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Aliases for DAZAP1 Gene

Aliases for DAZAP1 Gene

  • DAZ Associated Protein 1 2 3
  • Deleted In Azoospermia Associated Protein 1 2
  • Deleted In Azoospermia-Associated Protein 1 4

External Ids for DAZAP1 Gene

Previous GeneCards Identifiers for DAZAP1 Gene

  • GC19P001465
  • GC19P001347
  • GC19P001359
  • GC19P001360
  • GC19P001361
  • GC19P001170

Summaries for DAZAP1 Gene

Entrez Gene Summary for DAZAP1 Gene

  • In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAZAP1 Gene

DAZAP1 (DAZ Associated Protein 1) is a Protein Coding gene. Diseases associated with DAZAP1 include azoospermia. Among its related pathways are mRNA surveillance pathway. GO annotations related to this gene include RNA binding and RNA stem-loop binding. An important paralog of this gene is MSI1.

UniProtKB/Swiss-Prot for DAZAP1 Gene

  • RNA-binding protein, which may be required during spermatogenesis

Gene Wiki entry for DAZAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAZAP1 Gene

Genomics for DAZAP1 Gene

Regulatory Elements for DAZAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DAZAP1 Gene

Start:
1,407,569 bp from pter
End:
1,435,687 bp from pter
Size:
28,119 bases
Orientation:
Plus strand

Genomic View for DAZAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAZAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAZAP1 Gene

Proteins for DAZAP1 Gene

  • Protein details for DAZAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EP5-DAZP1_HUMAN
    Recommended name:
    DAZ-associated protein 1
    Protein Accession:
    Q96EP5
    Secondary Accessions:
    • Q96MJ3
    • Q9NRR9

    Protein attributes for DAZAP1 Gene

    Size:
    407 amino acids
    Molecular mass:
    43383 Da
    Quaternary structure:
    • Interacts with DAZ and DAZL.
    SequenceCaution:
    • Sequence=BAB71295.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DAZAP1 Gene

    Alternative splice isoforms for DAZAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAZAP1 Gene

Proteomics data for DAZAP1 Gene at MOPED

Post-translational modifications for DAZAP1 Gene

  • Acetylation at Lys-150 is predominantly observed in the nuclear fraction, and may regulate nucleocytoplasmic transport.
  • Ubiquitination at Lys59, Lys150, and Lys194
  • Modification sites at PhosphoSitePlus

Other Protein References for DAZAP1 Gene

Antibody Products

No data available for DME Specific Peptides for DAZAP1 Gene

Domains for DAZAP1 Gene

Gene Families for DAZAP1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for DAZAP1 Gene

Suggested Antigen Peptide Sequences for DAZAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96EP5

UniProtKB/Swiss-Prot:

DAZP1_HUMAN :
  • Q96EP5
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with DAZAP1: view

Function for DAZAP1 Gene

Molecular function for DAZAP1 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein, which may be required during spermatogenesis

Gene Ontology (GO) - Molecular Function for DAZAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 10857750
GO:0035613 RNA stem-loop binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DAZAP1: view
genes like me logo Genes that share phenotypes with DAZAP1: view

Animal Models for DAZAP1 Gene

MGI Knock Outs for DAZAP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAZAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DAZAP1 Gene

Localization for DAZAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAZAP1 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic (By similarity). Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAZAP1 Gene COMPARTMENTS Subcellular localization image for DAZAP1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for DAZAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with DAZAP1: view

Pathways for DAZAP1 Gene

SuperPathways for DAZAP1 Gene

Superpath Contained pathways
1 mRNA surveillance pathway
genes like me logo Genes that share pathways with DAZAP1: view

Pathways by source for DAZAP1 Gene

1 KEGG pathway for DAZAP1 Gene

Gene Ontology (GO) - Biological Process for DAZAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001893 maternal placenta development IEA --
GO:0007283 spermatogenesis IEA --
GO:0008283 cell proliferation IEA --
GO:0030154 cell differentiation IEA --
GO:0048026 positive regulation of mRNA splicing, via spliceosome IEA --
genes like me logo Genes that share ontologies with DAZAP1: view

Transcripts for DAZAP1 Gene

Unigene Clusters for DAZAP1 Gene

DAZ associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAZAP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DAZAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAZAP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1:
SP2: - - -
SP3: - - -
SP4: -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - -
SP9: -
SP10: -

Relevant External Links for DAZAP1 Gene

GeneLoc Exon Structure for
DAZAP1
ECgene alternative splicing isoforms for
DAZAP1

Expression for DAZAP1 Gene

mRNA expression in normal human tissues for DAZAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DAZAP1 Gene

SOURCE GeneReport for Unigene cluster for DAZAP1 Gene Hs.222510

mRNA Expression by UniProt/SwissProt for DAZAP1 Gene

Q96EP5-DAZP1_HUMAN
Tissue specificity: Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with DAZAP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DAZAP1 Gene

Orthologs for DAZAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAZAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAZAP1 35
  • 99.33 (n)
  • 100 (a)
DAZAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DAZAP1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAZAP1 35
  • 92.96 (n)
  • 99.51 (a)
DAZAP1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dazap1 16
Dazap1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DAZAP1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAZAP1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAZAP1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAZAP1 36
  • 99 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dazap1 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hrb27C 36
  • 37 (a)
OneToOne
Hrb27C 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea H28G03.1 36
  • 21 (a)
ManyToMany
sqd-1 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2449 36
  • 52 (a)
OneToMany
CSA.9650 36
  • 35 (a)
OneToMany
Species with no ortholog for DAZAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DAZAP1 Gene

ENSEMBL:
Gene Tree for DAZAP1 (if available)
TreeFam:
Gene Tree for DAZAP1 (if available)

Paralogs for DAZAP1 Gene

Paralogs for DAZAP1 Gene

genes like me logo Genes that share paralogs with DAZAP1: view

Variants for DAZAP1 Gene

Sequence variations from dbSNP and Humsavar for DAZAP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs265264 -- 1,423,052(+) CGCCC(A/G)CATGG intron-variant
rs265265 -- 1,420,085(+) ACGGC(A/G)GCGAG intron-variant
rs265266 -- 1,419,892(+) CACGC(A/G)CACAC intron-variant
rs265270 -- 1,413,249(+) CTGCC(C/T)GCGCC intron-variant
rs265271 -- 1,410,494(+) ACGCG(A/C)GATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAZAP1 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
dgv1055e1 CNV Complex 17122850
dgv3580n71 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3588n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3595n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
dgv3598n71 CNV Loss 21882294
nsv910489 CNV Loss 21882294
nsv910491 CNV Gain+Loss 21882294
nsv910492 CNV Loss 21882294
dgv3599n71 CNV Loss 21882294
nsv910494 CNV Loss 21882294
essv18235 CNV CNV 17122850
nsv833705 CNV Loss 17160897
nsv910499 CNV Loss 21882294
nsv910500 CNV Loss 21882294
nsv828374 CNV Gain 20364138
nsv828375 CNV Loss 20364138
dgv3600n71 CNV Loss 21882294
dgv3601n71 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
nsv910507 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
nsv828377 CNV Loss 20364138

Relevant External Links for DAZAP1 Gene

HapMap Linkage Disequilibrium report
DAZAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAZAP1 Gene

Disorders for DAZAP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DAZAP1 Gene including...

Search for DAZAP1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for DAZAP1 Gene

Disease -log(P) Hits PubMed IDs
azoospermia 78.6 3

Relevant External Links for DAZAP1

Genetic Association Database (GAD)
DAZAP1
genes like me logo Genes that share disorders with DAZAP1: view

No data available for UniProtKB/Swiss-Prot for DAZAP1 Gene

Publications for DAZAP1 Gene

  1. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PMID: 10857750) Tsui S. … Yen P.H. (Genomics 2000) 2 3 4
  2. DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins. (PMID: 19285026) Yang H.T. … Rousseau S. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. (PMID: 11604102) Dai T. … Yen P.H. (BMC Genomics 2001) 3 23
  4. Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. (PMID: 15744350) Prima V. … Hunger S.P. (Leukemia 2005) 3 23
  5. Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. (PMID: 16209998) Pan H.A. … Kuo P.L. (Fertil. Steril. 2005) 3 23

Products for DAZAP1 Gene

Sources for DAZAP1 Gene

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