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Aliases for AGO1 Gene

Aliases for AGO1 Gene

  • Argonaute 1, RISC Catalytic Component 2 3 5
  • Argonaute RISC Catalytic Component 1 2 3 4
  • Eukaryotic Translation Initiation Factor 2C, 1 2 3
  • Putative RNA-Binding Protein Q99 3 4
  • Argonaute 1 2 3
  • Argonaute1 3 4
  • EIF-2C 1 3 4
  • EIF2C 1 3 4
  • EIF2C1 3 4
  • HAgo1 3 4
  • Eukaryotic Translation Initiation Factor 2C 1 4
  • Golgi Endoplasmic Reticulum Protein 95 KDa 3
  • GERP95 3
  • EIF2C 3
  • Q99 3

External Ids for AGO1 Gene

Previous HGNC Symbols for AGO1 Gene

  • EIF2C1

Previous GeneCards Identifiers for AGO1 Gene

  • GC01P036336

Summaries for AGO1 Gene

Entrez Gene Summary for AGO1 Gene

  • This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

GeneCards Summary for AGO1 Gene

AGO1 (Argonaute 1, RISC Catalytic Component) is a Protein Coding gene. Diseases associated with AGO1 include fungal meningitis and swine influenza. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot for AGO1 Gene

  • Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

Gene Wiki entry for AGO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGO1 Gene

Genomics for AGO1 Gene

Regulatory Elements for AGO1 Gene

Promoters for AGO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AGO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AGO1 Gene

Chromosome:
1
Start:
35,869,791 bp from pter
End:
35,930,528 bp from pter
Size:
60,738 bases
Orientation:
Plus strand

Genomic View for AGO1 Gene

Genes around AGO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGO1 Gene

Proteins for AGO1 Gene

  • Protein details for AGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL18-AGO1_HUMAN
    Recommended name:
    Protein argonaute-1
    Protein Accession:
    Q9UL18
    Secondary Accessions:
    • Q5TA57
    • Q6P4S0

    Protein attributes for AGO1 Gene

    Size:
    857 amino acids
    Molecular mass:
    97214 Da
    Quaternary structure:
    • Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
    Miscellaneous:
    • Lacks RNA cleavage activity due to the absence of the conserved His at position 805, but also because it binds the RNA in a subtly different manner that precludes efficient cleavage.

    Three dimensional structures from OCA and Proteopedia for AGO1 Gene

neXtProt entry for AGO1 Gene

Proteomics data for AGO1 Gene at MOPED

Post-translational modifications for AGO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGO1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AGO1 (AGO1)

No data available for DME Specific Peptides for AGO1 Gene

Domains & Families for AGO1 Gene

Gene Families for AGO1 Gene

Suggested Antigen Peptide Sequences for AGO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL18

UniProtKB/Swiss-Prot:

AGO1_HUMAN :
  • Contains 1 PAZ domain.
  • Belongs to the argonaute family. Ago subfamily.
Domain:
  • Contains 1 PAZ domain.
  • Contains 1 Piwi domain.
Family:
  • Belongs to the argonaute family. Ago subfamily.
genes like me logo Genes that share domains with AGO1: view

Function for AGO1 Gene

Molecular function for AGO1 Gene

UniProtKB/Swiss-Prot Function:
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

Gene Ontology (GO) - Molecular Function for AGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 23809764
GO:0044212 transcription regulatory region DNA binding IEA --
genes like me logo Genes that share ontologies with AGO1: view
genes like me logo Genes that share phenotypes with AGO1: view

Animal Models for AGO1 Gene

MGI Knock Outs for AGO1:
  • Ago1 tm1a(KOMP)Wtsi

Animal Model Products

miRNA for AGO1 Gene

miRTarBase miRNAs that target AGO1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGO1 Gene

Localization for AGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGO1 Gene

Cytoplasm, P-body.

Gene Ontology (GO) - Cellular Components for AGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005844 polysome IDA 17932509
GO:0030529 intracellular ribonucleoprotein complex IDA 17932509
genes like me logo Genes that share ontologies with AGO1: view

No data available for Subcellular locations from COMPARTMENTS for AGO1 Gene

Pathways & Interactions for AGO1 Gene

genes like me logo Genes that share pathways with AGO1: view

Pathways by source for AGO1 Gene

Gene Ontology (GO) - Biological Process for AGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007219 Notch signaling pathway TAS --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0010501 RNA secondary structure unwinding IMP 22795694
GO:0010586 miRNA metabolic process IEA --
genes like me logo Genes that share ontologies with AGO1: view

No data available for SIGNOR curated interactions for AGO1 Gene

Drugs & Compounds for AGO1 Gene

No Compound Related Data Available

Transcripts for AGO1 Gene

Unigene Clusters for AGO1 Gene

Argonaute RISC catalytic component 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGO1 Gene

No ASD Table

Relevant External Links for AGO1 Gene

GeneLoc Exon Structure for
AGO1
ECgene alternative splicing isoforms for
AGO1

Expression for AGO1 Gene

mRNA expression in normal human tissues for AGO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AGO1 Gene

This gene is overexpressed in Lymph node (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AGO1 Gene



SOURCE GeneReport for Unigene cluster for AGO1 Gene Hs.22867

genes like me logo Genes that share expression patterns with AGO1: view

Protein tissue co-expression partners for AGO1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AGO1 Gene

Orthologs for AGO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF2C1 35
  • 95.33 (n)
  • 99.88 (a)
EIF2C1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGO1 35
  • 95.64 (n)
  • 100 (a)
AGO1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ago1 35
  • 93.5 (n)
  • 100 (a)
Ago1 16
Ago1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF2C1 35
  • 99.81 (n)
  • 100 (a)
EIF2C1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ago1 35
  • 93.39 (n)
  • 99.88 (a)
oppossum
(Monodelphis domestica)
Mammalia AGO1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGO1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF2C1 35
  • 83.94 (n)
  • 99.88 (a)
AGO1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGO1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ago4 35
  • 80.98 (n)
  • 98.25 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570775 35
  • 80.71 (n)
  • 96.92 (a)
AGO1 36
  • 96 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11707 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5272 35
Species with no ortholog for AGO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGO1 Gene

ENSEMBL:
Gene Tree for AGO1 (if available)
TreeFam:
Gene Tree for AGO1 (if available)

Paralogs for AGO1 Gene

Paralogs for AGO1 Gene

(5) SIMAP similar genes for AGO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AGO1: view

Variants for AGO1 Gene

Sequence variations from dbSNP and Humsavar for AGO1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs595055 -- 35,914,532(-) AAAGA(A/G)AGACA intron-variant
rs595961 -- 35,902,179(+) CACCT(A/G)GGCGC intron-variant
rs647690 -- 35,898,381(+) cctcc(C/G)gagta intron-variant
rs581459 -- 35,909,509(+) TTGCC(C/T)GGAGT intron-variant
rs636832 -- 35,897,874(+) ctcct(A/G)aaaga intron-variant

Variation tolerance for AGO1 Gene

Residual Variation Intolerance Score: 2.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGO1 Gene

HapMap Linkage Disequilibrium report
AGO1
Human Gene Mutation Database (HGMD)
AGO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AGO1 Gene

Disorders for AGO1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AGO1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fungal meningitis
  • meningitis, fungal
swine influenza
  • influenza due to influenza a virus subtype h1n1
- elite association - COSMIC cancer census association via MalaCards
Search AGO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AGO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGO1
genes like me logo Genes that share disorders with AGO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AGO1 Gene

Publications for AGO1 Gene

  1. Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. (PMID: 10534406) Koesters R. … Briner J. (Genomics 1999) 2 3 4 67
  2. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PMID: 19047128) Horikawa Y. … Wu X. (Clin. Cancer Res. 2008) 3 23
  3. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. (PMID: 16756390) Chu C.-Y. … Rana T.M. (PLoS Biol. 2006) 3 23
  4. Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T. … Shimizu N. (Genomics 2003) 2 3
  5. Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. (PMID: 12526743) Doi N. … Saigo K. (Curr. Biol. 2003) 3 23

Products for AGO1 Gene

Sources for AGO1 Gene

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