Aliases for MSTN Gene
External Ids for MSTN Gene
Previous HGNC Symbols for MSTN Gene
Previous GeneCards Identifiers for MSTN Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]
GeneCards Summary for MSTN Gene
MSTN (Myostatin) is a Protein Coding gene. Diseases associated with MSTN include Muscle Hypertrophy and Myostatin-Related Muscle Hypertrophy. Among its related pathways are Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling and Hypertrophy Model. GO annotations related to this gene include identical protein binding and cytokine activity. An important paralog of this gene is GDF11.
UniProtKB/Swiss-Prot for MSTN Gene
Acts specifically as a negative regulator of skeletal muscle growth.