene

Paralogs for ABL2 Gene

Selected SIMAP similar genes for ABL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ABL2: view

Variants for ABL2 Gene

Sequence variations from dbSNP and Humsavar for ABL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs596989 -- 179,111,136(-) tgtgg(G/T)ggcgg intron-variant
rs602757 -- 179,131,875(-) CATTT(C/T)TTTCT intron-variant
rs611649 -- 179,150,226(-) gagac(A/G)gggtc intron-variant
rs620474 -- 179,111,133(-) ggggg(C/G/T)gggct intron-variant
rs622078 -- 179,151,131(-) gtatc(A/C)ccata intron-variant

Relevant External Links for ABL2 Gene

HapMap Linkage Disequilibrium report
ABL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABL2 Gene

Disorders for ABL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ABL2 Gene including...

Search for ABL2 Gene in MalaCards »

(4) Novoseek inferred disease relationships for ABL2 Gene

Disease -log(P) Hits PubMed IDs
leukemia 38.7 3
cancer 1.58 1
colorectal cancer 0.318 1
carcinoma 0 2

Relevant External Links for ABL2

Genetic Association Database (GAD)
ABL2
Human Genome Epidemiology (HuGE) Navigator
ABL2
Tumor Gene Database (TGDB):
ABL2
genes like me logo Genes that share disorders with ABL2: view

No data available for UniProtKB/Swiss-Prot for ABL2 Gene

Publications for ABL2 Gene

  1. Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress. (PMID: 15735735) Cao C. … Kufe D. (Oncogene 2005) 3 4 23
  2. Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. (PMID: 16678104) Liu X. … Cao C. (Mol. Cell 2006) 3 4 23
  3. A novel human gene closely related to the abl proto-oncogene. (PMID: 3787260) Kruh G.D. … Aaronson S.A. (Science 1986) 2 3 4
  4. Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection. (PMID: 18810762) Bianchi C. … Perego R.A. (J. Cell. Biochem. 2008) 3 4 23
  5. Reciprocal regulation of Abl and receptor tyrosine kinases. (PMID: 19275932) Srinivasan D. … Plattner R. (Cell. Signal. 2009) 3 23

Products for ABL2 Gene

  • Addgene plasmids for ABL2

Sources for ABL2 Gene

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