Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GGT7 Gene

Aliases for GGT7 Gene

  • Gamma-Glutamyltransferase 7 2 3
  • Gamma-Glutamyltransferase-Like 3 2 3 4
  • GGTL3 3 4 6
  • GGTL5 3 4 6
  • Gamma-Glutamyltransferase-Like 5 3 4
  • Gamma-Glutamyltranspeptidase 7 3 4
  • Glutathione Hydrolase 7 3 4
  • EC 2.3.2.2 4 64
  • GGT 7 3 4
  • GGT4 3 6
  • Gamma-Glutamyltranspeptidase-Like 3 3
  • Gamma-Glutamyltransferase 4 3
  • EC 3.4.19.13 4
  • DJ18C9.2 3
  • D20S101 3

External Ids for GGT7 Gene

Previous Symbols for GGT7 Gene

  • GGTL5
  • GGTL3

Summaries for GGT7 Gene

Entrez Gene Summary for GGT7 Gene

  • This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGT7 Gene

GGT7 (Gamma-Glutamyltransferase 7) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include gamma-glutamyltransferase activity and glutathione hydrolase activity. An important paralog of this gene is GGT1.

UniProtKB/Swiss-Prot for GGT7 Gene

  • Cleaves glutathione conjugates.

Gene Wiki entry for GGT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT7 Gene

Genomics for GGT7 Gene

Genomic Location for GGT7 Gene

Start:
34,844,720 bp from pter
End:
34,872,860 bp from pter
Size:
28,141 bases
Orientation:
Minus strand

Genomic View for GGT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGT7 Gene

Regulatory Elements for GGT7 Gene

Proteins for GGT7 Gene

  • Protein details for GGT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ14-GGT7_HUMAN
    Recommended name:
    Gamma-glutamyltransferase 7
    Protein Accession:
    Q9UJ14
    Secondary Accessions:
    • Q8N899
    • Q8NF66
    • Q9BYP5
    • Q9BYP6

    Protein attributes for GGT7 Gene

    Size:
    662 amino acids
    Molecular mass:
    70467 Da
    Quaternary structure:
    • Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A.
    SequenceCaution:
    • Sequence=BAC03394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GGT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGT7 Gene

Proteomics data for GGT7 Gene at MOPED

Post-translational modifications for GGT7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GGT7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GGT7 Gene

Gene Families for GGT7 Gene

HGNC:
  • GGT :Gamma-glutamyltransferases

Protein Domains for GGT7 Gene

UniProtKB/Swiss-Prot:

GGT7_HUMAN
Family:
  • Belongs to the gamma-glutamyltransferase family.:
    • Q9UJ14
genes like me logo Genes that share domains with GGT7: view

Function for GGT7 Gene

Molecular function for GGT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid
UniProtKB/Swiss-Prot CatalyticActivity: Glutathione + H(2)O = L-cysteinylglycine + L-glutamate
UniProtKB/Swiss-Prot Function: Cleaves glutathione conjugates.

Enzyme Numbers (IUBMB) for GGT7 Gene

Gene Ontology (GO) - Molecular Function for GGT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003840 gamma-glutamyltransferase activity TAS 18357469
GO:0005515 protein binding IPI 25416956
GO:0036374 glutathione hydrolase activity IEA --
genes like me logo Genes that share ontologies with GGT7: view

Phenotypes for GGT7 Gene

GenomeRNAi human phenotypes for GGT7:
genes like me logo Genes that share phenotypes with GGT7: view

miRNA for GGT7 Gene

miRTarBase miRNAs that target GGT7

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GGT7 Gene

Localization for GGT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT7 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGT7 Gene COMPARTMENTS Subcellular localization image for GGT7 gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GGT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031362 anchored component of external side of plasma membrane TAS 18357469
genes like me logo Genes that share ontologies with GGT7: view

Pathways for GGT7 Gene

genes like me logo Genes that share pathways with GGT7: view

Pathways by source for GGT7 Gene

UniProtKB/Swiss-Prot Q9UJ14-GGT7_HUMAN

  • Pathway: Sulfur metabolism; glutathione metabolism

Gene Ontology (GO) - Biological Process for GGT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006749 glutathione metabolic process TAS 18357469
GO:0006750 glutathione biosynthetic process IEA --
GO:0019370 leukotriene biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGT7: view

Compounds for GGT7 Gene

(15) HMDB Compounds for GGT7 Gene

Compound Synonyms Cas Number PubMed IDs
5-L-Glutamyl-taurine
  • 5-Glutamyl-taurine
Not Available
Carbon dioxide
  • Carbon oxide
124-38-9
Cysteinylglycine
  • L-Cysteinylglycine
19246-18-5
Famotidine
  • Amfamox
76824-35-6
Gamma-Glutamyl-Se-methylselenocysteine
Not Available
genes like me logo Genes that share compounds with GGT7: view

Transcripts for GGT7 Gene

Unigene Clusters for GGT7 Gene

Gamma-glutamyltransferase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GGT7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
SP1: - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8: - - - - - - - -
SP9:
SP10: - -
SP11: -
SP12:
SP13:

ExUns: 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for GGT7 Gene

GeneLoc Exon Structure for
GGT7
ECgene alternative splicing isoforms for
GGT7

Expression for GGT7 Gene

mRNA expression in normal human tissues for GGT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GGT7 Gene

SOURCE GeneReport for Unigene cluster for GGT7 Gene Hs.433738

mRNA Expression by UniProt/SwissProt for GGT7 Gene

Q9UJ14-GGT7_HUMAN
Tissue specificity: Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea
genes like me logo Genes that share expressions with GGT7: view

Orthologs for GGT7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGT7 36
  • 97.81 (n)
  • 98.36 (a)
GGT7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GGT7 36
  • 91.99 (n)
  • 95.77 (a)
GGT7 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GGT7 36
  • 91.34 (n)
  • 97.73 (a)
GGT7 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ggt7 36
  • 89.88 (n)
  • 96.22 (a)
Ggt7 16
Ggt7 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GGT7 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GGT7 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ggt7 36
  • 89.02 (n)
  • 95.17 (a)
chicken
(Gallus gallus)
Aves GGT7 36
  • 68.19 (n)
  • 71.02 (a)
GGT7 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GGT7 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9126 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ggt7 36
  • 62.16 (n)
  • 61.12 (a)
zebrafish
(Danio rerio)
Actinopterygii GGT7 37
  • 54 (a)
OneToOne
LOC101882295 36
  • 59.58 (n)
  • 53.87 (a)
worm
(Caenorhabditis elegans)
Secernentea Y97E10AR.2 37
  • 13 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM38 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5921 37
  • 30 (a)
OneToOne
Species with no ortholog for GGT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GGT7 Gene

ENSEMBL:
Gene Tree for GGT7 (if available)
TreeFam:
Gene Tree for GGT7 (if available)

Paralogs for GGT7 Gene

Paralogs for GGT7 Gene

Selected SIMAP similar genes for GGT7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GGT7: view

Variants for GGT7 Gene

Sequence variations from dbSNP and Humsavar for GGT7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs761481 -- 34,855,120(-) GAGTT(C/G)AAGTC intron-variant
rs1984588 -- 34,848,071(-) ctgtc(A/G)cccag intron-variant
rs2076668 -- 34,849,818(-) GTGAA(C/T)GATCT intron-variant
rs2295094 -- 34,860,112(+) GGGGG(A/G)TTCCT intron-variant
rs3746452 -- 34,856,843(-) TACAG(C/T)GCCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GGT7 Gene

Variant ID Type Subtype PubMed ID
nsv912860 CNV Gain 21882294

Relevant External Links for GGT7 Gene

HapMap Linkage Disequilibrium report
GGT7

Disorders for GGT7 Gene

Relevant External Links for GGT7

Genetic Association Database (GAD)
GGT7
Human Genome Epidemiology (HuGE) Navigator
GGT7
genes like me logo Genes that share disorders with GGT7: view

No data available for UniProtKB/Swiss-Prot for GGT7 Gene

Publications for GGT7 Gene

  1. Molecular cloning and characterization of CT120, a novel membrane- associated gene involved in amino acid transport and glutathione metabolism. (PMID: 12270127) He X.H. … Gu J.R. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  2. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. (PMID: 8104871) Figlewicz D.A. … Rouleau G.A. (Genomics 1993) 2 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for GGT7 Gene

Sources for GGT7 Gene

Back to Top

Content