External Ids for MSTN Gene
Previous HGNC Symbols for MSTN Gene
Previous GeneCards Identifiers for MSTN Gene
This gene encodes a member of the TGF-beta (transforming growth factor-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate an N-terminal propeptide and a C-terminal subunit. The C-terminal subunits form the mature homodimer, which negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Nov 2015]
GeneCards Summary for MSTN Gene
MSTN (Myostatin) is a Protein Coding gene. Diseases associated with MSTN include Muscle Hypertrophy and Myostatin-Related Muscle Hypertrophy. Among its related pathways are Hypertrophy Model and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include identical protein binding and cytokine activity. An important paralog of this gene is INHBB.
UniProtKB/Swiss-Prot for MSTN Gene
Acts specifically as a negative regulator of skeletal muscle growth.