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Aliases for HSPB8 Gene

Aliases for HSPB8 Gene

  • Heat Shock 22kDa Protein 8 2 3
  • E2IG1 3 4 6
  • Small Stress Protein-Like Protein HSP22 3 4
  • Heat Shock 27kDa Protein 8 2 3
  • E2-Induced Gene 1 Protein 3 4
  • Alpha-Crystallin C Chain 3 4
  • Protein Kinase H11 3 4
  • CMT2L 3 6
  • DHMN2 3 6
  • HMN2A 3 6
  • HSP22 3 4
  • H11 3 6
  • Heat Shock Protein Beta-8 3
  • CRYAC 4
  • HspB8 4
  • HMN2 3

External Ids for HSPB8 Gene

Previous GeneCards Identifiers for HSPB8 Gene

  • GC12P118028
  • GC12P118079
  • GC12P119616
  • GC12P116624

Summaries for HSPB8 Gene

Entrez Gene Summary for HSPB8 Gene

  • The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPB8 Gene

HSPB8 (Heat Shock 22kDa Protein 8) is a Protein Coding gene. Diseases associated with HSPB8 include charcot-marie-tooth disease, axonal, type 2l and neuropathy, distal hereditary motor, type iia. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is CRYAA.

UniProtKB/Swiss-Prot for HSPB8 Gene

  • Displays temperature-dependent chaperone activity

Gene Wiki entry for HSPB8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB8 Gene

Genomics for HSPB8 Gene

Regulatory Elements for HSPB8 Gene

Genomic Location for HSPB8 Gene

119,178,642 bp from pter
119,221,131 bp from pter
42,490 bases
Plus strand

Genomic View for HSPB8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB8 Gene

Proteins for HSPB8 Gene

  • Protein details for HSPB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-8
    Protein Accession:
    Secondary Accessions:
    • B2R6A6
    • Q6FIH3
    • Q9UKS3

    Protein attributes for HSPB8 Gene

    196 amino acids
    Molecular mass:
    21604 Da
    Quaternary structure:
    • Monomer. Interacts with HSPB1. Interacts with DNAJB6.

neXtProt entry for HSPB8 Gene

Proteomics data for HSPB8 Gene at MOPED

Post-translational modifications for HSPB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HSPB8 (HSPB8)

No data available for DME Specific Peptides for HSPB8 Gene

Domains for HSPB8 Gene

Gene Families for HSPB8 Gene

Protein Domains for HSPB8 Gene

Suggested Antigen Peptide Sequences for HSPB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB8: view

Function for HSPB8 Gene

Molecular function for HSPB8 Gene

UniProtKB/Swiss-Prot Function:
Displays temperature-dependent chaperone activity
UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol

Gene Ontology (GO) - Molecular Function for HSPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 NOT protein kinase activity IDA 14985082
GO:0005515 protein binding IPI 14594798
GO:0042802 identical protein binding IPI 14594798
genes like me logo Genes that share ontologies with HSPB8: view
genes like me logo Genes that share phenotypes with HSPB8: view

Animal Models for HSPB8 Gene

MGI Knock Outs for HSPB8:

Animal Model Products

miRNA for HSPB8 Gene

miRTarBase miRNAs that target HSPB8

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HSPB8 Gene

Localization for HSPB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB8 Gene

Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.

Subcellular locations from

Jensen Localization Image for HSPB8 Gene COMPARTMENTS Subcellular localization image for HSPB8 gene
Compartment Confidence
nucleus 5
cytosol 3
chloroplast 2
cytoskeleton 1
extracellular 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HSPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA 19464326
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with HSPB8: view

Pathways for HSPB8 Gene

SuperPathways for HSPB8 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HSPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress --
GO:0008150 biological_process ND --
GO:0008219 cell death --
genes like me logo Genes that share ontologies with HSPB8: view

No data available for Pathways by source for HSPB8 Gene

Drugs for HSPB8 Gene

(1) Novoseek inferred chemical compound relationships for HSPB8 Gene

Compound -log(P) Hits PubMed IDs
glycogen 15.6 1
genes like me logo Genes that share compounds with HSPB8: view

Transcripts for HSPB8 Gene

mRNA/cDNA for HSPB8 Gene

Unigene Clusters for HSPB8 Gene

Heat shock 22kDa protein 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB8 Gene

No ASD Table

Relevant External Links for HSPB8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB8 Gene

mRNA expression in normal human tissues for HSPB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPB8 Gene

This gene is overexpressed in Muscle - Skeletal (7.3) and Heart - Left Ventricle (4.5).

Protein differential expression in normal tissues for HSPB8 Gene

This gene is overexpressed in Cervix (23.8), Placenta (7.1), and Heart (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPB8 Gene

SOURCE GeneReport for Unigene cluster for HSPB8 Gene Hs.400095

mRNA Expression by UniProt/SwissProt for HSPB8 Gene

Tissue specificity: Predominantly expressed in skeletal muscle and heart.
genes like me logo Genes that share expressions with HSPB8: view

Primer Products

In Situ Assay Products

No data available for Expression partners for HSPB8 Gene

Orthologs for HSPB8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPB8 35
  • 90.48 (n)
  • 95.92 (a)
HSPB8 36
  • 96 (a)
(Canis familiaris)
Mammalia HSPB8 35
  • 90.31 (n)
  • 93.88 (a)
HSPB8 36
  • 93 (a)
(Mus musculus)
Mammalia Hspb8 35
  • 87.24 (n)
  • 94.39 (a)
Hspb8 16
Hspb8 36
  • 94 (a)
(Pan troglodytes)
Mammalia HSPB8 35
  • 99.66 (n)
  • 100 (a)
HSPB8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hspb8 35
  • 88.61 (n)
  • 95.41 (a)
(Monodelphis domestica)
Mammalia HSPB8 36
  • 66 (a)
(Gallus gallus)
Aves HSPB8 35
  • 71.26 (n)
  • 69.9 (a)
HSPB8 36
  • 70 (a)
(Anolis carolinensis)
Reptilia HSPB8 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspb8 35
  • 64.29 (n)
  • 66.33 (a)
Str.13095 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64408 35
(Danio rerio)
Actinopterygii hspb8 35
  • 62.34 (n)
  • 62.16 (a)
wufc09c11 35
hspb8 36
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.195 36
  • 33 (a)
Species with no ortholog for HSPB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB8 Gene

Gene Tree for HSPB8 (if available)
Gene Tree for HSPB8 (if available)

Paralogs for HSPB8 Gene

Paralogs for HSPB8 Gene

(3) SIMAP similar genes for HSPB8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPB8: view

Variants for HSPB8 Gene

Sequence variations from dbSNP and Humsavar for HSPB8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11038 -- 119,194,502(+) ATCTG(A/G)CCTAG utr-variant-3-prime
rs1133026 -- 119,194,542(+) AAGTC(A/G)GGATT utr-variant-3-prime
rs1966544 -- 119,188,317(+) TGTCA(A/G)CTCAC intron-variant
rs2278181 -- 119,179,972(+) TTTAA(C/T)ATAAA intron-variant
rs2278182 -- 119,186,530(+) AGAAC(A/G)ACGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPB8 Gene

Variant ID Type Subtype PubMed ID
nsv902 CNV Loss 18451855
nsv899550 CNV Gain 21882294

Relevant External Links for HSPB8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB8 Gene

Disorders for HSPB8 Gene

(2) OMIM Diseases for HSPB8 Gene (608014)


  • Neuronopathy, distal hereditary motor, 2A (HMN2A) [MIM:158590]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. {ECO:0000269 PubMed:15122253}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Charcot-Marie-Tooth disease 2L (CMT2L) [MIM:608673]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. {ECO:0000269 PubMed:15565283}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for HSPB8 Gene

(5) Novoseek inferred disease relationships for HSPB8 Gene

Disease -log(P) Hits PubMed IDs
shock 67.6 21
neuromuscular diseases 60.7 2
cardiac hypertrophy 47.3 1
alzheimers disease 26.1 1
ischemia 0 1

Relevant External Links for HSPB8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HSPB8: view

No data available for Genatlas for HSPB8 Gene

Publications for HSPB8 Gene

  1. A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells. (PMID: 10833516) Smith C.C. … Aurelian L. (J. Biol. Chem. 2000) 2 3 4 23
  2. Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9. (PMID: 11470154) Kappe G. … de Jong W.W. (Biochim. Biophys. Acta 2001) 3 4 23
  3. Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. (PMID: 15122253) Irobi J. … Timmerman V. (Nat. Genet. 2004) 3 4 23
  4. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier A.H. … Aldaz C.M. (Cancer Res. 2000) 2 3 4
  5. Phosphorylation by cyclic AMP-dependent protein kinase inhibits chaperone-like activity of human HSP22 in vitro. (PMID: 18298377) Shemetov A.A. … Gusev N.B. (Biochemistry Mosc. 2008) 3 23

Products for HSPB8 Gene

  • Addgene plasmids for HSPB8

Sources for HSPB8 Gene

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