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Aliases for AATF Gene

Aliases for AATF Gene

  • Apoptosis Antagonizing Transcription Factor 2 3
  • CHE1 3 4 6
  • Apoptosis-Antagonizing Transcription Factor 3 4
  • Rb-Binding Protein Che-1 3 4
  • DED 3 4
  • Protein AATF 3
  • CHE-1 3
  • BFR2 3

External Ids for AATF Gene

Summaries for AATF Gene

Entrez Gene Summary for AATF Gene

  • The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AATF Gene

AATF (Apoptosis Antagonizing Transcription Factor) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and tau protein binding.

UniProtKB/Swiss-Prot for AATF Gene

  • May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Gene Wiki entry for AATF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AATF Gene

Genomics for AATF Gene

Genomic Location for AATF Gene

Start:
36,948,875 bp from pter
End:
37,056,871 bp from pter
Size:
107,997 bases
Orientation:
Plus strand

Genomic View for AATF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AATF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AATF Gene

Regulatory Elements for AATF Gene

Proteins for AATF Gene

  • Protein details for AATF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY61-AATF_HUMAN
    Recommended name:
    Protein AATF
    Protein Accession:
    Q9NY61
    Secondary Accessions:
    • A6NCJ6
    • B3KQ26
    • Q9P0A4
    • Q9UNX5

    Protein attributes for AATF Gene

    Size:
    560 amino acids
    Molecular mass:
    63133 Da
    Quaternary structure:
    • Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT
    SequenceCaution:
    • Sequence=AAD52016.1; Type=Frameshift; Positions=355, 365, 487, 498, 503; Evidence={ECO:0000305};

neXtProt entry for AATF Gene

Proteomics data for AATF Gene at MOPED

Post-translational modifications for AATF Gene

  • Hyperphosphorylated during the G1/S phase transition
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys159, Lys228, Lys246, Lys403, Lys475, Lys496, and Lys522

Other Protein References for AATF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AATF Gene

Domains for AATF Gene

Protein Domains for AATF Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

AATF_HUMAN
Family:
  • Belongs to the AATF family.:
    • Q9NY61
genes like me logo Genes that share domains with AATF: view

No data available for Gene Families for AATF Gene

Function for AATF Gene

Molecular function for AATF Gene

UniProtKB/Swiss-Prot Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Gene Ontology (GO) - Molecular Function for AATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 10580117
GO:0005515 protein binding IPI 10783144
GO:0019904 protein domain specific binding --
GO:0043522 leucine zipper domain binding IPI 10580117
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with AATF: view
genes like me logo Genes that share phenotypes with AATF: view

miRNA for AATF Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AATF Gene

Localization for AATF Gene

Subcellular locations from UniProtKB/Swiss-Prot for AATF Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AATF Gene COMPARTMENTS Subcellular localization image for AATF gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
golgi apparatus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 14627703
GO:0005794 Golgi apparatus IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with AATF: view

Pathways for AATF Gene

genes like me logo Genes that share pathways with AATF: view

Gene Ontology (GO) - Biological Process for AATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IEP 18049476
GO:0007155 cell adhesion IEA --
GO:0007346 regulation of mitotic cell cycle IEA --
GO:0032929 negative regulation of superoxide anion generation IDA 15207272
GO:0040016 embryonic cleavage IEA --
genes like me logo Genes that share ontologies with AATF: view

Compounds for AATF Gene

(2) Novoseek inferred chemical compound relationships for AATF Gene

Compound -log(P) Hits PubMed IDs
leucine 35.6 2
doxorubicin 34.9 1
genes like me logo Genes that share compounds with AATF: view

Transcripts for AATF Gene

Unigene Clusters for AATF Gene

Apoptosis antagonizing transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AATF Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: -
SP2: - - -
SP3:
SP4: - -
SP5:

Relevant External Links for AATF Gene

GeneLoc Exon Structure for
AATF
ECgene alternative splicing isoforms for
AATF

Expression for AATF Gene

mRNA expression in normal human tissues for AATF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for AATF Gene

SOURCE GeneReport for Unigene cluster for AATF Gene Hs.195740

mRNA Expression by UniProt/SwissProt for AATF Gene

Q9NY61-AATF_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
genes like me logo Genes that share expressions with AATF: view

Orthologs for AATF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AATF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AATF 36
  • 99.52 (n)
  • 99.64 (a)
cow
(Bos Taurus)
Mammalia AATF 36
  • 85.66 (n)
  • 85.84 (a)
dog
(Canis familiaris)
Mammalia AATF 36
  • 87.85 (n)
  • 87.97 (a)
mouse
(Mus musculus)
Mammalia Aatf 36
  • 83.17 (n)
  • 82.86 (a)
Aatf 16
rat
(Rattus norvegicus)
Mammalia Aatf 36
  • 83.52 (n)
  • 83.91 (a)
chicken
(Gallus gallus)
Aves AATF 36
  • 68.89 (n)
  • 66.23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7093 36
tropical clawed frog
(Silurana tropicalis)
Amphibia aatf 36
  • 64.73 (n)
  • 63.93 (a)
Str.10137 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13361 36
zebrafish
(Danio rerio)
Actinopterygii aatf 36
  • 60.93 (n)
  • 58.79 (a)
sbcb109 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007394 36
  • 47.27 (n)
  • 36.85 (a)
worm
(Caenorhabditis elegans)
Secernentea Y73E7A.2 36
  • 42.16 (n)
  • 33.99 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G61330 36
  • 46.06 (n)
  • 37.19 (a)
rice
(Oryza sativa)
Liliopsida Os01g0526200 36
  • 45.77 (n)
  • 37.69 (a)
Species with no ortholog for AATF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AATF Gene

ENSEMBL:
Gene Tree for AATF (if available)
TreeFam:
Gene Tree for AATF (if available)

Paralogs for AATF Gene

No data available for Paralogs for AATF Gene

Variants for AATF Gene

Sequence variations from dbSNP and Humsavar for AATF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs730003 -- 37,017,495(+) GGATT(G/T)GGATC intron-variant
rs873950 -- 37,020,629(-) GAGCT(A/G)CTTGG intron-variant
rs873951 -- 37,020,386(-) TATAA(A/G)TATTT intron-variant
rs972518 -- 37,031,261(+) TTTAC(A/G)TAGCA intron-variant
rs1001814 -- 36,948,490(-) GGATA(C/T)GCACG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AATF Gene

Variant ID Type Subtype PubMed ID
nsv833430 CNV Gain+Loss 17160897
esv2457233 CNV Deletion 19546169
esv2715886 CNV Deletion 23290073
esv2315584 CNV Deletion 18987734
esv1366836 CNV Deletion 17803354
nsv112350 CNV Insertion 16902084
nsv112468 CNV Insertion 16902084

Relevant External Links for AATF Gene

HapMap Linkage Disequilibrium report
AATF

Disorders for AATF Gene

Relevant External Links for AATF

Genetic Association Database (GAD)
AATF
Human Genome Epidemiology (HuGE) Navigator
AATF
genes like me logo Genes that share disorders with AATF: view

No data available for UniProtKB/Swiss-Prot for AATF Gene

Publications for AATF Gene

  1. Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. (PMID: 10783144) Fanciulli M. … Passananti C. (FASEB J. 2000) 2 3 4 23
  2. AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. (PMID: 14627703) Guo Q. … Xie J. (J. Biol. Chem. 2004) 3 4 23
  3. Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis. (PMID: 14697667) Barbato C. … Passananti C. (Mol. Cell. Neurosci. 2003) 3 4 23
  4. AATF protects neural cells against oxidative damage induced by amyloid beta-peptide. (PMID: 15207272) Xie J. … Guo Q. (Neurobiol. Dis. 2004) 3 4 23
  5. Identification of novel transcription factor-like gene from human intestinal cells. (PMID: 11027528) Lindfors K. … Kainulainen H. (Biochem. Biophys. Res. Commun. 2000) 2 3 4

Products for AATF Gene

Sources for AATF Gene

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