External Ids for GDF9 Gene
Previous GeneCards Identifiers for GDF9 Gene
This gene encodes a member of the transforming growth factor-beta superfamily. The encoded preproprotein is processed into a secreted factor that is required for ovarian folliculogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for GDF9 Gene
GDF9 (Growth Differentiation Factor 9) is a Protein Coding gene. Diseases associated with GDF9 include ovarian disease and premature ovarian failure. Among its related pathways are Ovarian steroidogenesis and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is GDF10.
UniProtKB/Swiss-Prot for GDF9 Gene
Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.