Aliases for AGO1 Gene
External Ids for AGO1 Gene
Previous HGNC Symbols for AGO1 Gene
Previous GeneCards Identifiers for AGO1 Gene
This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]
GeneCards Summary for AGO1 Gene
AGO1 (Argonaute RISC Catalytic Component 1) is a Protein Coding gene. Diseases associated with AGO1 include fungal meningitis and swine influenza. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is AGO2.
UniProtKB/Swiss-Prot for AGO1 Gene
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).