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Aliases for GFI1 Gene

Aliases for GFI1 Gene

  • Growth Factor Independent 1 Transcriptional Repressor 2 3 5
  • Growth Factor Independent Protein 1 3 4
  • Zinc Finger Protein 163 3 4
  • ZNF163 3 4
  • Growth Factor Independent 1 Transcription Repressor 3
  • Growth Factor Independence-1 3
  • Growth Factor Independent 1 2
  • Zinc Finger Protein Gfi-1 3
  • GFI-1 3
  • GFI1A 3
  • SCN2 3

External Ids for GFI1 Gene

Previous HGNC Symbols for GFI1 Gene

  • ZNF163

Previous GeneCards Identifiers for GFI1 Gene

  • GC01M093408
  • GC01M092149
  • GC01M092277
  • GC01M092652
  • GC01M092712
  • GC01M092940
  • GC01M091061

Summaries for GFI1 Gene

Entrez Gene Summary for GFI1 Gene

  • This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GFI1 Gene

GFI1 (Growth Factor Independent 1 Transcriptional Repressor) is a Protein Coding gene. Diseases associated with GFI1 include Neutropenia, Severe Congenital 2, Autosomal Dominant and Neutropenia, Nonimmune Chronic Idiopathic, Of Adults. Among its related pathways are Th2 Differentiation Pathway and Development and heterogeneity of the ILC family. GO annotations related to this gene include transcription regulatory region DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is GFI1B.

UniProtKB/Swiss-Prot for GFI1 Gene

  • Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5-TAAATCAC[AT]GCA-3 in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.

Gene Wiki entry for GFI1 Gene

Additional gene information for GFI1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFI1 Gene

Genomics for GFI1 Gene

Regulatory Elements for GFI1 Gene

Enhancers for GFI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H092482 1.6 FANTOM5 ENCODE dbSUPER 3.8 +2.0 1992 5 HDGF SIN3A ARID4B DMAP1 ZNF2 ZNF143 ZNF207 SP3 MXD4 REST MTF2 FAM69A CCDC18-AS1 SNORD21 EVI5 SNORA66 GLMN CCDC18 ENSG00000189195 GFI1
GH01H091608 1.1 Ensembl ENCODE 4.8 +876.3 876336 4 GTF2F1 JUN CEBPG RAD21 BRCA1 ZKSCAN1 ZNF664 CTBP1 POLR2A EGR1 GFI1 GC01P091601 HSP90B3P
GH01H092536 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -50.8 -50795 3 HDGF PKNOX1 FOXA2 MLX DMAP1 YBX1 YY1 ATF7 RUNX3 JUNB SNORA66 EVI5 CCDC18-AS1 SNORD21 RPL5 FAM69A RPAP2 GLMN GFI1 GC01P092533
GH01H092474 1.2 Ensembl ENCODE dbSUPER 0.4 +10.6 10649 2 ZNF687 L3MBTL2 NR2F1 MAX GABPA POLR2A EED IKZF1 ZNF143 ETV6 EVI5 LOC100289500 GC01P092471 GFI1
GH01H092503 1.2 ENCODE dbSUPER 0.4 -18.2 -18194 2 ELF3 TBP FOXA2 BATF THRB RAD21 RARA YY1 SCRT2 RUNX3 FAM69A EVI5 GC01P092511 GFI1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GFI1 on UCSC Golden Path with GeneCards custom track

Promoters for GFI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009835 776 1801 HDGF ARID4B FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 SP3 MXD4 REST

Transcription factor binding sites by QIAGEN in the GFI1 gene promoter:

Genomic Location for GFI1 Gene

Chromosome:
1
Start:
92,473,043 bp from pter
End:
92,486,876 bp from pter
Size:
13,834 bases
Orientation:
Minus strand

Genomic View for GFI1 Gene

Genes around GFI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFI1 Gene

Proteins for GFI1 Gene

  • Protein details for GFI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99684-GFI1_HUMAN
    Recommended name:
    Zinc finger protein Gfi-1
    Protein Accession:
    Q99684
    Secondary Accessions:
    • Q8N564

    Protein attributes for GFI1 Gene

    Size:
    422 amino acids
    Molecular mass:
    45297 Da
    Quaternary structure:
    • Interacts with U2AF1L4. Component of RCOR-GFI-KDM1A-HDAC complexes. Interacts directly with RCOR1, KDM1A and HDAC2 (By similarity). Also interacts with HDAC1. Interacts (via the zinc-finger domain) with ARIH2; the interaction prevents GFI1 ubiquitination and proteasomal degradation. Interacts with PIAS3; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity. Forms a complex with EHMT2 and HDAC1 to promote Lys-9 dimethylation of H3 (H3K9Me2) and repress expression of target genes. Interacts directly with EHMT2. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly with AJUBA (via ITS LIM domains); the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes and, occurs independently of the SNAG domain. Interacts with SPI1; the interaction inhibits SPI1 transcriptional activity and represses SPI1-regulated macrophage-specific genes required for proper granulocyte development. Interacts with RUNX1T1; the interaction represses HDAC-mediated transcriptional activity. Interacts with RELA; the interaction occurs on liposaccharide (LPS) stimulation and controls RELA DNA binding activity and regulates endotoxin-mediated TOLL-like receptor inflammatory response. Interacts (via the C-terminal zinc fingers) with ZBTB17; the interaction results in the recruitment of GFI1 to the CDKN1A/p21 and CDKN1B promoters and repression of transcription.

neXtProt entry for GFI1 Gene

Post-translational modifications for GFI1 Gene

  • Ubiquitinated. Ubiquitination and degradation by the proteasome is inhibited by the ubiquitin ligase, ARIH2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GFI1 Gene

Antibody Products

  • Abcam antibodies for GFI1

No data available for DME Specific Peptides for GFI1 Gene

Domains & Families for GFI1 Gene

Gene Families for GFI1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for GFI1 Gene

Suggested Antigen Peptide Sequences for GFI1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99684

UniProtKB/Swiss-Prot:

GFI1_HUMAN :
  • Zinc fingers 3, 4 and 5 are required for DNA-binding and for interaction with SPI1.
Domain:
  • Zinc fingers 3, 4 and 5 are required for DNA-binding and for interaction with SPI1.
  • The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors.
genes like me logo Genes that share domains with GFI1: view

Function for GFI1 Gene

Molecular function for GFI1 Gene

GENATLAS Biochemistry:
growth factor independence 1 (independent from IL2 for growth),expressed in bone marrow,associated with a constitutional translocation from a patient with stage 4S neuroblastoma
UniProtKB/Swiss-Prot Function:
Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5-TAAATCAC[AT]GCA-3 in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.

Phenotypes From GWAS Catalog for GFI1 Gene

Gene Ontology (GO) - Molecular Function for GFI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 19506020
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 11060035
GO:0044212 transcription regulatory region DNA binding IDA 15947108
genes like me logo Genes that share ontologies with GFI1: view
genes like me logo Genes that share phenotypes with GFI1: view

Human Phenotype Ontology for GFI1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GFI1 Gene

MGI Knock Outs for GFI1:

Animal Model Products

CRISPR Products

miRNA for GFI1 Gene

miRTarBase miRNAs that target GFI1

Transcription Factor Targets for GFI1 Gene

Selected GeneGlobe predicted Target genes for GFI1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GFI1
  • Applied Biological Materials Clones for GFI1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for GFI1 Gene

Localization for GFI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFI1 Gene

Nucleus. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GFI1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GFI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12874834
GO:0016363 nuclear matrix IDA 12874834
GO:0016604 nuclear body IDA 11060035
GO:0017053 transcriptional repressor complex IDA 12874834
genes like me logo Genes that share ontologies with GFI1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GFI1 Gene

Pathways & Interactions for GFI1 Gene

genes like me logo Genes that share pathways with GFI1: view

Gene Ontology (GO) - Biological Process for GFI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS 8441411
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15947108
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity IDA 15947108
genes like me logo Genes that share ontologies with GFI1: view

No data available for SIGNOR curated interactions for GFI1 Gene

Drugs & Compounds for GFI1 Gene

(2) Drugs for GFI1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GFI1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GFI1: view

Transcripts for GFI1 Gene

Unigene Clusters for GFI1 Gene

Growth factor independent 1 transcription repressor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GFI1
  • Applied Biological Materials Clones for GFI1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GFI1 Gene

No ASD Table

Relevant External Links for GFI1 Gene

GeneLoc Exon Structure for
GFI1
ECgene alternative splicing isoforms for
GFI1

Expression for GFI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GFI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GFI1 Gene

This gene is overexpressed in Whole Blood (x8.7), Pancreas (x7.2), Spleen (x4.7), and Small Intestine - Terminal Ileum (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of GFI1 Gene:

GFI1

SOURCE GeneReport for Unigene cluster for GFI1 Gene:

Hs.73172

Evidence on tissue expression from TISSUES for GFI1 Gene

  • Bone marrow(4.5)
  • Lung(4.3)
  • Blood(2)
  • Nervous system(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GFI1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • lymphatic
  • nervous
Organs:
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • red blood cell
  • white blood cell
genes like me logo Genes that share expression patterns with GFI1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GFI1 Gene

Orthologs for GFI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GFI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GFI1 34 33
  • 99.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GFI1 33 34
  • 90.05 (n)
cow
(Bos Taurus)
Mammalia GFI1 33 34
  • 89.44 (n)
rat
(Rattus norvegicus)
Mammalia Gfi1 33
  • 85.15 (n)
mouse
(Mus musculus)
Mammalia Gfi1 34 16 33
  • 84.76 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GFI1 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GFI1 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GFI1 33 34
  • 73.91 (n)
lizard
(Anolis carolinensis)
Reptilia GFI1 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gfi1 33
  • 69.03 (n)
zebrafish
(Danio rerio)
Actinopterygii gfi1ab 33 34
  • 64.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ly 35
  • 86 (a)
sens-2 34
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pag-3 35 34
  • 76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 77 (a)
OneToMany
Species where no ortholog for GFI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GFI1 Gene

ENSEMBL:
Gene Tree for GFI1 (if available)
TreeFam:
Gene Tree for GFI1 (if available)

Paralogs for GFI1 Gene

Paralogs for GFI1 Gene

(273) SIMAP similar genes for GFI1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GFI1: view

Variants for GFI1 Gene

Sequence variations from dbSNP and Humsavar for GFI1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs28936381 Pathogenic, Neutropenia, severe congenital 2, autosomal dominant (SCN2) [MIM:613107] 92,476,153(-) CTCCA(A/G)CCTCA reference, missense
rs28936382 Pathogenic, Dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847] 92,476,090(-) TGGGA(A/G)GGGTT reference, missense
rs114487177 Likely benign 92,480,480(+) GTGGA(A/G)AACAC reference, synonymous-codon
rs116093836 Likely benign 92,475,037(+) TTTGT(C/T)TACAC utr-variant-3-prime
rs139144506 Likely benign 92,478,646(+) CCACA(A/G)TACTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GFI1 Gene

Variant ID Type Subtype PubMed ID
dgv126n106 CNV deletion 24896259
esv2714684 CNV deletion 23290073
nsv523354 CNV gain 19592680

Variation tolerance for GFI1 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GFI1 Gene

Human Gene Mutation Database (HGMD)
GFI1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GFI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GFI1 Gene

Disorders for GFI1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for GFI1 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neutropenia, severe congenital 2, autosomal dominant
  • severe congenital neutropenia, autosomal dominant, 2
neutropenia, nonimmune chronic idiopathic, of adults
  • ni-cina
idiopathic neutropenia
  • ni-cina
severe congenital neutropenia autosomal dominant
  • autosomal dominant severe congenital neutropenia
neutropenia
  • leukopenia
- elite association - COSMIC cancer census association via MalaCards
Search GFI1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GFI1_HUMAN
  • Dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847]: Relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients. {ECO:0000269 PubMed:12778173}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Neutropenia, severe congenital 2, autosomal dominant (SCN2) [MIM:613107]: A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. {ECO:0000269 PubMed:12778173}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GFI1

Genetic Association Database (GAD)
GFI1
Human Genome Epidemiology (HuGE) Navigator
GFI1
Tumor Gene Database (TGDB):
GFI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GFI1
genes like me logo Genes that share disorders with GFI1: view

No data available for Genatlas for GFI1 Gene

Publications for GFI1 Gene

  1. A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A. (PMID: 20190815) Liu Q … Dong F (Oncogene 2010) 3 4 22 60
  2. A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia. (PMID: 20075157) Khandanpour C … Möröy T (Blood 2010) 3 22 45 60
  3. Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. (PMID: 19164764) Basu S … Dong F (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 22 60
  4. Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth. (PMID: 19026687) Ossovskaya VS … Basbaum AI (Journal of neuroscience methods 2009) 3 4 22 60
  5. Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. (PMID: 18805794) Montoya-Durango DE … Grimes HL (The Journal of biological chemistry 2008) 3 4 22 60

Products for GFI1 Gene

  • Addgene plasmids for GFI1

Sources for GFI1 Gene

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