Aliases for GIF Gene
External Ids for GIF Gene
Previous GeneCards Identifiers for GIF Gene
This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for GIF Gene
GIF (Gastric Intrinsic Factor) is a Protein Coding gene. Diseases associated with GIF include Intrinsic Factor Deficiency and Congenital Intrinsic Factor Deficiency. Among its related pathways are Diseases of metabolism and Defective AMN causes hereditary megaloblastic anemia 1. GO annotations related to this gene include cobalamin binding. An important paralog of this gene is TCN1.
UniProtKB/Swiss-Prot for GIF Gene
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.