Aliases for GGT5 Gene
External Ids for GGT5 Gene
Previous HGNC Symbols for GGT5 Gene
Previous GeneCards Identifiers for GGT5 Gene
This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
GeneCards Summary for GGT5 Gene
GGT5 (Gamma-Glutamyltransferase 5) is a Protein Coding gene. Diseases associated with GGT5 include Cataract 4, Multiple Types and Fructose-1,6-Bisphosphatase Deficiency. Among its related pathways are Glutathione metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include obsolete gamma-glutamyltransferase activity and glutathione hydrolase activity. An important paralog of this gene is GGT1.
UniProtKB/Swiss-Prot for GGT5 Gene
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).