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Aliases for GGT7 Gene

Aliases for GGT7 Gene

  • Gamma-Glutamyltransferase 7 2 3
  • Gamma-Glutamyltransferase-Like 3 2 3 4
  • GGTL3 3 4 6
  • GGTL5 3 4 6
  • Gamma-Glutamyltransferase-Like 5 3 4
  • Gamma-Glutamyltranspeptidase 7 3 4
  • Glutathione Hydrolase 7 3 4
  • EC 4 63
  • GGT 7 3 4
  • GGT4 3 6
  • Gamma-Glutamyltranspeptidase-Like 3 3
  • Gamma-Glutamyltransferase 4 3
  • EC 4
  • DJ18C9.2 3
  • D20S101 3

External Ids for GGT7 Gene

Previous HGNC Symbols for GGT7 Gene

  • GGTL5
  • GGTL3

Previous GeneCards Identifiers for GGT7 Gene

  • GC20M032897
  • GC20M033435
  • GC20M030198

Summaries for GGT7 Gene

Entrez Gene Summary for GGT7 Gene

  • This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGT7 Gene

GGT7 (Gamma-Glutamyltransferase 7) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include gamma-glutamyltransferase activity and glutathione hydrolase activity. An important paralog of this gene is GGT1.

UniProtKB/Swiss-Prot for GGT7 Gene

  • Cleaves glutathione conjugates.

Gene Wiki entry for GGT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT7 Gene

Genomics for GGT7 Gene

Regulatory Elements for GGT7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GGT7 Gene

34,844,720 bp from pter
34,872,860 bp from pter
28,141 bases
Minus strand

Genomic View for GGT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGT7 Gene

Proteins for GGT7 Gene

  • Protein details for GGT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-glutamyltransferase 7
    Protein Accession:
    Secondary Accessions:
    • Q8N899
    • Q8NF66
    • Q9BYP5
    • Q9BYP6

    Protein attributes for GGT7 Gene

    662 amino acids
    Molecular mass:
    70467 Da
    Quaternary structure:
    • Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A.
    • Sequence=BAC03394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GGT7 Gene


neXtProt entry for GGT7 Gene

Proteomics data for GGT7 Gene at MOPED

Post-translational modifications for GGT7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GGT7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GGT7 Gene

Gene Families for GGT7 Gene

  • GGT :Gamma-glutamyltransferases

Protein Domains for GGT7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UJ14
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGT7: view

Function for GGT7 Gene

Molecular function for GGT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid
UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione + H(2)O = L-cysteinylglycine + L-glutamate
UniProtKB/Swiss-Prot Function:
Cleaves glutathione conjugates.

Enzyme Numbers (IUBMB) for GGT7 Gene

Gene Ontology (GO) - Molecular Function for GGT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003840 gamma-glutamyltransferase activity TAS 18357469
GO:0005515 protein binding IPI 25416956
GO:0036374 glutathione hydrolase activity IEA --
genes like me logo Genes that share ontologies with GGT7: view

Phenotypes for GGT7 Gene

GenomeRNAi human phenotypes for GGT7:
genes like me logo Genes that share phenotypes with GGT7: view

Animal Model Products

miRNA for GGT7 Gene

miRTarBase miRNAs that target GGT7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGT7

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GGT7 Gene

Localization for GGT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT7 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for GGT7 Gene COMPARTMENTS Subcellular localization image for GGT7 gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GGT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031362 anchored component of external side of plasma membrane TAS 18357469
genes like me logo Genes that share ontologies with GGT7: view

Pathways for GGT7 Gene

genes like me logo Genes that share pathways with GGT7: view

UniProtKB/Swiss-Prot Q9UJ14-GGT7_HUMAN

  • Pathway: Sulfur metabolism; glutathione metabolism

Gene Ontology (GO) - Biological Process for GGT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006749 glutathione metabolic process TAS 18357469
GO:0006750 glutathione biosynthetic process IEA --
GO:0019370 leukotriene biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGT7: view

Compounds for GGT7 Gene

(15) HMDB Compounds for GGT7 Gene

Compound Synonyms Cas Number PubMed IDs
  • 5-Glutamyl-taurine
Not Available
Carbon dioxide
  • Carbon oxide
  • L-Cysteinylglycine
  • Amfamox
Not Available
genes like me logo Genes that share compounds with GGT7: view

Transcripts for GGT7 Gene

Unigene Clusters for GGT7 Gene

Gamma-glutamyltransferase 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGT7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGT7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
SP1: - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8: - - - - - - - -
SP10: - -
SP11: -

ExUns: 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
SP5: -
SP12: -

Relevant External Links for GGT7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GGT7 Gene

mRNA expression in normal human tissues for GGT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for GGT7 Gene

This gene is overexpressed in Frontal cortex (23.5), Brain (9.7), and Retina (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GGT7 Gene

SOURCE GeneReport for Unigene cluster for GGT7 Gene Hs.433738

mRNA Expression by UniProt/SwissProt for GGT7 Gene

Tissue specificity: Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea
genes like me logo Genes that share expressions with GGT7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for GGT7 Gene

Orthologs for GGT7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGT7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GGT7 35
  • 91.99 (n)
  • 95.77 (a)
GGT7 36
  • 96 (a)
(Canis familiaris)
Mammalia GGT7 35
  • 91.34 (n)
  • 97.73 (a)
GGT7 36
  • 98 (a)
(Mus musculus)
Mammalia Ggt7 35
  • 89.88 (n)
  • 96.22 (a)
Ggt7 16
Ggt7 36
  • 96 (a)
(Pan troglodytes)
Mammalia GGT7 35
  • 97.81 (n)
  • 98.36 (a)
GGT7 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ggt7 35
  • 89.02 (n)
  • 95.17 (a)
(Monodelphis domestica)
Mammalia GGT7 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia GGT7 36
  • 77 (a)
(Gallus gallus)
Aves GGT7 35
  • 68.19 (n)
  • 71.02 (a)
GGT7 36
  • 70 (a)
(Anolis carolinensis)
Reptilia GGT7 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ggt7 35
  • 62.16 (n)
  • 61.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9126 35
(Danio rerio)
Actinopterygii LOC101882295 35
  • 59.58 (n)
  • 53.87 (a)
GGT7 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea Y97E10AR.2 36
  • 13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM38 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5921 36
  • 30 (a)
Species with no ortholog for GGT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GGT7 Gene

Gene Tree for GGT7 (if available)
Gene Tree for GGT7 (if available)

Paralogs for GGT7 Gene

Paralogs for GGT7 Gene

Selected SIMAP similar genes for GGT7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GGT7: view

Variants for GGT7 Gene

Sequence variations from dbSNP and Humsavar for GGT7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs761481 -- 34,855,120(-) GAGTT(C/G)AAGTC intron-variant
rs1984588 -- 34,848,071(-) ctgtc(A/G)cccag intron-variant
rs2076668 -- 34,849,818(-) GTGAA(C/T)GATCT intron-variant
rs2295094 -- 34,860,112(+) GGGGG(A/G)TTCCT intron-variant
rs3746452 -- 34,856,843(-) TACAG(C/T)GCCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GGT7 Gene

Variant ID Type Subtype PubMed ID
nsv912860 CNV Gain 21882294

Relevant External Links for GGT7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGT7 Gene

Disorders for GGT7 Gene

Relevant External Links for GGT7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for GGT7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for GGT7 Gene

Publications for GGT7 Gene

  1. Molecular cloning and characterization of CT120, a novel membrane- associated gene involved in amino acid transport and glutathione metabolism. (PMID: 12270127) He X.H. … Gu J.R. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  2. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N. … Sneddon T.P. (Hum. Genet. 2008) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. (PMID: 8104871) Figlewicz D.A. … Rouleau G.A. (Genomics 1993) 2 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for GGT7 Gene

Sources for GGT7 Gene

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