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Aliases for COPG2 Gene

Aliases for COPG2 Gene

  • Coatomer Protein Complex, Subunit Gamma 2 2 3
  • Gamma-2-Coat Protein 3 4
  • Gamma-2-COP 3 4
  • Coat Protein, Nonclathrin, Gamma-2-Cop 3
  • Coatomer Subunit Gamma-2 3
  • Coat Protein 2
  • Nonclathrin 2
  • Gamma-2-Cop 2
  • 2-COP 3

External Ids for COPG2 Gene

Summaries for COPG2 Gene

GeneCards Summary for COPG2 Gene

COPG2 (Coatomer Protein Complex, Subunit Gamma 2) is a Protein Coding gene. Among its related pathways are G-protein signaling RAC1 in cellular process and COPI Mediated Transport. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is COPG1.

UniProtKB/Swiss-Prot for COPG2 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Gene Wiki entry for COPG2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPG2 Gene

Genomics for COPG2 Gene

Genomic Location for COPG2 Gene

Start:
130,506,238 bp from pter
End:
130,668,758 bp from pter
Size:
162,521 bases
Orientation:
Minus strand

Genomic View for COPG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPG2 Gene

Regulatory Elements for COPG2 Gene

Proteins for COPG2 Gene

  • Protein details for COPG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBF2-COPG2_HUMAN
    Recommended name:
    Coatomer subunit gamma-2
    Protein Accession:
    Q9UBF2
    Secondary Accessions:
    • A6NH74
    • Q2NLA0
    • Q54AC3
    • Q8WVW8

    Protein attributes for COPG2 Gene

    Size:
    871 amino acids
    Molecular mass:
    97622 Da
    Quaternary structure:
    • Oligomeric complex. Binds to CDC42. Interacts with JAGN1.

    Alternative splice isoforms for COPG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPG2 Gene

Proteomics data for COPG2 Gene at MOPED

Post-translational modifications for COPG2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys461 and Lys572

Other Protein References for COPG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COPG2 Gene

Domains for COPG2 Gene

UniProtKB/Swiss-Prot:

COPG2_HUMAN
Family:
  • Belongs to the COPG family.:
    • Q9UBF2
Similarity:
  • Contains 6 HEAT repeats.:
    • Q9UBF2
genes like me logo Genes that share domains with COPG2: view

No data available for Gene Families for COPG2 Gene

Function for COPG2 Gene

Molecular function for COPG2 Gene

GENATLAS Biochemistry: Golgi coatomer complex,gamma 2 subunit,component of the coat of non clathrin-coated vesicles,ubiquitously expressed from the paternal allele in most fetal tissues (maternally imprinted),expressed from both alleles in fetal brain,liver and adult peripheral blood,not likely to be involved in Silver-Russell syndrome
UniProtKB/Swiss-Prot Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Gene Ontology (GO) - Molecular Function for COPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005488 binding --
genes like me logo Genes that share ontologies with COPG2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COPG2 Gene

Localization for COPG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPG2 Gene

Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPG2 Gene COMPARTMENTS Subcellular localization image for COPG2 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for COPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0030117 membrane coat --
GO:0030126 COPI vesicle coat IDA 11056392
genes like me logo Genes that share ontologies with COPG2: view

Pathways for COPG2 Gene

genes like me logo Genes that share pathways with COPG2: view

Gene Ontology (GO) - Biological Process for COPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS 11030615
GO:0006891 intra-Golgi vesicle-mediated transport IDA 11056392
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with COPG2: view

Compounds for COPG2 Gene

(1) HMDB Compounds for COPG2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with COPG2: view

Transcripts for COPG2 Gene

mRNA/cDNA for COPG2 Gene

Unigene Clusters for COPG2 Gene

Coatomer protein complex, subunit gamma 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPG2 Gene

No ASD Table

Relevant External Links for COPG2 Gene

GeneLoc Exon Structure for
COPG2
ECgene alternative splicing isoforms for
COPG2

Expression for COPG2 Gene

mRNA expression in normal human tissues for COPG2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for COPG2 Gene

SOURCE GeneReport for Unigene cluster for COPG2 Gene Hs.6421

genes like me logo Genes that share expressions with COPG2: view

Orthologs for COPG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPG2 36
  • 99.89 (n)
  • 100 (a)
COPG2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPG2 36
  • 93.03 (n)
  • 96.33 (a)
COPG2 37
  • 28 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPG2 36
  • 93.03 (n)
  • 96.65 (a)
COPG2 37
  • 23 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copg2 36
  • 91.01 (n)
  • 97.59 (a)
Copg2 16
Copg2 37
  • 28 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPG2 37
  • 28 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPG2 37
  • 28 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copg2 36
  • 91.35 (n)
  • 97.47 (a)
chicken
(Gallus gallus)
Aves COPG2 36
  • 81.52 (n)
  • 93.8 (a)
COPG2 37
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPG2 37
  • 27 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia copg2 36
  • 78.15 (n)
  • 90.01 (a)
zebrafish
(Danio rerio)
Actinopterygii copg2 36
  • 76.5 (n)
  • 88.63 (a)
copg2 37
  • 26 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009291 36
  • 57.72 (n)
  • 61.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta gammaCop 36
  • 57.74 (n)
  • 60.25 (a)
gammaCop 37
  • 18 (a)
OneToMany
gammaCop 38
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea T14G10.5 36
  • 57.22 (n)
  • 56.45 (a)
T14G10.5 37
  • 17 (a)
OneToMany
T14G10.5 38
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL193W 36
  • 46.9 (n)
  • 39.98 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC21 36
  • 47.96 (n)
  • 39.31 (a)
SEC21 37
  • 9 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13289g 36
  • 47.74 (n)
  • 37.43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34450 36
  • 57.67 (n)
  • 54.09 (a)
rice
(Oryza sativa)
Liliopsida Os03g0227000 36
  • 55.95 (n)
  • 53.74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01992 36
  • 52.71 (n)
  • 48.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec21 36
  • 50.78 (n)
  • 41.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 9 (a)
ManyToMany
CSA.452 37
  • 57 (a)
ManyToMany
Species with no ortholog for COPG2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPG2 Gene

ENSEMBL:
Gene Tree for COPG2 (if available)
TreeFam:
Gene Tree for COPG2 (if available)

Paralogs for COPG2 Gene

Paralogs for COPG2 Gene

Selected SIMAP similar genes for COPG2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with COPG2: view

Variants for COPG2 Gene

Sequence variations from dbSNP and Humsavar for COPG2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1814 -- 130,645,623(+) AACAT(A/G)GGTGC intron-variant
rs10128 - 130,511,853(+) AAAGC(G/T)TTTGA intron-variant
rs158679 -- 130,654,956(+) ctctt(G/T)gtatc intron-variant
rs158680 -- 130,653,025(+) ACCCC(A/C)AGTAG intron-variant
rs158681 -- 130,653,075(+) CTACC(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPG2 Gene

Variant ID Type Subtype PubMed ID
nsv831130 CNV Loss 17160897
nsv831131 CNV Loss 17160897
nsv831132 CNV Gain+Loss 17160897

Relevant External Links for COPG2 Gene

HapMap Linkage Disequilibrium report
COPG2

Disorders for COPG2 Gene

(2) University of Copenhagen DISEASES for COPG2 Gene

genes like me logo Genes that share disorders with COPG2: view

No data available for UniProtKB/Swiss-Prot for COPG2 Gene

Publications for COPG2 Gene

  1. The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting. (PMID: 10995575) Yamasaki K. … Kishino T. (Genomics 2000) 2 3 23
  2. Gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome. (PMID: 10556286) Blagitko N. … Kalscheuer V.M. (Hum. Mol. Genet. 1999) 2 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Identification and characterization of novel isoforms of COP I subunits. (PMID: 11056392) Futatsumori M. … Nakayama K. (J. Biochem. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for COPG2 Gene

Sources for COPG2 Gene

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