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Aliases for HSPB8 Gene

Aliases for HSPB8 Gene

  • Heat Shock Protein Family B (Small) Member 8 2 3 5
  • Small Stress Protein-Like Protein HSP22 3 4
  • Heat Shock 27kDa Protein 8 2 3
  • Heat Shock 22kDa Protein 8 2 3
  • E2-Induced Gene 1 Protein 3 4
  • Alpha-Crystallin C Chain 3 4
  • Protein Kinase H11 3 4
  • E2IG1 3 4
  • HSP22 3 4
  • CMT2L 3
  • DHMN2 3
  • HMN2A 3
  • CRYAC 4
  • HspB8 4
  • HMN2 3
  • H11 3

External Ids for HSPB8 Gene

Previous GeneCards Identifiers for HSPB8 Gene

  • GC12P118028
  • GC12P118079
  • GC12P119616
  • GC12P116624

Summaries for HSPB8 Gene

Entrez Gene Summary for HSPB8 Gene

  • The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPB8 Gene

HSPB8 (Heat Shock Protein Family B (Small) Member 8) is a Protein Coding gene. Diseases associated with HSPB8 include Neuropathy, Distal Hereditary Motor, Type Iia and Charcot-Marie-Tooth Disease, Axonal, Type 2L. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is HSPB6.

UniProtKB/Swiss-Prot for HSPB8 Gene

  • Displays temperature-dependent chaperone activity.

Gene Wiki entry for HSPB8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB8 Gene

Genomics for HSPB8 Gene

Regulatory Elements for HSPB8 Gene

Enhancers for HSPB8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPB8 on UCSC Golden Path with GeneCards custom track

Promoters for HSPB8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPB8 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPB8 Gene

119,178,642 bp from pter
119,221,131 bp from pter
42,490 bases
Plus strand

Genomic View for HSPB8 Gene

Genes around HSPB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB8 Gene

Proteins for HSPB8 Gene

  • Protein details for HSPB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-8
    Protein Accession:
    Secondary Accessions:
    • B2R6A6
    • Q6FIH3
    • Q9UKS3

    Protein attributes for HSPB8 Gene

    196 amino acids
    Molecular mass:
    21604 Da
    Quaternary structure:
    • Monomer. Interacts with HSPB1. Interacts with DNAJB6.

neXtProt entry for HSPB8 Gene

Proteomics data for HSPB8 Gene at MOPED

Post-translational modifications for HSPB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HSPB8 (HSPB8)

No data available for DME Specific Peptides for HSPB8 Gene

Domains & Families for HSPB8 Gene

Gene Families for HSPB8 Gene

Protein Domains for HSPB8 Gene

Suggested Antigen Peptide Sequences for HSPB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB8: view

Function for HSPB8 Gene

Molecular function for HSPB8 Gene

UniProtKB/Swiss-Prot Function:
Displays temperature-dependent chaperone activity.
UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol.
genes like me logo Genes that share phenotypes with HSPB8: view

Human Phenotype Ontology for HSPB8 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HSPB8 Gene

MGI Knock Outs for HSPB8:

Animal Model Products

  • Taconic Biosciences Mouse Models for HSPB8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for HSPB8 Gene

Localization for HSPB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB8 Gene

Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.

Subcellular locations from

Jensen Localization Image for HSPB8 Gene COMPARTMENTS Subcellular localization image for HSPB8 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 4
chloroplast 2
mitochondrion 2
cytoskeleton 1
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HSPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19464326
genes like me logo Genes that share ontologies with HSPB8: view

Pathways & Interactions for HSPB8 Gene

SuperPathways for HSPB8 Gene

No Data Available

SIGNOR curated interactions for HSPB8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HSPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HSPB8: view

No data available for Pathways by source for HSPB8 Gene

Drugs & Compounds for HSPB8 Gene

(1) Additional Compounds for HSPB8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPB8: view

Transcripts for HSPB8 Gene

mRNA/cDNA for HSPB8 Gene

Unigene Clusters for HSPB8 Gene

Heat shock 22kDa protein 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB8 Gene

No ASD Table

Relevant External Links for HSPB8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB8 Gene

mRNA expression in normal human tissues for HSPB8 Gene

mRNA differential expression in normal tissues according to GTEx for HSPB8 Gene

This gene is overexpressed in Muscle - Skeletal (x7.3) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for HSPB8 Gene

This gene is overexpressed in Cervix (23.8), Placenta (7.1), and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPB8 Gene

SOURCE GeneReport for Unigene cluster for HSPB8 Gene Hs.400095

mRNA Expression by UniProt/SwissProt for HSPB8 Gene

Tissue specificity: Predominantly expressed in skeletal muscle and heart.
genes like me logo Genes that share expression patterns with HSPB8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HSPB8 Gene

Orthologs for HSPB8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPB8 35
  • 90.48 (n)
  • 95.92 (a)
HSPB8 36
  • 96 (a)
(Canis familiaris)
Mammalia HSPB8 35
  • 90.31 (n)
  • 93.88 (a)
HSPB8 36
  • 93 (a)
(Mus musculus)
Mammalia Hspb8 35
  • 87.24 (n)
  • 94.39 (a)
Hspb8 16
Hspb8 36
  • 94 (a)
(Pan troglodytes)
Mammalia HSPB8 35
  • 99.66 (n)
  • 100 (a)
HSPB8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hspb8 35
  • 88.61 (n)
  • 95.41 (a)
(Monodelphis domestica)
Mammalia HSPB8 36
  • 66 (a)
(Gallus gallus)
Aves HSPB8 35
  • 71.26 (n)
  • 69.9 (a)
HSPB8 36
  • 70 (a)
(Anolis carolinensis)
Reptilia HSPB8 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspb8 35
  • 64.29 (n)
  • 66.33 (a)
Str.13095 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64408 35
(Danio rerio)
Actinopterygii hspb8 35
  • 62.34 (n)
  • 62.16 (a)
wufc09c11 35
hspb8 36
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.195 36
  • 33 (a)
Species with no ortholog for HSPB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB8 Gene

Gene Tree for HSPB8 (if available)
Gene Tree for HSPB8 (if available)

Paralogs for HSPB8 Gene

(3) SIMAP similar genes for HSPB8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPB8: view

Variants for HSPB8 Gene

Sequence variations from dbSNP and Humsavar for HSPB8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_018504 Neuronopathy, distal hereditary motor, 2A (HMN2A)
VAR_018505 Charcot-Marie-Tooth disease 2L (CMT2L)
VAR_018505 Neuronopathy, distal hereditary motor, 2A (HMN2A)
VAR_042244 A glioblastoma multiforme sample
rs55826713 - 119,179,545(+) CGCCA(G/T)GTTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HSPB8 Gene

Variant ID Type Subtype PubMed ID
nsv902 CNV Loss 18451855
nsv899550 CNV Gain 21882294

Variation tolerance for HSPB8 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPB8 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB8 Gene

Disorders for HSPB8 Gene

MalaCards: The human disease database

(17) MalaCards diseases for HSPB8 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neuropathy, distal hereditary motor, type iia
  • distal hereditary motor neuronopathy, type iia
charcot-marie-tooth disease, axonal, type 2l
  • charcot-marie-tooth disease, type 2i
charcot-marie-tooth disease type 2l
  • charcot-marie-tooth disease, type 2i
distal hereditary motor neuropathy, type ii
  • spinal muscular atrophy, jerash type
charcot-marie-tooth hereditary neuropathy
  • charcot-marie-tooth disease
- elite association - COSMIC cancer census association via MalaCards
Search HSPB8 in MalaCards View complete list of genes associated with diseases


  • Charcot-Marie-Tooth disease 2L (CMT2L) [MIM:608673]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. {ECO:0000269 PubMed:15565283}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Neuronopathy, distal hereditary motor, 2A (HMN2A) [MIM:158590]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. {ECO:0000269 PubMed:15122253}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HSPB8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPB8: view

No data available for Genatlas for HSPB8 Gene

Publications for HSPB8 Gene

  1. A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells. (PMID: 10833516) Smith C.C. … Aurelian L. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. (PMID: 19845507) Fuchs M. … Landry J. (Biochem. J. 2010) 3 23
  3. Structure, properties, and functions of the human small heat-shock protein HSP22 (HspB8, H11, E2IG1): a critical review. (PMID: 17722063) Shemetov A.A. … Gusev N.B. (J. Neurosci. Res. 2008) 3 23
  4. Phosphorylation by cyclic AMP-dependent protein kinase inhibits chaperone-like activity of human HSP22 in vitro. (PMID: 18298377) Shemetov A.A. … Gusev N.B. (Biochemistry Mosc. 2008) 3 23
  5. Effect of mutations in the beta5-beta7 loop on the structure and properties of human small heat shock protein HSP22 (HspB8, H11). (PMID: 17922839) Kasakov A.S. … Gusev N.B. (FEBS J. 2007) 3 23

Products for HSPB8 Gene

Sources for HSPB8 Gene