External Ids for GCGR Gene
Previous GeneCards Identifiers for GCGR Gene
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
GeneCards Summary for GCGR Gene
GCGR (Glucagon Receptor) is a Protein Coding gene. Diseases associated with GCGR include diabetes mellitus, noninsulin-dependent and hyperglycemia. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and glucagon receptor activity. An important paralog of this gene is VIPR2.
UniProtKB/Swiss-Prot for GCGR Gene
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Glucagon receptors are members of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. Glucagon receptors regulate blood glucose levels via control of hepatic glycogenolysis and gluconeogenesis and via regulation of insulin release from the beta-cells of the pancreatic islets. Glucagon receptors are predominantly expressed in the pancreas, liver and kidneys, but are also found to a lesser extent in the heart, adipose tissue, spleen, thymus and adrenal glands. The human glucagon receptor gene is localized on chromosome 17q25.