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Aliases for GFRA2 Gene

Aliases for GFRA2 Gene

  • GDNF Family Receptor Alpha 2 2 3
  • GDNFRB 3 4 6
  • TGF-Beta-Related Neurotrophic Factor Receptor 2 3 4
  • Neurturin Receptor Alpha 3 4
  • GDNF Receptor Beta 3 4
  • GDNFR-Alpha-2 3 4
  • RET Ligand 2 3 4
  • NRTNR-ALPHA 3 4
  • GDNFR-Beta 3 4
  • NTNR-Alpha 3 4
  • RETL2 3 4
  • TRNR2 3 4
  • Glial Cell Line Derived Neurotrophic Factor Receptor, Beta 3
  • PI-Linked Cell-Surface Accessory Protein 3
  • GDNF Family Receptor Alpha-2 3
  • TRN Receptor, GPI-Anchored 3
  • GDNF Receptor Alpha-2 4
  • GFR-Alpha 2 3
  • GFR-Alpha-2 4
  • NTNRA 3

External Ids for GFRA2 Gene

Previous GeneCards Identifiers for GFRA2 Gene

  • GC08M021338
  • GC08M021863
  • GC08M021559
  • GC08M020092
  • GC08M021547

Summaries for GFRA2 Gene

Entrez Gene Summary for GFRA2 Gene

  • Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for GFRA2 Gene

GFRA2 (GDNF Family Receptor Alpha 2) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include glial cell-derived neurotrophic factor receptor activity. An important paralog of this gene is GFRA1.

UniProtKB/Swiss-Prot for GFRA2 Gene

  • Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor

  • Isoform 2: Participates to NRTN-induced Ser-727 phosphorylation of STAT3.

Gene Wiki entry for GFRA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFRA2 Gene

Genomics for GFRA2 Gene

Regulatory Elements for GFRA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GFRA2 Gene

Start:
21,690,403 bp from pter
End:
21,814,898 bp from pter
Size:
124,496 bases
Orientation:
Minus strand

Genomic View for GFRA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GFRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFRA2 Gene

Proteins for GFRA2 Gene

  • Protein details for GFRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00451-GFRA2_HUMAN
    Recommended name:
    GDNF family receptor alpha-2
    Protein Accession:
    O00451
    Secondary Accessions:
    • E9PD47
    • O15316
    • O15328
    • Q58J92
    • Q6GTR9
    • Q7Z5C2

    Protein attributes for GFRA2 Gene

    Size:
    464 amino acids
    Molecular mass:
    51544 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GFRA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GFRA2 Gene

Proteomics data for GFRA2 Gene at MOPED

Post-translational modifications for GFRA2 Gene

  • Glycosylation at Asn52, Asn357, and Asn413
  • Modification sites at PhosphoSitePlus

Other Protein References for GFRA2 Gene

Antibody Products

  • R&D Systems Antibodies for GFRA2 (GFR alpha-2/GDNF R alpha-2)

No data available for DME Specific Peptides for GFRA2 Gene

Domains for GFRA2 Gene

Gene Families for GFRA2 Gene

Suggested Antigen Peptide Sequences for GFRA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00451

UniProtKB/Swiss-Prot:

GFRA2_HUMAN :
  • O00451
Family:
  • Belongs to the GDNFR family.
genes like me logo Genes that share domains with GFRA2: view

Function for GFRA2 Gene

Molecular function for GFRA2 Gene

GENATLAS Biochemistry: glial cell line-derived neurotrophic factor (GDNF) receptor alpha 2,47kDa,mediating the autophosphorylation of RET,abundantly expressed in adult brain,intestine,placenta,fetal brain,lung,kidney,also receptor for neurturin and TGF-beta-related neurotrophic factor
UniProtKB/Swiss-Prot Function: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor
UniProtKB/Swiss-Prot Function: Isoform 2: Participates to NRTN-induced Ser-727 phosphorylation of STAT3.

Gene Ontology (GO) - Molecular Function for GFRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016167 glial cell-derived neurotrophic factor receptor activity IEA --
genes like me logo Genes that share ontologies with GFRA2: view
genes like me logo Genes that share phenotypes with GFRA2: view

Animal Models for GFRA2 Gene

MGI Knock Outs for GFRA2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GFRA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GFRA2 Gene

Localization for GFRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFRA2 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GFRA2 Gene COMPARTMENTS Subcellular localization image for GFRA2 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GFRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0019898 extrinsic component of membrane TAS 10829012
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with GFRA2: view

Pathways for GFRA2 Gene

genes like me logo Genes that share pathways with GFRA2: view

Pathways by source for GFRA2 Gene

1 Sino Biological pathway for GFRA2 Gene
1 Qiagen pathway for GFRA2 Gene
1 GeneGo (Thomson Reuters) pathway for GFRA2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GFRA2 Gene

Gene Ontology (GO) - Biological Process for GFRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 9192898
GO:0007399 nervous system development IEA --
GO:0031953 negative regulation of protein autophosphorylation IEA --
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GFRA2: view

Compounds for GFRA2 Gene

(2) Novoseek inferred chemical compound relationships for GFRA2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 50 9
retinoic acid 8.67 1
genes like me logo Genes that share compounds with GFRA2: view

Transcripts for GFRA2 Gene

Unigene Clusters for GFRA2 Gene

GDNF family receptor alpha 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GFRA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GFRA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3: - -
SP4: -

Relevant External Links for GFRA2 Gene

GeneLoc Exon Structure for
GFRA2
ECgene alternative splicing isoforms for
GFRA2

Expression for GFRA2 Gene

mRNA expression in normal human tissues for GFRA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GFRA2 Gene

This gene is overexpressed in Brain - Cortex (6.3), Brain - Frontal Cortex (BA9) (5.8), Brain - Anterior cingulate cortex (BA24) (5.0), and Thyroid (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GFRA2 Gene

SOURCE GeneReport for Unigene cluster for GFRA2 Gene Hs.441202

mRNA Expression by UniProt/SwissProt for GFRA2 Gene

O00451-GFRA2_HUMAN
Tissue specificity: Isoform 1 is found in both brain and placenta
genes like me logo Genes that share expressions with GFRA2: view

In Situ Assay Products

Orthologs for GFRA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GFRA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GFRA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GFRA2 35
  • 91.52 (n)
  • 94.4 (a)
GFRA2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GFRA2 35
  • 93.89 (n)
  • 96.98 (a)
GFRA2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gfra2 35
  • 90.86 (n)
  • 93.95 (a)
Gfra2 16
Gfra2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GFRA2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GFRA2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gfra2 35
  • 91.24 (n)
  • 94.61 (a)
chicken
(Gallus gallus)
Aves GFRA2 35
  • 76.7 (n)
  • 75.97 (a)
GFRA2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gfra2 35
  • 60.45 (n)
  • 55.99 (a)
zebrafish
(Danio rerio)
Actinopterygii gfra2a 35
  • 68.3 (n)
  • 64.74 (a)
gfra2a 36
  • 48 (a)
OneToMany
gfra2b 36
  • 53 (a)
OneToMany
Species with no ortholog for GFRA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GFRA2 Gene

ENSEMBL:
Gene Tree for GFRA2 (if available)
TreeFam:
Gene Tree for GFRA2 (if available)

Paralogs for GFRA2 Gene

Paralogs for GFRA2 Gene

Selected SIMAP similar genes for GFRA2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GFRA2: view

Variants for GFRA2 Gene

Sequence variations from dbSNP and Humsavar for GFRA2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs15881 -- 21,693,256(-) CAGAA(G/T)ATTTT utr-variant-3-prime
rs899420 -- 21,812,580(+) CAGGA(C/T)GCTTT intron-variant
rs899421 -- 21,813,320(+) AAAAA(A/T)TTTTT intron-variant
rs899422 -- 21,813,612(+) ataga(G/T)agata intron-variant
rs1128397 - 21,693,288(-) GAAAC(A/T)GGCCT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for GFRA2 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
esv2675982 CNV Deletion 23128226
esv25058 CNV Loss 19812545

Relevant External Links for GFRA2 Gene

HapMap Linkage Disequilibrium report
GFRA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GFRA2 Gene

Disorders for GFRA2 Gene

(3) Novoseek inferred disease relationships for GFRA2 Gene

Disease -log(P) Hits PubMed IDs
hirschsprung disease 40.6 1
retinal degeneration 37.9 2
tumors 0 1

Relevant External Links for GFRA2

Genetic Association Database (GAD)
GFRA2
Human Genome Epidemiology (HuGE) Navigator
GFRA2
genes like me logo Genes that share disorders with GFRA2: view

No data available for UniProtKB/Swiss-Prot for GFRA2 Gene

Publications for GFRA2 Gene

  1. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. (PMID: 9177201) Sanicola M. … Cate R.L. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. (PMID: 9182803) Baloh R.H. … Milbrandt J. (Neuron 1997) 3 4 23
  3. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PMID: 18521090) Lavedan C. … Polymeropoulos M.H. (Mol. Psychiatry 2009) 3 23 48
  4. Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia. (PMID: 20369355) Souza R.P. … Wong A.H. (Psychopharmacology (Berl.) 2010) 3 23 48
  5. Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. (PMID: 9259272) Suvanto P. … Saarma M. (Hum. Mol. Genet. 1997) 3 4 23

Products for GFRA2 Gene

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