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Aliases for HBP1 Gene

Aliases for HBP1 Gene

  • HMG-Box Transcription Factor 1 2 3
  • High Mobility Group Box Transcription Factor 1 4
  • HMG Box Transcription Factor 1 4
  • USMCC2 6

External Ids for HBP1 Gene

Summaries for HBP1 Gene

GeneCards Summary for HBP1 Gene

HBP1 (HMG-Box Transcription Factor 1) is a Protein Coding gene. Diseases associated with HBP1 include ureter cancer. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and E2F transcription factor network. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for HBP1 Gene

  • Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5-TTCATTCATTCA-3. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

Gene Wiki entry for HBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HBP1 Gene

Genomics for HBP1 Gene

Genomic Location for HBP1 Gene

Start:
107,168,961 bp from pter
End:
107,202,529 bp from pter
Size:
33,569 bases
Orientation:
Plus strand

Genomic View for HBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HBP1 Gene

Regulatory Elements for HBP1 Gene

Transcription factor binding sites by QIAGEN in the HBP1 gene promoter:

Proteins for HBP1 Gene

  • Protein details for HBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60381-HBP1_HUMAN
    Recommended name:
    HMG box-containing protein 1
    Protein Accession:
    O60381
    Secondary Accessions:
    • B3KVB7
    • Q8TBM1
    • Q8TE93
    • Q96AJ2

    Protein attributes for HBP1 Gene

    Size:
    514 amino acids
    Molecular mass:
    57645 Da
    Quaternary structure:
    • Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1.
    SequenceCaution:
    • Sequence=BAB85059.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HBP1 Gene

    Alternative splice isoforms for HBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HBP1 Gene

Proteomics data for HBP1 Gene at MOPED

Post-translational modifications for HBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys16 and Lys398

No data available for DME Specific Peptides for HBP1 Gene

Domains for HBP1 Gene

Protein Domains for HBP1 Gene

UniProtKB/Swiss-Prot:

HBP1_HUMAN
Domain:
  • Contains 1 AXH domain.:
    • O60381
  • Contains 1 HMG box DNA-binding domain.:
    • O60381
genes like me logo Genes that share domains with HBP1: view

No data available for Gene Families for HBP1 Gene

Function for HBP1 Gene

Molecular function for HBP1 Gene

GENATLAS Biochemistry: histone hairpin binding protein 1,31kDa,involved in replication-dependent histone gene expression
UniProtKB/Swiss-Prot Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5-TTCATTCATTCA-3. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

Gene Ontology (GO) - Molecular Function for HBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 23859194
genes like me logo Genes that share ontologies with HBP1: view
genes like me logo Genes that share phenotypes with HBP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HBP1 Gene

Localization for HBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HBP1 Gene COMPARTMENTS Subcellular localization image for HBP1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for HBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HBP1: view

Pathways for HBP1 Gene

genes like me logo Genes that share pathways with HBP1: view

Gene Ontology (GO) - Biological Process for HBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007050 cell cycle arrest NAS 9030690
GO:0016055 Wnt signaling pathway IEA --
GO:0043268 positive regulation of potassium ion transport IEA --
genes like me logo Genes that share ontologies with HBP1: view

Transcripts for HBP1 Gene

Unigene Clusters for HBP1 Gene

HMG-box transcription factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HBP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: -
SP5: - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - - -
SP12:
SP13:

ExUns: 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for HBP1 Gene

GeneLoc Exon Structure for
HBP1
ECgene alternative splicing isoforms for
HBP1

Expression for HBP1 Gene

mRNA expression in normal human tissues for HBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HBP1 Gene

SOURCE GeneReport for Unigene cluster for HBP1 Gene Hs.162032

genes like me logo Genes that share expressions with HBP1: view

Orthologs for HBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HBP1 36
  • 99.87 (n)
  • 100 (a)
HBP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HBP1 36
  • 92.78 (n)
  • 94.83 (a)
HBP1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HBP1 36
  • 94.19 (n)
  • 96.74 (a)
HBP1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hbp1 36
  • 92.37 (n)
  • 95.23 (a)
Hbp1 16
Hbp1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HBP1 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HBP1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hbp1 36
  • 90.87 (n)
  • 93.3 (a)
chicken
(Gallus gallus)
Aves HBP1 36
  • 81.41 (n)
  • 84.15 (a)
HBP1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HBP1 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hbp1-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hbp1 36
  • 75.98 (n)
  • 77.46 (a)
Str.1878 36
zebrafish
(Danio rerio)
Actinopterygii hbp1 36
  • 66.6 (n)
  • 67.96 (a)
hbp1 37
  • 68 (a)
OneToOne
Species with no ortholog for HBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HBP1 Gene

ENSEMBL:
Gene Tree for HBP1 (if available)
TreeFam:
Gene Tree for HBP1 (if available)

Paralogs for HBP1 Gene

genes like me logo Genes that share paralogs with HBP1: view

No data available for Paralogs for HBP1 Gene

Variants for HBP1 Gene

Sequence variations from dbSNP and Humsavar for HBP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs257385 -- 107,167,003(+) TTAGT(C/T)TTCTA upstream-variant-2KB
rs257386 -- 107,167,338(+) GTGAA(C/G)ATAGA upstream-variant-2KB
rs257387 -- 107,168,035(+) AAAAT(A/G)CCGCT upstream-variant-2KB
rs957666 -- 107,167,533(-) CACAG(C/T)TAGTT upstream-variant-2KB
rs957667 -- 107,167,523(-) TATTT(C/T)TTTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HBP1 Gene

Variant ID Type Subtype PubMed ID
nsv831087 CNV Gain 17160897

Relevant External Links for HBP1 Gene

HapMap Linkage Disequilibrium report
HBP1

Disorders for HBP1 Gene

(1) MalaCards Diseases for HBP1 Gene

Search for HBP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HBP1 Gene

(2) Novoseek inferred disease relationships for HBP1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 36.3 2
tumors 5.38 7
genes like me logo Genes that share disorders with HBP1: view

No data available for UniProtKB/Swiss-Prot for HBP1 Gene

Publications for HBP1 Gene

  1. Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. (PMID: 11500377) Sampson E.M. … Yee A.S. (EMBO J. 2001) 2 3 4 23
  2. HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. (PMID: 9030690) Tevosian S.G. … Yee A.S. (Genes Dev. 1997) 2 3 23
  3. Human HMG box transcription factor HBP1: a role in hCD2 LCR function. (PMID: 10562551) Zhuma T. … Kioussis D. (EMBO J. 1999) 3 4 23
  4. HBP1 repression of the p47phox gene: cell cycle regulation via the NADPH oxidase. (PMID: 15024088) Berasi S.P. … Paulson K.E. (Mol. Cell. Biol. 2004) 3 23
  5. Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells. (PMID: 16179914) Yao C.J. … Austin G.E. (Leukemia 2005) 3 23

Products for HBP1 Gene

  • Addgene plasmids for HBP1

Sources for HBP1 Gene

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